Epstein-Barr herpesvirus infection: inhibition by immunologically induced mediators with interferon-like properties.

abstract：:To investigate whether addition of local therapy to EGFR-TKIs could provide survival benefit than EGFR-TKIs alone in EGFR-mutant NSCLC patients with oligometastatic or oligoprogressive liver metastases (LM). Patients with EGFR-mutant NSCLC and oligometastatic or oligoprogressive LM who met inclusion criteria were retr...

journal_title：International journal of cancer

authors： Jiang T,Chu Q,Wang H,Zhou F,Gao G,Chen X,Li X,Zhao C,Xu Q,Li W,Wu F,Xiong A,Zhao J,Xu Y,Su C,Ren S,Zhou C,Hirsch FR

更新日期：2019-05-15 00:00:00

abstract：:We recently reported the potential of genistein in augmenting gemcitabine-induced killing of pancreatic cancer (Banerjee, S. et al., Cancer Research 2005;65:9064-72). Since cis-diaminedichloroplatinum (II) (cisplatin) is widely used against solid tumors, we further investigated whether genistein pretreatment could be ...

journal_title：International journal of cancer

authors： Banerjee S,Zhang Y,Wang Z,Che M,Chiao PJ,Abbruzzese JL,Sarkar FH

更新日期：2007-02-15 00:00:00

abstract：:We have investigated the effect of pre-treatment with the anti-cancer drugs cisplatin and etoposide on the susceptibility of P815 murine mastocytoma cells to lysis by murine spleen-derived anti-CD3-activated killer-T (AK-T) cells. A 20 hr pre-treatment with cisplatin (0.2-2 microg/ml) or etoposide (0.01-1 microg/ml) r...

journal_title：International journal of cancer

authors： Williams BA,Makrigiannis AP,Blay J,Hoskin DW

更新日期：1997-11-04 00:00:00

abstract：:Protocadherin 10 (PCDH10), a novel tumor suppressor gene in human cancers, is located in a common deleted region at chromosome 4q28 in colorectal cancer (CRC). This study aimed to ascertain the genetic loss of PCDH10 and its clinical relevance in CRC and to explore the tumor suppressor function of PCDH10. The genetic ...

journal_title：International journal of cancer

authors： Jao TM,Tsai MH,Lio HY,Weng WT,Chen CC,Tzeng ST,Chang CY,Lai YC,Yen SJ,Yu SL,Yang YC

更新日期：2014-12-01 00:00:00

abstract：:The MLN64 gene, which is localized in q12-q21 of the human chromosome 17, encodes a novel protein containing 2 distinct domains. At the N-terminal, MLN64 exhibits a potential trans-membrane region, while at the C-terminal, it shares homology with the F26F4.4 protein of Coenorhabditis elegans and the steroidogenic acut...

journal_title：International journal of cancer

authors： Moog-Lutz C,Tomasetto C,Régnier CH,Wendling C,Lutz Y,Muller D,Chenard MP,Basset P,Rio MC

更新日期：1997-04-10 00:00:00

abstract：:Data from a series of case-control studies, conducted in Italy and Switzerland between 1991 and 2001, have been analyzed to evaluate the role of n-3 polyunsaturated fatty acid (PUFA) intake in the etiology of cancer of oral cavity and pharynx (736 cases, 1772 controls), esophagus (395 cases, 1066 controls), large bowe...

journal_title：International journal of cancer

authors： Tavani A,Pelucchi C,Parpinel M,Negri E,Franceschi S,Levi F,La Vecchia C

更新日期：2003-05-20 00:00:00

abstract：:The anatomic site-dependent expression of hematopoietic progenitor cell antigen CD34 is a feature of gastrointestinal stromal tumours (GISTs). The basis for the differential CD34 expression is only incompletely understood. This study aimed at understanding the regulation of CD34 in GISTs and clarification of its site-...

journal_title：International journal of cancer

authors： Bure I,Braun A,Kayser C,Geddert H,Schaefer IM,Cameron S,Ghadimi MB,Ströbel P,Werner M,Hartmann A,Wiemann S,Agaimy A,Haller F,Moskalev EA

