Tumor progression in human malignant melanoma is associated with changes in alpha 6/beta 1 laminin receptor.


:Cells of the melanocytic lineage have been shown to be capable of producing laminin and to lose this property during transformation. In the present study, we have evaluated immunohistochemically whether these changes are paralleled by an altered expression of the alpha 6/beta 1 laminin receptor. Results of this analysis have shown that while nevic cells display high levels of the receptor, this heterodimer undergoes a progressive decrease in expression in cutaneous melanomas of increasing invasiveness. A loss or unco-ordinated expression of the alpha 1/beta complex is present in the majority of the metastatic foci at different body sites. The present results show that during transformation the alpha 6/beta 1 laminin receptor undergoes quantitative alterations and deregulated expression of the 2 subunits. Although the functional relevance of these changes remains unknown, their occurrence in association with modifications of other cellular and extracellular macromolecules associated with tumor progression, strongly suggests a role in human melanoma progression.


Int J Cancer


Natali PG,Nicotra MR,Cavaliere R,Giannarelli D,Bigotti A




Has Abstract


1991-09-09 00:00:00












  • STLV-I antibodies in feral populations of East African vervet monkeys (Cercopithecus aethiops).

    abstract::Serum samples from feral populations of African green monkeys (Cercopithecus aethiops) were screened for antibodies to the simian T-lymphotropic virus, type I (STLV-I). Blood samples had been collected from 336 monkeys in 4 regions of central and southern Kenya in 1978 and 1979, from 114 monkeys in central Ethiopia in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dracopoli NC,Turner TR,Else JG,Jolly CJ,Anthony R,Gallo RC,Saxinger WC

    更新日期:1986-10-15 00:00:00

  • Therapeutic anti-tumor response induced with epitope-pulsed fibroblasts genetically engineered for B7.1 expression and IFN-gamma secretion.

    abstract::Mouse fibroblasts (H-2(b)) were genetically engineered to express a co-stimulatory B7.1 and an IFN-gamma (Fb/IFN-gamma/B7.1). The Fb/IFN-gamma/B7.1 cells were then pulsed with an ovalbumin epitope (amino acids 257-264, SIINFEKL, H-2K(b)-restricted) as a model antigen (Fb/IFN-gamma/B7.1/OVA) and tested for the inductio...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kim TS,Chung SW,Kim SH,Kang SN,Kang BY

    更新日期:2000-08-01 00:00:00

  • Thyroid and androgen receptor signaling are antagonized by μ-Crystallin in prostate cancer.

    abstract::Androgen deprivation therapy (ADT) remains a key approach in the treatment of prostate cancer (PCa). However, PCa inevitably relapses and becomes ADT resistant. Besides androgens, there is evidence that thyroid hormone thyroxine (T4) and its active form 3,5,3'-triiodo-L-thyronine (T3) are involved in the progression o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Aksoy O,Pencik J,Hartenbach M,Moazzami AA,Schlederer M,Balber T,Varady A,Philippe C,Baltzer PA,Mazumder B,Whitchurch JB,Roberts CJ,Haitel A,Herac M,Susani M,Mitterhauser M,Marculescu R,Stangl-Kremser J,Hassler MR,Kr

    更新日期:2021-02-01 00:00:00

  • Dichlorodiphenyltrichloroethane and risk of hepatocellular carcinoma.

    abstract::Dichlorodiphenyltrichloroethane (p,p'-DDT), an organochlorine pesticide known to have deleterious health effects in humans, has been linked to hepatocellular carcinoma (HCC) in rodents. A recent study has reported that p,p'-DDT and its most persistent metabolite, dichlorodiphenyldichloroethylene (p,p'-DDE), may also b...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Persson EC,Graubard BI,Evans AA,London WT,Weber JP,LeBlanc A,Chen G,Lin W,McGlynn KA

