Abstract:
:Adequate consumption of folate may reduce the risk of colorectal cancer. We performed a meta-analysis of 7 cohort and 9 case-control studies that examined the association between folate consumption and colorectal cancer risk. In cohort studies, the association between folate consumption and colorectal cancer risk was stronger for dietary folate (folate from foods alone; relative risk for high vs. low intake = 0.75; 95% CI = 0.64-0.89) than for total folate (folate from foods and supplements; relative risk for high vs. low intake = 0.95; 95% CI = 0.81-1.11) and there was no significant heterogeneity between studies. There was significant heterogeneity between case-control studies. These results offer some support for the hypothesis that folate has a small protective effect against colorectal cancer but confounding by other dietary factors cannot be ruled out.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Sanjoaquin MA,Allen N,Couto E,Roddam AW,Key TJdoi
10.1002/ijc.20648keywords:
subject
Has Abstractpub_date
2005-02-20 00:00:00pages
825-8issue
5eissn
0020-7136issn
1097-0215journal_volume
113pub_type
杂志文章,meta分析abstract::HtrA1, a member of serine protease family, has been previously found to be involved in resistance to chemotherapy in ovarian cancer although the underlying mechanism is not clear. Using mixture-based oriented peptide library approach, previously we identified X-linked inhibitor of apoptosis protein (XIAP), a member of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26044
更新日期:2012-03-01 00:00:00
abstract::Menopausal hormone therapy (HT) may influence colorectal cancer risk. A total of 136,275 postmenopausal women from the European Prospective Investigation into Cancer and Nutrition were followed for an average of 9 years, during which time 1,186 colorectal cancers were diagnosed. Hazard ratios (HR) and 95% confidence i...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.25504
更新日期:2011-04-15 00:00:00
abstract::Crizotinib is an oral tyrosine kinase inhibitor approved for treating patients with non-small cell lung cancer (NSCLC) containing an anaplastic lymphoma kinase (ALK) rearrangement. We used knockout mice to study the roles of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) in plasma pharmacokinetics...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28475
更新日期:2014-03-15 00:00:00
abstract::Interleukin-12 (IL-12) has potent antitumor activities via natural killer cells and cytotoxic T lymphocytes. However, the molecular mechanisms whereby IL-12 induces tumoricidal activities are poorly understood. Here, we report the genome-wide analysis of gene expression in a primary murine mammary carcinoma model that...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20145
更新日期:2004-07-01 00:00:00
abstract::Lethal phenotypes of human prostate cancer are characterized by progression to androgen-independence and metastasis. For want of a clinically relevant animal model, mechanisms behind this progression remain unclear. Our study used an in vivo model of androgen-sensitive LNCaP human prostate cancer cell xenografts in ma...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20206
更新日期:2004-07-20 00:00:00
abstract::Ninety-eight cases of transitional-cell carcinoma (TCC) of the renal pelvis and ureter, including dysplastic lesions, were studied for tumor incorporation of human papillomavirus (HPV) type-16 and type-18 DNA by in situ hybridization (ISH) with DNA probes for each HPV viral type. Immunohistochemical analysis of p53 ex...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910640503
更新日期:1995-10-20 00:00:00
abstract::To find out whether manipulation of H-2 expression on metastatic cells could alter their metastatic properties, we immunoselected in vivo H-2 antigen variants from a metastatic clone of the T10 sarcoma [originating in a (C57BL/6J X C3H.eB)FI mouse] and tested their metastatic capacity. The unselected metastatic cells ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910330320
更新日期:1984-03-15 00:00:00
abstract::To identify tumor-suppressor genes on chromosome 10 in non-small cell lung cancers, we isolated 10 types of splicing variant of the HELLS/SMARCA6 gene transcripts. HELLS/SMARCA6 is a novel member of SNF2 family, which is implicated in cellular functions like chromatin remodeling. Variant 1 was an alternatively spliced...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20407
更新日期:2004-10-20 00:00:00
