Abstract：
:To assess whether there has been a change in histological features and prognostic factors of primary cutaneous malignant melanoma (CMM) in young individuals in Sweden, an unselected, population-based study was undertaken; 177 cases of primary CMM in persons below 20 years of age were reported to the Swedish National Cancer Registry between 1973 and 1992. In 87% of the cases, original tumor tissue was available for histo-pathological review. The original diagnosis was verified in 88% (n = 126) of these cases. All tumors had histological features similar to adult CMM; 17% had an associated precursor lesion. Superficial spreading melanoma (SSM) was the most common sub-type, constituting 20/36 cases in the first decade and 59/90 in the second. Corresponding figures for nodular melanoma (NM) were 11/36 and 23/90. Only 5 melanomas in situ were diagnosed. In girls, the mean thickness of SSM decreased from 1.5 to 0.6 mm (p < 0.001). Overall mortality was 10%, 22% in the group with CMM diagnosed 0-15 years of age and 8% in individuals 15-19 years. Fatal CMM cases diagnosed below 15 years of age (n = 4) were NM > 1.6 mm thick and in subjects 15-19 years (n = 9) 44% of fatal tumors were NM with a mean thickness of 2.2 mm. Breslow index was the single most important prognostic factor. However, when known prognostic factors were adjusted for in a Cox regression analysis, young age remained an independent risk factor, with a relative death rate of 0.21 for individuals aged 15-19 compared with children < 15 years of age.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Sander B,Karlsson P,Rosdahl I,Westermark P,Boeryd Bdoi
10.1002/(sici)1097-0215(19990301)80:5<646::aid-ijckeywords:
subject
Has Abstractpub_date
1999-03-01 00:00:00pages
646-51issue
5eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(19990301)80:5<646::AID-IJCjournal_volume
80pub_type
杂志文章,多中心研究abstract：:Azathioprine (AZ) was injected into C57 Black mice before or after IM implantation of the syngeneic fibrosarcoma FS6, and observations were made on tumour growth and on the cellular composition of the fibrosarcomas. When multiple injections were given to the tumour-bearing host the tumours regressed. The percentage of...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910200119
更新日期：1977-07-15 00:00:00
abstract：:The impact of screening by visual inspection with acetic acid (VIA), cytology or HPV testing on cervical cancer incidence and mortality is investigated in a cluster randomized controlled trial in India. We report findings after the screening phase, when 52 clusters, with a total of 142,701 women aged 30-59 years in Os...
journal_title：International journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1002/ijc.21050
更新日期：2005-09-10 00:00:00
abstract：:Biliary tract cancers have dismal prognoses even when cytotoxic chemotherapy is administered. There is an unmet need to develop precision treatment approaches using comprehensive genomic profiling. A total of 121 patients with biliary tract cancers were analyzed for circulating-tumor DNA (ctDNA) and/or tissue-based tu...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.33230
更新日期：2021-02-01 00:00:00
abstract：:In 2011, a novel form of genome instability was reported by Stephens et al., characterized by tens to hundreds of locally clustered rearrangements affecting one or a few chromosome(s) in cancer cells. This phenomenon, termed chromothripsis, is likely due to a single catastrophic event leading to the simultaneous forma...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/ijc.29888
更新日期：2016-05-15 00:00:00
abstract：:Dietary information from a case-control study of pancreatic cancer conducted in Metropolitan Toronto between 1983 and 1986 is reported. A total of 249 cases and 505 population-based controls completed quantitative diet histories from which total caloric intake and the intake of a number of nutrients were estimated. A ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910450405
更新日期：1990-04-15 00:00:00
abstract：:Studies with purified DT-diaphorase have shown that the enzyme is capable of catalyzing a two-electron reduction of the novel indoloquinone EO9 to a DNA-damaging alkylating species. The aim of this study was to determine to what extent DT-diaphorase may be involved in the metabolic activation of EO9 and mitomycin C in...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910560124
更新日期：1994-01-02 00:00:00
abstract：:Carcinomatous meningitis is a devastating metastatic complication of systemic carcinoma, which may occur insidiously, accompanied by a confusing spectrum of clinical symptoms and signs. In the absence of reliable diagnostic tumour markers, the diagnosis is established by the demonstration of malignant cells within the...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910440310
