Tamoxifen modulation of cisplatin cytotoxicity in human malignancies.

abstract：:In combination with xenogeneic immune RNA (l-RNA) and tumor antigen (TA), syngeneic spleen cells inhibited the growth of a N-methyl-N-nitrosourethane-induced colon carcinoma (CT-26) in BALB/c mice. The sequential administration of 1 X 10(7) spleen cells, l mg of anti-CT-26 l-RNA and 0.4 mg of CT-26 TA resulted in a 20...

journal_title：International journal of cancer

authors： Fukushima M,Colmerauer ME,Nayak SK,Koziol JA,Pilch YH

更新日期：1982-01-15 00:00:00

abstract：:Most breast cancer patients in sub-Saharan Africa are diagnosed at advanced stages after prolonged symptomatic periods. In the multicountry African Breast Cancer-Disparities in Outcomes cohort, we dissected the diagnostic journey to inform downstaging interventions. At hospital presentation for breast cancer, women re...

journal_title：International journal of cancer

authors： Foerster M,McKenzie F,Zietsman A,Galukande M,Anele A,Adisa C,Parham G,Pinder L,Schüz J,McCormack V,Dos-Santos-Silva I

更新日期：2021-01-15 00:00:00

abstract：:Sera from 450 individuals between the age of 1 and 80 years, representing the general population of the Czech Republic, were tested for the presence of antibodies to human-papillomavirus(HPV)-derived antigens. The following antigens were used: (i) HPV1 virions; (ii) HPV16, -18 and -33-virus-like particles (VLP); (iii)...

journal_title：International journal of cancer

authors： Hamsíková E,Ludvíková V,Smahel M,Sapp M,Vonka V

更新日期：1998-08-31 00:00:00

abstract：:We assessed prospectively whether residual cervical intraepithelial neoplasia (CIN) after treatment for high-grade CIN can be predicted by genotype-specific high-risk HPV (HR-HPV) detection in follow-up cervical scrapes. A broad spectrum, highly sensitive SPF(10)-LiPA-PCR HPV detection technique was used on cervical s...

journal_title：International journal of cancer

authors： Bekkers RL,Melchers WJ,Bakkers JM,Hanselaar AG,Quint WG,Boonstra H,Massuger LF

更新日期：2002-11-10 00:00:00

abstract：:A case-control study involving interviews with 227 lung-cancer cases and 227 matched hospital controls was conducted in Heilongjiang Province in northeast China to examine the influence of dietary factors on the risk of developing lung cancer. Lung-cancer cases were all incident cases judged to be suitable candidates ...

journal_title：International journal of cancer

authors： Hu J,Johnson KC,Mao Y,Xu T,Lin Q,Wang C,Zhao F,Wang G,Chen Y,Yang Y

更新日期：1997-06-11 00:00:00

abstract：:This article describes the characteristics of 3 dominant features of breast cancer epidemiology. These characteristics include the association of disease risk with childbearing, its relationship to ovarian activity and its international variation (particularly as the latter differs in the years before and after menopa...

journal_title：International journal of cancer

authors： MacMahon B

更新日期：2006-05-15 00:00:00

abstract：:Increasing evidence indicates the importance of the tumor microenvironment, in particular cancer-associated fibroblasts, in cancer development and progression. In our study, we developed a novel, visually based method to identify new immunohistochemical signatures of these fibroblasts. The method employed a protein li...

journal_title：International journal of cancer

authors： Bozóky B,Savchenko A,Csermely P,Korcsmáros T,Dúl Z,Pontén F,Székely L,Klein G

更新日期：2013-07-15 00:00:00

abstract：:We studied the effect of retinoids on the growth and differentiation of a cell line (U 343 MG-A) derived from a human malignant astrocytoma. Cultures treated with all-trans or 13-cis retinoic acid showed a dose-dependent inhibition of proliferation and a marked reduction in the mean cell number at the plateau phase of...

journal_title：International journal of cancer

authors： Rutka JT,De Armond SJ,Giblin J,McCulloch JR,Wilson CB,Rosenblum ML

更新日期：1988-09-15 00:00:00

abstract：:We have previously reported a complete allelotype study of 86 primary breast carcinomas, in which each non-acrocentric chromosome arm was studied with at least one polymorphic DNA-marker for the presence of allelic imbalance (AI, allelic loss or allelic gain) in the tumor. Here we report the statistical analysis of th...

journal_title：International journal of cancer

authors： Cornelisse CJ,Kuipers-Dijkshoorn N,van Vliet M,Hermans J,Devilee P

更新日期：1992-02-20 00:00:00

abstract：:Cancer incidence rates and patterns are reported for a rural population, living in the Eastern Cape Province of South Africa for the period 1998-2002. The population-based cancer registry has operated for 20 years, using both active and passive methods for case finding, through collaborations with 19 health facilities...

