Fifty years of cancer incidence: CI5 I-IX.

abstract：:We have previously reported that losses of genomic material from the long arm of chromosome 18 are frequent in atypical and anaplastic meningiomas but rare in benign meningiomas. In the present study, we have investigated a series of 37 meningiomas for mutation and expression of 4 tumor suppressor genes (MADH2, MADH4,...

journal_title：International journal of cancer

authors： Büschges R,Boström J,Wolter M,Blaschke B,Weber RG,Lichter P,Collins VP,Reifenberger G

更新日期：2001-05-15 00:00:00

abstract：:The effects of galanin on pancreatic carcinogenesis induced by azaserine and on the norepinephrine concentration in the pancreas were investigated in male Wistar rats. Rats were given weekly injections of 10 mg/kg body weight of azaserine for 25 weeks and 8 microg/kg body weight of galanin in depot form every other da...

journal_title：International journal of cancer

authors： Iishi H,Tatsuta M,Baba M,Yano H,Iseki K,Uehara H,Nakaizumi A

更新日期：1998-01-30 00:00:00

abstract：:Fibronectin in human solid tumors was studied by indirect immunofluorescence staining of biopsy material. Altogether 73 tumors were examined, comprising 12 sarcomas, 3 melanomas 1 reticulum cell sarcoma, 39 carcinomas, 6 benign soft-tissue tumors and 12 benign epithelial tumors. In all sarcomas the individual tumor ce...

journal_title：International journal of cancer

authors： Stenman S,Vaheri A

更新日期：1981-01-01 00:00:00

abstract：:Allogeneic mixed leukocytes reaction has been reported to activate vast numbers of T lymphocytes and produce large amounts of type 1 cytokines that are linked to an initiation of antitumor immunity. Using poor immunogeneic B16-F10 and Lewis lung carcinoma (LLC) tumor model, we evaluated the effects of inactivated allo...

journal_title：International journal of cancer

authors： Su X,Guo S,Zhou C,Wang D,Ma W,Zhang S

更新日期：2009-03-01 00:00:00

abstract：:Lymphoma EL-4 of B6 origin was inoculated into lethally-irradiated syngeneic B6 or resistant BD2F1 hybrid recipients. Marked impairment of lymphoma cell proliferation (i.e. hybrid resistance, HR) occurred in the spleen but not in the liver or lung of BD2F1 hosts. Treatment with DTIC at the optimal dose of 80 mg/kg i.p...

journal_title：International journal of cancer

authors： Iorio AM,Neri M,Enrico P,Goldin A,Bonmassar E

更新日期：1981-10-15 00:00:00

abstract：:We have previously reported a complete allelotype study of 86 primary breast carcinomas, in which each non-acrocentric chromosome arm was studied with at least one polymorphic DNA-marker for the presence of allelic imbalance (AI, allelic loss or allelic gain) in the tumor. Here we report the statistical analysis of th...

journal_title：International journal of cancer

authors： Cornelisse CJ,Kuipers-Dijkshoorn N,van Vliet M,Hermans J,Devilee P

更新日期：1992-02-20 00:00:00

abstract：:Epithelial ovarian cancer is the most lethal gynecological malignancy and the fifth leading cause of cancer deaths in women in the Western world. ETS transcription factors are known to act as positive or negative regulators of the expression of genes that are involved in various biological processes, including those t...

journal_title：International journal of cancer

authors： Llauradó M,Abal M,Castellví J,Cabrera S,Gil-Moreno A,Pérez-Benavente A,Colás E,Doll A,Dolcet X,Matias-Guiu X,Vazquez-Levin M,Reventós J,Ruiz A

更新日期：2012-04-01 00:00:00

abstract：:Commercial cow milk contains considerable amounts of estrogens. Our study assessed the effect of commercial low-fat milk on the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats. Eighty 6-week-old female Sprague-Dawley rats received a single oral dose of 5 mg DMBA. Twenty-four hours l...

journal_title：International journal of cancer

authors： Qin LQ,Xu JY,Wang PY,Ganmaa D,Li J,Wang J,Kaneko T,Hoshi K,Shirai T,Sato A

