Abstract：
:Some studies suggest a favorable role of antioxidants on breast cancer risk but this is still inconclusive. The aim of this study was to assess whether overall dietary antioxidant capacity, as assessed by dietary ferric reducing antioxidant potential (FRAP), and individual dietary antioxidant intake were associated with breast cancer risk. Data was used from women participating in the Rotterdam Study, a prospective cohort study among subjects aged 55 years and older (N = 3,209). FRAP scores and antioxidant intake (i.e., vitamin A, C, E, selenium, flavonoids and carotenoids) was assessed at baseline by a food frequency questionnaire. Incident cases of breast cancer were confirmed through medical reports. During a median follow-up of 17 years, 199 cases with breast cancer were identified. High dietary FRAP score was associated with a lower risk of breast cancer [hazard ratio (HR): 0.68; 95% confidence intervals (CI): 0.49, 0.96]. No overall association between individual antioxidant intake and breast cancer risk was found. However, low intake of alpha carotene and beta carotene was associated with a higher risk of breast cancer among smokers (HR: 2.48; 95% CI: 1.21, 5.12 and HR: 2.31; 95% CI: 1.12, 4.76 for alpha and beta carotene, respectively) and low intake of flavonoids was associated with breast cancer risk in women over the age of 70 (HR: 1.80; 95% CI: 1.09, 2.99). These results suggest that high overall dietary antioxidant capacity is associated with a lower risk of breast cancer. Individual effects of dietary carotenoids and dietary flavonoids may be restricted to subgroups such as smokers and elderly.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Pantavos A,Ruiter R,Feskens EF,de Keyser CE,Hofman A,Stricker BH,Franco OH,Kiefte-de Jong JCdoi
10.1002/ijc.29249subject
Has Abstractpub_date
2015-05-01 00:00:00pages
2178-86issue
9eissn
0020-7136issn
1097-0215journal_volume
136pub_type
杂志文章abstract：:Survival for breast cancer (BC) is lower in eastern than northern/central Europe, and in older than younger women. We analysed how comorbidities at diagnosis affected whether selected standard treatments (STs) were given, across Europe and over time, also assessing consequences for survival/relapse. We analysed 7581 s...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.31974
更新日期：2019-05-01 00:00:00
abstract：:Human mammary carcinoma cell lines (MCF-7) were analysed for their hormone sensitivity before and after transfection with a v-Ha-ras oncogene or with a neomycin-resistance gene followed by selection in vitro or in vivo. Our aim was to test how the expression of the ras oncogene would influence the estradiol sensitivit...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910460332
更新日期：1990-09-15 00:00:00
abstract：:EPLIN is frequently downregulated or lost in various cancers. The purpose of this study was to evaluate the importance of EPLIN in prostate cancer progression, with particular focus on the mechanistic implications to elucidate EPLIN's tumor suppressive function in cancer. EPLIN expression was evaluated in prostate can...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.31786
更新日期：2018-11-15 00:00:00
abstract：:In this study, a cell-penetrating peptide, the transactivating transcriptional factor (TAT) domain from HIV, was linked to a chitosan/doxorubicin (chitosan/DOX) conjugate to form a chitosan/DOX/TAT hybrid. The synthesized chitosan/DOX/TAT conjugate showed a different intracellular distribution pattern from a conjugate...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25578
更新日期：2011-05-15 00:00:00
abstract：:A significant proportion of screen-detected men with prostate cancer is likely to be overtreated, especially in older age groups. We aim to find which groups of screen-detected older men (65+) benefit the most from Immediate Radical Treatment or Active Surveillance (AS) for prostate cancer, depending on age, screening...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.29976
更新日期：2016-05-15 00:00:00
abstract：:The coincubation of liposomes with mouse leukemia cells or fibroblasts can cause a wide of effects on their viability. These effects are not particular specific in terms of destroying the leukemic cells. However, it was observed that the combination of phosphorylcholine-cholesterol (PC-CHOL)1-liposomes, which are not ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910270616
更新日期：1981-06-15 00:00:00
abstract：:We have developed novel 3-dimensional in vitro and in vivo tissue models that mimic premalignant disease of human stratified epithelium in order to analyze the stromal contribution of extracellular matrix and basement membrane proteins to the progression of intraepithelial neoplasia. Three-dimensional, organotypic cul...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.11525
更新日期：2004-01-20 00:00:00
abstract：:A glycolipid extract was prepared from an SV40-transformed hamster cell line (EH-SV) according to the Folch partition procedure. The glycolipids from the aqueous layer were incorporated in liposomal membranes composed of lecithin/sphingomyelin/cholesterol (1:1:2 by weight). This liposomal preparation was inoculated in...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910250616
更新日期：1980-06-15 00:00:00
