Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications.

abstract：:This population-based cohort study investigated the occurrence of familial astrocytoma among first-degree relatives of patients with astrocytoma diagnosed between 1985 and 1993 in the northern region of Sweden. The 432 cases received a questionnaire. They were asked to provide names and cancer diagnoses of first-degre...

journal_title：International journal of cancer

authors： Malmer B,Grönberg H,Bergenheim AT,Lenner P,Henriksson R

更新日期：1999-05-05 00:00:00

abstract：:From an assessment of the presence of a junctional component in 8,380 pigmented naevi, and histological review of its extent and the presence of inflammation and regression in a sample of 216 junctional and compound naevi, it was determined that naevi excised in summer were more likely to have a junctional component a...

journal_title：International journal of cancer

authors： Holman CD,Heenan PJ,Caruso V,Glancy RJ,Armstrong BK

更新日期：1983-02-15 00:00:00

abstract：:Nuclear factor-κB (NF-κB) is constitutively activated in many cancers, including oral squamous cell carcinoma (OSCC), and is involved in the invasive characteristics of OSCC, such as growth, antiapoptotic activity and protease production. However, the cellular mechanism underlying NF-κB's promotion of bone invasion by...

journal_title：International journal of cancer

authors： Furuta H,Osawa K,Shin M,Ishikawa A,Matsuo K,Khan M,Aoki K,Ohya K,Okamoto M,Tominaga K,Takahashi T,Nakanishi O,Jimi E

更新日期：2012-09-01 00:00:00

abstract：:The macrophage electrophoretic mobility (MEM) test was performed on guinea-pig macrophages treated with the interaction products of encephalitogenic protein and peripheral lymphocytes from 44 patients with colorectal cancer and 33 "healthy" controls. In 54/60 tests involving patients, statistically significant reducti...

journal_title：International journal of cancer

authors： Glaves D,Harlos JP,Weiss L

更新日期：1977-04-15 00:00:00

abstract：:The matrix metalloproteinase (MMP) family of proteins mediates various cellular pathways, including apoptosis and angiogenesis. Polymorphisms of MMP genes are associated with increased esophageal adenocarcinoma (EAC) risk. Gastroesophageal reflux disease (GERD) is an established EAC risk factor. We examined whether MM...

journal_title：International journal of cancer

authors： Cheung WY,Zhai R,Bradbury P,Hopkins J,Kulke MH,Heist RS,Asomaning K,Ma C,Xu W,Wang Z,Hooshmand S,Su L,Christiani DC,Liu G

更新日期：2012-12-01 00:00:00

abstract：:In advanced stages of malignant melanoma (MM), metastases to the CNS are frequently observed. Few results are available on trophic factors and immunological features involved in the process of invasion and adhesion of circulating metastatic cells into the CNS. A direct comparison of remote metastases found in differen...

journal_title：International journal of cancer

authors： Geertsen R,Zenklusen R,Kamarashev J,Burg G,Dummer R

更新日期：1999-09-24 00:00:00

abstract：:Knowledge about the prevalence of human papillomavirus (HPV) on a population level is important. We conducted a large population-based study in Denmark to determine the overall and age-specific HPV prevalence, and HPV type distribution in women. Liquid-based cytology samples (SurePath) were collected consecutively. HP...

journal_title：International journal of cancer

authors： Kjaer SK,Breugelmans G,Munk C,Junge J,Watson M,Iftner T

更新日期：2008-10-15 00:00:00

abstract：:The epidemiological literature reports inconsistent associations between consumption or circulating concentrations of micronutrients and breast cancer risk. We investigated associations between genetically predicted concentrations of 11 micronutrients (beta-carotene, calcium, copper, folate, iron, magnesium, phosphoru...

journal_title：International journal of cancer

authors： Papadimitriou N,Dimou N,Gill D,Tzoulaki I,Murphy N,Riboli E,Lewis SJ,Martin RM,Gunter MJ,Tsilidis KK

更新日期：2021-02-01 00:00:00

abstract：:DNA sequences coding for simian virus 40 (SV40) large T antigen have been detected at different frequencies in human non-Hodgkin's lymphomas (NHL) by PCR techniques as well as immunohistochemistry. A highly sensitive quantitative real-time PCR specific for a sequence of SV40 large T antigen was established to test whe...

journal_title：International journal of cancer

authors： Schüler F,Dölken SC,Hirt C,Dölken MT,Mentel R,Gürtler LG,Dölken G

更新日期：2006-01-15 00:00:00

abstract：:Phenotypic and functional characteristics of tumor-infiltrating lymphocytes (TIL) obtained from human primary and metastatic liver tumors were studied. Lymphocytes isolated from 18 tumors and autologous (A) peripheral blood (6 cases) were phenotyped by 2-color flow cytometry and cloned in a limiting dilution system, w...