    更新日期:2012-11-01 00:00:00

  • Gene expression profiling of alpha-radiation-induced rat osteosarcomas: identification of dysregulated genes involved in radiation-induced tumorigenesis of bone.

    abstract::To better understand the molecular basis of radiation-induced osteosarcoma (OS), we performed global gene expression profiling of rat OS tumors induced by the bone-seeking alpha emitter (238)Pu, and the expression profiles were compared with those of normal osteoblasts (OB). The expressions of 72 genes were significan...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Daino K,Ugolin N,Altmeyer-Morel S,Guilly MN,Chevillard S

    更新日期:2009-08-01 00:00:00

  • Relationship of SNCG, S100A4, S100A9 and LCN2 gene expression and DNA methylation in bladder cancer.

    abstract::Microarray analysis of paired cultures of normal and cancerous urothelial cells revealed differences in cytokeratin and adhesion gene expression. Normal cells expressed autocrine growth factor genes more strongly whereas carcinoma cells were distinguished by concomitant expression of urothelial and epidermal different...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dokun OY,Florl AR,Seifert HH,Wolff I,Schulz WA

    更新日期:2008-12-15 00:00:00

  • Embryo-derived teratocarcinoma: I. The role of strain and gender in the control of teratocarcinogenesis.

    abstract::The role of gender and genetic (strain-specific) factors in the regulation of teratocarcinogenesis was studied by monitoring the outgrowth of benign and malignant embryo-derived teratoid tumors, i.e., teratomas and teratocarconomas in several mouse strains. Teratocarcinomas were produced in all mouse strains tested, b...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Solter D,Dominis M,Damjanov I

    更新日期:1979-12-15 00:00:00

  • Targeting of T lymphocytes against EGF-receptor+ tumor cells by bispecific monoclonal antibodies: requirement of CD3 molecule cross-linking for T-cell activation.

    abstract::Targeting of T lymphocytes against epidermal growth-factor-receptor (EGF-R)+ tumor cells was achieved by constructing a hybrid hybridoma which secretes an anti-EGF-R/anti-CD3 bispecific monoclonal antibody (biMAb) of hybrid isotype (IgG1/IgG2a). Purification of biMAb molecules from parental anti-EGF-R and anti-CD3 MAb...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ferrini S,Cambiaggi A,Sforzini S,Marciano S,Canevari S,Mezzanzanica D,Colnaghi MI,Grossi CE,Moretta L

    更新日期:1993-12-02 00:00:00

  • The combination of epigallocatechin gallate and curcumin suppresses ER alpha-breast cancer cell growth in vitro and in vivo.

    abstract::Both epigallocatechin gallate (EGCG) and curcumin have shown efficacy in various in vivo and in vitro models of cancer. This study was designed to determine the efficacy of these naturally derived polyphenolic compounds in vitro and in vivo, when given in combination. Studies in MDA-MB-231 cells demonstrated that EGCG...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Somers-Edgar TJ,Scandlyn MJ,Stuart EC,Le Nedelec MJ,Valentine SP,Rosengren RJ

    更新日期:2008-05-01 00:00:00

  • Effects of anti-transferrin receptor antibodies on growth of normal and malignant myeloid cells.

    abstract::The effects of three monoclonal antibodies (B3/25, 43/31, and 42/6) reactive with human transferrin (Tf) receptors on growth of normal and malignant myeloid cells were examined using in vitro culture techniques. When added directly to cultures, all three antibodies caused dose-dependent inhibition of normal granulocyt...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Taetle R,Honeysett JM,Trowbridge I

    更新日期:1983-09-15 00:00:00

  • Secretion of basement membrane collagen degrading enzyme and plasminogen activator by transformed cells--role in metastasis.

    abstract::The relationship of a basement membrane collagen degrading enzyme (BM collagenase) and plasminogen activator (PA) was studied in a number of non-malignant and malignant human and murine cell lines. Several non-malignant cell lines secreted significant amounts of PA but not detectable BM collagenase activity whereas th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Salo T,Liotta LA,Keski-Oja J,Turpeenniemi-Hujanen T,Tryggvason K

