Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy.


:The purpose of this study was to assess the relationship between progression-free survival (PFS) in patients treated with DFMO + PCV (procarbazine, CCNU, vincristine) chemotherapy for malignant gliomas with tumor cell ornithine decarboxylase (ODC) activity. Formalin-fixed slides were obtained for study patients with anaplastic gliomas (AGs) and glioblastoma treated on protocol DM92-035. ODC levels were measured using an antibody to ODC coupled to Alexa 647 dye (Ab-ODC-Alexa 647). Ab-ODC-Alexa 647 intensity in transgenic murine hearts of differing ODC activity was used to calculate ODC activity in tumor cell nucleoplasm. In total, tumor specimens for 31 of 114 (27%) patients treated on the AG strata and 10 patients from the GBM strata were obtained. We found that tumor ODC level heterogeneity increased with increasing tumor malignancy. In a Cox proportional hazards model, PFS was found to be inversely related to median tumor ODC activity, with an unadjusted hazard ratio for median ODC group (>3.3 vs. 3.3 nmol/30 min/mug protein. Of AG tumors in which ODC activity was evaluated, 26% had ODC levels > 3.3 nmol/30 min/mug protein. This study shows that Ab-ODC-Alexa 647 fluorescence intensity can be used as a surrogate marker of ODC biochemical activity in AGs and can predict PFS to DFMO-based chemotherapy.


Int J Cancer


Levin VA,Jochec JL,Shantz LM,Aldape KD




Has Abstract


2007-11-15 00:00:00












  • Reciprocal activating interaction between 6-sulfo LacNAc+ dendritic cells and NK cells.

    abstract::Dendritic cells (DCs) display an extraordinary capacity to induce T-cell responses providing the opportunity of DC-based cancer vaccination strategies. Additional findings indicate that DCs may also play a crucial role for the activation of natural killer (NK) cells, which are important effectors in innate antitumor i...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wehner R,Löbel B,Bornhäuser M,Schäkel K,Cartellieri M,Bachmann M,Rieber EP,Schmitz M

    更新日期:2009-01-15 00:00:00

  • Tumor-promoting activity of 2,4-dinitrofluorobenzene.

    abstract::The aim of this study was to determine whether the skin-sensitizing agent 2,4-dinitrofluorobenzene (DNFB) would elicit the same morphological and biochemical events that are characteristic of 12-O-tetradecanoylphorbol-13-acetate (TPA). While single applications of 0.1% or 0.2% DNFB produced only mild epidermal hyperpl...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Maldve RE,Fischer SM

    更新日期:1995-02-08 00:00:00

  • Farnesyl transferase inhibitor treatment of breast cancer cells leads to altered RhoA and RhoC GTPase activity and induces a dormant phenotype.

    abstract::Farnesyl transferase inhibitors (FTIs) were shown to be effective in modulating tumor growth in Ras-transformed tumor cells. Recent studies have focused on Rho GTPases as putative targets of FTI action. Previously, we demonstrated that FTIs were effective in inhibiting the growth and invasiveness of RhoC GTPase-overex...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chatterjee M,van Golen KL

    更新日期:2011-07-01 00:00:00

  • Natural killer cell activity associated with reticulum cell neoplasms.

    abstract::A marked increase in natural killer (NK) activity is observed with lymphoid cells prepared from SJL/J mouse spleen and lymph nodes, in which a transplantable reticulum-cell neoplasm (RCN) is growing. The killer cells are non-adherent, non-phagocytic, relatively resistant to X-ray, and scarcely or only partially inacti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chang KS,Log T

    更新日期:1980-03-15 00:00:00

  • Flow cytometric analysis of the expression of 9A3 antigen, E-cadherin and EGF receptor in TMK-1 stomach cancer cells.

    abstract::We have previously produced a monoclonal antibody (MAb) against TMK-1 cells, a poorly differentiated stomach-cancer cell line, and designated the antigen as 9A3. Immunohistochemical analysis of various tumor tissues revealed that the expression of 9A3 antigen is specific for human adenocarcinoma. In the present study,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fukuyama R,Minoshima S,Ochiai A,Tahara E,Shimizu N

