Abstract:
:Sprague-Dawley rats were given combinations of aminopyrine or oxytetracycline and sodium nitrite in drinking water. Of 30 animals receiving 0.1% (1,000 ppm) of aminopyrine and sodium nitrite for 30 weeks, 29 died with hemangioendothelial sarcomas of the liver. The same tumor caused death in 26 of 30 animals that received 0.025% (250 ppm) of both aminopyrine and sodium nitrite for 50 weeks. No animals in a control group of the same size that received 0.1% aminopyrine for 30 weeks developed this tumor, although one-half of them were still alive 2 years after the experiment was begun. After feeding a comparable dose (0.1%) of oxytetracycline and sodium nitrite for 60 weeks, liver tumors were present in 4 of 30 rats (3 hepatocellular tumors and 1 cholangioma). Since aminopyrine has been widely used for medicinal purposes in the human population, it is possible that many people have been exposed to a potent carcinogen (dimethylnitrosamine) by its formation in vivo. It is not certain whether the result of feeding oxytetracycline and sodium nitrite indicates significant carcinogenicity of this combination.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Taylor HW,Lijinsky Wdoi
10.1002/ijc.2910160203subject
Has Abstractpub_date
1975-08-15 00:00:00pages
211-5issue
2eissn
0020-7136issn
1097-0215journal_volume
16pub_type
杂志文章abstract::Infection with erbB-2 (E) of Ha-ras (H) oncogene-transfected cells has been previously shown to cooperatively induce anchorage-independent growth of the MCF10A human mammary epithelial cell line in vitro, but not to induce nude mouse tumorigenicity. Here we show that oncogene-transformed MCF10A are able to halt in the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910630612
更新日期:1995-12-11 00:00:00
abstract::Clinical trials utilizing strategies to manipulate tumor oxygenation, blood flow and angiogenesis are under way, although limited quantitative information exists regarding basic tumor pathophysiology. The current study utilized murine KHT fibrosarcomas, spontaneous mammary carcinomas and first-generation spontaneous t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1401
更新日期:2001-09-01 00:00:00
abstract::Oncogenic HPV types are the major cause of worldwide cervical cancer, but only a small proportion of infected women will develop high-grade cervical intraepithelial neoplasia or cancer (CIN2/3+). We performed a prospective study including 781 women with normal, atypical squamous cells of undetermined significance (ASC...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11222
更新日期:2003-09-01 00:00:00
abstract::Integrins are extracellular matrix receptors involved in tumour invasion and angiogenesis. Although there is evidence that inhibiting integrins might enhance the efficiency of radiotherapy, little is known about the exact mechanisms involved in the integrin-dependent modulation of tumor radiosensitivity. The purpose o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23498
更新日期:2008-07-15 00:00:00
abstract::The presence of carcinogen-DNA adducts in human tissues is evidence of exposure to carcinogens and may be an indicator of cancer risk. DNA was isolated from non-tumorous bronchial tissue of 37 cigarette smokers, 8 former smokers and 8 non-smokers and analyzed for the presence of aromatic and/or hydrophobic DNA adducts...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910460403
更新日期:1990-10-15 00:00:00
abstract::We have previously shown that AEV infection of leukosis-free chickens provokes an erythroleukemia in the infected birds, and that the target cell for virus transformation is most likely an early pro-erythroblast comparable to the BFU-E. The virus infection correlates with a block in differentiation which was studied a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290511
更新日期:1982-05-15 00:00:00
abstract::A G to T mutation at nucleotide position 2128 in the human FGFR3b coding region resulting in a Cys for Gly substitution (G697C) in the tyrosine kinase domain was observed in 62% (44/71) of oral squamous cell carcinomas (OSCC) examined. Immunostained FGFR3b was found in the cytoplasm of prickle cells in normal epitheli...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21145
更新日期:2005-10-20 00:00:00
abstract::A gene product (p42) of the long open reading frame, now termed tax, of the viral genome of human T-cell leukemia virus type I (HTLV-I) may be related to the transformation of T cells in adult T-cell leukemia-lymphoma (ATLL). To evaluate its association with the disease, we compared the prevalence of antibody to p42 i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430603