更新日期：2017-12-01 00:00:00

abstract：:Natural killer (NK)6 cell activity of peripheral blood lymphocytes against human leukemia cell lines was measured in patients with chronic B-cell lymphocytic leukemia (CLL) and age- and sex-matched controls. In order to remove the leukemia cells that interfere with the in vitro assay we (1) isolated lymphocytes that f...

journal_title：International journal of cancer

authors： Ziegler HW,Kay NE,Zarling JM

更新日期：1981-03-15 00:00:00

abstract：:We characterized 8 human hepatocellular-carcinoma cell lines established from the primary tumors of Korean patients. All lines showed substrate adherence and one line from anaplastic tumor also grew as floating aggregates. Most cultured cells maintained many morphological characteristics of the original tumors from wh...

journal_title：International journal of cancer

authors： Park JG,Lee JH,Kang MS,Park KJ,Jeon YM,Lee HJ,Kwon HS,Park HS,Yeo KS,Lee KU

更新日期：1995-07-28 00:00:00

abstract：:Human epidermoid carcinoma A431 cells attach more rapidly to collagen type-I and -IV substrates than to surfaces coated with laminin or fibronectin. The diminished intercellular interaction and rounding up manifested when these cells are exposed to epidermal growth factor (EGF) in tissue culture plastic or collagen fi...

journal_title：International journal of cancer

authors： Rieber M,Gil F,Rieber MS,Urbina C

更新日期：1986-03-15 00:00:00

abstract：:Nitric oxide may serve as one cofactor for human papillomavirus (HPV)-induced development of cervical cancer. Therefore, we first assessed the levels of cervical fluid nitric oxide metabolite (NOx) in 283 women with and without high-risk (hr) HPV. The NOx level in women with hr HPV (48.4 μmol/L [95% CI: 39.4-56.6], n ...

journal_title：International journal of cancer

authors： Rahkola P,Väisänen-Tommiska M,Tuomikoski P,Ylikorkala O,Mikkola TS

更新日期：2011-06-15 00:00:00

abstract：:Multifocal occurrence and frequent recurrence are characteristic features of urothelial carcinomas of both the urinary bladder and the upper urinary tract. To describe the clonal nature of these tumors, 2 theories have been proposed. The monoclonality hypothesis describes the multiple tumors as descendants of a single...

journal_title：International journal of cancer

authors： Hafner C,Knuechel R,Stoehr R,Hartmann A

更新日期：2002-09-01 00:00:00

abstract：:A randomized clinical trial designed to compare the effectiveness of cytoxan (CTX) alone versus a combination consisting of CTX, vincristine (Oncovin) and methotrexate (COM) in the treatment of Burkitt's lymphoma (BL) was carried out. Nineteen patients were selected at random to receive CTX alone while 21 received COM...

journal_title：International journal of cancer

authors： Olweny CL,Katongole-Mbidde E,Kaddu-Mukasa A,Atine I,Owor R,Lwanga S,Carswell W,Magrath IT

更新日期：1976-04-15 00:00:00

abstract：:Marine omega-3 polyunsaturated fatty acids (MO3PUFAs) have anticancer properties and may improve colon cancer survival. However, it remains unknown whether the benefit differs by tumor molecular subtype. We examined data from a phase III randomized trial of FOLFOX or FOLFOX + cetuximab among 1,735 stage III colon canc...

journal_title：International journal of cancer

authors： Song M,Ou FS,Zemla TJ,Hull MA,Shi Q,Limburg PJ,Alberts SR,Sinicrope FA,Giovannucci EL,Van Blarigan EL,Meyerhardt JA,Chan AT

更新日期：2019-07-15 00:00:00

abstract：:Breast cancer can be classified into molecular sub-types that have distinct survival patterns. We evaluated the prognostic significance of breast cancer sub-types in a cohort of women taking part in the NEAT and BR9601 clinical trials comparing cyclophosphamide, methotrexate and fluorouracil (CMF) with ECMF (epirubici...

