Comparative biological responses of rabbits infected with human T-lymphotropic virus type I isolates from patients with lymphoproliferative and neurodegenerative disease.

abstract：:A general concern exists that cervical cancer screening using human papillomavirus (HPV) testing may lead to considerable overtreatment. We evaluated the trade-off between benefits and overtreatment among different screening strategies differing by primary tests (cytology, p16/Ki-67, HPV alone or in combinations), int...

journal_title：International journal of cancer

authors： Sroczynski G,Esteban E,Widschwendter A,Oberaigner W,Borena W,von Laer D,Hackl M,Endel G,Siebert U

更新日期：2020-08-15 00:00:00

abstract：:Artemisia asiatica Nakai has been used in traditional Asian medicine for the treatment of inflammatory and other disorders. Previous studies have revealed that the formulated ethanol extract (DA-9601) of A. asiatica has pronounced antioxidative and antiinflammatory activities and exhibits cytoprotective effects agains...

journal_title：International journal of cancer

authors： Seo HJ,Park KK,Han SS,Chung WY,Son MW,Kim WB,Surh YJ

更新日期：2002-08-01 00:00:00

abstract：:In 584 consecutive patients with no previous history of cancer or polypectomy, 769 adenomas were excised endoscopically and classified retrospectively according to the following parameters: macroscopic growth pattern, size, histological type, grade of dysplasia, anatomical site, presence of adenocarcinoma (ADK), numbe...

journal_title：International journal of cancer

authors： Gatteschi B,Costantini M,Bruzzi P,Merlo F,Torcoli R,Nicolo G

更新日期：1991-10-21 00:00:00

abstract：:We have reported the establishment of a mitomycin-C (MMC)-resistant non-small-cell lung-cancer cell line, PC-9/MC4. As determined by an MTT assay, this resistant cell line was found to be 4 times more sensitive to adriamycin (ADM) than was the parental PC-9. There were no significant differences in sensitivity to etop...

journal_title：International journal of cancer

authors： Kasahara K,Shibata K,Bando T,Numata Y,Fujimura M,Matsuda T

更新日期：1994-10-15 00:00:00

abstract：:EPLIN is frequently downregulated or lost in various cancers. The purpose of this study was to evaluate the importance of EPLIN in prostate cancer progression, with particular focus on the mechanistic implications to elucidate EPLIN's tumor suppressive function in cancer. EPLIN expression was evaluated in prostate can...

journal_title：International journal of cancer

authors： Collins RJ,Morgan LD,Owen S,Ruge F,Jiang WG,Sanders AJ

更新日期：2018-11-15 00:00:00

abstract：:Peripheral blood lymphocytes from 32 patients with malignant melanoma were tested for cell-mediated cytotoxicity (CMC) against cultured autologous melanoma cells. Effector cells were prepared from venous blood by defibrination, gel sedimentation, nylon column filtration, and lysis of remaining erythrocytes with NH4Cl....

journal_title：International journal of cancer

authors： Livingston PO,Shiku H,Bean MA,Pinsky CM,Oettgen HF,Old LJ

更新日期：1979-07-15 00:00:00

abstract：:Trends in the incidence of stomach cancer among 52,604 patients notified to the National Swedish Cancer Registry in 1960 through 1984 were analysed. Age-standardized incidence rates declined throughout the period, from 47.1 to 24.6 per 10(5) in males and from 23.8 to 12.7 per 10(5) in females. Among males the decline ...

journal_title：International journal of cancer

authors： Hansson LE,Bergström R,Sparén P,Adami HO

更新日期：1991-02-20 00:00:00

abstract：:Recent suggestions that tumor-cell targeting of elastin-rich tissues (e.g., lung) correlates with the presence of surface elastin receptors have been investigated. Receptors for insoluble (fibrous) elastin and for soluble elastin peptides have been implemented in these correlations. A rapid assay for binding of insolu...