更新日期:1989-06-15 00:00:00
abstract::The hedgehog (Hh) signaling pathway is essential for the development of tissues and organs. Hyperactive Hh signaling has been implicated in many gastric cancers, including esophageal cancer. However, the interaction between the Hh pathway and other potential signaling pathways in primary esophageal tumorigenesis has n...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25673
更新日期:2011-07-15 00:00:00
abstract::Variants of human papillomavirus (HPV) type 31 have been shown to be related both to risk of cervical lesions and racial composition of a population. It is largely undetermined whether variants differ in their likelihood of persistence. Study subjects were women who participated in the ASCUS-LSIL Triage Study and who ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27689
更新日期:2013-02-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma is among the top 10 causes of death from cancer in industrialized countries. In comparison with other gastrointestinal malignancies, pancreatic cancer is one of the tumors most resistant to chemotherapy. An important mechanism of tumor multidrug resistance is increased drug efflux medi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20831
更新日期:2005-06-20 00:00:00
abstract::The association between the consumption of preserved foods in infancy, childhood and adulthood and the risk of nasopharyngeal carcinoma was investigated in a case-control study among Singapore Chinese: 200 cases (73% male) were compared with 406 hospital controls (71% male). Significantly increased risks were observed...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910590502
更新日期:1994-12-01 00:00:00
abstract::In the perspective of in vivo therapeutic applications, the monoclonal antibody (MAb) MOv18 was selected for its restricted reactivity with human ovarian carcinoma. Using the pH 2.8 desorption assay, we found that the antigen recognized by MOv18 had a high stability on the cell membrane and poor internalization. There...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410422
更新日期:1988-04-15 00:00:00
abstract::The family of protein kinases includes many oncogenes and growth-factor receptors, as well as genes that are involved in cell-cycle regulation. We have identified protein kinases expressed in a human breast-cancer cell line, 600PEI, and a primary human breast carcinoma, using PCR cloning techniques based on consensus ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910540409
更新日期:1993-06-19 00:00:00
abstract::Human papillomavirus (HPV) is detected in nearly all cervical cancers and approximately half of vaginal cancers. However, vaginal cancer is an order of magnitude less common than cervical cancer, not only in the general population but also among women with HIV/AIDS. It is interesting therefore that recent studies foun...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27363
更新日期:2012-09-15 00:00:00
abstract::Targeting the GA733 antigen (also known as CO17-1A, EGP, KS1-4, KSA, Ep-CAM) by monoclonal antibody CO17-1A or anti-idiotypic antibodies mimicking the CO17-1A or GA733 epitope has induced prolonged survival and specific immune responses to the antigen, respectively, in colorectal cancer (CRC) patients. In pre-clinical...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:2001-04-01 00:00:00
abstract::Our previous study has suggested that the cell cycle-related kinase (CCRK) is a putative candidate oncogene in glioblastoma tumorigenesis. The potential oncogenic role of CCRK and its clinical/prognostic significance, however, in ovarian carcinoma are unclear. In this study, CCRK expression was examined by immunohisto...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24630
更新日期:2009-12-01 00:00:00
abstract::Four human colon cancer cell lines (SW620, LS 180, DLD-I, and HCT-15) and Adriamycin-resistant sub-lines with varying degrees of P-glycoprotein expression were studied to evaluate the reversibility of Adriamycin resistance in human colon cancer. Two groups of cell lines were studied. In the first, including a series o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490512
更新日期:1991-11-11 00:00:00
abstract::APC10.1 is a new intestinal cell line derived from ApcMin/+ mice that retains both the heterozygous Apc genotype and a nonactivated Wnt signaling pathway and displays an early neoplastic phenotype. Although tumorigenic both in immunodepressed and in immunocompetent syngeneic mice, it requires a high cell dose and a lo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11690