journal_title：International journal of cancer

authors： Somdyala NI,Bradshaw D,Gelderblom WC,Parkin DM

更新日期：2010-11-15 00:00:00

abstract：:IL-10 mRNA expression and protein production in established melanoma cell lines and freshly cultured primary and metastatic melanoma cells was examined. The in situ distribution of IL-10 in native melanoma tissue was also investigated by immunohistochemistry in primary tumors, metastases, benign melanocytic nevi and n...

journal_title：International journal of cancer

authors： Dummer W,Bastian BC,Ernst N,Schänzle C,Schwaaf A,Bröcker EB

更新日期：1996-05-29 00:00:00

abstract：:Esophageal cancer is ranked as the eighth most common cancer and the sixth leading cause of cancer deaths worldwide. To identify candidate tumor suppressor genes related to esophageal squamous cell carcinoma (ESCC) development, a cDNA microarray analysis was performed using paired tumor and nontumor tissue samples fro...

journal_title：International journal of cancer

authors： Ng HY,Ko JM,Yu VZ,Ip JC,Dai W,Cal S,Lung ML

更新日期：2016-06-15 00:00:00

abstract：:Detectable post-therapy plasma Epstein-Barr virus (EBV) DNA predicts poor survival in non-metastatic nasopharyngeal carcinoma (NPC). However, some patients subsequently experience spontaneous remission of residual EBV DNA during follow-up and it was unclear whether these patients were still at high risk of disease fai...

journal_title：International journal of cancer

authors： Zhang Y,Tang LL,Li YQ,Liu X,Liu Q,Ma J

更新日期：2019-05-01 00:00:00

abstract：:The presence of androgen receptor variant 7 (AR-V7) variants becomes a significant hallmark of castration-resistant prostate cancer (CRPC) relapsed from hormonal therapy and is associated with poor survival of CRPC patients because of lacking a ligand-binding domain. Currently, it still lacks an effective agent to tar...

journal_title：International journal of cancer

authors： Wang B,Lo UG,Wu K,Kapur P,Liu X,Huang J,Chen W,Hernandez E,Santoyo J,Ma SH,Pong RC,He D,Cheng YQ,Hsieh JT

更新日期：2017-11-15 00:00:00

abstract：:Limited and inefficient treatment options exist for metastatic relapsed cervical cancer (MRCC), and there are currently no reliable indicators to guide therapeutic selection. We performed deep sequencing analyses targeting 322 cancer-related genes in plasma cell-free DNA and matched white blood cells in 173 serial blo...

journal_title：International journal of cancer

authors： Tian X,Ge D,Zhang F,Zhang B,Bai W,Xu X,Li Z,Cao Y,Li P,Zou K,Zou L

更新日期：2021-02-15 00:00:00

abstract：:Tonsillar squamous cell carcinoma (TSCC) is frequently associated with human papillomavirus (HPV) and chromosome instability. Data from cellular model systems are, however, controversial concerning a relation between HPV and chromosome instability development. Here we studied this association in 77 primary TSCC with k...

journal_title：International journal of cancer

authors： Mooren JJ,Kremer B,Claessen SM,Voogd AC,Bot FJ,Peter Klussmann J,Huebbers CU,Hopman AH,Ramaekers FC,Speel EJ

更新日期：2013-04-15 00:00:00

abstract：:ECOG 1696 was a Phase II multi-center trial testing vaccination with melanoma peptides, gp100, MART-1 and tyrosinase delivered alone, with GM-CSF, IFN-α2b or both cytokines to HLA-A2(+) patients with metastatic melanoma. Here, the frequency of circulating CD8(+) tetramer(+) (tet(+) ) T cells and maturation stages of...

journal_title：International journal of cancer

authors： Schaefer C,Butterfield LH,Lee S,Kim GG,Visus C,Albers A,Kirkwood JM,Whiteside TL

更新日期：2012-08-15 00:00:00

abstract：:By means of a chemical extraction procedure and confocal laser scanning microscopy, we investigated the kinetic patterns of uptake and biolocalization of 5-aminolevulinic acid (ALA)-induced porphyrins in s.c. transplanted tumors, adjacent normal skin and muscle, and liver of mice bearing mammary carcinoma, after i.p. ...

journal_title：International journal of cancer

authors： Peng Q,Moan J,Warloe T,Nesland JM,Rimington C

更新日期：1992-09-30 00:00:00

abstract：:Cell populations resistant to high doses (30 microM) of 6-thioguanine (6-TG, 6-TG(r) cells) were selected from a human colon carcinoma cell line, LoVo. This cell line, which lacks hMSH2, a component of the human mismatch binding heterodimer hMutSalpha, is resistant to low doses of 6-TG. The level of activity of hypoxa...

journal_title：International journal of cancer

authors： Bemi V,Turchi G,Margotti E,Giorgelli F,Pesi R,Sgarrella F,Tozzi MG,Camici M

更新日期：1999-08-12 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare tumor, partially explained by mutations in the rearranged during transfection (RET) proto-oncogene. The nonsynonymous RET polymorphism G691S has been reported as associated with MTC, but findings are discordant. We sought to clarify the role of G691S in MTCs through in silic...

