Association of a functional polymorphism in the promoter of the MDM2 gene with risk of nonsmall cell lung cancer.

abstract：:Medulloblastoma is a primitive neuroectodermal tumor of the cerebellum with poorly understood pathogenesis. Previous studies have reported loss of heterozygosity (LOH) on chromosome arms 17p, 11p and 9q and cytogenetic abnormalities of chromosome 1 in medulloblastoma. We have used the polymerase chain reaction to ampl...

journal_title：International journal of cancer

authors： Kraus JA,Koch A,Albrecht S,Von Deimling A,Wiestler OD,Pietsch T

更新日期：1996-07-03 00:00:00

abstract：:In Bloom's syndrome (BS) the regulation of uracil-DNA glycosylase, an enzyme involved in the repair of DNA containing 5-FU, is altered. 5-FU induces higher levels of DNA fragmentation in BS cells than in non-BS cells. The increase in DNA fragmentation is connected to the cytotoxic mechanism where 5-FU is incorporated ...

journal_title：International journal of cancer

authors： Lönn U,Lönn S,Nylen U,Winblad G

更新日期：1990-03-15 00:00:00

abstract：:von Willebrand factor (vWF), a glycoprotein produced uniquely by endothelial cells and megakaryocytes, is routinely used to identify vessels in tissue sections. Vessel density in tumor specimens, as determined by immuno-histochemical staining for vWF or other endothelial cell markers, is a negative prognostic factor f...

journal_title：International journal of cancer

authors： Zanetta L,Marcus SG,Vasile J,Dobryansky M,Cohen H,Eng K,Shamamian P,Mignatti P

更新日期：2000-01-15 00:00:00

abstract：:MYCN and insulin-like growth factor (IGF) system are important for the pathogenesis and development of neuroblastoma. We previously reported evidence of a direct linkage between MycN and the IGF system in KP-N-RT human neuroblastoma cells, where IGF-I induced both MycN expression at the RNA level and G1-S cell cycle p...

journal_title：International journal of cancer

authors： Misawa A,Hosoi H,Tsuchiya K,Sugimoto T

更新日期：2003-03-20 00:00:00

abstract：:To find out whether manipulation of H-2 expression on metastatic cells could alter their metastatic properties, we immunoselected in vivo H-2 antigen variants from a metastatic clone of the T10 sarcoma [originating in a (C57BL/6J X C3H.eB)FI mouse] and tested their metastatic capacity. The unselected metastatic cells ...

journal_title：International journal of cancer

authors： Katzav S,Segal S,Feldman M

更新日期：1984-03-15 00:00:00

abstract：:The cytogenetic response to G2-phase X-irradiation was examined in phytohemagglutinin-stimulated peripheral-blood lymphocytes from 69 individuals, a few of whom were cancer patients. The cancer patients had not received radiation or chemotherapy. The responses of cells arrested by Colcemid 30 to 90 min after X-irradia...

journal_title：International journal of cancer

authors： Knight RD,Parshad R,Price FM,Tarone RE,Sanford KK

更新日期：1993-06-19 00:00:00

abstract：:Esophageal cancer is ranked as the eighth most common cancer and the sixth leading cause of cancer deaths worldwide. To identify candidate tumor suppressor genes related to esophageal squamous cell carcinoma (ESCC) development, a cDNA microarray analysis was performed using paired tumor and nontumor tissue samples fro...

journal_title：International journal of cancer

authors： Ng HY,Ko JM,Yu VZ,Ip JC,Dai W,Cal S,Lung ML

更新日期：2016-06-15 00:00:00

abstract：:To evaluate the relation between the degree of lymph node metastasis and the growth potential of tumour cells and the local immune function in gastric cancer, we analyzed data on 444 patients with advanced serosally invasive gastric cancer who underwent curative gastrectomy. Tumour growth potential was evaluated based...