abstract：:Treatment of older mice with pyran copolymer, a known interferon-inducer, was found to result in a rapid boosting of cell-mediated cytolytic activity against YAC-1 tumor target cells. The effector cells were characterized as being non-adherent and were presumed to be natural killer (NK) cells. Augmentation occurred in...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910240520
更新日期：1979-11-15 00:00:00
abstract：:More than two-thirds of patients with hepatocellular carcinoma (HCC) cannot receive curative therapy and have poor survival due to late diagnosis and few prognostic directions. In our study, nontargeted and targeted metabolomics analyses were conducted by liquid chromatography-mass spectrometry to characterize metabol...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.32599
更新日期：2020-03-15 00:00:00
abstract：:Histologic characteristics of bladder cancer in Boston, USA, Manchester, UK, and Nagoya, Japan, were evaluated. In each of these areas broadly-based series of cases were assembled during a collaborative case-control study. The present analysis was based on 589 cases in Boston, 484 cases in Manchester, and 241 cases in...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910300605
更新日期：1982-12-15 00:00:00
abstract：:The activity of systemic and in situ natural killer (NK) cells was measured in 3- to 5-week-old CBA mice with progressively growing murine sarcoma virus (MSV)-induced tumors. Splenic NK activity was depressed in tumor-bearing mice. NK activity was quite low or not detectable in unfractionated cell suspensions from the...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910270218
更新日期：1981-02-15 00:00:00
abstract：:Epstein-Barr virus genome-positive Burkitt's lymphoma is endemic in Africa and Papua New Guinea and in both countries the tumour is restricted to regions with holoendemic malaria. The present work has compared groups of healthy indigenous individuals living in malarious and non-malarious regions of Papua New Guinea fo...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910310609
更新日期：1983-06-15 00:00:00
abstract：:Diabetes has been consistently associated with an increased risk of liver, pancreas and endometrial cancer and has been implicated as a risk factor for esophageal and gastric cancers, although this association has been less well studied. We sought to determine the role of diabetes in the etiology of esophageal, gastri...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.27390
更新日期：2012-09-15 00:00:00
abstract：:We use the population-based Family-Cancer Database from Sweden to study familial breast cancer. The size of the population and the nation-wide registration of cancer offer unique possibilities for epidemiological studies of familial cancer, including complete and unbiased identification of cases in the probands and in...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19980729)77:3<386::aid-ijc
更新日期：1998-07-29 00:00:00
abstract：:Immunization of mice with 10(6) irradiated LSTRA murine leukemia cells (LX) induced weak immunity to subsequent tumor-cell challenge. Admixture of low doses (1.4-14 micrograms of C. parvum with the LX usually augmented the immunity. Higher doses (1,400-7,000 micrograms) of admixed C. parvum not only failed to augment ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910290617
更新日期：1982-06-15 00:00:00
abstract：:A cDNA library specific for mRNA over-expressed in prostate cancer was generated by subtractive hybridization of transcripts originating from prostatic hyperplasia and cancer tissues. cDNA encoding ribosomal proteins L4, L5, L7a, L23a, L30, L37, S14 and S18 was found to be present among 100 analyzed clones. Levels of ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19980925)78:1<27::aid-ijc6
更新日期：1998-09-25 00:00:00
abstract：:The application of dendritic cells (DC) to the active immunotherapy of cancer currently relies on the generation of potent DC capable of presenting tumor antigens such as carcinoembryonic antigen (CEA). It is unknown whether the T cells of patients with advanced malignancies can be reliably stimulated against tumor an...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19990702)82:1<121::aid-ijc
更新日期：1999-07-02 00:00:00
abstract：:We previously reported that ganglioside GD1a, which is highly expressed in poorly metastatic FBJ-S1 cells, inhibits the serum-induced motility of FBJ-LL cells and that the metastatic potential of FBJ-LL cells is completely suppressed by enforced GD1a expression (Hyuga et al., Int J Cancer 1999;83:685-91). We recently ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.1481
更新日期：2001-11-01 00:00:00
abstract：:A considerable public concern about cancer risk from acrylamide-rich foods followed the announcement that high concentrations of acrylamide are found in fried potatoes and potato chips and, more generally, in starch-containing foods cooked at high temperatures. From a series of hospital-based case-control studies cond...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.11118
更新日期：2003-07-01 00:00:00
abstract：:Bone-marrow (BM) hematopoietic precursors are recruited into proliferative activity when colony-stimulating factors (CSF) are sequenced with chemotherapy (CT). Previous studies suggested that further CT can be safely administered only when the increased proliferative activity of these cells has subsided, because most ...