journal_title：International journal of cancer

authors： Lantieri F,Caroli F,Ceccherini I,Griseri P

更新日期：2013-06-15 00:00:00

abstract：:Abnormal cell adhesion is an important contributing factor in invasion and metastasis. Here, we show that morphologically 'normal' cell-cell and cell-substratum adhesion can be restored to a poorly differentiated carcinoma cell line by activation of protein kinase C (PKC). This cell line, VACO 10MS, grows as multicell...

journal_title：International journal of cancer

authors： Cowell HE,Garrod DR

更新日期：1999-01-29 00:00:00

abstract：:Salvicine is a diterpenoid quinone derived from a traditional Chinese medication that has been shown to possess potent in vitro and in vivo antitumor effects. This compound, which inhibits the activity of Topoisomerase II, was found to equipotently kill various multidrug-resistant tumor cells and their corresponding p...

journal_title：International journal of cancer

authors： Miao ZH,Tong LJ,Zhang JS,Han JX,Ding J

更新日期：2004-07-10 00:00:00

abstract：:The topic of this review is the role of stromal-epithelial interactions in normal and malignant prostatic growth. Because cell-cell interactions and androgens play such key roles in the prostate, the goal of this review will be to apply endocrinologic and developmental concepts to the understanding of normal and malig...

journal_title：International journal of cancer

authors： Cunha GR,Hayward SW,Wang YZ,Ricke WA

更新日期：2003-10-20 00:00:00

abstract：:Matrix metalloproteinase 2 (MMP-2) plays a crucial role in invasion and metastasis of malignant tumors. Membrane type 1-MMP (MT1-MMP) was originally identified as an activator of MMP-2. Tissue inhibitor of MMP-2 (TIMP-2) was identified as an inhibitor of MMP-2 and MT1-MMP. However, TIMP-2 was reported to be essential ...

journal_title：International journal of cancer

authors： Yoshizaki T,Maruyama Y,Sato H,Furukawa M

更新日期：2001-01-20 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) has profound impacts on cancer progression and also on drug resistance, including epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Nowadays, there is still no predictive biomarker identified for the use of EGFR-TKIs in non-small cell lung cancer (NSCLC...

journal_title：International journal of cancer

authors： Ren S,Su C,Wang Z,Li J,Fan L,Li B,Li X,Zhao C,Wu C,Hou L,He Y,Gao G,Chen X,Ren J,Li A,Xu G,Zhou X,Zhou C,Schmid-Bindert G

更新日期：2014-12-15 00:00:00

abstract：:Oxidative stress plays a role in the regulation of cancer cell metastasis which involves cell invasion and adhesion that could be supported by ADAM proteins through the activities of their metalloprotease and disintegrin domains. We hypothesized that oxidative stress could act through the induction of ADAM9 protein in...

journal_title：International journal of cancer

authors： Mongaret C,Alexandre J,Thomas-Schoemann A,Bermudez E,Chéreau C,Nicco C,Goldwasser F,Weill B,Batteux F,Lemare F

更新日期：2011-08-15 00:00:00

abstract：:In a previous study, we showed that targeted delivery of bovine liver catalase to hepatocytes by direct galactosylation augmented the inhibitory effect of the enzyme on experimental hepatic metastasis of colon carcinoma cells (unpublished data). Here, we examined the ability of catalase to inhibit tumor metastasis to ...

journal_title：International journal of cancer

authors： Nishikawa M,Tamada A,Kumai H,Yamashita F,Hashida M

更新日期：2002-05-20 00:00:00

abstract：:The clinical pathological findings of eight cases of ovarian endodermal sinus tumour (yolk sac tumour) are presented. Histological exmination in all eight cases showed a typical endodermal sinus tumour pattern, and in six of the patients other tumour elements such as dysgerminoma, choriocarcinoma, malignant teratoma, ...

journal_title：International journal of cancer

authors： Sell A,Sogaard H,Norgaard-Pedersen B

更新日期：1976-11-15 00:00:00

abstract：:Previous literature, although not consistent, suggests that moderate alcohol consumption might be associated with decreased risk of renal cell carcinoma (RCC) in women. Thus, we examined the association between alcohol intake and the incidence of RCC by analyzing data from the Swedish Mammography Cohort, a population-...

journal_title：International journal of cancer

authors： Rashidkhani B,Akesson A,Lindblad P,Wolk A

更新日期：2005-12-10 00:00:00

abstract：:DNA copy number alterations (CNAs) are frequent in cancer, and recently developed CNA signatures revealed their value in molecular tumor stratification for patient prognosis and platinum resistance prediction in ovarian cancer. Head and neck squamous cell carcinoma (HNSCC) is also characterized by high CNAs. In this s...

journal_title：International journal of cancer

authors： Essers PBM,van der Heijden M,Vossen D,de Roest RH,Leemans CR,Brakenhoff RH,van den Brekel MWM,Bartelink H,Verheij M,Vens C

更新日期：2020-09-15 00:00:00