Abstract:
:Cells of the melanocytic lineage have been shown to be capable of producing laminin and to lose this property during transformation. In the present study, we have evaluated immunohistochemically whether these changes are paralleled by an altered expression of the alpha 6/beta 1 laminin receptor. Results of this analysis have shown that while nevic cells display high levels of the receptor, this heterodimer undergoes a progressive decrease in expression in cutaneous melanomas of increasing invasiveness. A loss or unco-ordinated expression of the alpha 1/beta complex is present in the majority of the metastatic foci at different body sites. The present results show that during transformation the alpha 6/beta 1 laminin receptor undergoes quantitative alterations and deregulated expression of the 2 subunits. Although the functional relevance of these changes remains unknown, their occurrence in association with modifications of other cellular and extracellular macromolecules associated with tumor progression, strongly suggests a role in human melanoma progression.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Natali PG,Nicotra MR,Cavaliere R,Giannarelli D,Bigotti Adoi
10.1002/ijc.2910490203subject
Has Abstractpub_date
1991-09-09 00:00:00pages
168-72issue
2eissn
0020-7136issn
1097-0215journal_volume
49pub_type
杂志文章abstract::The EBV-encoded membrane protein (LMP) and the nuclear antigen EBNA-1 were compared for their capacity to induce rejection of transfected murine mammary carcinoma cells in syngeneic hosts. The tumorigenic potential of stable LMP and EBNA-1 expressing sublines of the ACA (H-2f)-derived mammary carcinoma line S6C was te...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480527
更新日期:1991-07-09 00:00:00
abstract::The anti-tumor effects of actinomycin D (Act D) and recombinant human tumor necrosis factor (TNF)-alpha have been studied on 4 established murine tumor cell lines: MmB16 melanoma, Lewis lung (LL/2) carcinoma, L1 sarcoma and L1210 leukemia. During short-term incubation (24 hr) Act D produced dose-dependent cytostatic/c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960503)66:3<374::AID-IJC
更新日期:1996-05-03 00:00:00
abstract::A series of 722 lung carcinomas, surgically resected and typed some years ago according to the 1967 WHO classification, was independently reviewed by 2 observers in order to test the reproducibility of histopathological typing when using the criteria of the 1981 WHO classification. Typing was fully agreed upon in 87% ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530205
更新日期:1993-01-21 00:00:00
abstract::In Japan, cervical cancer incidence has increased since the late 1990s especially among young women, despite a decreasing trend in most developed countries. Here, we examined age, period and birth cohort trends in cervical cancer incidence rates from 1985 to 2012. Incidence rates were ascertained using three populatio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32014
更新日期:2019-05-01 00:00:00
abstract::Several promising chemopreventive agents have for lung cancer emerged in preclinical models and in retrospective trials. These agents have been shown to modulate pathways altered in carcinogenesis and reduce markers of carcinogenesis in animal and cell culture models. Cancer-prone transgenic mice with oncogenic Kras e...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31152
更新日期:2018-04-01 00:00:00
abstract::Imbalance in the Kb and Db region encoded molecules is observed in Lewis lung carcinoma clones. The uncloned metastatic population and the D122 high-metastatic clone show no expression of H-2Kb products, while the nonmetastatic A9 clone expresses Kb products. Twenty-nine new subclones of 3LL and A9 were analyzed for D...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910320118
更新日期:1983-07-15 00:00:00
abstract::Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disease characterized by early-onset colorectal tumors, primarily in the right colon, that are frequently associated with other cancers. In the absence of a reliable biomarker, clinical criteria for diagnosing HNPCC have been proposed by the I...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580608
更新日期:1994-09-15 00:00:00
abstract::Ewing sarcoma (EWS) is the second most common and aggressive type of metastatic bone tumor in adolescents and young adults. There is unmet medical need to develop and test novel pharmacological targets and novel therapies to treat EWS. Here, we found that EWS expresses high levels of a p53 isoform, delta133p53. We fur...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32743
