Epithelial phenotype as a predictive marker for response to EGFR-TKIs in non-small cell lung cancer patients with wild-type EGFR.

abstract：:Activation-induced cytidine deaminase (AID) plays a role as a genome mutator in activated B cells, and inappropriate expression of AID has been implicated in the immunopathological phenotype of human B-cell malignancies. Notably, we found that the transgenic mice overexpressing AID developed lung adenocarcinoma and he...

journal_title：International journal of cancer

authors： Kou T,Marusawa H,Kinoshita K,Endo Y,Okazaki IM,Ueda Y,Kodama Y,Haga H,Ikai I,Chiba T

更新日期：2007-02-01 00:00:00

abstract：:Very late antigen-4 (VLA-4) composed of alpha 4 and beta 1, a member of the beta 1-integrin subfamily, facilitates cell-to-cell interaction with vascular cell-adhesion molecule-1 (VCAM-1) on endothelial cells (EC). Attachment of blood-borne tumor cells to EC is a crucial step for hematogenous metastasis, and VLA-4-pos...

journal_title：International journal of cancer

authors： Tomita Y,Saito T,Saito K,Oite T,Shimizu F,Sato S

更新日期：1995-03-16 00:00:00

abstract：:Oxaliplatin, which is widely used as chemotherapy for certain solid cancers, frequently causes peripheral neuropathy. Commonly described neuropathic symptoms include aberrant sensations such as mechanical allodynia (hypersensitivity to normally innocuous stimuli). Although oxaliplatin neuropathy is a dose-limiting tox...

journal_title：International journal of cancer

authors： Yamamoto S,Yamashita T,Ito M,Caaveiro JMM,Egashira N,Tozaki-Saitoh H,Tsuda M

更新日期：2019-10-15 00:00:00

abstract：:A critical requirement for cancer vaccines is that they stimulate CD8+ T cell responses. In this study, we tested the ability of a polyvalent melanoma vaccine to induce CD8+ T cell responses to the melanoma associated antigens MAGE-3 and Melan A/MART-1. Fifteen HLA-A2+ patients with resected malignant melanoma were im...

journal_title：International journal of cancer

authors： Reynolds SR,Oratz R,Shapiro RL,Hao P,Yun Z,Fotino M,Vukmanović S,Bystryn JC

更新日期：1997-09-17 00:00:00

abstract：:A case-control study involving interviews with 1,244 patients (758 males and 486 females) with cancer of the esophagus or gastric cardia and 1,314 population-based controls (789 males, 525 females) was carried out in Linxian, a rural county in North Central China with one of the world's highest mortality rates for the...

journal_title：International journal of cancer

authors： Li JY,Ershow AG,Chen ZJ,Wacholder S,Li GY,Guo W,Li B,Blot WJ

更新日期：1989-05-15 00:00:00

abstract：:Smoking and second-hand smoke (SHS) exposure have been recently linked to a higher risk of breast cancer in women. The aim of this work is to estimate the number of deaths and disability-adjusted life years (DALYs) from breast cancer attributable to these two risk factors in the European Union (EU-28) in 2017. The com...

journal_title：International journal of cancer

authors： Carreras G,Lachi A,Boffi R,Clancy L,Gallus S,Fernández E,López MJ,Soriano JB,López Nicolás Á,Semple S,Behrakis P,Gorini G,TackSHS Project Investigators.

更新日期：2020-11-01 00:00:00

abstract：:The transcription factor PAX3 is expressed during early embryogenesis and in multiple cancer types, including embryonal rhabdomyosarcoma (ERMS), Ewing sarcoma (ES) and malignant melanoma (MEL), suggesting that it could function as a general tumor associated antigen. Major histocompatibility complex (MHC) peptide bindi...

journal_title：International journal of cancer

authors： Rodeberg DA,Nuss RA,Elsawa SF,Erskine CL,Celis E

更新日期：2006-07-01 00:00:00

abstract：:We previously reported that some single nucleotide polymorphisms (SNPs) of candidate genes involved in the MTOR complex1 (MTORC1) were associated with risk of gastric cancer (GCa). In the present study, we further evaluated associations of eight potentially functional SNPs of MTOR, MLST8 and RPTOR with survival of 100...

