Abstract:
:By transmission and scanning electron microscopic studies of MC-29 virus-infected CEC cultures, C-type virus particles were detected in the medium of infected cultures, in infected cells and in intracellular vacuoles. Virus budding was also observed. In the scanning electron microscope (SEM) so-called blebs appeared on the surfaces of the infected cells, in a number proportional to the concentration of the virus preparation. On the basis of the size of the blebs, it could be considered that virus formation was taking place in their center. In control cells, neither viruses nor blebs were observed. This method will presumably be suitable for the titration of virus preparations.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Podmaniczky E,Szende B,Lapis K,Ferenc Gdoi
10.1002/ijc.2910180419subject
Has Abstractpub_date
1976-10-15 00:00:00pages
536-9issue
4eissn
0020-7136issn
1097-0215journal_volume
18pub_type
杂志文章abstract::Mutant KRAS provides a driving force for enhancement of cancer stem cells (CSCs) characteristics contributing transformation of colorectal cancer (CRC) cells harboring adenomatous polyposis coli (APC) mutations. Here, we identified the factors mediating the promotion of CSCs properties induced by KRAS mutation through...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32728
更新日期:2020-05-15 00:00:00
abstract::HPP1 is a recently discovered gene that is epigenetically silenced in a number of tumor types, suggesting a potential role as a tumor suppressor. However, whether HPP1 has tumor suppressor activity is not clearly known. We have sought to investigate the effects of HPP1 on tumor growth and survival and to identify sign...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23202
更新日期:2008-04-01 00:00:00
abstract::During the 7th annual follow-up of our cohort of homosexual men in 1989, we tested the hypotheses that infection with human immunodeficiency virus (HIV) may enhance the expression of human papilloma virus (HPV) and that the development of anal epithelial abnormality is related to a biologic interaction between these t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910460212
更新日期:1990-08-15 00:00:00
abstract::In this study, a cell-penetrating peptide, the transactivating transcriptional factor (TAT) domain from HIV, was linked to a chitosan/doxorubicin (chitosan/DOX) conjugate to form a chitosan/DOX/TAT hybrid. The synthesized chitosan/DOX/TAT conjugate showed a different intracellular distribution pattern from a conjugate...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25578
更新日期:2011-05-15 00:00:00
abstract::Tobacco-related carcinogens cause a variety of DNA damage that is repaired by different enzymatic pathways, suggesting that DNA repair plays an important role in tobacco-induced carcinogenesis. In a large hospital-based case-control study, we investigated DNA repair capacity (DRC) as a biomarker for susceptibility to ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11346
更新日期:2003-10-20 00:00:00
abstract::A subgroup of medulloblastomas shows constitutive activation of the Sonic hedgehog pathway with expression of GLI1. We identified the subset of GLI1 transforming target genes specifically expressed in medulloblastomas by comparing GLI1 targets in RK3E cells transformed by GLI1 with the gene expression profile of Sonic...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23929
更新日期:2009-01-01 00:00:00
abstract::Polymorphisms in nucleotide oligomerization domain 2 gene (NOD2) have been associated with increased susceptibility to Crohn's disease. Recently, possible association of the NOD2 variants R702W, G908R and 3020insC with colorectal cancer (CRC) has been studied among Polish, Greek, Finnish and New Zealand Caucasian CRC ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22651
更新日期:2007-07-01 00:00:00
abstract::Therapeutics targeting the phosphatidylinositol 3-kinase/mammalian target of rapamycin (PI3K/mTOR) pathway initially produce potent antitumor effects, but resistance frequently occurs. Using a phosphoproteome analysis, we found that colorectal cancer (CRC) cells exhibit resistance against PI3K/mTOR inhibition through ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33047