更新日期:2020-06-01 00:00:00
abstract::It has been suggested that phytoestrogens protect against hormone-dependent cancers. Lignans are the main class of phytoestrogens in Western diets. We conducted a prospective study of endometrial cancer and circulating levels of the main human lignan, enterolactone. The design was a case-control study nested within 3 ...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.22140
更新日期:2006-11-15 00:00:00
abstract::DU-PAN-2 is a high-molecular-weight glycoprotein defined by a murine monoclonal antibody (MAb) against a pancreatic ductal adenocarcinoma cell line. In order to evaluate the usefulness of this antigen as a tumor marker, we determined the serum level of the antigen by competitive inhibition radioimmunoassay in sera fro...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910370509
更新日期:1986-05-15 00:00:00
abstract::Drug-induced DNA demethylation in normal human cells and inherited localized hypomethylation in mitogen-stimulated lymphocytes from patients with a rare recessive disease (ICF: immunodeficiency, centromeric region instability, facial anomalies) are associated with karyotypic instability. This chromosomal recombination...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980911)77:6<833::aid-ijc
更新日期:1998-09-11 00:00:00
abstract::Tumors need to acquire an angiogenic phenotype for outgrowth and metastasis formation. Limited information on the angiogenic potential of specific tissues, especially human breast tissues is available. Here we describe an in vivo model, using the dorsal skin fold chamber in immunodeficient nude mice, where various tis...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980729)77:3<455::aid-ijc
更新日期:1998-07-29 00:00:00
abstract::The MDR1 gene product P-glycoprotein (Pgp) plays a key role in multidrug resistance of cancer cells. Pgp is an ATP-driven efflux pump that extrudes a variety of dissimilar hydrophobic cytotoxic compounds. P-glycoprotein overexpression results in multidrug resistance (MDR) of tumor cell lines in vitro as well as in can...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1552
更新日期:2001-12-15 00:00:00
abstract::Lifestyle factors and medical history are known to influence risk of non-Hodgkin lymphoma (NHL). Whether these factors affect the prognosis of NHL, especially its subtypes, is unclear. To investigate this, the association between these factors and all-cause and lymphoma-related mortality was assessed in a population-b...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27944
更新日期:2013-06-01 00:00:00
abstract::Hormonal therapies targeting androgen receptor (AR) are effective in prostate cancer (PCa), but often the cancers progress to fatal castrate-resistant disease. Improved understanding of the cellular events during androgen deprivation would help to identify survival and stress pathways whose inhibition could synergize ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29303
更新日期:2015-06-01 00:00:00
abstract::A population-based study was conducted on 256 southern Chinese with cervical intraepithelial neoplasia grade III (CIN III) or invasive cervical cancer (ICC) and on 258 controls to examine the associations between HLA-B alleles, infection with high-risk human papillomaviruses (HPVs) and the development of cervical neop...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21528
更新日期:2006-03-15 00:00:00
abstract::To elucidate the relationship, if any, of p53 gene expression according to smoking and drinking habits, 135 subjects with cancer of the upper aero-digestive tract were sampled from a case-control investigation conducted in Pordenone province, Northeast Italy, between 1986 and 1991. Adequate pathological material for i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600625
更新日期:1995-03-16 00:00:00
abstract::Our aim was to compare the occurrence and prognostic significance over 14-20 years of immunocytochemically detected S100A4 and other tumour variables in primary tumours from 349 patients with operable breast cancer. For a cut-off of 1% staining of the malignant cells, the antibody to S100A4 stains positively 56% of th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-03-20 00:00:00
abstract::Serum biomarkers are urgently needed for patient stratification and efficient treatment monitoring in pancreatic cancer (PC). Within a prospective diagnostic observation study, blood samples were obtained from 78 patients with advanced PC before and weekly during the course of palliative chemotherapy. Circulating nucl...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28294