journal_title：International journal of cancer

authors： Shimizu Y,Iwatsuki S,Herberman RB,Whiteside TL

更新日期：1990-11-15 00:00:00

abstract：:Loss of heterozygosity on chromosome arm 16q frequently occurs in human breast carcinomas regardless of the histological grade or type. To reveal whether the status of chromosome 16 corresponds to the histology of breast carcinomas, we examined the signal number of 16cen, 16q breakpoints and 1;16 fusions in the interp...

journal_title：International journal of cancer

authors： Tsuda H,Takarabe T,Hirohashi S

更新日期：1999-08-20 00:00:00

abstract：:Signal transducer and activator of transcription 5b (STAT5b) is likely the relevant STAT5 isoform with respect to the process of malignant progression in gliomas. STAT5b is a latent cytoplasmic protein involved in cell signaling through the modulation of growth factors, apoptosis, and angiogenesis. Previous in vitro s...

journal_title：International journal of cancer

authors： Gressot LV,Doucette TA,Yang Y,Fuller GN,Heimberger AB,Bögler O,Rao A,Latha K,Rao G

更新日期：2015-05-01 00:00:00

abstract：:We assessed whether split dosing with the methylating agent DTIC is an effective strategy for inactivating the DNA repair protein O6-alkylguanine DNA-ATase in order to decrease tumour resistance to BCNU. ATase levels in PBMCs were used as a surrogate for tumour ATase depletion to determine whether this correlated with...

journal_title：International journal of cancer

authors： Clemons M,Ranson M,Margison JM,El Teraifi H,Griffiths A,Kelly J,Morris CQ,Howell A,Margison GP

更新日期：2003-02-20 00:00:00

abstract：:The loss of E-cadherin expression and the translocation of beta-catenin to the nucleus are frequently associated with the metastatic conversion of epithelial cells. In the nucleus, beta-catenin binds to the TCF/LEF-1 (T-cell factor/ lymphoid enhancer factor) transcription factor family resulting in the activation of s...

journal_title：International journal of cancer

authors： Mestdagt M,Polette M,Buttice G,Noël A,Ueda A,Foidart JM,Gilles C

更新日期：2006-01-01 00:00:00

abstract：:Chemokines and chemokine receptors mediate lymphocyte migration and tissue localization. To analyze CCL5 (RANTES) expression by EBV-infected cells, we examined the expression of CCL5 in BL cell lines. Among 4 BL cell lines, those infected with EBV selectively expressed the CCL5 gene and secreted CCL5. Four cell lines ...

journal_title：International journal of cancer

authors： Uchihara JN,Krensky AM,Matsuda T,Kawakami H,Okudaira T,Masuda M,Ohta T,Takasu N,Mori N

更新日期：2005-05-01 00:00:00

abstract：:Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B-cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of...

journal_title：International journal of cancer

authors： Hosnijeh FS,Matullo G,Russo A,Guarrera S,Modica F,Nieters A,Overvad K,Guldberg P,Tjønneland A,Canzian F,Boeing H,Aleksandrova K,Trichopoulou A,Lagiou P,Trichopoulos D,Tagliabue G,Tumino R,Panico S,Palli D,Olsen KS,

更新日期：2014-12-15 00:00:00

abstract：:Thirty-one different long-term established human carcinoma culture cell lines were examined for the presence or absence of receptors for the Fc portion of immunoglobulin G (IgG) ("Fc receptors"), the third component of complement (C3 receptors), sheep erythrocytes and mouse erythrocytes. Included in the catalogue of l...

journal_title：International journal of cancer

authors： Kerbel RS,Pross HF,Leibovitz A

更新日期：1977-11-15 00:00:00

abstract：:CXCR1 and CXCR2 are receptors for CXCL-8 and are differentially expressed on melanoma and endothelial cells. In this study, we determined the functional role of these receptors in melanoma progression. We stably knock-down the expression of CXCR1 and/or CXCR2 in A375-SM (SM; high metastatic) human melanoma cells by sh...

journal_title：International journal of cancer

authors： Singh S,Sadanandam A,Varney ML,Nannuru KC,Singh RK

更新日期：2010-01-15 00:00:00

abstract：:UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme which catalyses not only the glucuronidation of tobacco smoke carcinogens like benzopyrene, but also of the endogenous substrate bilirubin. Bilirubin for a long time was considered to be only a toxic waste product of hemoglobin degradation, but recent findings have...

journal_title：International journal of cancer

authors： Lacko M,Roelofs HM,Te Morsche RH,Voogd AC,Ophuis MB,Peters WH,Manni JJ

更新日期：2010-12-15 00:00:00

abstract：:Heat shock protein (HSP) gp96/grp94 contains a signal peptide at the amino terminus and a -KDEL sequence at the carboxy terminus and is a major component of the lumen of the mammalian endoplasmic reticulum (ER). We show, by a number of immunolocalization methods using light and electron microscopy, that a significant ...

journal_title：International journal of cancer

authors： Altmeyer A,Maki RG,Feldweg AM,Heike M,Protopopov VP,Masur SK,Srivastava PK

