Abstract:
:Paclitaxel is widely used to treat cancer patients through the blocking of mitosis and result in formation of polyploidy giant cancer cells (PGCCs), which are generally believed to be nondividing cells or in mitotic catastrophe. Here, we showed that PGCCs following the treatment of paclitaxel of MCF-7 breast cancer cell line have capability to generate regular-sized progeny cells through budding. The PGCCs not only grew into well-differentiated cancer cells that formed cancer organotypic structures in vitro but also trans-differentiated into multiple tumor stromal cells including myoepithelial, endothelial and erythroid cells. PGCCs formed glandular and vessel-like cancer organotypic structures that expressed normal stem cell markers. These progeny cells generated from PGCCs showed decreased ability of proliferation, invasion and tumor growth and became more resistant to paclitaxel than parental MCF-7 cells. These results demonstrated that paclitaxel-induced PGCCs have properties of cancer stem cells that can generate both epithelial cancer cells and multilineage of stromal cells. PGCCs are not only the morphogenic determinant to tumor histogenesis and but also contribute to paclitaxel resistance.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Zhang S,Mercado-Uribe I,Liu Jdoi
10.1002/ijc.28319subject
Has Abstractpub_date
2014-02-01 00:00:00pages
508-18issue
3eissn
0020-7136issn
1097-0215journal_volume
134pub_type
杂志文章abstract::The role of alcoholic beverages in the etiology of gastric cancer is unclear. Recent summaries showed a positive association between higher alcohol intake and gastric cancer risk, but the magnitude of association is small, there is moderate heterogeneity among studies, and most cases were from Asian populations. We pr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31740
更新日期:2018-12-01 00:00:00
abstract::Non-neoplastic mesenchymal cells, along with 33 benign and 87 malignant soft-tissue tumors (STT) were examined for expression of HLA-A,B,C, beta 2-microglobulin (beta 2m), HLA-DR, -DP, and -DQ molecules and the HLA-D associated invariant chain (Ii). Serial frozen sections were immunostained using monoclonal antibodies...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910460512
更新日期:1990-11-15 00:00:00
abstract::Current ovarian cancer maintenance therapy is limited by toxicity and no proven impact on overall survival. To study a maintenance strategy targeted at missense mutant p53, we hypothesized that the release of mutant p53 from mortalin inhibition by the SHetA2 drug combined with reactivation of mutant p53 with the PRIMA...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32830
更新日期:2020-08-15 00:00:00
abstract::The age-adjusted incidence rates of cutaneous melanoma in Queensland in 1987 have been analysed for 16 anatomic sites, taking into account their surface areas. In men, the incidence of invasive melanoma on the ears, a chronically sun-exposed site, was extraordinarily high with annual rates of over 200 per 10(5) units ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530210
更新日期:1993-01-21 00:00:00
abstract::Data from a large, multicenter, population-based case-control study were analyzed to investigate the relation between multiple birth pregnancies and subsequent breast-cancer risk in the gravidas. Women less than 75 years old who had breast cancer were identified from statewide tumor registries in Wisconsin, western Ma...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.2910620209
更新日期:1995-07-17 00:00:00
abstract::To study the drug delivery to tumor by utilization of an oligopeptide transport activity, we examined the accumulation of dipeptides and the peptide-mimetic anti-cancer drug, bestatin, a substrate of oligopeptide transporter PepT1. Firstly, we established HeLa cells stably expressing human peptide transporter (hPepT1)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-10-15 00:00:00
abstract::By transmission and scanning electron microscopic studies of MC-29 virus-infected CEC cultures, C-type virus particles were detected in the medium of infected cultures, in infected cells and in intracellular vacuoles. Virus budding was also observed. In the scanning electron microscope (SEM) so-called blebs appeared o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910180419
更新日期:1976-10-15 00:00:00
abstract::Esophageal cancer is a leading cause of cancer death, especially in developing countries. In high-risk regions, squamous cell carcinoma is the most common type of esophageal cancer, and its etiology remains poorly understood. The purpose of this study was to evaluate the association between human papillomavirus (HPV) ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21980