更新日期:2013-12-01 00:00:00
abstract::In Bloom's syndrome (BS) the regulation of uracil-DNA glycosylase, an enzyme involved in the repair of DNA containing 5-FU, is altered. 5-FU induces higher levels of DNA fragmentation in BS cells than in non-BS cells. The increase in DNA fragmentation is connected to the cytotoxic mechanism where 5-FU is incorporated ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450321
更新日期:1990-03-15 00:00:00
abstract::Mutations of the p53 tumor-suppressor gene universally occur on exons 5-8 in human cancer. We analyzed these mutations in esophageal cancer tissue from 207 patients in China using 2 methods, single-strand conformation polymorphism (SSCP), one of the most frequently used methods, and the recently developed denaturing h...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20712
更新日期:2005-03-10 00:00:00
abstract::The subsets of small lymphocytes (surface Igm-positive or B, Thy-I-positive or T and "double-negative" or null) appearing within spontaneous mammary tumors of C3H retired breeder female mice and in various lymphoid organs of the host at different stages of tumor development were characterized directly using a radioaut...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910250122
更新日期:1980-01-15 00:00:00
abstract::The present study was undertaken to define the gene(s) of importance on the long arm of chromosome 18 (chromosome 18q) in endometrial carcinomas. We analyzed loss of heterozygosity (LOH) at 3 loci on chromosome 18q and DCC gene expression by the reverse-transcriptase/polymerase chain reaction (RT-PCR) method. Among 61...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570407
更新日期:1994-05-15 00:00:00
abstract::Several pathways have been implicated in the pathogenesis of endometrial carcinoma. Based on recent reports, BRAF mutations provide an alternative route for activation of the RAS signalling pathway. The CDKN2A (p16) tumour suppressor gene is also altered in several tumour types. We therefore wanted to assess the patte...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20702
更新日期:2005-07-20 00:00:00
abstract::Modulation of cytoplasmic Ca++ concentration is a mechanism common to signal transduction pathways regulating many cellular phenomena, including the interactions of tumors with the hemostatic system. We have investigated the pro-aggregating and pro-coagulant activities of human tumor cell lines cultured in vitro and t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910620310
更新日期:1995-07-28 00:00:00
abstract::Using a recently developed autochthonous mouse model of squamous cell carcinoma (SCC), a combination therapy targeting polyamine metabolism was evaluated. The therapy combined 2-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC), and MQT 1426, a polyamine transport inhibitor. In 1 trial last...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21621
更新日期:2006-05-01 00:00:00
abstract::Protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) is an endogenous inhibitor of STAT3 that negatively regulates STAT3 transcriptional activity and cell growth and demonstrates limited expression in the majority of human squamous cell carcinomas of the lung. In this study...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28448
更新日期:2014-03-01 00:00:00
abstract::Ninety-seven Japanese patients with so-called primary non-Hodgkin's lymphoma of the central nervous system (CNS-NHL), unrelated to the acquired immunodeficiency syndrome (AIDS) or organ transplantation, were reviewed. The patients' ages ranged from 1 to 87 years (median: 58 years) with a male to female ratio of 1.77:1...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450410
更新日期:1990-04-15 00:00:00
abstract::Ras expression induces increased expression and altered targeting of lysosomal proteases in multiple cell types, but the specific downstream cytoplasmic signaling pathways mediating these changes have not been identified. In this study, we compared the involvement of 3 major Ras effectors, Raf, phosphatidylinositol 3-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20398
更新日期:2004-11-01 00:00:00
abstract::In EBV-immortalized lymphoblastoid cell lines (LCLs) a small number of "latent" proteins are expressed. These are the EBV nuclear antigens, EBNAs 1-6, and a latent membrane protein, LMP. We have investigated the expression of these proteins in a variety of EBV-associated tumours and cell lines. Whereas transplant and ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450623
更新日期:1990-06-15 00:00:00