更新日期:2020-11-15 00:00:00
abstract::Estrogen signaling plays an important role in breast carcinogenesis. An increased understanding of estrogen gene targets and their effects will allow for more directed and effective therapies for individuals with breast cancer, particularly those with estrogen receptor positive tumors resistant to tamoxifen therapy. H...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26239
更新日期:2012-05-15 00:00:00
abstract::The effect of the glycosylation inhibitor, tunicamycin, on synthesis and secretion of the membrane-associated glycoprotein carcinoembryonic antigen (CEA), was studied in the LS174T human colon cancer cell line. Tunicamycin treatment inhibited total cellular glycoprotein synthesis but did not affect CEA levels of cellu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910380209
更新日期:1986-08-15 00:00:00
abstract::A novel cell culture system is reported for the growth of ovarian tumors. Two approaches were developed to isolate tumor cells, one for ovarian carcinomas and the other for benign cystomas or borderline cystadenomas, which yield virtually pure tumor-cell clusters. The plating efficiency exceeded 10% in approximately 8...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410606
更新日期:1988-06-15 00:00:00
abstract::Using comparative genomic hybridisation, we investigated chromosomal imbalances in 28 cases of thymic epithelial neoplasms including type A, B2, B3, the A component of type AB and different subtypes of type C thymoma. To identify different patterns of chromosomal aberrations associated with the biological behaviour an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11101
更新日期:2003-07-01 00:00:00
abstract::Oral leukoplakia is a heterogeneous lesion with risk of cancer development; there are no biomarkers to predict its potential of malignant transformation. Tissue proteomic analysis of oral leukoplakia using iTRAQ labeling liquid chromatography-mass spectrometry showed overexpression of heterogeneous ribonucleoprotein K...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24517
更新日期:2009-09-15 00:00:00
abstract::Our previous study has suggested that the cell cycle-related kinase (CCRK) is a putative candidate oncogene in glioblastoma tumorigenesis. The potential oncogenic role of CCRK and its clinical/prognostic significance, however, in ovarian carcinoma are unclear. In this study, CCRK expression was examined by immunohisto...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24630
更新日期:2009-12-01 00:00:00
abstract::Epstein-Barr virus (EBV) is present in Reed-Sternberg (RS) cells of a substantial proportion of Hodgkin's lymphoma cases. Most EBV-positive cases are also MHC class I-positive, whereas the majority of EBV-negative cases lack detectable levels of MHC class I expression. Application of the SAGE technique has led to the ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000515)86:4<548::aid-ijc
更新日期:2000-05-15 00:00:00
abstract::Serum biomarkers are urgently needed for patient stratification and efficient treatment monitoring in pancreatic cancer (PC). Within a prospective diagnostic observation study, blood samples were obtained from 78 patients with advanced PC before and weekly during the course of palliative chemotherapy. Circulating nucl...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28294
更新日期:2013-12-01 00:00:00
abstract::Cultured cells derived from pregnancy-dependent mouse mammary tumors (plaques) when transplanted into the gland-free mammary fat pad display a heterogeneous developmental potential. They not only gave rise to plaques but also produced normal mammary gland, hyperplastic alvoelar nodules (HAN), and autonomous mammary tu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910230520
更新日期:1979-05-15 00:00:00
abstract::In this study we investigated the effect of Tax on nucleotide excision repair (NER) in human T-cell lines by using the host cell repair analysis of UVC-irradiated reporter plasmid. This analysis revealed a p53-dependent NER activity in wild type (w.t.) p53-containing T-cells and p53-independent NER in w.t. p53-lacking...
