Abstract：
:Wnt signaling pathway activation via mutation of genetic components, commonly adenomatous polyposis coli (APC), has a major role in colorectal cancer (CRC). Most components have not been assessed for mutation in sporadic CRC. We have analyzed AXIN2, CK1alpha, DKK1, GSK-3beta, SOX17, LRP6 and PPP2R1B, beta-catenin and APC in a collection of sporadic CRCs (n = 47) and CRC cell lines (CLs; n = 26). The CRC set was enriched for microsatellite unstable cancers (MSI+, 30%, 14/47). Somatic mutation was not found in CK1alpha, DKK1, LRP6, beta-catenin or GSK-3beta; but heterozygous frame-shift mutations, and an in-frame deletion mutation were detected in exon 7 of AXIN2 (CRCs, 11%, 5/47; CLs, 8%, 2/26). Our data refute a previous suggestion that a CRC-related mutational hot-spot occurred in the Huntington elongation A subunit TOR (HEAT) repeat 2 of PPP2R1B; this "hotspot" is, more likely, a rare germline polymorphism. An early investigation proposing a high mutational frequency in HEAT repeat 13 was not substantiated. A heterozygous SOX17 mutation (L194P) was also found in a cell line. APC gene mutations were identified in 64% (30/47) of cancers and 7% of these (2/30) had an additional mutation in another Wnt gene. Overall, 70% (33/47) of CRCs had a somatic mutation in a Wnt pathway gene. The number of tumors containing such a mutation was not significantly higher in MSI+ (57%, 8/14) compared to MSI- (76%, 25/33) cancers (p = 0.3, Fisher's exact test); APC mutation was significantly increased in the MSI- subgroup (p = 0.02, Fisher's exact test). Further, mutational screening of other Wnt pathway genes is warranted.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Suraweera N,Robinson J,Volikos E,Guenther T,Talbot I,Tomlinson I,Silver Adoi
10.1002/ijc.22046subject
Has Abstractpub_date
2006-10-15 00:00:00pages
1837-42issue
8eissn
0020-7136issn
1097-0215journal_volume
119pub_type
杂志文章abstract：:The spontaneously arising immunocytoma of the Louvain rat (RIC) carries a consistent chromosomal translocation between chromosomes 6 and 7. This translocation juxtaposes immunoglobulin heavy chain and c-myc sequences. In an earlier study on 14 RIC tumors, we found that the translocation breakpoint is located within 1....
journal_title：International journal of cancer
pub_type： 杂志文章
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abstract：:Radiotherapy and chemotherapy are known risk factors for second cancers after lymphoma. The role of genetic influences, however, remains largely unknown. We assessed risk of second cancers associated with family history of any cancer in 41,181 patients with Hodgkin lymphoma (HL) (n = 7,476), non-Hodgkin lymphoma (NHL)...
journal_title：International journal of cancer
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更新日期：2007-03-01 00:00:00
abstract：:There is little long-term follow-up information about how the number of melanoma deaths and case fatality vary over time according to the measured thickness of melanoma at diagnosis. This population-based longitudinal cohort study examines patterns and trends in case fatality among 44,531 people in Queensland (Austral...
journal_title：International journal of cancer
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
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更新日期：2011-08-15 00:00:00
abstract：:The human bowel contains a large and dynamic bacterial population that is not only essential for intestinal health, but also critical for the development of diseases such as cancer. In this respect, the Gram-positive bacterium Streptococcus bovis has been associated with colon cancer for many years. To investigate the...
journal_title：International journal of cancer
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abstract：:Complement-dependent cytotoxic antibodies to three cervical carcinoma cell lines (Me-180, SW-732 and HeLa) and to Herpes simplex virus type 2 (HSV-2)-infected cells were determined in a long-term study of women with cervical carcinoma. Cytolysis of surface antigens differed significantly between the cervical carcinoma...
journal_title：International journal of cancer
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journal_title：International journal of cancer
pub_type： 杂志文章
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更新日期：2001-04-15 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910290616
更新日期：1982-06-15 00:00:00
abstract：:Cancer incidence disparities exist among specific Asian American populations. However, the existing reports exclude data from large metropoles like Chicago, Houston and New York. Moreover, incidence rates by subgroup have been underestimated due to the exclusion of Asians with unknown subgroup. Cancer incidence data f...
journal_title：International journal of cancer
pub_type： 杂志文章
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journal_title：International journal of cancer
pub_type： 杂志文章
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更新日期：1992-04-01 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910400219
更新日期：1987-08-15 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910170417
更新日期：1976-04-15 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910270103
更新日期：1981-01-15 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(SICI)1097-0215(19960301)65:5<671::AID-IJC
更新日期：1996-03-01 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.10314
更新日期：2002-05-01 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910170410
更新日期：1976-04-15 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910240419
更新日期：1979-10-15 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910520113
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pub_type： 杂志文章
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journal_title：International journal of cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1989-02-15 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章,评审
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更新日期：2018-12-15 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
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更新日期：2000-01-15 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：
更新日期：1991-04-22 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章,评审
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更新日期：2020-11-24 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19970127)70:3<291::aid-ijc
更新日期：1997-01-27 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
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更新日期：2006-10-15 00:00:00
abstract：:The Stockholm-Gotland Cancer Register was used to evaluate the clinical observation that patients with non-Hodgkin's lymphoma (NHL) had an increased risk of malignant melanoma or squamous-cell carcinoma of the skin (SCCS) and vice versa. During 1958-1992, NHL was diagnosed in a total of 6,176 patients. Of these patien...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910620505
更新日期：1995-09-04 00:00:00
abstract：:It was suggested that the brain microenvironment plays a role in glioma progression. Here we investigate the mechanism by which astrocytes which are abundant in glioma tumors, promote cancer cell invasion. In this study, we evaluated the effects of astrocytes on glioma biology both in vitro and in vivo and determined ...
journal_title：International journal of cancer
pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