    更新日期:1982-11-15 00:00:00

  • Resistance-associated factors in human small-cell lung-carcinoma GLC4 sub-lines with increasing adriamycin resistance.

    abstract::Previous studies have shown that the in vitro-selected adriamycin-resistant human small-cell lung-carcinoma cell line GLC4-ADR150 displays multidrug resistance as the result of 3-fold decreased DNA-topoisomerase II (topo II) activity and a 6-fold reduction in adriamycin accumulation. Not the MDR1 gene, but the MRP gen...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Versantvoort CH,Withoff S,Broxterman HJ,Kuiper CM,Scheper RJ,Mulder NH,de Vries EG

    更新日期:1995-05-04 00:00:00

  • Insulin-like growth factor-1 receptor as a novel prognostic marker and its implication as a cotarget in the treatment of human adenocarcinoma of the esophagus.

    abstract::Insulin-like growth factor-1 receptor (IGF-1R) and human epidermal growth factor receptor-2 (HER2) receptor expression has been found to be a key regulator of tumorigenesis. The purpose of our study was to establish the prognostic significance of IGF-1R in esophageal cancer and to determine the effect of IGF-1R and HE...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kalinina T,Bockhorn M,Kaifi JT,Thieltges S,Güngör C,Effenberger KE,Strelow A,Reichelt U,Sauter G,Pantel K,Izbicki JR,Yekebas EF

    更新日期:2010-10-15 00:00:00

  • Diagnosis of digestive system tumours.

    abstract::The WHO Classification of Tumours provides the international standards for the classification and diagnosis of tumours. It enables direct comparisons to be made between different countries. In the new fifth edition, the series has gone digital with the launch of a website as well as a series of books, known widely as ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Washington MK,Goldberg RM,Chang GJ,Limburg P,Lam AK,Salto-Tellez M,Arends MJ,Nagtegaal ID,Klimstra DS,Rugge M,Schirmacher P,Lazar AJ,Odze RD,Carneiro F,Fukayama M,Cree IA,WHO Classification of Tumours Editorial Board.

    更新日期:2021-03-01 00:00:00

  • A portion of the feline leukaemia virus genome is not endogenous in cat cells.

    abstract::Although viral sequences closely related to feline leukaemia virus are represented in multiple copies in cellular DNA of all domestic cats, a specific fraction was present only in the virus-infected cells. This fraction was detected by viral cDNA enriched by a prior absorption of a total complementary DNA (cDNA) trans...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Okabe H,DuBuy J,Gilden RV,Gardner MB

    更新日期:1978-07-15 00:00:00

  • Gene transfer of a secretable form of IL-15 in murine adenocarcinoma cells: effects on tumorigenicity, metastatic potential and immune response.

    abstract::IL-15 is an immunostimulatory cytokine with IL-2-like activities. To exploit the potential role of IL-15 in cancer immuno-/gene therapy, we engineered murine TS/A cells with different IL-15 cDNA constructs. Significant IL-15 secretion was achieved only by the use of a modified cDNA encoding for an IL-15 pre-protein be...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Meazza R,Lollini PL,Nanni P,De Giovanni C,Gaggero A,Comes A,Cilli M,Di Carlo E,Ferrini S,Musiani P

    更新日期:2000-08-15 00:00:00

  • Smoking, snus use and risk of right- and left-sided colon, rectal and anal cancer: a 37-year follow-up study.

    abstract::Although some authorities consider smoking to be an established risk factor for colorectal cancer, the international literature is not entirely consistent. Further, only 1 study has addressed the association with smokeless tobacco and none with Scandinavian moist snuff (snus). This retrospective cohort study included ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nordenvall C,Nilsson PJ,Ye W,Nyrén O