更新日期:2006-09-15 00:00:00
abstract::In experimental tumor immunotherapy, incomplete Freund's adjuvant (IFA) has been considered as the "gold standard" for T-cell vaccination in mice and humans in spite of its considerable adverse effects. Recently, we succeeded in eliciting strong CTL responses in mice after vaccination with biodegradable poly(D,L-lacti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25914
更新日期:2011-07-15 00:00:00
abstract::Mitotic and meiotic cell cycle regulation is essential for normal development and tumor prevention. The underlying molecular mechanisms are not completely characterized. The aim of our analysis was to derive a global expression map of cell cycle regulators in mitosis and meiosis. First, the expression of cyclins, CDKs...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21034
更新日期:2005-08-20 00:00:00
abstract::Although surgical resection is considered the adequate treatment in early stages of nonsmall cell lung cancer, long-term survival is not satisfactory and recurrence rate is high. We previously showed that postoperative chemotherapy at stage IB reduces recurrences and prolongs overall survival. We extended size and obs...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.21933
更新日期:2006-08-15 00:00:00
abstract::MM is a B-cell malignancy mainly characterized by monoclonal expansion of plasma cells in the BM, presence of paraprotein in serum and occurrence of osteolytic bone lesions. MMPs are a family of proteolytic enzymes that can contribute to cancer growth, invasion, angiogenesis, bone degradation and other processes impor...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10642
更新日期:2002-10-20 00:00:00
abstract::We have examined several types of tumor cell lines and shown that they invariably expressed little or no Egr-1, in contrast to their normal counterparts. We have previously shown that the expression of exogenous Egr-1 in human breast and other tumor cells markedly reduces transformed growth and tumorigenicity. We ther...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970703)72:1<102::aid-ijc
更新日期:1997-07-03 00:00:00
abstract::The Hong Kong Chinese population has an unusually high incidence of colorectal cancer in the young, suggestive of hereditary susceptibility. To search for a genetic basis for this predisposition, we studied the incidence of microsatellite instability (MSI) in paraffin-embedded colectomy specimens of 124 young (<50 yea...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20000720)89:4<356::aid-ijc7>3.0.
更新日期:2000-07-20 00:00:00
abstract::Cancer awareness public campaigns aim to shorten the interval between symptom onset and presentation to a doctor (the 'patient interval'). Appreciating variation in promptness of presentation can help to better target awareness campaigns. We explored variation in patient intervals recorded in consultations with genera...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28763
更新日期:2014-09-01 00:00:00
abstract::CpG island methylator phenotype (CIMP) involves the targeting of multiple genes by promoter hypermethylation. Telomerase plays an important role in the development of cellular immortality and oncogenesis. To gain insight into the role of epigenetic aberration of telomerase-related genes in hepatocarcinogenesis, we det...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23650
更新日期:2008-09-01 00:00:00
abstract::Cyclic AMP (cAMP) analogues that selectively bind to either one of the two binding sites of cAMP-dependent protein kinase demonstrate a potent inhibition of the growth stimulated by estrogen in MCF-7 human breast-cancer cells in culture. The site-selective analogues, which are more potent activators of protein kinase ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410616
更新日期:1988-06-15 00:00:00
abstract::Increased exposure to estrogen is a risk factor for postmenopausal breast cancer, and dietary factors can influence estrogen metabolism. However, studies of diet and breast cancer have been inconclusive. We developed a dietary pattern associated with levels of unconjugated estradiol and the ratio of 2- and 16-hydroxyl...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31387
更新日期:2018-08-01 00:00:00
abstract::Gene silencing by DNA hypermethylation of CpG islands is a well-characterized phenomenon in cancer. The effect of hypomethylation in particular of non-CpG island genes is much less well described. By genome-wide screening, we identified 105 genes in microsatellite stable (MSS) colorectal adenocarcinomas with an invers...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27921