journal_title：International journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1002/ijc.2910630508
更新日期：1995-11-27 00:00:00
abstract：:Sperm protein 17 (Sp17) is an antigenic protein highly expressed in spermatozoa. Sp17 expression was demonstrated recently in multiple myeloma, suggesting that it may be a novel cancer-testis antigen. Expression of Sp17 mRNA and protein was examined in human ovarian tumors. Sp17 mRNA was evaluated by reverse transcrip...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.11617
更新日期：2004-03-01 00:00:00
abstract：:Six permanent human tumor cell lines (OV-MZ-1 to 6) were established from 6 patients with serous adenocarcinomas of the ovary. These cell lines were derived from both solid tumors and ascites, from pre-treated and untreated patients, and are available over a range of in vitro passage numbers. The tumor cells grow as m...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910520115
更新日期：1992-08-19 00:00:00
abstract：:Epithelial-to-mesenchymal transition (EMT) has profound impacts on cancer progression and also on drug resistance, including epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Nowadays, there is still no predictive biomarker identified for the use of EGFR-TKIs in non-small cell lung cancer (NSCLC...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.28925
更新日期：2014-12-15 00:00:00
abstract：:The t(14;19)(q32;q13) is a recurrent chromosomal translocation reported in a variety of B-cell leukemias and lymphomas, including chronic lymphocytic leukemia (CLL). CLL cases associated with t(14;19) often have atypical morphologic and immunophenotypic features and unmutated immunoglobulin heavy chain (IGH) variable ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25605
更新日期：2011-06-01 00:00:00
abstract：:Epigenetic alterations play a major role in cancer. Recently we reported that stem cell Polycomb group targets (PcGTs) are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than nontargets. To identify potential, prognostic DNA methylation markers in ovarian cancer we analyzed the DNA met...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.23563
更新日期：2008-08-01 00:00:00
abstract：:The cytogenetic response to G2-phase X-irradiation was examined in phytohemagglutinin-stimulated peripheral-blood lymphocytes from 69 individuals, a few of whom were cancer patients. The cancer patients had not received radiation or chemotherapy. The responses of cells arrested by Colcemid 30 to 90 min after X-irradia...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910540412
更新日期：1993-06-19 00:00:00
abstract：:Transforming growth factor-beta (TGF-beta1) is a potent negative regulator of cell growth that transduces signals through interactions with type I and II receptors. Abnormal expression and mutational alterations of these receptors have been observed in several human malignancies. In this study, we investigated the exp...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19970516)71:4<573::aid-ijc
更新日期：1997-05-16 00:00:00
abstract：:Although adult obesity is known to increase endometrial cancer risk, evidence for childhood obesity is limited. We prospectively examined the association between body fatness throughout life and endometrial cancer risk. 47,289 participants in the Nurses' Health Study (NHS) and 105,386 of the Nurses' Health Study II (N...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.29427
更新日期：2015-08-01 00:00:00
abstract：:Cell populations resistant to high doses (30 microM) of 6-thioguanine (6-TG, 6-TG(r) cells) were selected from a human colon carcinoma cell line, LoVo. This cell line, which lacks hMSH2, a component of the human mismatch binding heterodimer hMutSalpha, is resistant to low doses of 6-TG. The level of activity of hypoxa...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19990812)82:4<556::aid-ijc
更新日期：1999-08-12 00:00:00