更新日期：2004-07-01 00:00:00

abstract：:Human papillomavirus (HPV) has been identified as a causative agent of cervical cancer and oropharyngeal cancer (OPC). Intriguingly, estrogen and HPV were shown to play synergistic roles in cervical carcinogenesis. We recently demonstrated that the apolipoprotein B mRNA-editing catalytic polypeptide 3 (APOBEC3, A3) fa...

journal_title：International journal of cancer

authors： Kano M,Kondo S,Wakisaka N,Wakae K,Aga M,Moriyama-Kita M,Ishikawa K,Ueno T,Nakanishi Y,Hatano M,Endo K,Sugimoto H,Kitamura K,Muramatsu M,Yoshizaki T

更新日期：2019-09-15 00:00:00

abstract：:By means of a chemical extraction procedure and confocal laser scanning microscopy, we investigated the kinetic patterns of uptake and biolocalization of 5-aminolevulinic acid (ALA)-induced porphyrins in s.c. transplanted tumors, adjacent normal skin and muscle, and liver of mice bearing mammary carcinoma, after i.p. ...

journal_title：International journal of cancer

authors： Peng Q,Moan J,Warloe T,Nesland JM,Rimington C

更新日期：1992-09-30 00:00:00

abstract：:The irregular vasculature and high interstitial pressure of solid tumors hinder the delivery of cytotoxic agents to cancer cells. As a consequence, the doses of chemotherapy necessary to achieve complete tumor eradication are associated with unacceptably high toxicities. The selective thrombosis of tumor blood vessels...

journal_title：International journal of cancer

authors： Fabbrini M,Trachsel E,Soldani P,Bindi S,Alessi P,Bracci L,Kosmehl H,Zardi L,Neri D,Neri P

更新日期：2006-04-01 00:00:00

abstract：:AKR-2B mouse fibroblasts were treated with 50 micrograms/ml of crude transforming growth factor (TGF) of human origin. Cell surface proteins of treated cells were radioiodinated and compared to untreated cells at various times after the addition of TGF. Treated cells showed a severalfold increase (approximately 6-fold...

journal_title：International journal of cancer

authors： Marks ME,Brattain MG

更新日期：1984-01-15 00:00:00

abstract：:A variety of analytical approaches have indicated that melanoma cell line UCLA-SO-M14 (M14) and breast carcinoma cell line MDA-MB-435 originate from a common donor. This indicates that at some point in the past, one of these cell lines became misidentified, meaning that it ceased to correspond to the reported donor an...

journal_title：International journal of cancer

authors： Korch C,Hall EM,Dirks WG,Ewing M,Faries M,Varella-Garcia M,Robinson S,Storts D,Turner JA,Wang Y,Burnett EC,Healy L,Kniss D,Neve RM,Nims RW,Reid YA,Robinson WA,Capes-Davis A

更新日期：2018-02-01 00:00:00

abstract：:ET-743, an experimental antitumor drug with promising activity in sarcoma, breast and ovarian carcinoma, is currently under phase 2 clinical evaluation. It is hepatotoxic in animals and patients. We tested the hypothesis that indole-3-carbinol (I3C), the hydrolysis product of glucosinolates occurring in cruciferous ve...

journal_title：International journal of cancer

authors： Donald S,Verschoyle RD,Greaves P,Colombo T,Zucchetti M,Falcioni C,Zaffaroni M,D'Incalci M,Manson MM,Jimeno J,Steward WP,Gescher AJ

更新日期：2004-10-10 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a tumour classification that is defined by oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 receptor negativity. TNBCs share a similar gene expression profile to BRCA-mutated tumours, have been shown to carry a high proportion of BRCA mutati...

journal_title：International journal of cancer

authors： Wong-Brown MW,Avery-Kiejda KA,Bowden NA,Scott RJ

更新日期：2014-01-15 00:00:00

abstract：:Breast cancer can be classified into molecular sub-types that have distinct survival patterns. We evaluated the prognostic significance of breast cancer sub-types in a cohort of women taking part in the NEAT and BR9601 clinical trials comparing cyclophosphamide, methotrexate and fluorouracil (CMF) with ECMF (epirubici...