    更新日期:2011-01-01 00:00:00

  • HPV-associated flat penile lesions in men of a non-STD hospital population: less frequent and smaller in size than in male sexual partners of women with CIN.

    abstract::Human papillomavirus (HPV) infections and HPV-associated penile lesions are frequently found in male sexual partners of women with cervical intraepithelial neoplasia (CIN). To determine the significance of these findings, we studied the prevalence of HPV and HPV associated penile lesions in a male hospital population ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bleeker MC,Hogewoning CJ,Voorhorst FJ,van den Brule AJ,Berkhof J,Hesselink AT,Lettink M,Starink TM,Stoof TJ,Snijders PJ,Meijer CJ

    更新日期:2005-01-01 00:00:00

  • Risk factors for tumors of the brain and meninges: results from the Adelaide Adult Brain Tumor Study.

    abstract::A population-based case-control study of incident primary brain tumors in adults was carried out in Adelaide, Australia in the period 1987 through 1990. It included 110 subjects with newly diagnosed primary glioma, 60 subjects with meningioma and 417 controls selected from the Australian Electoral Roll and frequency-m...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ryan P,Lee MW,North B,McMichael AJ

    更新日期:1992-04-22 00:00:00

  • Loss of EphA2 receptor tyrosine kinase reduces ApcMin/+ tumorigenesis.

    abstract::The Eph receptor A2 (EphA2) is overexpressed in a range of human epithelial cancers, a phenotype that is associated with cancer cell proliferation, progression and angiogenesis. Mouse models of mammary neoplasia have confirmed the role of EphA2 as mice carrying a knockout allele of EphA2 were resistant to breast cance...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bogan C,Chen J,O'Sullivan MG,Cormier RT

    更新日期:2009-03-15 00:00:00

  • Survival in patients with human papillomavirus positive tonsillar cancer in relation to treatment.

    abstract::The incidence of tonsillar cancer and the proportion of human papillomavirus (HPV) positive tonsillar cancer cases have increased in the last decades. In parallel, treatment for tonsillar cancer has been intensified e.g., by accelerated radiotherapy, and chemotherapy, resulting in more side effects. Patients with HPV-...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Attner P,Näsman A,Du J,Hammarstedt L,Ramqvist T,Lindholm J,Munck-Wikland E,Dalianis T,Marklund L

    更新日期:2012-09-01 00:00:00

  • Detection of occult tumour cells in lymph nodes of colorectal cancer patients using real-time quantitative RT-PCR for CEA and CK20 mRNAS.

    abstract::The purpose of our study was to develop specific, sensitive, objective assays for early detection of disseminated tumour cells in patients with colorectal cancer (CRC). Carcinoembryonic antigen (CEA) and cytokeratin 20 (CK20) were chosen as markers because they are selectively expressed in epithelial cells with mainta...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Oberg AN,Lindmark GE,Israelsson AC,Hammarström SG,Hammarström ML

    更新日期:2004-08-10 00:00:00

  • Folate intake and colorectal cancer risk: a meta-analytical approach.

    abstract::Adequate consumption of folate may reduce the risk of colorectal cancer. We performed a meta-analysis of 7 cohort and 9 case-control studies that examined the association between folate consumption and colorectal cancer risk. In cohort studies, the association between folate consumption and colorectal cancer risk was ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析


    authors: Sanjoaquin MA,Allen N,Couto E,Roddam AW,Key TJ

    更新日期:2005-02-20 00:00:00

  • Transcriptional repression of the human galactocerebrosidase gene in squamous cell carcinomas of the larynx.

    abstract::Alterations of gene expression in squamous cell carcinoma (SCC) cell lines derived from the larynx and keratinocytes derived from adjacent normal mucosa of the larynx have been studied using the mRNA differential display technique. Lane-to-lane comparison of reverse transcribed mRNA showed a strong repression of a 148...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Görögh T,Rudert H,Lippert BM,Gottschlich S,Maune S,Heidorn K,Maass J,Hoffmann M,Meyer JE,Rathcke IO,Folz BJ,Hortobagyi T,Werner JA