    更新日期:1991-04-22 00:00:00

  • Androgen receptor polymorphisms: association with prostate cancer risk, relapse and overall survival.

    abstract::Several reports have suggested that one or both of the trinucleotide repeat polymorphisms in the human androgen receptor (hAR) gene, (CAG)n coding for polyglutamine and (GGC)n coding for polyglycine, may be associated with prostate cancer risk; but no study has investigated their association with disease progression. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Edwards SM,Badzioch MD,Minter R,Hamoudi R,Collins N,Ardern-Jones A,Dowe A,Osborne S,Kelly J,Shearer R,Easton DF,Saunders GF,Dearnaley DP,Eeles RA

    更新日期:1999-10-22 00:00:00

  • HIPEC ROC I: a phase I study of cisplatin administered as hyperthermic intraoperative intraperitoneal chemoperfusion followed by postoperative intravenous platinum-based chemotherapy in patients with platinum-sensitive recurrent epithelial ovarian cancer.

    abstract::This phase I study tested the safety, feasibility, pharmacokinetics and pharmacodynamics of cisplatin administered as hyperthermic intraoperative intraperitoneal chemoperfusion (HIPEC) in patients with platinum-sensitive recurrent epithelial ovarian cancer (EOC) undergoing secondary cytoreductive surgery followed by p...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zivanovic O,Abramian A,Kullmann M,Fuhrmann C,Coch C,Hoeller T,Ruehs H,Keyver-Paik MD,Rudlowski C,Weber S,Kiefer N,Poelcher ML,Thiesler T,Rostamzadeh B,Mallmann M,Schaefer N,Permantier M,Latten S,Kalff J,Thomale J,

    更新日期:2015-02-01 00:00:00

  • Concomitant increase of LMP1 and CD25 (IL-2-receptor alpha) expression induced by IL-10 in the EBV-positive NK lines SNK6 and KAI3.

    abstract::Extranodal, nasal NK/T-cell lymphomas are regularly Epstein-Barr virus (EBV)-positive, with a type II latency pattern, expressing thus EBNA-1 and LMP1. The contribution of EBV to the tumor development is not known. Similarly to normal natural killer (NK) cells, cell lines derived from malignancies with a NK phenotype ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Takahara M,Kis LL,Nagy N,Liu A,Harabuchi Y,Klein G,Klein E

    更新日期:2006-12-15 00:00:00

  • Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding.

    abstract::Vitamin D has anticarcinogenic properties and might influence colorectal cancer (CRC) risk, but the epidemiological evidence is inconsistent. Many mechanisms of action for vitamin D have been proposed, with some of them initiating via its binding to the vitamin D receptor (VDR). Using a large Scottish case-control stu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Theodoratou E,Farrington SM,Tenesa A,McNeill G,Cetnarskyj R,Barnetson RA,Porteous ME,Dunlop MG,Campbell H

    更新日期:2008-11-01 00:00:00

  • Heat shock and cytokines modulate the expression of adhesion molecules on different human gastric-cancer cell lines.

    abstract::In order to understand the expression and modulation of adhesion molecules (AMs) on the surface of different gastric cancers, we studied 4 gastric-cancer cell lines including SC-M1, KATO-III, AGS and AZ-521. The expression of E-cadherin, integrins (beta1, beta2 and beta3), ICAMs (1 and 2), and CD11 (a, b and c) on the...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hsieh MC,Wu CW,Wu LH,Lui WY,P'eng FK,Yu CL

    更新日期:1996-09-04 00:00:00

  • Antibody-induced growth inhibition is mediated through immunochemically and functionally distinct epitopes on the extracellular domain of the c-erbB-2 (HER-2/neu) gene product p185.