journal_title：International journal of cancer

authors： Maehara Y,Tomisaki S,Oda S,Kakeji Y,Tsujitani S,Ichiyoshi Y,Akazawa K,Sugimachi K

更新日期：1997-04-22 00:00:00

abstract：:Ocimum sp. is a traditionally used medicinal herb, which shows anti-oxidant, anti-carcinogenic, radio-protective and free radical scavenging properties. So far no detailed studies have been reported on its effects on human cancers. Thus, we analyzed its effects on human breast cancer utilizing in vitro and in vivo met...

journal_title：International journal of cancer

authors： Nangia-Makker P,Tait L,Shekhar MP,Palomino E,Hogan V,Piechocki MP,Funasaka T,Raz A

更新日期：2007-08-15 00:00:00

abstract：:The sensitivity of human tissues and tumors to infection with type C adenoviruses correlates with the expression of the human coxsackie B- and adenovirus receptor, hCAR. HCAR is heterogeneously expressed in various tissues and types of human cancer cells, which has implications for the use of adenoviruses as vectors i...

journal_title：International journal of cancer

authors： Fuxe J,Liu L,Malin S,Philipson L,Collins VP,Pettersson RF

更新日期：2003-03-01 00:00:00

abstract：:Metastasis is one of the most important and complex processes in human neoplastic disease. A large number of both positive and negative events must occur to permit a tumor cell to colonize a distant site successfully. To identify mouse strains that harbor dominant genetic modifiers of this process, a strain survey was...

journal_title：International journal of cancer

authors： Lifsted T,Le Voyer T,Williams M,Muller W,Klein-Szanto A,Buetow KH,Hunter KW

更新日期：1998-08-12 00:00:00

abstract：:Prostate cancer (PC) has the highest degree of genetic transmission of any form of malignancy. In some families, the hereditary pattern is so strong as to mimic an autosomal dominance trait. We reviewed the known predisposing genetic markers to assess possible strategies for screening of families at risk. We carried o...

journal_title：International journal of cancer

authors： Lynch HT,Kosoko-Lasaki O,Leslie SW,Rendell M,Shaw T,Snyder C,D'Amico AV,Buxbaum S,Isaacs WB,Loeb S,Moul JW,Powell I

更新日期：2016-06-01 00:00:00

abstract：:Although tobacco smoking, pan chewing and alcohol drinking are important risk factors for head and neck cancer (HNC), the HNC risks conferred by products available in Nepal for these habits are unknown. We assessed the associations of tobacco smoking, chewing habits, and alcohol drinking with HNC risk in Nepal. A case...

journal_title：International journal of cancer

authors： Chang CP,Siwakoti B,Sapkota A,Gautam DK,Lee YA,Monroe M,Hashibe M

更新日期：2020-08-01 00:00:00

abstract：:Postmenopausal hormone replacement therapy (HRT) was found to be associated with lower risk of colorectal cancer (CRC). However, little is known regarding associations with molecular subtypes of CRC. The current study includes female participants of a large German population-based case-control study (922 CRC cases and...

journal_title：International journal of cancer

authors： Amitay EL,Carr PR,Jansen L,Alwers E,Roth W,Herpel E,Kloor M,Bläker H,Chang-Claude J,Brenner H,Hoffmeister M

更新日期：2020-08-15 00:00:00

abstract：:Primary cultures derived from pre-cancerous and cancerous human colon tissue are essential for understanding normal and abnormal growth function in the large intestine. Here presented are (i) the methodology for routine establishment of primary cultures of normal, adenoma- and carcinoma-derived cells, and (ii) data fo...

journal_title：International journal of cancer

authors： Tong WM,Bises G,Sheinin Y,Ellinger A,Genser D,Pötzi R,Wrba F,Wenzl E,Roka R,Neuhold N,Peterlik M,Cross HS

更新日期：1998-01-30 00:00:00

abstract：:Growing evidence suggests that people with autoimmune conditions may be at increased risk of hepatobiliary tumors. In the present study, we evaluated associations between autoimmune conditions and hepatobiliary cancers among adults aged ≥66 in the United States. We used Surveillance, Epidemiology, and End Results (SEE...