journal_title：International journal of cancer

authors： Cheng L,Qiu L,Zhang R,Qian D,Wang M,Sun M,Zhu X,Wang Y,Guo W,Wei Q

更新日期：2019-01-15 00:00:00

abstract：:The presence of carcinogen-DNA adducts in human tissues is evidence of exposure to carcinogens and may be an indicator of cancer risk. DNA was isolated from non-tumorous bronchial tissue of 37 cigarette smokers, 8 former smokers and 8 non-smokers and analyzed for the presence of aromatic and/or hydrophobic DNA adducts...

journal_title：International journal of cancer

authors： Phillips DH,Schoket B,Hewer A,Bailey E,Kostic S,Vincze I

更新日期：1990-10-15 00:00:00

abstract：:Dose-dense adjuvant chemotherapy is standard of care in high-risk early breast cancer patients. However, its role in HER2-positive patients is still uncertain. In this exploratory analysis of the GIM2 trial, we investigated the efficacy of dose-dense chemotherapy in HER2-positive breast cancer patients with or without...

journal_title：International journal of cancer

authors： Lambertini M,Poggio F,Bruzzone M,Conte B,Bighin C,de Azambuja E,Giuliano M,De Laurentiis M,Cognetti F,Fabi A,Bisagni G,Durando A,Turletti A,Urracci Y,Garrone O,Puglisi F,Montemurro F,Ceppi M,Del Mastro L,GIM2 invest

更新日期：2020-07-01 00:00:00

abstract：:High circulating glucose, insulin resistance and obesity appear to be associated with increased risk of breast cancer (BC). We sought further insight into the relation of these variables to BC. We assessed associations of BC risk with serum fasting glucose, insulin, homeostasis model assessment-insulin resistance (HOM...

journal_title：International journal of cancer

authors： Sieri S,Muti P,Claudia A,Berrino F,Pala V,Grioni S,Abagnato CA,Blandino G,Contiero P,Schunemann HJ,Krogh V

更新日期：2012-02-15 00:00:00

abstract：:A panel of human breast cancer specimens was examined for single base change mutations by DNA sequencing and for larger deletions using a PCR-based assay. In the cancer specimens examined, no sequencing variants were detected other than a previously characterized polymorphism. Although most of the specimens contained ...

journal_title：International journal of cancer

authors： Anandappa SY,Sibson R,Platt-Higgins A,Winstanley JH,Rudland PS,Barraclough R

更新日期：2000-10-15 00:00:00

abstract：:We examined the biologic properties of a small-cell-lung-carcinoma (SCLC) cell line (designated MN-1112) established from a patient with SCLC who showed paraneoplastic retinopathy syndrome. Morphologic and immunocytochemical analyses showed that MN-1112 cells possess features of the classic type of SCLC. MN-1112 cells...

journal_title：International journal of cancer

authors： Yamaji Y,Matsubara S,Yamadori I,Sato M,Fujita T,Fujita J,Takahara J

更新日期：1996-03-01 00:00:00

abstract：:Classical Hodgkin lymphoma (HL) is characterized by the presence of Hodgkin and Reed-Sternberg cells (H&RS) and a prominent lymphocytic infiltration. We previously reported Hodgkin-like adult T-cell leukemia/lymphoma (HL-like ATLL) (new WHO classification). Various CXC and CC chemokines are expressed on H&RS cells and...

journal_title：International journal of cancer

authors： Ohshima K,Karube K,Hamasaki M,Suefuji H,Tutiya T,Yamaguchi T,Suzumiya J,Kikuchi M

更新日期：2003-09-20 00:00:00

abstract：:IL-2 gene was introduced through retroviral vectors into the highly malignant and poorly immunogenic 3LL-D122 clone. Both high and low D122-IL-2 secretors showed elimination of tumorigenicity in syngeneic immune-competent mice; however, in nude mice only the high IL-2 secretor showed reduced tumorigenicity as compared...