    abstract::Over-expression of the c-erbB-2 (HER-2/neu) gene product p185 occurs in 30% of breast and ovarian cancers. The p185 protein might serve as a target for serotherapy in that antibodies against different epitopes on the extracellular domain of p185 can inhibit growth of tumor cells in the absence of cellular or humoral e...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Xu F,Lupu R,Rodriguez GC,Whitaker RS,Boente MP,Berchuck A,Yu Y,DeSombre KA,Boyer CM,Bast RC Jr

    更新日期:1993-02-01 00:00:00

  • Elevated expression of ICAM1 (CD54) and minimal expression of LFA3 (CD58) in Epstein-Barr-virus-positive nasopharyngeal carcinoma cells.

    abstract::Undifferentiated nasopharyngeal carcinoma (NPC) is a remarkable entity among human tumors because of its constant association with the Epstein-Barr virus (EBV). Malignant epithelial cells harbor the EBV genome and often express at least 2 species of latent EBV protein (EBNA1 and LMP1). Despite the massive presence of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Busson P,Zhang Q,Guillon JM,Gregory CD,Young LS,Clausse B,Lipinski M,Rickinson AB,Tursz T

    更新日期:1992-04-01 00:00:00

  • Ileal FGF15 contributes to fibrosis-associated hepatocellular carcinoma development.

    abstract::Fibroblast growth factor 15 (FGF15), FGF19 in humans, is a gut-derived hormone and a key regulator of bile acids and carbohydrate metabolism. FGF15 also participates in liver regeneration after partial hepatectomy inducing hepatocellular proliferation. FGF19 is overexpressed in a significant proportion of human hepato...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Uriarte I,Latasa MU,Carotti S,Fernandez-Barrena MG,Garcia-Irigoyen O,Elizalde M,Urtasun R,Vespasiani-Gentilucci U,Morini S,de Mingo A,Mari M,Corrales FJ,Prieto J,Berasain C,Avila MA

    更新日期:2015-05-15 00:00:00

  • Lung cancer mortality trends in 36 European countries: secular trends and birth cohort patterns by sex and region 1970-2007.

    abstract::Smoking is a major contributor to all-cause mortality in Europe and accounts for one-fifth of the cancer-related deaths. Monitoring the tobacco epidemic via an analysis of lung cancer trends is essential in helping countries arrest the effects of tobacco epidemic in the region. The study aims to provide a comprehensiv...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bray FI,Weiderpass E

    更新日期:2010-03-15 00:00:00

  • Ectopic expression of herpes simplex virus-thymidine kinase gene in human non-small cell lung cancer cells conferred caspase-activated apoptosis sensitized by ganciclovir.

    abstract::Human non-small cell lung cancer (NSCLC) cells were transfected with recombinant prodrug herpes simplex virus type I thymidine kinase (HSV-tk) cDNA, and the selected clones underwent apoptosis in response to induction by antiviral ganciclovir (GCV). The efficiency of GCV-induced growth inhibition and the extent of the...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chiu CC,Kang YL,Yang TH,Huang CH,Fang K

    更新日期:2002-12-01 00:00:00

  • PBX3 is a putative biomarker of aggressive prostate cancer.

    abstract::There is a great need to identify new and better prognostic and predictive biomarkers to stratify prostate cancer patients for optimal treatment. The aims of this study were to characterize the expression profile of pre-B cell leukemia homeobox (PBX) transcription factors in prostate cancer with an emphasis on investi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ramberg H,Grytli HH,Nygård S,Wang W,Ögren O,Zhao S,Løvf M,Katz B,Skotheim RI,Bjartell A,Eri LM,Berge V,Svindland A,Taskén KA

    更新日期:2016-10-15 00:00:00

  • Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development.

    abstract::Mitotic and meiotic cell cycle regulation is essential for normal development and tumor prevention. The underlying molecular mechanisms are not completely characterized. The aim of our analysis was to derive a global expression map of cell cycle regulators in mitosis and meiosis. First, the expression of cyclins, CDKs...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Diederichs S,Bäumer N,Schultz N,Hamra FK,Schrader MG,Sandstede ML,Berdel WE,Serve H,Müller-Tidow C