更新日期：1989-09-15 00:00:00
abstract：:Nitric oxide (NO) and its metabolites are implicated in carcinogenesis and metastasis. Both stimulatory and inhibitory effects of NO have been reported in relation to breast cancer and its role in the development of malignancies and metastasis remains uncertain. We have used the polyomavirus middle T antigen (PyV-mT) ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.11178
更新日期：2003-08-10 00:00:00
abstract：:The SIL gene expression is increased in multiple cancers and correlates with the expression of mitotic spindle checkpoint genes and with increased metastatic potential. SIL regulates mitotic entry, organization of the mitotic spindle and cell survival. The E2F transcription factors regulate cell cycle progression by c...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.23665
更新日期：2008-10-01 00:00:00
abstract：:We have reported the establishment of a mitomycin-C (MMC)-resistant non-small-cell lung-cancer cell line, PC-9/MC4. As determined by an MTT assay, this resistant cell line was found to be 4 times more sensitive to adriamycin (ADM) than was the parental PC-9. There were no significant differences in sensitivity to etop...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910590211
更新日期：1994-10-15 00:00:00
abstract：:Our previous clinicopathologic study revealed an inverse association of liver metastasis of colorectal cancer and stromal expression of matrix metalloproteinase-9 (MMP-9) or urokinase receptor (uPAR). This suggests that host cells, particularly macrophages, expressing matrix-degrading enzymes/factors could be protecti...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(20000401)86:1<24::aid-ijc4
更新日期：2000-04-01 00:00:00
abstract：:There is strong evidence of a protection of high consumption of plant foods against squamous cell carcinoma of the oesophagus, but the respective role of fruits and vegetables is not well elucidated. In the time period 1996-2003, a case-control study designed in order to address this question was conducted in Uruguay....
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.20950
更新日期：2005-08-10 00:00:00
abstract：:People living with lymphohematopoietic neoplasms (LHNs) are known to have increased risks of second cancer; however, the incidence of second cancers after LHNs has not been studied extensively in Australia. The Australian Cancer Database was used to analyze site-specific risk of second primary cancer after LHNs in 127...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25706
更新日期：2011-08-15 00:00:00
abstract：:Breast cancer is one of the most common and feared cancers faced by women. The prognosis of patients with advanced or recurrent breast cancer remains poor despite refinements in multimodality therapies involving chemotherapeutic and hormonal agents. Multimodal therapy with more specific and effective strategy is urgen...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.29163
更新日期：2015-04-01 00:00:00
abstract：:The studies reported here explore the relationship between tumor-specific transplantation antigens (TSTA) and (1) the expression of serologically defined specificities, and (2) the immunogenicity of H-2K- or H-2D-determined alloantigens on methylcholanthrene (MCA)-induced murine fibrosarcomas. Expression of H-2K and H...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910220115
更新日期：1978-07-15 00:00:00
abstract：:We have established a number of cell lines from Merkel cell carcinoma (MCC) of the skin. In many respects these cell lines resemble those established from small cell lung cancer (SCLC) and it is difficult to differentiate between metastatic MCC and SCLC on morphological or histochemical criteria. Both are thought to b...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910580223
更新日期：1994-07-15 00:00:00
abstract：:The natural history of human T-lymphotropic virus type I (HTLV-I) has been shown to differ markedly by geographic area. The differences include contrasting patterns of risk of adult T-cell lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), which may be due in part to differences in...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24012
更新日期：2009-02-01 00:00:00
abstract：:Vaccination against oncogenic human papillomavirus (HPV) types is one key intervention for cervical cancer prevention. This follow-up study assessed the persistence of the systemic and mucosal immune responses together with the safety profile of the HPV-16/18 AS04-adjuvanted vaccine administered to young women aged 10...
