Proliferating cell nuclear antigen (PCNA) in relation to ras, c-erbB-2,p53, clinico-pathological variables and prognosis in colorectal adenocarcinoma.


:Proliferating cell nuclear antigen (PCNA) expression was studied by immunohistochemistry on paraffin-embedded sections of 293 primary colorectal adenocarcinomas and 56 corresponding lymph node metastases. PCNA-positive expression was detected in <25% of tumour cells in 172 (59%) cases and in > 25% in 121 (41%) cases. PCNA accumulation was related to over-expression of c-erbB-2 and p53 and tended to be increased in cases with ras over-expression. PCNA expression was identical in primary and corresponding metastases. No significant relationship was observed between PCNA expression and prognosis and other clinico-pathological variables, including grade of differentiation, growth pattern, Dukes' stage, site, age or sex. We conclude that PCNA expression may be related to alterations of oncoproteins but that PCNA itself could not provide additional information for the development of metastasis and prognosis in colorectal adenocarcinoma.


Int J Cancer


Sun XF,Carstensen JM,Stål O,Zhang H,Nordenskjöld B




Has Abstract


1996-02-20 00:00:00














  • The mTOR kinase inhibitor everolimus synergistically enhances the anti-tumor effect of the Bruton's tyrosine kinase (BTK) inhibitor PLS-123 on Mantle cell lymphoma.

    abstract::Mantle cell lymphoma (MCL) is an aggressive and incurable malignant disease. Despite of general chemotherapy, relapse and mortality are common, highlighting the need for the development of novel targeted drugs or combination of therapeutic regimens. Recently, several drugs that target the B-cell receptor (BCR) signali...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Li J,Wang X,Xie Y,Ying Z,Liu W,Ping L,Zhang C,Pan Z,Ding N,Song Y,Zhu J

    更新日期:2018-01-01 00:00:00

  • Expression of MAGE genes in transitional-cell carcinomas of the urinary bladder.

    abstract::Human genes MAGE-1 and MAGE-3 code for distinct antigens, which are recognized on melanoma cells by autologous cytolytic T lymphocytes (CTL). These antigens may constitute useful targets for anti-cancer immunotherapy, since no expression of MAGE genes has been observed in normal tissues other than testis. Out of 57 sa...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Patard JJ,Brasseur F,Gil-Diez S,Radvanyi F,Marchand M,François P,Abi-Aad A,Van Cangh P,Abbou CC,Chopin D

    更新日期:1995-02-20 00:00:00

  • Intracellular localization of metaiodobenzyl guanidine in human neuroblastoma cells by electron spectroscopic imaging.

    abstract::The targeted radiotherapy of neuroblastoma with 131l-labelled metaiodobenzyl guanidine (mIBG) is now the subject of several clinical studies. The precise intracellular localization of mIBG, necessary for nuclear microdosimetry, has not previously been described. We report the use of electron-energy-loss spectroscopy a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gaze MN,Huxham IM,Mairs RJ,Barrett A

    更新日期:1991-04-01 00:00:00

  • Elevated cerebrospinal fluid fibronectin concentration at diagnosis indicates poor prognosis in children with acute lymphoblastic leukemia.

    abstract::We investigated whether the concentration of fibronectin (FN) in the cerebrospinal fluid (CSF) could be used for identifying patients with subclinical blast-cell infiltration in the central nervous system (CNS) and an increased risk of CNS relapse later in the course of their leukemia. Our series comprised 36 children...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rautonen J,Koskiniemi M,Siimes MA,Salonen EM,Vaheri A

    更新日期:1989-01-15 00:00:00

  • Applicability of an absolute quantitative procedure to monitor intra-individual bcr/abl transcript kinetics in clinical samples from chronic myelogenous leukemia patients.

    abstract::Chimeric bcr/abl fusion proteins are thought to be the molecular 'pathogen' of chronic myelogenous leukaemia (CML). Expression levels of the respective fusion RNAs reflect disease progression as well as remission upon therapeutic intervention in CML patients. However, there is no quick and reliable method that would a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kreuzer KA,Lass U,Nagel S,Ellerbrok H,Pauli G,Pawlaczyk-Peter B,Siegert W,Huhn D,Schmidt CA

    更新日期:2000-06-01 00:00:00

  • Genetic variants in RUNX3, AMD1 and MSRA in the methionine metabolic pathway and survival in nonsmall cell lung cancer patients.