    更新日期:2005-08-20 00:00:00

  • CD66b, CD66c and carcinoembryonic antigen (CEA) are independently regulated markers in sera of tumor patients.

    abstract::Non-specific cross-reacting antigens (NCA-95 = CD66b and NCA-50/90 = CD66c) are members of the CEA (carcinoembryonic antigen = CD66e) family. Analysis of mRNA levels of CD66c in colon tumors suggests that this antigen is strongly up-regulated compared to its normal counterpart and could, therefore, be of clinical inte...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Grunert F,Daniel S,Nagel G,von Kleist S,Jantscheff P

    更新日期:1995-11-03 00:00:00

  • Beta-galactoside alpha2,6 sialyltransferase in human colon cancer: contribution of multiple transcripts to regulation of enzyme activity and reactivity with Sambucus nigra agglutinin.

    abstract::Colon cancer tissues display an increased activity of beta-galactoside alpha2,6 sialyltransferase (ST6Gal.I) and an increased reactivity with the lectin from Sambucus nigra (SNA), specific for alpha2,6-sialyl-linkages. Experimental and clinical studies indicate a contribution of these alterations to tumor progression,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dall'Olio F,Chiricolo M,Ceccarelli C,Minni F,Marrano D,Santini D

    更新日期:2000-10-01 00:00:00

  • Lymphocyte stimulation by autologous tumor cells in the presence of serum from the same patient or from healthy donors.

    abstract::Lymphocyte blastogenesis induced by autologous tumor biopsy cells, by allogeneic lymphocytes and by PHA, was performed in the presence of autologous or allogeneic serum collected from normal blood donors. In 13 of the 15 cases lymphocyte stimulation by autologous tumor cells was inhibited in the presence of autologous...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vánky F,Klein E,Stjernswärd J,Trempe G

    更新日期:1975-11-15 00:00:00

  • Melphalan availability in hypoxia-inducible factor-1alpha+/+ and factor-1alpha-/- tumors is independent of tumor vessel density and correlates with melphalan erythrocyte transport.

    abstract::Many tumors are impervious to anticancer agents. Resistance due to lack of cytotoxic penetration into the tumor is often overlooked but can play a significant role in undermining therapy. Insufficient and irregular vascularization of tumors is a possible barrier to drug delivery, but there are others, e.g., impaired v...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wildiers H,Guetens G,de Boeck G,Landuyt W,Verbeken E,Highley M,de Bruijn EA,van Oosterom AT

    更新日期:2002-06-01 00:00:00

  • Elevated risk for squamous cell carcinoma of the conjunctiva among adults with AIDS in the United States.

    abstract::Squamous cell carcinoma of the conjunctiva (SCCC) has been associated with HIV infection in equatorial Africa, but the evidence for association with HIV in developed countries, where SCCC is rarer, is controversial. We investigated the risk for SCCC and other eye cancers in the updated U.S. HIV/AIDS Cancer Match Regis...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Guech-Ongey M,Engels EA,Goedert JJ,Biggar RJ,Mbulaiteye SM

    更新日期:2008-06-01 00:00:00

  • Single nucleotide polymorphisms in the IGF-IRS pathway are associated with outcome in mCRC patients enrolled in the FIRE-3 trial.

    abstract::The Insulin-like growth factor (IGF)/IGF-receptor pathway with its scaffolding proteins Insulin Receptor Substrate (IRS)1 and IRS2 are crucial regulators of metabolism and progression in metastatic colorectal cancer (mCRC). The goal of the study was the identification of predictive and prognostic markers among IRS1, I...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Schirripa M,Zhang W,Heinemann V,Cao S,Okazaki S,Yang D,Loupakis F,Berger MD,Ning Y,Miyamoto Y,Suenaga M,Gopez RF,West JD,Hanna D,Barzi A,Falcone A,Stintzing S,Lenz HJ

    更新日期:2017-07-15 00:00:00

  • Chromothripsis in cancer cells: An update.