更新日期:2004-03-20 00:00:00
abstract::It has been debated whether the reported increased risk of Hodgkin's lymphoma (HL) after tonsillectomy could be due to some underlying factor rather than the surgery itself. We studied whether not only tonsillectomy but also tonsillitis was associated with HL. This nationwide cohort study included all Danish residents...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24973
更新日期:2010-08-01 00:00:00
abstract::The Swedish Family-Cancer Database was used to analyze second cancers after oral, esophageal, rectal, cervical, genital and skin (squamous cell carcinoma) cancers. A strong and consistent association of second cancers was observed at all these sites, in men and women. As a novel finding, an association of rectal cance...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1319
更新日期:2001-07-15 00:00:00
abstract::Membrane-type metalloproteinase-1 (MT1-MMP) is a transmembrane metalloproteinase overexpressed in tumors, which plays a major role in the first step of pro-MMP-2 activation, leading to the generation of an intermediate 62 kDa species. The second step of MMP-2 activation that yields to the mature form is less understoo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10134
更新日期:2002-03-01 00:00:00
abstract::Thymidylate synthase (TYMS) is an important enzyme for 5-fluorouracil (5-FU) metabolism in metastatic colorectal cancer (mCRC) patients. The search for this enzyme in circulating tumor cells (CTCs) can be a powerful tool to follow-up cancer patients. mCRC patients were enrolled before the beginning of 5-FU-based chemo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29495
更新日期:2015-09-15 00:00:00
abstract::PCNA and esophagin have been implicated in the multistep process of carcinogenesis, but simultaneous characterization of these proteins in the early stages of esophageal neoplastic progression has yet to be undertaken. In morphologically normal esophageal epithelium, esophagin stains the granular layer cells, principa...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20267
更新日期:2004-09-01 00:00:00
abstract::A glucuronide doxorubicin prodrug N-[4-doxorubicin-N-carbonyl (oxymethyl) phenyl] O-beta-glucuronyl carbamate (DOX-GA3) has been developed to improve the antitumor effects of doxorubicin (DOX). The prodrug was originally designed to be activated into drug by human beta-glucuronidase (GUS) released from tumor cells in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(200002)9999:9999<::aid-ijc1075>3
更新日期:2001-02-15 00:00:00
abstract::By centrifuging total cellular DNA derived from human genital warts (condylomata acuminata) in CsCl-ethidium bromide gradients, supercoiled DNA was isolated. The molecular weight of this DNA was determined by agarose gel electrophoresis and amounted to 5.1 X 10(4). This DNA isolated from an individual genital wart was...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910250509
更新日期:1980-05-15 00:00:00
abstract::Transferrin is required for proliferation of most cells in culture. This effect is presumably mediated by the binding of transferrin to its receptor, a surface glycoprotein which is preferentially expressed by actively growing cells. Here we show that normal human fibroblasts cultured in serum, and other media contain...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910310118
更新日期:1983-01-15 00:00:00
abstract::Multiple myeloma (MM) is the second most common hematologic malignancy characterized by the clonal expansion of plasma cells. Despite continuing advances, novel biomarkers are needed for diagnosis and prognosis of MM. In our study, we characterized the diagnostic and prognostic potential of circulating microRNAs (miRN...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29199
更新日期:2015-04-15 00:00:00
abstract::Peripheral or tonsil lymphocyte populations of EBV-seropositive donors give rise to EBV-carrying LCLs upon in vitro explantation. Such lines can arise either by a 2-step mechanism, namely release of virus from some of the explanted cells followed by infection of previously uninfected B cells, or by direct outgrowth of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390411
更新日期:1987-04-15 00:00:00
abstract::The sensitivity of human tissues and tumors to infection with type C adenoviruses correlates with the expression of the human coxsackie B- and adenovirus receptor, hCAR. HCAR is heterogeneously expressed in various tissues and types of human cancer cells, which has implications for the use of adenoviruses as vectors i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10891
更新日期:2003-03-01 00:00:00