journal_title：International journal of cancer

authors： McGee EE,Castro FA,Engels EA,Freedman ND,Pfeiffer RM,Nogueira L,Stolzenberg-Solomon R,McGlynn KA,Hemminki K,Koshiol J

更新日期：2019-02-15 00:00:00

abstract：:The transcription factor PAX3 is expressed during early embryogenesis and in multiple cancer types, including embryonal rhabdomyosarcoma (ERMS), Ewing sarcoma (ES) and malignant melanoma (MEL), suggesting that it could function as a general tumor associated antigen. Major histocompatibility complex (MHC) peptide bindi...

journal_title：International journal of cancer

authors： Rodeberg DA,Nuss RA,Elsawa SF,Erskine CL,Celis E

更新日期：2006-07-01 00:00:00

abstract：:Genetic and epigenetic alterations during development of pancreatic ductal adenocarcinomas (PDACs) are well known. This study investigates genetic and epigenetic data together with tumor biology to find specific alterations responsible for metastasis formation. Using 16 human PDAC cell lines in a murine orthotopic PDA...

journal_title：International journal of cancer

authors： Mees ST,Mardin WA,Wendel C,Baeumer N,Willscher E,Senninger N,Schleicher C,Colombo-Benkmann M,Haier J

更新日期：2010-01-01 00:00:00

abstract：:Several reports have suggested that one or both of the trinucleotide repeat polymorphisms in the human androgen receptor (hAR) gene, (CAG)n coding for polyglutamine and (GGC)n coding for polyglycine, may be associated with prostate cancer risk; but no study has investigated their association with disease progression. ...

journal_title：International journal of cancer

authors： Edwards SM,Badzioch MD,Minter R,Hamoudi R,Collins N,Ardern-Jones A,Dowe A,Osborne S,Kelly J,Shearer R,Easton DF,Saunders GF,Dearnaley DP,Eeles RA

更新日期：1999-10-22 00:00:00

abstract：:In a formal prospective-retrospective analysis of the phase III SBG0102 clinical trial randomizing metastatic breast cancer patients to gemcitabine-docetaxel or to single agent docetaxel, patients with basal-like tumors by PAM50 gene expression had significantly better overall survival in the gemcitabine arm. By immun...

journal_title：International journal of cancer

authors： Asleh K,Lyck Carstensen S,Tykjaer Jørgensen CL,Burugu S,Gao D,Won JR,Jensen MB,Balslev E,Laenkholm AV,Nielsen DL,Ejlertsen B,Nielsen TO

更新日期：2019-05-15 00:00:00

abstract：:Although childhood exposure to ionizing radiation is a well-established risk factor for thyroid cancer, the risk associated with adulthood exposure remains unclear. We prospectively examined the association between cumulative, low-to-moderate dose occupational radiation exposure to the thyroid and thyroid cancer incid...

journal_title：International journal of cancer

authors： Kitahara CM,Preston DL,Neta G,Little MP,Doody MM,Simon SL,Sigurdson AJ,Alexander BH,Linet MS

更新日期：2018-11-01 00:00:00

abstract：:Major etiologic factors associated with human hepatocellular carcinomas (HCCs) include infection with hepatitis C (HCV) and hepatitis B virus (HBV), excess alcohol intake and aflatoxin B(1) exposure. While the G-->T p53 mutation at codon 249 has been identified as a genetic hallmark of HCC caused by aflatoxin B(1), th...

journal_title：International journal of cancer

authors： Edamoto Y,Hara A,Biernat W,Terracciano L,Cathomas G,Riehle HM,Matsuda M,Fujii H,Scoazec JY,Ohgaki H