journal_title：International journal of cancer

authors： Ali AM,Provenzano E,Bartlett JM,Abraham J,Driver K,Munro AF,Twelves C,Poole CJ,Hiller L,Dunn JA,Earl HM,Caldas C,Pharoah PD

更新日期：2013-09-15 00:00:00

abstract：:Leukemic stem cells (LSC) might be the source for leukemic disease self-renewal and account for disease relapse after treatment, which makes them a critical target for further therapeutic options. We investigated the role of cytotoxic T-lymphocytes (CTL) counteracting and recognizing LSC. Leukemia-associated antigens ...

journal_title：International journal of cancer

authors： Schneider V,Zhang L,Rojewski M,Fekete N,Schrezenmeier H,Erle A,Bullinger L,Hofmann S,Götz M,Döhner K,Ihme S,Döhner H,Buske C,Feuring-Buske M,Greiner J

更新日期：2015-11-01 00:00:00

abstract：:Dietary factors in the aetiology of stomach cancer were investigated using data from a case-control study conducted in Northern Italy on 206 histologically confirmed carcinomas and 474 control subjects in hospital for acute, non-digestive conditions, unrelated to any of the potential risk factors for gastric cancer. D...

journal_title：International journal of cancer

authors： La Vecchia C,Negri E,Decarli A,D'Avanzo B,Franceschi S

更新日期：1987-10-15 00:00:00

abstract：:Reverse-transcriptase polymerase chain reaction has been used to analyze the expression of 2 latent genes (EBNA-1 and LMP-1) and one replicative gene (BZLF-1) of Epstein-Barr virus in mononuclear cells from bone marrow and peripheral blood of healthy donors. EBV-gene transcription was detected in 8 out of 15 bone-marr...

journal_title：International journal of cancer

authors： Gonnella R,Angeloni A,Calogero A,Farina A,Santarelli R,Gentile G,Arcese W,Martino P,Mandelli F,Frati L,Faggioni A,Ragona G

更新日期：1997-03-04 00:00:00

abstract：:Ovarian cancer is the fourth most common cause of cancer deaths among females in the western world after cancer of the breast, colon and lung. The inability to control the disease within the peritoneal cavity is the major cause of treatment failure in patients with ovarian cancer. The majority of ovarian carcinomas ex...

journal_title：International journal of cancer

authors： Dijkgraaf I,Kruijtzer JA,Frielink C,Corstens FH,Oyen WJ,Liskamp RM,Boerman OC

更新日期：2007-02-01 00:00:00

abstract：:The enzyme alpha1,3galactosyltransferase synthesizes the alphaGal epitope, a carbohydrate structure (Galalpha1,3Galbeta1,4GlcNAc-R), on glycoconjugates in lower mammals. The enzyme is absent in humans but large amounts of natural antibodies that recognize alphaGal epitopes are present in human serum. It is likely that...

journal_title：International journal of cancer

authors： Aubert M,Crotte C,Bernard JP,Lombardo D,Sadoulet MO,Mas E

更新日期：2003-12-20 00:00:00

abstract：:The effect of the glycosylation inhibitor, tunicamycin, on synthesis and secretion of the membrane-associated glycoprotein carcinoembryonic antigen (CEA), was studied in the LS174T human colon cancer cell line. Tunicamycin treatment inhibited total cellular glycoprotein synthesis but did not affect CEA levels of cellu...

journal_title：International journal of cancer

authors： Miura S,Kim YS

更新日期：1986-08-15 00:00:00

abstract：:The human HBL-100 cell line harbours SV40 DNA integrated in tandem at a unique site. The SV40 T-antigen expressed in these cells is defective in a function essential to the replication of the viral genome. The integrated SV40 sequences were molecularly cloned in a bacteriophage, and a subclone (plasmid pSVHBI) contain...