abstract::Genetic and epigenetic alterations during development of pancreatic ductal adenocarcinomas (PDACs) are well known. This study investigates genetic and epigenetic data together with tumor biology to find specific alterations responsible for metastasis formation. Using 16 human PDAC cell lines in a murine orthotopic PDA...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24695
更新日期:2010-01-01 00:00:00
abstract::Expression of the monocyte chemoattractant protein-1 (MCP-1) was examined in human central nervous system tumours (glioblastomas and astrocytomas) and normal human brain. Northern blot analysis demonstrated constitutive expression of MCP-1 mRNA in 6 of 12 glioblastoma cell lines. Expression could be stimulated by inte...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580216
更新日期:1994-07-15 00:00:00
abstract::The p16INK4a gene product acts as a negative regulator of the cell cycle by binding to cyclin-dependent kinases (CDKs) 4 and 6, thereby inhibiting the formation of an active CDK/cyclin D complex. Deletion of the p16 locus has been observed in tumor cell lines and, less frequently, in primary human neoplasms. We analyz...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970926)73:1<57::aid-ijc1
更新日期:1997-09-26 00:00:00
abstract::Cancer incidence rates are presented for the Nairobi Cancer Registry, a population-based cancer registry (PBCR) covering the population of the capital city of Kenya (3.2 million inhabitants in 2009). Case finding was by active methods, with standard and checks for accuracy and validity. During the period 2004-2008 a t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29674
更新日期:2015-11-01 00:00:00
abstract::The prognostic impact of distinct KRAS mutations in colorectal carcinomas is not fully characterized. We hypothesized that the prognostic impact of KRAS mutations is modulated by KRAS mutant allele-specific imbalance (MASI). KRAS MASI was assessed by sequencing electropherograms in KRAS-mutated colorectal carcinomas (...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27461
更新日期:2012-10-15 00:00:00
abstract::Risk of adult lymphoid malignancy is associated with recent adiposity. Some have reported apparent associations with adiposity in childhood or early adulthood, but whether these associations are independent of recent adiposity is unknown. Birth weight, body size at age 10 years, clothes size at age 20 years, and recen...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30044
更新日期:2016-07-01 00:00:00
abstract::The hedgehog (Hh) signaling pathway is essential for the development of tissues and organs. Hyperactive Hh signaling has been implicated in many gastric cancers, including esophageal cancer. However, the interaction between the Hh pathway and other potential signaling pathways in primary esophageal tumorigenesis has n...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25673
更新日期:2011-07-15 00:00:00
abstract::The relationship between breast cancer-associated fatty acid synthase (FAS; oncogenic antigen-519) and chemotherapy-induced cell damage has not been studied. We examined the ability of C75, a synthetic slow-binding inhibitor of FAS activity, to modulate the cytotoxic activity of the microtubule-interfering agent Taxol...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20754
更新日期:2005-05-20 00:00:00
abstract::Infection with a simian retrovirus (STLV-I) closely related to human T-lymphotropic virus type I (HTLV-I) was investigated in non-human primates living in their native countries in Africa and Asia. Serum antibodies cross-reacting with HTLV-I antigens were detected in 85 of 567 non-human primates of 30 species. Seropos...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910400219
更新日期:1987-08-15 00:00:00
abstract::Expression of the MDR1 (P-glycoprotein) gene confers resistance to several classes of chemotherapeutic drugs (multi-drug resistance). Colon carcinomas frequently express high levels of MDR1 mRNA and P-glycoprotein, presumably reflecting the origin of these tumors from MDR1-expressing normal colonic cells. In 4 colon c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550221
更新日期:1993-09-09 00:00:00
abstract::Breast cancers diagnosed between screening examinations among women who attend a breast cancer screening program are defined as interval cancers. The Norwegian Breast Cancer Screening Program started as a pilot project in 1996, and data from the first 2-year interval are available. Our study quantifies interval cancer...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1511
更新日期:2001-11-01 00:00:00