    abstract::Abnormal methionine dependence in cancer cells has led to methionine restriction as a potential therapeutic strategy. We hypothesized that genetic variants involved in methionine-metabolic genes are associated with survival in nonsmall cell lung cancer (NSCLC) patients. Therefore, we investigated associations of 16,37...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析


    authors: Chen K,Liu H,Liu Z,Luo S,Patz EF Jr,Moorman PG,Su L,Shen S,Christiani DC,Wei Q

    更新日期:2019-08-01 00:00:00

  • Constitutive activating mutation of the FGFR3b in oral squamous cell carcinomas.

    abstract::A G to T mutation at nucleotide position 2128 in the human FGFR3b coding region resulting in a Cys for Gly substitution (G697C) in the tyrosine kinase domain was observed in 62% (44/71) of oral squamous cell carcinomas (OSCC) examined. Immunostained FGFR3b was found in the cytoplasm of prickle cells in normal epitheli...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zhang Y,Hiraishi Y,Wang H,Sumi KS,Hayashido Y,Toratani S,Kan M,Sato JD,Okamoto T

    更新日期:2005-10-20 00:00:00

  • Measurement of a pancreatic cancer-associated antigen (DU-PAN-2) detected by a monoclonal antibody in sera of patients with digestive cancers.

    abstract::DU-PAN-2 is a high-molecular-weight glycoprotein defined by a murine monoclonal antibody (MAb) against a pancreatic ductal adenocarcinoma cell line. In order to evaluate the usefulness of this antigen as a tumor marker, we determined the serum level of the antigen by competitive inhibition radioimmunoassay in sera fro...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sawabu N,Toya D,Takemori Y,Hattori N,Fukui M

    更新日期:1986-05-15 00:00:00

  • Combretastatin family member OXI4503 induces tumor vascular collapse through the induction of endothelial apoptosis.

    abstract::The mechanism of tumor cell killing by OXI4503 was investigated by studying vascular functional and morphological changes post drug administration. SCID mice bearing MHEC5-T hemangioendothelioma were given a single dose of OXI4503 at 100 mg/kg. Tumor blood flow, measured by microsphere fluorescence, was reduced by 50%...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sheng Y,Hua J,Pinney KG,Garner CM,Kane RR,Prezioso JA,Chaplin DJ,Edvardsen K

    更新日期:2004-09-10 00:00:00

  • Inhibition of tumor growth by biodegradable microspheres containing all-trans-retinoic acid in a human head-and-neck cancer xenograft.

    abstract::Retinoids play essential roles in the regulation of cell differentiation and in the proliferation of various epithelial tissues, and atRA is one such active metabolite of retinoids. However, despite the known functions of atRA, its clinical applications are limited due to the induced metabolism by the specific cytochr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Choi Y,Kim SY,Kim SH,Yang J,Park K,Byun Y

    更新日期:2003-10-20 00:00:00

  • Progenitor and pre-B lymphocytes transformed by Epstein-Barr virus.

    abstract::By rosetting with SRBC coupled to rabbit-anti-human IgM, the surface IgM-negative cells of human fetal bone marrow were enriched, and subsequently infected and transformed by Epstein-Barr virus (EBV). Single clones of the transformed cells were obtained. Ninety percent of the resulting cell clones were surface-immunog...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ernberg I,Falk K,Hansson M

    更新日期:1987-02-15 00:00:00

  • Melanoma in Western Australia 1975-76 to 1980-81: trends in demographic and pathological characteristics.

    abstract::Trends in incidence rates of cutaneous malignant melanoma in Western Australia from 1975-76 to 1980-1981 have been examined with reference to age, sex, body site, presence or absence of dermal invasion, tumour thickness, histological type, socioeconomic status and occupation. The incidence rates of all melanomas incre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: English DR,Heenan PJ,Holman CD,Armstrong BK,Blackwell JB,Kelsall GR,Matz LR,Singh A,ten Seldam RE

    更新日期:1986-02-15 00:00:00

  • Modulation of immune parameters in patients with metastatic renal-cell cancer receiving combination immunotherapy (IL-2, IFN alpha and autologous IL-2-activated lymphocytes).

    abstract::We treated 72 patients with metastatic renal-cell cancer according to 2 protocols consisting of two 5-week induction cycles of continuous i.v. high-dose interleukin-2 (IL-2), i.m. interferon-alpha (IFN alpha) and ex vivo IL-2-activated lymphocytes, followed for patients with stable disease (SD), partial response (PR) ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gratama JW,Schmitz PI,Goey SH,Lamers CH,Stoter G,Bolhuis RL

    更新日期:1996-01-17 00:00:00

  • Akt promotes cisplatin resistance in human ovarian cancer cells through inhibition of p53 phosphorylation and nuclear function.