journal_title：International journal of cancer

authors： Svitkina TM,Parsons DF

更新日期：1993-03-12 00:00:00

abstract：:Cancer vaccines directed against tumor associate antigen (TAA) have produced encouraging results in preclinical models but not in cancer patients. A major limitation of this strategy is the relative degree of tolerance to these antigens and the low and heterogeneous tumor cell expression of TAA and major histocompatib...

journal_title：International journal of cancer

authors： Correale P,Aquino A,Giuliani A,Pellegrini M,Micheli L,Cusi MG,Nencini C,Petrioli R,Prete SP,De Vecchis L,Turriziani M,Giorgi G,Bonmassar E,Francini G

更新日期：2003-04-20 00:00:00

abstract：:Aberrant cyclin expression has been implicated in oncogenesis in a number of human cancers. Since altered function of regulators of cyclin-dependent kinase (CDK) activity other than cyclins, in particular CDK inhibitors, might play a similar role in oncogenesis, we examined the expression and regulation of the CDK inh...

journal_title：International journal of cancer

authors： Musgrove EA,Lilischkis R,Cornish AL,Lee CS,Setlur V,Seshadri R,Sutherland RL

更新日期：1995-11-15 00:00:00

abstract：:As a key enzyme in folate metabolism, the thymidylate synthase (TS) is important for the synthesis of nucleotides. Its polymorphisms may affect the TS gene expression and the susceptibility for Fluoropyrimidine (FU)-based chemotherapies. In this study, we assessed the relationship between the TS genotypes and clinical...

journal_title：International journal of cancer

authors： Schwarzenbach H,Goekkurt E,Pantel K,Aust DE,Stoehlmacher J

更新日期：2010-08-15 00:00:00

abstract：:Mismatch repair-deficient (dMMR) and/or microsatellite instability-high (MSI) colorectal cancers (CRC) represent about 5% of metastatic CRC (mCRC). Prognosis and chemosensitivity of dMMR/MSI mCRC remain unclear. This multicenter study included consecutive patients with dMMR/MSI mCRC from 2007 to 2017. The primary endp...

journal_title：International journal of cancer

authors： Tougeron D,Sueur B,Zaanan A,de la Fouchardiére C,Sefrioui D,Lecomte T,Aparicio T,Des Guetz G,Artru P,Hautefeuille V,Coriat R,Moulin V,Locher C,Touchefeu Y,Lecaille C,Goujon G,Ferru A,Evrard C,Chautard R,Gentilhomme

更新日期：2020-07-01 00:00:00

abstract：:A population-based case-control study was performed to evaluate the risk of endometrial cancer related to tamoxifen or toremifene treatment. All patients with breast cancer diagnosis since 1980 in Finland who subsequently developed an endometrial cancer by the end of 1995 and 3 matched controls were identified among t...

journal_title：International journal of cancer

authors： Pukkala E,Kyyrönen P,Sankila R,Holli K

更新日期：2002-07-20 00:00:00

abstract：:Transforming growth factor-beta (TGFbeta1) enhances human MDA-MB-231 breast tumour cell invasion of reconstituted basement membrane in vitro but does not inhibit proliferation of this cell line. In contrast to basal invasion, which is plasmin-, urokinase (uPA)-, tissue-type plasminogen activator (t-PA)-, matrix metall...

journal_title：International journal of cancer

authors： Farina AR,Coppa A,Tiberio A,Tacconelli A,Turco A,Colletta G,Gulino A,Mackay AR

更新日期：1998-03-02 00:00:00

abstract：:The antineoplastic effect of paclitaxel is mainly related to its ability to bind the beta subunit of tubulin, thus preventing tubulin chain depolarization and inducing apoptosis. The relevance of the Class I beta-tubulin characteristics have also been confirmed in the clinical setting where mutations of paclitaxel-bin...

journal_title：International journal of cancer

authors： Tommasi S,Mangia A,Lacalamita R,Bellizzi A,Fedele V,Chiriatti A,Thomssen C,Kendzierski N,Latorre A,Lorusso V,Schittulli F,Zito F,Kavallaris M,Paradiso A

