Abstract：
:Hooded rats bearing a syngeneic methylcholanthrene-induced tumour were evaluated for extent of in vivo host immunity and this was correlated by in vitro techniques with the levels of circulating tumour antigen and specific antibody. Early tumour growth was associated with detectable immunity, as measured by the capacity of the animal to reject a second direct challenge of the same tumour at a remote site. Radioimmunoassay for circulating tumour antigen and indirect membrane immunofluorescence for antitumour antibody did not detect either component at this stage. Animals with advanced tumours lost immunity as detected by direct tumour challenge, and this closely coincided with the appearance of rising levels of circulating soluble tumour antigen. Although the host possessed the immunologic ability to react against its own neoplasm, this ability was insufficient to produce tumour rejection. Active immunotherapy initiated at the time of, or up to 10 days after, intramuscular challenge with tumour, increased tumour immunity sufficiently for tumour growth to be prevented. Successful immunization was associated with the early appearance (16 days) of measurable levels of antitumour antibody and absence of circulating antigen. It is concluded that soluble tumour antigen present in the local microenvironment of the tumour in the early stages of tumour growth interferes with the ability of immune cells to cause tumour rejection. As the tumour progressively grows, sufficient soluble antigen is produced and released systemically to suppress the effector arm of the host's tumour immune response at distant sites. The levels of circulating soluble tumour antigen attained may be of critical importance in the suppression of rejection responses that prevent metastasis.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Thomson DMdoi
10.1002/ijc.2910150619subject
Has Abstractpub_date
1975-06-15 00:00:00pages
1016-29issue
6eissn
0020-7136issn
1097-0215journal_volume
15pub_type
杂志文章abstract：:Results of epidemiologic studies of physical activity and ovarian cancer risk are inconsistent. Few have attempted to measure physical activity over the lifetime or in specific age windows, which may better capture etiologically relevant exposures. We examined participation in moderate-to-vigorous recreational physica...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.32513
更新日期：2020-04-01 00:00:00
abstract：:Multiple myeloma (MM) is characterized by accumulation of monoclonal plasma cells in the bone marrow and progression of lytic bone lesions. The mechanisms of enhanced bone resorption in patients with myeloma are not fully defined. We have previously identified the role of brain-derived neurotrophic factor (BDNF) in pr...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.26059
更新日期：2012-02-15 00:00:00
abstract：:Sunlight is essential for the production of vitamin D in the body. Evidence exists to suggest that vitamin D metabolites may have a role in tumor growth suppression. In this large study, involving over a million cancer patients from the United Kingdom, we have analyzed the role of season of diagnosis and sunlight expo...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22052
更新日期：2006-10-01 00:00:00
abstract：:Mantle cell lymphoma (MCL) is an aggressive form of Non-Hodgkin-lymphoma (NHL) with an ongoing need for novel treatments. Apart from the translocation t(11:14), which facilitates constitutive transcription of cyclin D1, additional aberrations are frequently observed in MCL, including a recurrent dysregulation of the p...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.28206
更新日期：2013-10-15 00:00:00
abstract：:Modern life involves mistimed sleeping and eating patterns that in experimental studies are associated with adverse health effects. We assessed whether timing of meals is associated with breast and prostate cancer risk taking into account lifestyle and chronotype, a characteristic correlating with preference for morni...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.31649
更新日期：2018-11-15 00:00:00
abstract：:Human malignant glioma cell lines and clones were incubated with various concentrations of recombinant human TNF-alpha, either alone or in combination with recombinant human IFN-gamma. The surface expression of HLA-ABC (class I) antigens and beta 2-microglobulin, was significantly enhanced by TNF-alpha alone on every ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910420525
更新日期：1988-11-15 00:00:00
abstract：:The amplification of the q21 band of chromosome 8 (8q21) occurs in a large percentage of breast cancers. WWP1, an HECT domain-containing ubiquitin E3 ligase located in the 8q21 region, negatively regulates the TGF-beta tumor suppressor pathway. To characterize the role of WWP1 in breast cancer, we analyzed WWP1 gene d...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22653