    abstract::In 2011, a novel form of genome instability was reported by Stephens et al., characterized by tens to hundreds of locally clustered rearrangements affecting one or a few chromosome(s) in cancer cells. This phenomenon, termed chromothripsis, is likely due to a single catastrophic event leading to the simultaneous forma...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Rode A,Maass KK,Willmund KV,Lichter P,Ernst A

    更新日期:2016-05-15 00:00:00

  • H-Ras selectively up-regulates MMP-9 and COX-2 through activation of ERK1/2 and NF-kappaB: an implication for invasive phenotype in rat liver epithelial cells.

    abstract::One of the most frequent events in carcinogenesis is uncontrolled activation of Ras signaling pathway. A previous study demonstrated that the introduction of H-Ras into the normal WB-F344 rat liver epithelial (WB) cell line and adult male F344 rats resulted in tumorigenicity. The present study investigated whether H-R...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lee KW,Kim MS,Kang NJ,Kim DH,Surh YJ,Lee HJ,Moon A

    更新日期:2006-10-15 00:00:00

  • Lectin-resistant variants of mouse melanoma cells. I. Altered metastasizing capacity and tumorigenicity.

    abstract::From C57BL mouse melanoma B-16 cells, variant clones were selected in vitro which were resistant to the lectins wheat-germ agglutinin and ricin. Cells were also selected which survived toxic concentrations of concanavalin A. Four different in vivo assays using intradermal, intravenous, intraperitoneal and intramuscula...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tao TW,Burger MM

    更新日期:1982-04-15 00:00:00

  • Curcumin enhances dasatinib-induced inhibition of growth and transformation of colon cancer cells.

    abstract::Colorectal cancer is the third most common form of malignancy, behind prostate and lung cancers. Despite recent advances in medicine, mortality from colorectal cancer remains high, highlighting the need for improved therapies. Numerous studies have demonstrated increased activation of EGFR and its family members (EGFR...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nautiyal J,Banerjee S,Kanwar SS,Yu Y,Patel BB,Sarkar FH,Majumdar AP

    更新日期:2011-02-15 00:00:00

  • Circulating levels of sex steroid hormones and risk of endometrial cancer in postmenopausal women.

    abstract::Experimental and epidemiological data support a role for sex steroid hormones in the pathogenesis of endometrial cancer. The associations of pre-diagnostic blood concentrations of estradiol, estrone, testosterone, androstenedione, DHEAS and SHBG with endometrial cancer risk were investigated. A case-control study was ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Lukanova A,Lundin E,Micheli A,Arslan A,Ferrari P,Rinaldi S,Krogh V,Lenner P,Shore RE,Biessy C,Muti P,Riboli E,Koenig KL,Levitz M,Stattin P,Berrino F,Hallmans G,Kaaks R,Toniolo P,Zeleniuch-Jacquotte A

    更新日期:2004-01-20 00:00:00

  • c-erbB-2 oncoprotein in screen-detected breast carcinoma: an immunohistological study.

    abstract::This study was aimed at comparing screen-detected and symptomatic breast carcinomas with regard to the prevalence of positive immunostaining for c-erb-B-2 oncoprotein. Paraffin sections of 81 breast carcinomas detected through the National Screening Programme were examined for the over-expression of c-erbB-2 oncoprote...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Soomro S,Taylor P,Shepard HM,Feldmann M,Sinnett HD,Shousha S

    更新日期:1993-08-19 00:00:00

  • Role of activated c-H-ras oncogene in the induction and progression of immortal liver epithelial cell lines derived from normal C3H mice.

    abstract::The nature of 15 immortal mouse liver epithelial cell (MLEC) lines established from normal C3H mice was investigated specifically in terms of ras oncogene activation. Neither transforming activity nor point mutation within codon 61 of c-H-ras could be demonstrated in any of the cell lines by DNA transfection in a NIH/...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lee GH,Sakai R,Nagao M,Kitagawa T

    更新日期:1991-01-02 00:00:00