journal_title：International journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1002/ijc.25887
更新日期：2011-11-01 00:00:00
abstract：:As a part of an assessment of the potential use of retinoids in preventive and adjuvant treatment of HNSCC, we examined the effects of beta-all-trans retinoic acid (RA) on the growth and cell-surface glycoconjugates of 2 HNSCC cell lines. These lines, designated 1483 and 183A, were established from an untreated patien...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910400217
更新日期：1987-08-15 00:00:00
abstract：:Detectable post-therapy plasma Epstein-Barr virus (EBV) DNA predicts poor survival in non-metastatic nasopharyngeal carcinoma (NPC). However, some patients subsequently experience spontaneous remission of residual EBV DNA during follow-up and it was unclear whether these patients were still at high risk of disease fai...
journal_title：International journal of cancer
pub_type： 杂志文章
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更新日期：2019-05-01 00:00:00
abstract：:Although thyroid cancer is suspected to have a nutritional etiology, prospective studies examining the relationship between diet and thyroid cancer are lacking. During 1996-1997, NIH-AARP Diet and Health Study participants, ages 51-72 years, completed a 37-item food frequency questionnaire about diet at ages 12-13 yea...
journal_title：International journal of cancer
pub_type： 杂志文章
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更新日期：2015-11-15 00:00:00
abstract：:Cancer incidence disparities exist among specific Asian American populations. However, the existing reports exclude data from large metropoles like Chicago, Houston and New York. Moreover, incidence rates by subgroup have been underestimated due to the exclusion of Asians with unknown subgroup. Cancer incidence data f...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.29958
更新日期：2016-05-01 00:00:00
abstract：:MaTu is a novel agent which may be of relevance in human oncogenesis, and has 2 components. One of them, the exogenous MX (coding for protein p58X), is transmissible to human fibroblasts, to HeLa and to HeLa x fibroblast (H/F) hybrids. The other component, MN, is a cellular gene. Its product, the protein p54/58N, is i...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910540218
更新日期：1993-05-08 00:00:00
abstract：:EBNA-positive lymphoblast cells were detected in 0.1 to 0.9% of the T-cell-depleted lymphocytes obtained from peripheral blood samples of five patients with infectious mononucleosis (IM). The same blood specimens from four of the five patients contained cells that formed EBNA-positive colonies in soft agar containing ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910230603
更新日期：1979-06-15 00:00:00
abstract：:In an attempt to obtain cell lines from the different components found in primary breast cancers, we used a low-calcium medium to culture epithelial cells of mixed phenotype and a recombinant T antigen containing retrovirus to immortalize cells found in these cultures. In each case, the histology of the sample used fo...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910510417
更新日期：1992-06-19 00:00:00
abstract：:Although a screening program for gastric cancer, using barium X-ray examination, has been carried out widely in Japan for the past 3 decades, there is insufficient evidence to confirm its effectiveness in terms of reducing mortality. To evaluate the effectiveness of the screening, a population-based case-control study...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910600106
更新日期：1995-01-03 00:00:00
abstract：:The numbers of new cancer cases in 16 common sites occurring in 1980 have been estimated for 24 areas of the world for which the United Nations produces population estimates. For the world as a whole, the total number of new cases was 6.35 million, almost exactly evenly divided between the developed and developing cou...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910410205
更新日期：1988-02-15 00:00:00
abstract：:Metastasis is a multistep process that involves the dissemination of cells from the primary tumor and colonization of distant secondary organs. Epithelial cells at the invasive front of a carcinoma acquire an enhanced migratory phenotype in a process called epithelial-to-mesenchymal transition (EMT). This cellular pla...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/ijc.30039
更新日期：2016-07-15 00:00:00
abstract：:We have studied the occurrence and association of 11q deletions with other chromosomal imbalances in Stage 4 neuroblastomas. To this purpose we have performed comparative genomic hybridization (CGH) analysis on 50 Stage 4 neuroblastomas and these data were analyzed together with those from 33 previously published case...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/1097-0215(200002)9999:9999<::aid-ijc1114>3
更新日期：2001-03-01 00:00:00
abstract：:Insulin-like growth factor binding protein-3 (IGFBP-3) inhibits the mitogenic and antiapoptotic activity of insulin-like growth factor (IGF) by blocking the binding of IGF to its receptor. However, under certain circumstances, IGFBP-3 can enhance the activity of IGF by protecting IGF from degradation. More than half o...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21339
更新日期：2006-01-15 00:00:00