journal_title：International journal of cancer

authors： Porgador A,Gansbacher B,Bannerji R,Tzehoval E,Gilboa E,Feldman M,Eisenbach L

更新日期：1993-02-01 00:00:00

abstract：:p27Kip1, one of the cyclin-dependent kinase (CDK) inhibitors (CDKIs), blocks progression from G1 to S phase by binding cyclin D1-CDK4 and/or cyclin E-CDK2 and inhibiting their activities. Reflecting the function of p27 as a CDKI in vitro, a reduced expression of protein p27 has recently been reported to be associated ...

journal_title：International journal of cancer

authors： Anayama T,Furihata M,Ishikawa T,Ohtsuki Y,Ogoshi S

更新日期：1998-08-21 00:00:00

abstract：:It has been demonstrated that the chemopreventive agent N-(4-hydroxyphenyl)retinamide (4-HPR) induces apoptotic cell death, but recent data has suggested that late stage/recurrent tumours lose their response to 4-HPR-induced cell death by mechanisms that are unknown. Our study investigated the ability of 4-HPR to indu...

journal_title：International journal of cancer

authors： Davies M,Paterson IC,Ganapathy A,Prime SS

更新日期：2006-12-15 00:00:00

abstract：:Freshly isolated human peripheral blood monocytes from healthy volunteers are not cytotoxic to allogeneic A375 melanoma cells, but they were rendered tumoricidal by incubation in vitro with either liposomes containing 5 micrograms/mumol phospholipid of muramyl tripeptide phosphatidylethanolamine (liposome-MTP-PE; opti...

journal_title：International journal of cancer

authors： Sone S,Tandon P,Utsugi T,Ogawara M,Shimizu E,Nii A,Ogura T

更新日期：1986-10-15 00:00:00

abstract：:Previous work from this laboratory established a large bank of human colon carcinoma cell lines in culture and classified them with respect to growth regulatory phenotypes based on several biological and biochemical characteristics. In the present report, Northern analysis indicates that addition of the maturational a...

journal_title：International journal of cancer

authors： Mulder KM,Brattain MG

更新日期：1988-07-15 00:00:00

abstract：:A human cancer vaccine composed of autologous tumor cells modified with the hapten dinitrofluorobenzene (DNP) induces cell-mediated immunity to the tumor cells and the development of inflammatory responses within metastatic sites. In this study we determined whether DNP vaccine could induce regression of established m...

journal_title：International journal of cancer

authors： Berd D,Sato T,Cohn H,Maguire HC Jr,Mastrangelo MJ

更新日期：2001-11-01 00:00:00

abstract：:The relationship between the strength of the estrogenic and progestational components of combined oral contraceptives and risk of endometrial carcinoma was examined in a multinational hospital-based case-control study comparing 220 cases from 7 countries with 1,537 age- and hospital-matched controls. Oral contraceptiv...

journal_title：International journal of cancer

authors： Rosenblatt KA,Thomas DB

更新日期：1991-12-02 00:00:00

abstract：:Mouse-transformed keratinocytes cultured in the presence of transforming growth factor beta1 (TGF-beta1) acquire an array of morphologic and functional properties that give rise to a migratory phenotype that expresses mesenchymal molecular markers. This cellular conversion involves activation of the Ras-ERK pathway, e...

journal_title：International journal of cancer

authors： Santibáñez JF,Olivares D,Guerrero J,Martínez J

更新日期：2003-12-10 00:00:00

abstract：:Prostate cancer is an extremely heterogeneous disease; patients that do progress to late-stage metastatic prostate cancer have limited treatment options, mostly palliative. Molecules involved in the metastatic cascade may prove beneficial in stratifying patients to assign appropriate treatment modalities and may also ...