更新日期：2003-09-01 00:00:00

abstract：:TP63 gene is a member of TP53 tumor suppressor gene family that encodes several protein isoforms involved in the process of epithelial stratification and in epithelial-mesenchyme interactions. TP63 is amplified in a significant proportion of squamous cell carcinoma of the esophagus (ESCC), resulting in the hyper-expre...

journal_title：International journal of cancer

authors： Thépot A,Hautefeuille A,Cros MP,Abedi-Ardekani B,Pétré A,Damour O,Krutovskikh V,Hainaut P

更新日期：2010-11-01 00:00:00

abstract：:We previously reported identifying SOX6 as a glioma antigen by serological screening using a testis cDNA library. Its preferential expression and frequent IgG responses in glioma patients indicate that SOX6 may be a useful target for immunotherapy. To examine whether cytotoxic T-lymphocyte (CTL) responses specific for...

journal_title：International journal of cancer

authors： Ueda R,Kinoshita E,Ito R,Kawase T,Kawakami Y,Toda M

更新日期：2008-05-15 00:00:00

abstract：:Reverse-transcriptase polymerase chain reaction has been used to analyze the expression of 2 latent genes (EBNA-1 and LMP-1) and one replicative gene (BZLF-1) of Epstein-Barr virus in mononuclear cells from bone marrow and peripheral blood of healthy donors. EBV-gene transcription was detected in 8 out of 15 bone-marr...

journal_title：International journal of cancer

authors： Gonnella R,Angeloni A,Calogero A,Farina A,Santarelli R,Gentile G,Arcese W,Martino P,Mandelli F,Frati L,Faggioni A,Ragona G

更新日期：1997-03-04 00:00:00

abstract：:Therapeutic effectiveness against metastatic or even locally advanced pancreatic ductal adenocarcinoma (PDAC) is dismal, with 5-year survival less than 5%. Even in patients who undergo potentially curative resection, most patients' tumors recur in the liver. Improving therapies targeting or preventing liver metastases...

journal_title：International journal of cancer

authors： Kurahara H,Bohl C,Natsugoe S,Nishizono Y,Harihar S,Sharma R,Iwakuma T,Welch DR

更新日期：2016-08-01 00:00:00

abstract：:Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is a member of the EGF family of polypeptide growth factors, which includes EGF, transforming growth factor alpha(TGF-alpha), amphiregulin (AR) and betacellulin (BTC). To assess the potential role of HB-EGF in human gastric carcinomas, the expre...

journal_title：International journal of cancer

authors： Naef M,Yokoyama M,Friess H,Büchler MW,Korc M

更新日期：1996-05-03 00:00:00

abstract：:During malignant progression cancer cells undergo a series of changes, which promote their survival, invasiveness and metastatic process. One of them is a change in glucose metabolism. Unlike normal cells, which mostly rely on the tricarboxylic acid cycle (TCA), many cancer types rely on glycolysis. Pyruvate dehydroge...

journal_title：International journal of cancer

authors： Golias T,Kery M,Radenkovic S,Papandreou I

更新日期：2019-02-15 00:00:00

abstract：:Primary mediastinal B-cell lymphoma is a locally highly aggressive but poorly disseminating tumor composed of medium sized or large cells most probably of thymic medullary origin. It has a mature B-cell phenotype, typically lacks immunoglobulin expression and has variable defects in expression of HLA-molecules. We pre...

journal_title：International journal of cancer

authors： Möller P,Brüderlein S,Sträter J,Leithäuser F,Hasel C,Bataille F,Moldenhauer G,Pawlita M,Barth TF

更新日期：2001-05-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a cell plasticity process required for metastasis and chemoresistance of carcinoma cells. We report a crucial role of the signal adaptor proteins CRK and CRKL in promoting EMT and tumor aggressiveness, as well as resistance against chemotherapy in colorectal and pancreatic ca...

journal_title：International journal of cancer

authors： Franke FC,Slusarenko BO,Engleitner T,Johannes W,Laschinger M,Rad R,Nitsche U,Janssen KP

更新日期：2020-09-15 00:00:00