    abstract::Resistance to cisplatin-based chemotherapy is a major cause of treatment failure in human ovarian cancer. Wild-type TP53 status is often, but not always, associated with cisplatin sensitivity, suggesting that additional factors may be involved. Overexpression/activation of the phosphatidylinositol-3-kinase/Akt pathway...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fraser M,Bai T,Tsang BK

    更新日期:2008-02-01 00:00:00

  • AFP-synthesis induction in mouse hepatomas.

    abstract::Highly differentiated, spontaneous hepatomas occurring in 13- to 15-month-old CBA mice were unable to produce embryo-specific serum protein alpha-fetoprotein (AFP). AFP synthesis, however, was induced in such tumors by minimal mechanical damage (small incisions of the tumors). On the 3rd day following surgery, AFP-pos...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shipova LY,Gleiberman AS

    更新日期:1985-01-15 00:00:00

  • Isolation of a human prostate carcinoma cell line (DU 145).

    abstract::A long-term tissue culture cell line has been derived from a human prostate adenocarcinoma metastatic to the brain. The cell line, DU 145, has been passaged 90 times in vitro over a period of 2 years. The cells are epithelial, grow in isolated islands on plastic Petri dishes, and form colonies in soft agar suspension ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Stone KR,Mickey DD,Wunderli H,Mickey GH,Paulson DF

    更新日期:1978-03-15 00:00:00

  • Home kitchen ventilation, cooking fuels, and lung cancer risk in a prospective cohort of never smoking women in Shanghai, China.

    abstract::Indoor air pollution (IAP) caused by cooking has been associated with lung cancer risk in retrospective case-control studies in developing and rural countries. We report the association of cooking conditions, fuel use, oil use, and risk of lung cancer in a developed urban population in a prospective cohort of women in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kim C,Gao YT,Xiang YB,Barone-Adesi F,Zhang Y,Hosgood HD,Ma S,Shu XO,Ji BT,Chow WH,Seow WJ,Bassig B,Cai Q,Zheng W,Rothman N,Lan Q

    更新日期:2015-02-01 00:00:00

  • Permissive expansion and homing of adoptively transferred T cells in tumor-bearing hosts.

    abstract::Activated T cells expressing endogenous or transduced TCRs are two cell types currently used in clinical adoptive T-cell therapy. The ability of these cells to recognize their antigen, expand and traffic to the tumor site are the initial steps necessary for successful therapy. In this study, we used in vivo biolumines...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Perez C,Jukica A,Listopad JJ,Anders K,Kühl AA,Loddenkemper C,Blankenstein T,Charo J

    更新日期:2015-07-15 00:00:00

  • A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma.

    abstract::The miR-34 family members are direct transcriptional targets of tumor suppressor p53, and loss of miR-34 function can impair p53-mediated cell cycle arrest and apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region of pri-miR-34b/c (423 bp from the transcription start site), located...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Xu Y,Liu L,Liu J,Zhang Y,Zhu J,Chen J,Liu S,Liu Z,Shi H,Shen H,Hu Z

    更新日期:2011-01-15 00:00:00

  • Overexpression of the met/HGF receptor in renal cell carcinomas.

    abstract::The c-met oncogene encodes the receptor for hepatocyte growth factor/scatter factor (HGF/SF), a multifunctional cytokine able to mediate morphogenesis as well as mitogenesis, motogenesis and invasiveness of epithelial cells. HGF/SF has been implicated in branching tubulogenesis of the developing kidney and in regenera...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Natali PG,Prat M,Nicotra MR,Bigotti A,Olivero M,Comoglio PM,Di Renzo MF

    更新日期:1996-06-21 00:00:00

  • Radiosensitivity of small-cell lung cancer xenografts compared with activity of c-myc, N-myc, L-myc, c-raf-1 and K-ras proto-oncogenes.

    abstract::Oncogenes of the myc family c-raf-1 and K-ras have been reported to modulate radiosensitivity. We examined the possible relationship between in vivo radiosensitivity to single-dose irradiation with 3-10 Gy, and activity of these proto-oncogenes in 2 sets of small-cell lung cancer (SCLC) xenografts, the CPH and the GLC...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rygaard K,Slebos RJ,Spang-Thomsen M

    更新日期:1991-09-09 00:00:00

  • The ability of normal mouse cells to reduce the malignant potential of transformed mouse bladder epithelial cells depends on their somatic origin.

    abstract::Somatic cell hybrids have been made between a transformed mouse bladder carcinoma cell line and normal mouse bladder epithelium and mesenchyme. In the epithelial tumour/mesenchyme hybrids the malignant phenotype was expressed dominantly whereas in the carcinoma/normal epithelium hybrids the malignant potential was gre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cowell JK,Franks LM