journal_title：International journal of cancer

authors： Saint-Ruf C,Nardeux P,Cebrian J,Lacasa M,Lavialle C,Cassingena R

更新日期：1989-08-15 00:00:00

abstract：:We established gastric cancer-specific CD8+ T-cell (T(CD8+)) lines derived from different lymphocyte sources in the same patients by repeated stimulation with mitomycin-C-treated autologous tumor cells with low-dose interleukin-2, and we compared recognition patterns among the T(CD8+) derived from solid tumor, lymph n...

journal_title：International journal of cancer

authors： Kono K,Ichihara F,Iizuka H,Sekikawa T,Matsumoto Y

更新日期：1997-06-11 00:00:00

abstract：:Immune cells in tumor microenvironment play a prominent role in tumor progression and metastasis. MicroRNA-155 (miR-155) represents an important player in innate and adaptive immunity by regulating differentiation, maturation and activation of macrophages, dendritic cells, B cells and T cells. However, the role of miR...

journal_title：International journal of cancer

authors： Wang J,Yu F,Jia X,Iwanowycz S,Wang Y,Huang S,Ai W,Fan D

更新日期：2015-03-15 00:00:00

abstract：:Breast cancer is the cancer diagnosed most frequently in women worldwide. In Europe it is the most common cancer in the female population, with approximately 350,000 new cases diagnosed each year including 130,000 deaths. Incidence rates are increasing in the majority of European countries, whereas a decline in mortal...

journal_title：International journal of cancer

authors： Tyczynski JE,Plesko I,Aareleid T,Primic-Zakelj M,Dalmas M,Kurtinaitis J,Stengrevics A,Parkin DM

更新日期：2004-12-20 00:00:00

abstract：:Numerous prospective and retrospective studies have clearly demonstrated a dose-related increased lung cancer risk associated with cigarette smoking, with evidence also for a genetic component to risk. In this study, using the two-stage clonal expansion stochastic model framework, for the first time we investigated th...

journal_title：International journal of cancer

authors： Deng L,Kimmel M,Foy M,Spitz M,Wei Q,Gorlova O

更新日期：2009-05-01 00:00:00

abstract：:Targeting of T lymphocytes against epidermal growth-factor-receptor (EGF-R)+ tumor cells was achieved by constructing a hybrid hybridoma which secretes an anti-EGF-R/anti-CD3 bispecific monoclonal antibody (biMAb) of hybrid isotype (IgG1/IgG2a). Purification of biMAb molecules from parental anti-EGF-R and anti-CD3 MAb...

journal_title：International journal of cancer

authors： Ferrini S,Cambiaggi A,Sforzini S,Marciano S,Canevari S,Mezzanzanica D,Colnaghi MI,Grossi CE,Moretta L

更新日期：1993-12-02 00:00:00

abstract：:Genetic and epigenetic alterations during development of pancreatic ductal adenocarcinomas (PDACs) are well known. This study investigates genetic and epigenetic data together with tumor biology to find specific alterations responsible for metastasis formation. Using 16 human PDAC cell lines in a murine orthotopic PDA...

journal_title：International journal of cancer

authors： Mees ST,Mardin WA,Wendel C,Baeumer N,Willscher E,Senninger N,Schleicher C,Colombo-Benkmann M,Haier J

更新日期：2010-01-01 00:00:00

abstract：:Although aneuploidy is commonly observed in human cancers, the molecular mechanism underlying aneuploidization remains unclear. We used multiploid cancer model that had diploid and aneuploid cancer cells within the same cancerous tissue and attempted to detect specific epigenetic alterations associated with tumor cell...

journal_title：International journal of cancer

authors： Habano W,Sugai T,Jiao YF,Nakamura S

更新日期：2007-10-01 00:00:00

abstract：:The mutated in colorectal cancer (MCC) is a multifunctional gene showing loss of expression in colorectal and liver cancers. MCC mutations can drive colon carcinogenesis in the mouse and in vitro experiments suggest that loss of MCC function promotes cancer through several important cellular pathways. In particular, t...

journal_title：International journal of cancer

authors： Pangon L,Mladenova D,Watkins L,Van Kralingen C,Currey N,Al-Sohaily S,Lecine P,Borg JP,Kohonen-Corish MR

更新日期：2015-01-01 00:00:00