更新日期:2013-05-15 00:00:00
abstract::Allelic losses on the chromosome arms 1p and 19q have been associated with favorable response to chemotherapy and good prognosis in anaplastic oligodendroglioma patients, but the molecular mechanisms responsible for this relationship are as yet unknown. The DNA repair enzyme O(6)-methylguanine DNA methyltransferase (M...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20575
更新日期:2005-01-20 00:00:00
abstract::An epithelioid cell line, started from a human pancreatic carcinoma of ductal cell origin, has been maintained in culture for over 2 years and has been subcultured more than 40 times. The PANC-1 cell line has a doubling time of 52 h and G6PD activity of the slow mobility of B type. Chromosome studies show a modal numb...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910150505
更新日期:1975-05-15 00:00:00
abstract::Infection of (C57BL/6 X DBA/2)F1 (BDF1) mice with 2,500 FFU of Friend virus complex (FV) resulted in erythroleukemia followed by recovery, at which time virus could not be detected in the spleens of mice, and with splenomegaly (progressor mice) or without splenomegaly (regressor mice). Progressor and regressor mice de...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290610
更新日期:1982-06-15 00:00:00
abstract::Mouse IFN gamma preparations purified 30-fold were found to have direct cytolytic activity against a number of tumor and normal cells. Cell killing was determined using a sensitive, rapid and accurate assay which employed very low numbers of cells and very small quantities of interferon. The cytolytic activity of IFN ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910300111
更新日期:1982-07-15 00:00:00
abstract::The red bone marrow (BM) is an important indicator organ of hematogenous micrometastatic spread of carcinomas. Characterization of biological properties specific for BM micrometastatic cells, however, is technically challenging due to the limited number of target cells usually available for the purpose. This report pr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1564
更新日期:2002-01-01 00:00:00
abstract::Desmoids represent the most important cause of death, after colorectal cancer, in patients affected with familial adenomatous polyposis (FAP), an inherited disease due to mutations in the APC gene. The aims of our study were to estimate the risk of developing desmoids in FAP patients and to evaluate the association be...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20010320)95:2<102::aid-ijc1018>3
更新日期:2001-03-20 00:00:00
abstract::There are no reliable serologic tumor markers for transitional cell carcinoma (TCC) of the urinary bladder and noninvasive urine investigations are inadequate. We used fluorescent microsatellite analysis (MSA) to detect serum DNA and urine-sediment DNA alterations in patients with bladder cancer and prospectively coll...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1434
更新日期:2001-10-01 00:00:00
abstract::Spleen cells from BALB/c mice bearing syngeneic, methylcholanthrene-induced sarcomas were cultured in vitro. In agreement with previous observations, two tumor-specific activities could be demonstrated in the culture supernatants: the supernatants suppressed (blocked) specific lymph-node cell-mediated cytotoxicity dir...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910160404
更新日期:1975-10-15 00:00:00
abstract::Cancer-germline genes (CGGs) code for immunogenic antigens that are present on various human tumors but not on normal tissues. The importance of CGGs in cancer immunotherapy has led to detailed studies of their expression in a range of human tumors. We measured the levels of expression of 12 CGGs in various pediatric ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22118
更新日期:2007-01-01 00:00:00
abstract::We aimed to identify risk factors for Kaposi's sarcoma (KS) among HIV-positive patients and behaviors associated with human Herpesvirus 8 (HHV-8) infection, as well as to assess KS incidence and mortality rates longitudinally. To fulfill the first objective, a European case-control study was designed in the early 1990...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.22281
更新日期:2007-03-01 00:00:00
abstract::A reanalysis of the Women's Health Initiative (WHI) randomized clinical trial found a significant interaction between supplementation with vitamin D/calcium and estrogen therapy and the risk of colorectal cancer risk, with reduced risks from supplementation limited to the placebo arms of the estrogen trials. To explor...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24903
更新日期:2010-04-15 00:00:00