journal_title：International journal of cancer

authors： Ali AM,Provenzano E,Bartlett JM,Abraham J,Driver K,Munro AF,Twelves C,Poole CJ,Hiller L,Dunn JA,Earl HM,Caldas C,Pharoah PD

更新日期：2013-09-15 00:00:00

abstract：:To better understand the molecular basis of radiation-induced osteosarcoma (OS), we performed global gene expression profiling of rat OS tumors induced by the bone-seeking alpha emitter (238)Pu, and the expression profiles were compared with those of normal osteoblasts (OB). The expressions of 72 genes were significan...

journal_title：International journal of cancer

authors： Daino K,Ugolin N,Altmeyer-Morel S,Guilly MN,Chevillard S

更新日期：2009-08-01 00:00:00

abstract：:The enzyme alpha1,3galactosyltransferase synthesizes the alphaGal epitope, a carbohydrate structure (Galalpha1,3Galbeta1,4GlcNAc-R), on glycoconjugates in lower mammals. The enzyme is absent in humans but large amounts of natural antibodies that recognize alphaGal epitopes are present in human serum. It is likely that...

journal_title：International journal of cancer

authors： Aubert M,Crotte C,Bernard JP,Lombardo D,Sadoulet MO,Mas E

更新日期：2003-12-20 00:00:00

abstract：:G-banding analyses of 14 independently derived B-cell lymphomas showed the frequent occurrence of chromosome 15 trisomy. It was present in seven of nine spontaneous B-cell lymphomas, but in company with other trisomies, monosomies and marker chromosomes. In five carcinogen-induced primary B-cell leukemias, trisomy 15 ...

journal_title：International journal of cancer

authors： Wiener F,Babonits M,Spira J,Bregula U,Klein G,Merwin RM,Asofsky R,Lynes M,Haughton G

更新日期：1981-01-15 00:00:00

abstract：:CDKN2A (p16) disruption is reported as a frequent event in head and neck squamous cell carcinomas that confers poor prognosis. We investigated the frequency of different potential mechanisms of CDKN2A inactivation in oral tongue squamous cell carcinomas (OTSCC) and their impact on patient outcome. From a cohort of 153...

journal_title：International journal of cancer

authors： Lim AM,Do H,Young RJ,Wong SQ,Angel C,Collins M,Takano EA,Corry J,Wiesenfeld D,Kleid S,Sigston E,Lyons B,Fox SB,Rischin D,Dobrovic A,Solomon B

更新日期：2014-08-15 00:00:00

abstract：:The variable domain of functional heavy chain antibodies (VHH) devoid of light chains, found in camels, constitute the smallest intact antigen-binding domain fragment. Two camel single-domain fragments, cAb-Lys2 and cAb-Lys3, recognizing an overlapping epitope of lysozyme with a dissociation constant of 2 nM and 65 nM...

journal_title：International journal of cancer

authors： Cortez-Retamozo V,Lauwereys M,Hassanzadeh Gh G,Gobert M,Conrath K,Muyldermans S,De Baetselier P,Revets H

更新日期：2002-03-20 00:00:00

abstract：:Cancer initiation is presumed to occur in utero for many childhood cancers and it has been hypothesized that advanced paternal age may have an impact due to the increasing number of mutations in the sperm DNA with increasing paternal age. We examined the association between paternal age and specific types of childhood...

journal_title：International journal of cancer

authors： Urhoj SK,Raaschou-Nielsen O,Hansen AV,Mortensen LH,Andersen PK,Nybo Andersen AM

更新日期：2017-06-01 00:00:00

abstract：:Aberrant DNA methylation, microsatellite instability (MSI) and chromosomal instability (CIN) are well-characterised molecular features of sporadic colorectal cancers (CRCs). In addition to CpG island methylator phenotype (CIMP) associated with MSI, an intermediate methylation subgroup is also a feature of non-MSI canc...