更新日期：2007-05-15 00:00:00

abstract：:The matrix metalloproteinase (MMP) family of proteins mediates various cellular pathways, including apoptosis and angiogenesis. Polymorphisms of MMP genes are associated with increased esophageal adenocarcinoma (EAC) risk. Gastroesophageal reflux disease (GERD) is an established EAC risk factor. We examined whether MM...

journal_title：International journal of cancer

authors： Cheung WY,Zhai R,Bradbury P,Hopkins J,Kulke MH,Heist RS,Asomaning K,Ma C,Xu W,Wang Z,Hooshmand S,Su L,Christiani DC,Liu G

更新日期：2012-12-01 00:00:00

abstract：:Our objective was to examine whether parental exposure to atomic bomb radiation has led to increased cancer and/or noncancer mortality rates among the offspring. We studied 41,010 subjects born from May 1946 through December 1984 (i.e., conceived between 1 month and 38 years after the bombings) and surviving for at le...

journal_title：International journal of cancer

authors： Izumi S,Suyama A,Koyama K

更新日期：2003-11-01 00:00:00

abstract：:PAX3 encodes a transcription factor, which with Zic1 is necessary for induction of the neural crest during early embryonic development. There are 7 human PAX3 isoforms (a-h). PAX3e is the full length isoform comprising 10 exons. PAX3c comprises 8 exons plus 5 codons of intron 8, while PAX3g has a truncated transactiva...

journal_title：International journal of cancer

authors： Wang Q,Kumar S,Mitsios N,Slevin M,Kumar P

更新日期：2007-03-15 00:00:00

abstract：:High epidermal growth factor (EGF) concentration (10(-8) M) induces inhibition of A431 cell proliferation, resulting in part from an apoptotic process. For some cells escaping this process, proliferation was associated with a decrease in apoptosis. Moreover, these surviving cells displayed marked morphological changes...

journal_title：International journal of cancer

authors： Smida Rezgui S,Honore S,Rognoni JB,Martin PM,Penel C

更新日期：2000-08-01 00:00:00

abstract：:Human lymphoblastoid interferon inhibited the growth in vitro of fibroblasts and epithelial cells from normal, hyperplastic and neoplastic human breast tissue. At an interferon concentration of 10(3) inter-national units (IU) per ml, the inhibitory effects on monolayer growth were completely reversible but the growth ...

journal_title：International journal of cancer

authors： Balkwill F,Watling D,Taylor-Papadimitriou J

更新日期：1978-09-15 00:00:00

abstract：:To evaluate the role of chromosome 13 deletions in oral squamous cell carcinoma (SCC) progression and to define the precise localization of putative tumor suppressor genes, we studied tumors from 34 unrelated patients with oral SCC by the polymerase chain reaction (PCR)-loss of heterozygosity (LOH) assay, using 18 dif...

journal_title：International journal of cancer

authors： Ogawara K,Miyakawa A,Shiba M,Uzawa K,Watanabe T,Wang XL,Sato T,Kubosawa H,Kondo Y,Tanzawa H

更新日期：1998-08-21 00:00:00

abstract：:Spontaneous tumor development and primary oncogenesis were compared in a large number of NK4-deficient, homozygous C57Bl/6-bg/bg mice and their NK normal, heterozygous +/bg littermate controls. In a group of 167 retired breeders followed for spontaneous tumors, the probability of survival for mice eventually dying wit...

journal_title：International journal of cancer

authors： Haliotis T,Ball JK,Dexter D,Roder JC

更新日期：1985-04-15 00:00:00

abstract：:Immunohistochemical and/or indirect immunofluorescence analysis with monoclonal antibody (MAb) H19 demonstrated the expression of protectin (CD59) in 54 surgically removed metastatic melanoma lesions and on 8 out of 12 melanoma cell lines. CD59 expression had a low degree of intra- and intertumor heterogeneity. SDS-PA...