journal_title：International journal of cancer

authors： Copeland BT,Bowman MJ,Boucheix C,Ashman LK

更新日期：2013-10-15 00:00:00

abstract：:We evaluated RS5444, a thiazolidinedione high affinity PPARgamma agonist, for the ability to inhibit colon carcinogenesis in azoxymethane (AOM)-treated mice. In our initial experiment, mice were treated with RS5444 during AOM treatment, and the drug was withdrawn 12 weeks after the last injection of AOM. RS5444 signif...

journal_title：International journal of cancer

authors： Su W,Necela BM,Fujiwara K,Kurakata S,Murray NR,Fields AP,Thompson EA

更新日期：2008-09-01 00:00:00

abstract：:Breast cancer incidence increases considerably in women who migrate from Japan to the United States. Based on the hypothesis that mammographic density in healthy mammograms reflects differences in breast cancer risk, we compared mammographic density in 3 groups of women at different levels of risk: Caucasian and Japan...

journal_title：International journal of cancer

authors： Maskarinec G,Nagata C,Shimizu H,Kashiki Y

更新日期：2002-11-01 00:00:00

abstract：:Recent alcohol consumption is an established risk factor for squamous cell carcinoma (SCC) of the upper aero-digestive tract. In contrast, the role of lifetime exposure to alcohol with regard to risk of SCC is not well established. Historical data on alcohol use are available in 271,253 participants of the European Pr...

journal_title：International journal of cancer

authors： Weikert C,Dietrich T,Boeing H,Bergmann MM,Boutron-Ruault MC,Clavel-Chapelon F,Allen N,Key T,Lund E,Olsen A,Tjønneland A,Overvad K,Rohrmann S,Linseisen J,Pischon T,Trichopoulou A,Weinehall L,Johansson I,Sánchez MJ,Ag

更新日期：2009-07-15 00:00:00

abstract：:Studies have shown that the calcium-sensing receptor (CaSR) mediates the antitumorigenic effects of calcium against colorectal cancer (CRC). Expression of the CaSR in colorectal tumors is often reduced. We have reported previously that silencing of CaSR in CRC is caused in part by methylation of CaSR promoter 2 and lo...

journal_title：International journal of cancer

authors： Fetahu IS,Tennakoon S,Lines KE,Gröschel C,Aggarwal A,Mesteri I,Baumgartner-Parzer S,Mader RM,Thakker RV,Kállay E

更新日期：2016-01-01 00:00:00

abstract：:Human papillomavirus (HPV) is detected in nearly all cervical cancers and approximately half of vaginal cancers. However, vaginal cancer is an order of magnitude less common than cervical cancer, not only in the general population but also among women with HIV/AIDS. It is interesting therefore that recent studies foun...

journal_title：International journal of cancer

authors： D'Souza G,Burk RD,Zhong Y,Minkoff H,Massad LS,Xue X,Watts DH,Anastos K,Palefsky JM,Levine AM,Colie C,Castle PE,Strickler HD

更新日期：2012-09-15 00:00:00

abstract：:The objective of this study was to assess the utility of a second generation human papillomavirus (HPV) virus-like particle (VLP)-based ELISA as an adjunct to HPV DNA testing to identify women at risk for high-grade cervical intraepithelial neoplasia (CIN). Participants provided blood, cervical samples and interviewer...

journal_title：International journal of cancer

authors： Einstein MH,Studentsov YY,Ho GY,Fazzari M,Marks M,Kadish AS,Goldberg GL,Runowicz CD,Burk RD

更新日期：2007-01-01 00:00:00

abstract：:Immunotherapy targeting programmed cell death-1 (PD-1) has become a standard pharmacological therapy. Although tumor mutation burden level was reported to depend on the tumor location in nonsmall cell lung cancer (NSCLC), predictive impact of the tumor location on the response to anti-PD-1 therapy is unknown. Two hund...

journal_title：International journal of cancer

authors： Takamori S,Takada K,Shimokawa M,Matsubara T,Haratake N,Miura N,Toyozawa R,Yamaguchi M,Takenoyama M,Yoneshima Y,Tanaka K,Okamoto I,Tagawa T,Mori M

更新日期：2020-10-15 00:00:00