更新日期：2007-07-01 00:00:00
abstract：:Moderate to high-dose radiotherapy is known to increase the risk of breast cancer. Uncertainties remain about the effects of low-dose chest X-rays, particularly in individuals at increased genetic risk. We analyzed case-control data from the Breast Cancer Family Registry. Self-reported data on therapeutic and diagnost...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22668
更新日期：2007-07-15 00:00:00
abstract：:Serum tyrosinase activity has been measured by adapting the [3]tyrosine assay for tyrosinase and significant elevations of serum tyrosinase activity were found in patients with malignant melanoma. In contrast to findings in a study which utilized [14C]tyrosine, augmented levels of tyrosinase activity were not observed...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910200507
更新日期：1977-11-15 00:00:00
abstract：:Analysis of the length of circulating DNA in plasma has been reported as a marker for solid tumor detection. We assessed the sensitivity and specificity of increased plasma DNA length to identify patients with head and neck squamous cell carcinoma (HNSCC) and monitor posttreatment disease status. Fifty-eight HNSCC pat...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22250
更新日期：2006-12-01 00:00:00
abstract：:Melanoma is the most lethal human skin cancer. If metastatic, it becomes very aggressive and resistant to standard modalities of anticancer treatment. During the last 10 years, several therapeutic strategies have been tested including the use of single and combined small drugs. Experimental results indicate that RAS a...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24926
更新日期：2010-04-01 00:00:00
abstract：:Organochlorine insecticides have been studied extensively in relation to breast cancer incidence, and results from two meta-analyses have been null for late-life residues, possibly due to measurement error. Whether these compounds influence survival remains to be fully explored. We examined associations between organo...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.29806
更新日期：2016-02-01 00:00:00
abstract：:We have induced plasmacytomas (MPC) in BALB/c radiochimeras (RCh) repopulated with syngeneic hemopoietic cells carrying distinctive chromosomal markers. A group of 38 RCh that received 0.5 ml pristane, followed by Abelson virus infection 2-3 weeks later, developed 7 tumors (18.5%) of donor origin after a relatively sh...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910440225
更新日期：1989-08-15 00:00:00
abstract：:The role of different types of alcoholic beverage on cancer of the upper digestive tract was investigated in a case-control study conducted in the northern part of Italy on 305 male cases of cancer of the oral cavity and pharynx, 288 of oesophageal cancer and 1621 controls admitted to hospital for acute, non-neoplasti...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910460612
更新日期：1990-12-15 00:00:00
abstract：:Epithelial ovarian cancer (EOC) is a complex disease comprising discrete histological and molecular subtypes, for which survival rates remain unacceptably low. Tailored approaches for this deadly heterogeneous disease are urgently needed. Efflux pumps belonging to the ATP-binding cassette (ABC) family of transporters ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.33005
更新日期：2020-10-15 00:00:00
abstract：:The loss of E-cadherin expression and the translocation of beta-catenin to the nucleus are frequently associated with the metastatic conversion of epithelial cells. In the nucleus, beta-catenin binds to the TCF/LEF-1 (T-cell factor/ lymphoid enhancer factor) transcription factor family resulting in the activation of s...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21291
更新日期：2006-01-01 00:00:00
abstract：:The role of alcoholic beverages in the etiology of gastric cancer is unclear. Recent summaries showed a positive association between higher alcohol intake and gastric cancer risk, but the magnitude of association is small, there is moderate heterogeneity among studies, and most cases were from Asian populations. We pr...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.31740
更新日期：2018-12-01 00:00:00
abstract：:The 1100delC mutation of the cell cycle checkpoint kinase 2 (CHEK2) gene confers an increased risk for breast cancer, but the clinical impact of other CHEK2 gene variants remains unclear. We determined the frequency of two functionally relevant CHEK2 gene mutations, I157T and IVS2+1G > A, in two large series of breast...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21022
更新日期：2005-08-20 00:00:00
abstract：:Resistance to anticancer drugs is the major problem in the treatment of many advanced cancers, including androgen-independent prostate cancer. Recently, increased expression of Id-1, a basic helix-loop-helix protein, is reported in several types of advanced cancer. It is suggested that high expression of Id-1 may prov...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21592