    更新日期:1999-12-10 00:00:00

  • Implementation of the 7th edition AJCC staging system: Effects on staging and survival for pT1 melanoma. A Dutch population based study.

    abstract::In the 7th edition of the AJCC staging system, the mitotic rate criterion replaced Clark level to increase correct classification of high-risk thin melanoma patients (pT1B). Additionally, sentinel node biopsy (SNB) was recommended for nodal staging of pT1B melanomas. The aim of this article was to evaluate the effects...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Oude Ophuis CM,Louwman MW,Grünhagen DJ,Verhoef K,van Akkooi AC

    更新日期:2017-04-15 00:00:00

  • Expression of plasminogen activator inhibitor-2 in epithelial ovarian cancer: a favorable prognostic factor related to the actions of CSF-1.

    abstract::In ovarian cancer cells, the macrophage colony-stimulating factor-1 (CSF-1) induces the release of plasminogen activator inhibitor-2 (PAI-2), and high levels of PAI-2 as well as of CSF-1 in ovarian cancer ascites are independently correlated with poor outcome. We now study the effect of CSF-1 on PAI-2 expression in vi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chambers SK,Ivins CM,Carcangiu ML

    更新日期:1997-12-19 00:00:00

  • Production by EBV infection of an EBNA-positive subline from an EBNA-negative human lymphoma cell line without detectable EBV DNA.

    abstract::A continuous lymphoma cell line, BJAB, derived from the tumour of an exceptional African case of Burkitt's lymphoma, has previously been described. Unlike 97% of African BL cases studied, neither the original tumour cells nor the cell line contained detectable amounts of EBV (Epstein-Barr virus) DNA, nor did they expr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Clements GB,Klein G,Povey S

    更新日期:1975-07-15 00:00:00

  • The mTOR kinase inhibitor everolimus synergistically enhances the anti-tumor effect of the Bruton's tyrosine kinase (BTK) inhibitor PLS-123 on Mantle cell lymphoma.

    abstract::Mantle cell lymphoma (MCL) is an aggressive and incurable malignant disease. Despite of general chemotherapy, relapse and mortality are common, highlighting the need for the development of novel targeted drugs or combination of therapeutic regimens. Recently, several drugs that target the B-cell receptor (BCR) signali...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Li J,Wang X,Xie Y,Ying Z,Liu W,Ping L,Zhang C,Pan Z,Ding N,Song Y,Zhu J

    更新日期:2018-01-01 00:00:00

  • Potentiation of the anti-tumor effect of actinomycin D by tumor necrosis factor alpha in mice: correlation between in vitro and in vivo results.

    abstract::The anti-tumor effects of actinomycin D (Act D) and recombinant human tumor necrosis factor (TNF)-alpha have been studied on 4 established murine tumor cell lines: MmB16 melanoma, Lewis lung (LL/2) carcinoma, L1 sarcoma and L1210 leukemia. During short-term incubation (24 hr) Act D produced dose-dependent cytostatic/c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lasek W,Giermasz A,Kuc K,Wańkowicz A,Feleszko W,Gołab J,Zagozdzon R,Stokłosa T,Jakóbisiak M

    更新日期:1996-05-03 00:00:00

  • Inhibition of a complement regulator in vivo enhances antibody therapy in a model of mammary adenocarcinoma.

    abstract::Membrane-bound complement regulatory proteins provide tumor cells with protection from antibody and complement in vitro. However, complement regulators are widely expressed on normal tissue, and inhibiting the function of complement regulatory proteins on tumor cells in vivo has not been investigated due to the absenc...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Imai M,Ohta R,Okada N,Tomlinson S

    更新日期:2004-07-20 00:00:00