abstract::A population-based case-control study was conducted to examine the effect of ingestion of vitamin C, carotenoids and retinol on risk of pharyngeal cancer. Data were available from 166 cases of pharyngeal cancer or their next-of-kin, and from 547 controls similar in age and sex to the cases. Odds ratios (ORs) relating ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910440406
更新日期:1989-10-15 00:00:00
abstract::Previous studies have revealed a robust association between exposure to asbestos and human lung cancer. Accumulating evidence has highlighted the role of epigenome deregulation in the mechanism of carcinogen-induced malignancies. We examined the impact of asbestos on DNA methylation. Our genome-wide studies (using Ill...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30897
更新日期:2017-11-15 00:00:00
abstract::Co-injection of fibroblasts with human epithelial breast-tumor MCF7 cells in the presence of Matrigel enhances tumor growth in nude mice. While most of the matrix metalloproteinases (MMPs) have been shown to be produced by stromal cells, tumor cells such as MCF7 cells are unable to produce MMPs. We therefore, hypothes...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980413)76:2<267::aid-ijc
更新日期:1998-04-13 00:00:00
abstract::Langerhans' cells (LCs) are thought to play an important role in presentation of tumour antigens for the induction of anti-tumour immunity. Epidermis overlying some transplanted murine skin tumours contains increased numbers of LCs; however, alterations in LC numbers are not related to tumour antigenicity or host immu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980119)75:2<210::aid-ijc
更新日期:1998-01-19 00:00:00
abstract::A population-based case-control study of gastric cancer was conducted in areas with contrasting incidence rates in Sweden. Face-to-face interviews were carried out with 338 (74.1%) of all eligible cases and 679 (77.3%) of the selected controls. Consumption of selected nutrients during adolescence and 20 years prior to...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570505
更新日期:1994-06-01 00:00:00
abstract::AKT/PKB is a central signaling molecule related to stimulation of cell proliferation and inhibition of apoptosis. Perturbations of AKT expression and function play an important role in tumor development and progression. We wanted to determine (a) whether AKT is overexpressed in human prostatic tumors, (b) whether AKT ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11471
更新日期:2003-11-20 00:00:00
abstract::Primary rabbit kidney cells were transformed by BKV(MM), a papovavirus isolated from the urine of a child with the Wiskott-Aldrich syndrome. The transformed cells contained BK T-antigen, but no antigen that reacted with SV40 U-antiserum. The transformed cells failed to produce tumors in nude mice, and BKV (MM) was not...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910190317
更新日期:1977-03-15 00:00:00
abstract::To examine the relationship between human T-lymphotrophic virus type I (HTLV-I) proviral DNA and its expression in the lymph nodes, HTLV-I DNA and tax/rex mRDA were directly amplified by polymerase chain reaction in situ hybridization (PCR/ISH), and reverse transcription (RT)-PCR/ISH [RT-PCR/ISH]. We studied 24 lymph ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960328)66:1<18::AID-IJC4
更新日期:1996-03-28 00:00:00
abstract::T-cell responses have been reported to be impaired in cancer patients, and lymphocytes infiltrating human tumors (T-TIL) appear to be more affected than those in the peripheral blood. T-TIL display a poor proliferative response when compared to peripheral blood T (T-PBL) cells that show a strong response to all stimul...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580311
更新日期:1994-08-01 00:00:00
abstract::The partition-defective 3 (PAR-3) protein is implicated in the development and maintenance of cell polarity and is associated with proteins that mediate the changes in cytoskeleton organization required for cell polarity establishment. In this work, we used two original primary cell lines (R-180 and R-305) derived fro...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28548
更新日期:2014-05-01 00:00:00
abstract::Isothiocyanates (ITC) in cruciferous vegetables may be chemopreventive against gastric cancer development. Glutathione S-transferases (GSTs) may modify the chemopreventive effect of ITC. The relationship between urinary total ITC and risk of gastric cancer was prospectively examined. Between 1986 and 1989, 18,244 midd...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24583
更新日期:2009-12-01 00:00:00