    更新日期:1984-05-15 00:00:00

  • Malignant neoplasms in cyclosporin A-induced autoimmunity (CyA-AI).

    abstract::Lethally X-irradiated LEW rats reconstituted with syngeneic bone marrow and given low-dose Cyclosporine A (CyA) for 5 weeks develop, after withdrawal of CyA, symptoms of disease resembling graft-vs.-host disease (GVHD) as seen after allogeneic bone-marrow transplantation. Symptoms of disease may include acute dermatit...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wodzig KW,Beijleveld LJ,Damoiseaux JG,Arends JW,van Breda Vriesman PJ

    更新日期:1997-07-29 00:00:00

  • Risk factors for Kaposi's sarcoma among HHV-8 seropositive homosexual men with AIDS.

    abstract::Kaposi's sarcoma (KS) is a frequent complication of the acquired immunodeficiency syndrome (AIDS) in homosexual men. Risk factors for developing this malignancy are uncertain, other than immunosuppression and coinfection with human herpesvirus 8 (HHV-8). We therefore examined factors associated with KS in a cross-sect...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nawar E,Mbulaiteye SM,Gallant JE,Wohl DA,Ardini M,Hendershot T,Goedert JJ,Rabkin CS,AIDS Cancer Cohort (ACC) Study Collaborators.

    更新日期:2005-06-10 00:00:00

  • Deciphering the roles of FOXO1 in human neoplasms.

    abstract::Neoplasms constituted an enormous burden and contributed to an estimated 8.2 million deaths in 2012 worldwide. FOXO1 (forkhead box O1), a member of the forkhead box (FOX) family, is a transcriptional factor involved in diverse cellular functions. Herein, we concentrate on recent studies of the antineoplastic roles of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Jiang S,Li T,Yang Z,Hu W,Yang Y

    更新日期:2018-10-01 00:00:00

  • Cytotoxicity against the K562 erythroleukemia cell line by human natural killer (NK) cells which do not bear free Fc receptors for IgG.

    abstract::When Fc receptors (FcR) on normal human peripheral blood lymphocytes were induced to modulate by overnight (18 h) incubation in the presence of soluble or particulate immune complexes, the natural killer (NK) activity of the effector lymphocyte suspension, as measured against the K562 erythroleukemia cell line, was si...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kay HD,Fagnani R,Bonnard GD

    更新日期:1979-08-01 00:00:00

  • Differential utilization of the SV40 enhancer and early promoter in various human lung carcinoma cell lines.

    abstract::Cell lines derived from the major morphological types of human lung cancer were tested for their ability to utilize the SV40 enhancer/early promoter. These cell lines were transfected with a recombinant plasmid containing a reporter gene, coding for chloramphenicol acetyltransferase (CAT), under the control of the SV4...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wong YC,Bernal SD

    更新日期:1990-05-15 00:00:00

  • The mitotic checkpoint gene, SIL is regulated by E2F1.

    abstract::The SIL gene expression is increased in multiple cancers and correlates with the expression of mitotic spindle checkpoint genes and with increased metastatic potential. SIL regulates mitotic entry, organization of the mitotic spindle and cell survival. The E2F transcription factors regulate cell cycle progression by c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Erez A,Chaussepied M,Castiel A,Colaizzo-Anas T,Aplan PD,Ginsberg D,Izraeli S

    更新日期:2008-10-01 00:00:00

  • Human papillomavirus type 16 E6 variants and HLA class II alleles among Japanese women with cervical cancer.

    abstract::The enhanced oncogenicity of particular human papillomavirus type 16 (HPV16) E6 variants is population-dependent, implying the involvement of additional genetic cofactors. This study was designed to investigate the association between E6 variants and human leukocyte antigen (HLA) polymorphism within a Japanese populat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Matsumoto K,Yasugi T,Nakagawa S,Okubo M,Hirata R,Maeda H,Yoshikawa H,Taketani Y

    更新日期:2003-10-10 00:00:00

  • Effect of epidermal growth factor on clonogenic growth of primary human tumor cells.

    abstract::The effect of EGF on the soft agar colony-forming ability of fresh human tumor cells was assessed in 40 specimens obtained from various types of carcinoma including those of the breast, endometrium ovary, and other sites. Cells from four established human tumor cell lines (three breast and one endometrial) were also i...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pathak MA,Matrisian LM,Magun BE,Salmon SE

    更新日期:1982-12-15 00:00:00