更新日期：1996-08-22 00:00:00

abstract：:The ability of verapamil to overcome resistance to adriamycin in a multidrug-resistant derivative of the V79 cell line (LZ), grown as multicellular spheroids or as monolayers, was examined. Verapamil was much less effective in overcoming resistance to adriamycin in spheroids than in monolayers. Verapamil increased the...

journal_title：International journal of cancer

authors： Sakata K,Kwok TT,Gordon GR,Waleh NS,Sutherland RM

更新日期：1994-10-15 00:00:00

abstract：:The impact of variations in serum thyroid hormone concentration within the euthyroid range on breast cancer risk remains unclear. We investigated the effect of serum thyrotropin (TSH) and thyroid hormone concentration on breast cancer risk. This cohort study involved 62,546 Korean women, aged ≥40 years, who were free ...

journal_title：International journal of cancer

authors： Kim EY,Chang Y,Lee KH,Yun JS,Park YL,Park CH,Ahn J,Shin H,Ryu S

更新日期：2019-12-15 00:00:00

abstract：:Human papillomavirus (HPV) infections and HPV-associated penile lesions are frequently found in male sexual partners of women with cervical intraepithelial neoplasia (CIN). To determine the significance of these findings, we studied the prevalence of HPV and HPV associated penile lesions in a male hospital population ...

journal_title：International journal of cancer

authors： Bleeker MC,Hogewoning CJ,Voorhorst FJ,van den Brule AJ,Berkhof J,Hesselink AT,Lettink M,Starink TM,Stoof TJ,Snijders PJ,Meijer CJ

更新日期：2005-01-01 00:00:00

abstract：:Folate receptor alpha (FRA) is a GPI-anchored glycoprotein and encoded by the FOLR1 gene. High expression of FRA is observed in specific malignant tumors of epithelial origin, including ovarian cancer, but exhibits very limited normal tissue expression, making it as an attractive target for the ovarian cancer therapy....

journal_title：International journal of cancer

authors： Kurosaki A,Hasegawa K,Kato T,Abe K,Hanaoka T,Miyara A,O'Shannessy DJ,Somers EB,Yasuda M,Sekino T,Fujiwara K

更新日期：2016-04-15 00:00:00

abstract：:CD22 antibodies (Abs) bound to B-cell lymphomas are known to be internalized and catabolized rapidly. Therefore, it would be expected that use of CD22 as a target for radioimmunotherapy should be enhanced by the use of "residualizing" radiolabels, which are trapped within the cell after catabolism of the Ab to which t...

journal_title：International journal of cancer

authors： Mattes MJ,Shih LB,Govindan SV,Sharkey RM,Ong GL,Xuan H,Goldenberg DM

更新日期：1997-05-02 00:00:00

abstract：:To evaluate renal pelvis and ureter (RPU) cancer risk in relation to lifetime use of analgesics, a population-based case-control study was carried out in 3 areas of the United States. Among 502 cases and 496 controls diagnosed and interviewed during 1983-1986, no significant increases in risk were found for any of the...

journal_title：International journal of cancer

authors： Linet MS,Chow WH,McLaughlin JK,Wacholder S,Yu MC,Schoenberg JB,Lynch C,Fraumeni JF Jr

更新日期：1995-07-04 00:00:00

abstract：:The effects on breast cancer mortality seen after 16 years of biennial screening of younger women are assessed in this prospective cohort study. Since 1975 some 13,500 women, aged 35-49 in 1975, were invited to participate in the Nijmegen screening programme comprising a mammographic examination every 2 years. By the ...

journal_title：International journal of cancer

authors： Peer PG,Werre JM,Mravunac M,Hendriks JH,Holland R,Verbeek AL

更新日期：1995-03-16 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) have been suggested, on the basis of animal-model studies, to be related not only to cancer development but also to chemotherapeutic effects. Controversy persists, however, as to which types of PUFAs are beneficial in terms of chemosensitivity. In this study, we used the NIH3T3 cell...

journal_title：International journal of cancer

authors： Tsai WS,Nagawa H,Muto T

更新日期：1997-01-27 00:00:00

abstract：:Adenoviral oncolysis is a promising new modality for treatment of cancer based on selective viral replication in tumor cells. However, tumor cell killing by adenoviral oncolysis needs to be improved to achieve therapeutic benefit in the clinic. Towards this end, the activation of anti-tumor immunity by adenoviral onco...

journal_title：International journal of cancer

authors： Schierer S,Hesse A,Müller I,Kämpgen E,Curiel DT,Schuler G,Steinkasserer A,Nettelbeck DM

更新日期：2008-01-01 00:00:00

abstract：:The APTIMA HPV Assay (AHPV) allows detection of 14 high-risk human papillomavirus (HPV) RNA types in cervical specimens. Until present, the assay has been compared to HPV DNA tests only in triage settings. Herein, we compare AHPV with a DNA assay (Hybrid Capture 2; HC2) and liquid-based cytology (LBC; using PreservCyt...

journal_title：International journal of cancer

authors： Monsonego J,Hudgens MG,Zerat L,Zerat JC,Syrjänen K,Halfon P,Ruiz F,Smith JS

更新日期：2011-08-01 00:00:00