journal_title：International journal of cancer

authors： Brasoveanu LI,Altomonte M,Gloghini A,Fonsatti E,Coral S,Gasparollo A,Montagner R,Cattarossi I,Simonelli C,Cattelan A

更新日期：1995-05-16 00:00:00

abstract：:Tumorigenic clonal lines derived from soft agar colonies induced by DMBA-transformed feline embryo cells were isolated and characterized. The morphologically altered clonal cells formed large aggregates, growing in this aggregate form when suspended in liquid growth medium above an agar base and forming colonies in so...

journal_title：International journal of cancer

authors： Rhim JS,Koh KS,Chen A,Essex M

更新日期：1981-07-15 00:00:00

abstract：:Our aim was to analyze the expression of the serine protease HtrA1 in human bladder tissue and urine in order to point out its possible association with the presence of urothelial bladder cancer. Bladder tissue and urine specimens from cancer patients with different tumor grades and stages (n = 68) and from individual...

journal_title：International journal of cancer

authors： Lorenzi T,Lorenzi M,Altobelli E,Marzioni D,Mensà E,Quaranta A,Paolinelli F,Morroni M,Mazzucchelli R,De Luca A,Procopio AD,Baldi A,Muzzonigro G,Montironi R,Castellucci M

更新日期：2013-12-01 00:00:00

abstract：:Microspheres containing cisplatin (CDDP) embedded in poly-d,l-lactic acid (PLA) and polyethylene glycol acid (CDDP-PPMS) were developed to improve treatment of malignant effusions. In vitro studies demonstrated that CDDP was released continuously for more than 4 weeks from CDDP-PPMS without initial burst. CDDP-PPMS wa...

journal_title：International journal of cancer

authors： Tokuda K,Natsugoe S,Shimada M,Kumanohoso T,Baba M,Takao S,Nakamura K,Yamada K,Yoshizawa H,Hatate Y,Aikou T

更新日期：1998-05-29 00:00:00

abstract：:In this study, a cell-penetrating peptide, the transactivating transcriptional factor (TAT) domain from HIV, was linked to a chitosan/doxorubicin (chitosan/DOX) conjugate to form a chitosan/DOX/TAT hybrid. The synthesized chitosan/DOX/TAT conjugate showed a different intracellular distribution pattern from a conjugate...

journal_title：International journal of cancer

authors： Lee JY,Choi YS,Suh JS,Kwon YM,Yang VC,Lee SJ,Chung CP,Park YJ

更新日期：2011-05-15 00:00:00

abstract：:Epstein-Barr virus (EBV) can be detected in Hodgkin and Reed-Sternberg (HRS) cells in about one-half of cases of Hodgkin's disease (HD) in Western countries. To determine whether EBV is also associated with HD in a developing country such as China, we studied paraffin sections from 28 Chinese cases of HD for expressio...

journal_title：International journal of cancer

authors： Zhou XG,Hamilton-Dutoit SJ,Yan QH,Pallesen G

更新日期：1993-09-30 00:00:00

abstract：:Residential proximity to electrical power lines of different voltage in relation to childhood leukemia was investigated through a case-control study undertaken in Greece during 1993-1994. The study comprised 117 incident cases of childhood leukemia and 202 age-, gender- and place-of-residence-matched controls. Four me...

journal_title：International journal of cancer

authors： Petridou E,Trichopoulos D,Kravaritis A,Pourtsidis A,Dessypris N,Skalkidis Y,Kogevinas M,Kalmanti M,Koliouskas D,Kosmidis H,Panagiotou JP,Piperopoulou F,Tzortzatou F,Kalapothaki V

更新日期：1997-11-04 00:00:00

abstract：:Recent analyses have suggested decreases over time in colorectal cancer incidence at older ages (≥55 years) but increases at younger ages (20-54 years). Understanding the geographic heterogeneity of incidence facilitates resource allocation for potential interventions and advances our knowledge of differential etiolog...

journal_title：International journal of cancer

authors： Chernyavskiy P,Kennerley VM,Jemal A,Little MP,Rosenberg PS

更新日期：2019-04-15 00:00:00