journal_title:International journal of cancer
pub_type: 杂志文章,收录出版
doi:10.1002/ijc.23091
更新日期:2008-01-15 00:00:00
abstract::Sulfotransferase (SULT) 1A1 detoxifies and bioactivates a broad spectrum of substrates including xenobiotics. It has been suggested that the SULT1A1 his (histidine) allele, which is caused by a his for arg (arginine) substitution due to a G-->A transition at codon 213, carries a significantly higher risk for women to ...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.10805
更新日期:2003-01-01 00:00:00
abstract::HPV35 has been found in only ∼2% of invasive cervical cancers (ICC) worldwide but up to 10% in Sub-Saharan Africa, warranting further investigation and consideration of impact on preventive strategies. We studied HPV35 and ethnicity, in relation to the known steps in cervical carcinogenesis, using multiple large epide...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33033
更新日期:2020-11-15 00:00:00
abstract::Recent alcohol consumption is an established risk factor for squamous cell carcinoma (SCC) of the upper aero-digestive tract. In contrast, the role of lifetime exposure to alcohol with regard to risk of SCC is not well established. Historical data on alcohol use are available in 271,253 participants of the European Pr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24393
更新日期:2009-07-15 00:00:00
abstract::Diet is the primary source of cadmium-a proven Group 1 human carcinogen-for non-smokers. Observational studies investigating the effect of cadmium from food sources on breast cancer risk have produced inconsistent results. We examined the association between dietary cadmium and risk of breast cancer defined by estroge...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32039
更新日期:2019-05-01 00:00:00
abstract::An orang-utan (Pongo pygmaeus) suspension line, CP81, was shown to lack myeloid markers of lysozyme activity an d phagocytosis but to be positive for lymphocytic N-alkaline phosphatase activity, and to release a B-cell-tropic herpesvirus. This herpesvirus, termed Herpesvirus pongo, had 30--40% DNA homology with EBV an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210614
更新日期:1978-06-15 00:00:00
abstract::Lung cancer is one of the greatest threats to human health, and is initially detected and attacked by the immune system through tumor-reactive T cells. The aim of this study was to determine the basic characteristics and clinical significance of the peripheral blood T-cell receptor (TCR) repertoire in patients with ad...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32145
更新日期:2019-09-01 00:00:00
abstract::Endostatin, the proteolytic fragment of collagen XVIII, is an inhibitor of angiogenesis and tumor growth. Interestingly, elevated circulating endostatin levels have been found to correlate with poor patients' prognosis in several cancers. The aim of this study was to assess the prognostic value of endostatin in bladde...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26343
更新日期:2012-06-15 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a common neoplasm in Southeastern Asia, and cisplatin-containing regimens for combinational chemotherapy are widely used for treating locally recurrent or metastatic diseases. However, resistance to cisplatin is not infrequently seen and its associated side effects may be life-threate...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24130
更新日期:2009-04-15 00:00:00
abstract::NDRG3 belongs to the N-myc down-regulated gene (NDRG) family that contains 4 paralogs: NDRG1, -2, -3 and -4. The function of NDRG3 and its relationship to cancer has not been studied. We herein report our examination of the expression and biological roles of NDRG3 in prostate cancers. We showed that NDRG3 expression i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23961
更新日期:2009-02-01 00:00:00
abstract::Using a method optimized in hepatocellular carcinoma (HCC), we established patient-derived xenograft (PDX) models with an increased take rate (42.2%) and demonstrated that FBS +10% dimethyl sulfoxide exhibited the highest tumor take rate efficacy. Among 254 HCC patients, 103 stably transplantable xenograft lines that ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32564
更新日期:2020-03-15 00:00:00
abstract::Although new treatments have been widely studied to improve the survival of patients with metastatic breast cancer (BC), prognosis continues to be poor with an average survival time no longer than 3 years. We carried on a population-based study with the purpose of evaluating the outcome of metastatic breast cancer in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29503
更新日期:2015-09-15 00:00:00
abstract::To determine whether variations in DNA repair genes are related to host DNA damage, we investigated the association between polymorphism in the XPD gene (codon 199, 312, 751) and the XRCC1 gene (codon 194, 399) and the presence of benzo(a)pyrene diolepoxide adducts to lymphocyte DNA (BPDE-DNA) in a group of male patie...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10463
更新日期:2002-07-01 00:00:00