更新日期：2006-04-15 00:00:00
abstract：:Activation-induced cytidine deaminase (AID) plays a role as a genome mutator in activated B cells, and inappropriate expression of AID has been implicated in the immunopathological phenotype of human B-cell malignancies. Notably, we found that the transgenic mice overexpressing AID developed lung adenocarcinoma and he...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22292
更新日期：2007-02-01 00:00:00
abstract：:ErbB-2 and EGF receptors are often co-expressed in human tumors and have been shown to synergize in the transformation of cells in experimental model systems. Transactivation of ErbB-2 can occur via ligand-induced heterodimerization with EGF receptor or other members of the ErbB family of receptor tyrosine kinases. We...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(SICI)1097-0215(19960208)65:4<538::AID-IJC
更新日期：1996-02-08 00:00:00
abstract：:Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is a member of the EGF family of polypeptide growth factors, which includes EGF, transforming growth factor alpha(TGF-alpha), amphiregulin (AR) and betacellulin (BTC). To assess the potential role of HB-EGF in human gastric carcinomas, the expre...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(SICI)1097-0215(19960503)66:3<315::AID-IJC
更新日期：1996-05-03 00:00:00
abstract：:We show that siRNA-mediated suppression of protein tyrosine phosphatase alpha (PTP alpha) reduces Src activity 2 to 4-fold in breast, colon and other human cancer cell lines. Src and PTP alpha RNAi induced apoptosis in estrogen receptor (ER)-negative breast cancer and colon cancer cells, but not in immortalized noncan...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.23321
更新日期：2008-05-01 00:00:00
abstract：:Identification of loss of heterozygosity on specific genetic loci is crucial for understanding the pathogenesis of prostate cancer at the molecular level. This is especially important because the deleted regions may contain putative tumor suppressor genes. Chromosome 3p loss appears to be frequently associated with va...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19970328)71:1<20::aid-ijc5
更新日期：1997-03-28 00:00:00
abstract：:Breast cancer is the cancer diagnosed most frequently in women worldwide. In Europe it is the most common cancer in the female population, with approximately 350,000 new cases diagnosed each year including 130,000 deaths. Incidence rates are increasing in the majority of European countries, whereas a decline in mortal...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.20514
更新日期：2004-12-20 00:00:00
abstract：:I-compounds are bulky indigenous DNA adducts that can be detected by (32)P-postlabeling. A subgroup, termed type II I-compounds, represents DNA lesions induced by oxidative stress. Several major type II I-compounds have been identified as dinucleotides containing 3'-terminal 8,5'-cyclo-2'-deoxyadenosine (cA). Levels o...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.20375
更新日期：2004-12-10 00:00:00
abstract：:Ciclopirox olamine (CPX) is a synthetic antifungal agent clinically used to treat mycoses of the skin and nails. Here, we show that CPX inhibited tumor growth in human breast cancer MDA-MB-231 xenografts. To unveil the underlying mechanism, we further studied the antitumor activity of CPX in cell culture. The results ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25255
更新日期：2010-11-15 00:00:00
abstract：:In this study the antigenic profile of Hodgkin (H) and Sternberg-Reed (SR) cells from cases of Hodgkin's disease was analysed using a large panel of monoclonal and polyclonal antibodies reactive with cells of lymphoid and haemotopoietic origin. The aim of this investigation was, firstly, to throw light on the origin o...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910300411
更新日期：1982-10-15 00:00:00
abstract：:The relationship between breast cancer-associated fatty acid synthase (FAS; oncogenic antigen-519) and chemotherapy-induced cell damage has not been studied. We examined the ability of C75, a synthetic slow-binding inhibitor of FAS activity, to modulate the cytotoxic activity of the microtubule-interfering agent Taxol...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.20754
更新日期：2005-05-20 00:00:00
abstract：:Regional lymph-node (LN) lymphocytes may constitute an important defence against the spread of human melanoma beyond regional LNs. The present study was directed to clonal analysis of lymphocytes cultured either directly from the LNs or after stimulation in cultures with autologous melanoma (MLTC). T-cell clones deriv...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910510209
更新日期：1992-05-08 00:00:00