journal_title：International journal of cancer

authors： Silver A,Sengupta N,Propper D,Wilson P,Hagemann T,Patel A,Parker A,Ghosh A,Feakins R,Dorudi S,Suraweera N

更新日期：2012-03-01 00:00:00

abstract：:Our study directly compares the performance of liquid-based (LBC) and conventional cytology for detecting high-grade cervical intraepithelial neoplasia and cancer (CIN 2+) in high-risk, previously unscreened women. As part of a larger randomized clinical trial assessing the efficacy and safety of a "screen and treat" ...

journal_title：International journal of cancer

authors： Taylor S,Kuhn L,Dupree W,Denny L,De Souza M,Wright TC Jr

更新日期：2006-02-15 00:00:00

abstract：:The correlation between tumorigenicity and cell-surface adhesiveness was investigated in eight mouse fibroblastoid cell lines. Four of the lines (Mc 11-Mc 15) were derived from mouse MC-induced fibrosarcomas, two were derivatives of L cells (A9, A9HT), and two (clone 3 and clone 7 H7F4) were obtained by fusion of A9HT...

journal_title：International journal of cancer

authors： Bubeník J,Perlmann P,Fenyö EM,Jandlová T,Suhajová E,Malkovský M

更新日期：1979-03-15 00:00:00

abstract：:Obesity has been postulated to increase the risk of colorectal cancer by mechanisms involving insulin resistance and the metabolic syndrome. We examined the associations of body mass index (BMI), waist circumference, the metabolic syndrome, metabolic obesity phenotypes and homeostasis model-insulin resistance (HOMA-IR...

journal_title：International journal of cancer

authors： Kabat GC,Kim MY,Stefanick M,Ho GYF,Lane DS,Odegaard AO,Simon MS,Bea JW,Luo J,Wassertheil-Smoller S,Rohan TE

更新日期：2018-08-01 00:00:00

abstract：:Postmenopausal hormone replacement therapy (HRT) was found to be associated with lower risk of colorectal cancer (CRC). However, little is known regarding associations with molecular subtypes of CRC. The current study includes female participants of a large German population-based case-control study (922 CRC cases and...

journal_title：International journal of cancer

authors： Amitay EL,Carr PR,Jansen L,Alwers E,Roth W,Herpel E,Kloor M,Bläker H,Chang-Claude J,Brenner H,Hoffmeister M

更新日期：2020-08-15 00:00:00

abstract：:Women diagnosed with cervical cancer report longer duration and more recent use of combined oral contraceptives (COCs). It is unclear whether COC use is associated with upstream events of human papillomavirus (HPV) infection prior to development of clinical disease. The objective of our study was to assess the associa...

journal_title：International journal of cancer

authors： Marks M,Gravitt PE,Gupta SB,Liaw KL,Kim E,Tadesse A,Phongnarisorn C,Wootipoom V,Yuenyao P,Vipupinyo C,Rugpao S,Sriplienchan S,Celentano DD

更新日期：2011-06-15 00:00:00

abstract：:Using a method optimized in hepatocellular carcinoma (HCC), we established patient-derived xenograft (PDX) models with an increased take rate (42.2%) and demonstrated that FBS +10% dimethyl sulfoxide exhibited the highest tumor take rate efficacy. Among 254 HCC patients, 103 stably transplantable xenograft lines that ...

journal_title：International journal of cancer

authors： Hu B,Li H,Guo W,Sun YF,Zhang X,Tang WG,Yang LX,Xu Y,Tang XY,Ding GH,Qiu SJ,Zhou J,Li YX,Fan J,Yang XR

更新日期：2020-03-15 00:00:00

abstract：:Primary cultures of rat microvascular endothelial cells were transformed, in vitro, by exposure to Rous sarcoma virus. Transformed cells were followed and evaluated cytogenetically through numerous passages. Highly specific karyotypic changes in karyotype (both structural and numerical) were documented. These changes ...

journal_title：International journal of cancer

authors： Tyrkus M,Diglio CA,Gohle N

更新日期：1983-10-15 00:00:00