Abstract:
:In a retrospective analysis of 203 patients with small cell lung cancer (SCLC), we examined the prognostic value of c-kit expression on survival. Expression of c-kit was examined immunohistochemically in formalin-fixed, paraffin-embedded tissue sections. c-kit was observed in 87.7% of SCLC tumors. Using the Kaplan-Meier model, we found that lack of c-kit expression was associated with significantly shorter survival time compared to the presence of c-kit expression (mean survival 151 +/- 27 vs. 358 +/- 49 days, p = 0.0084). Moreover, the proportion of c-kit(+) cells within the tumor was also related to survival time. Patients with tumors in which >75% of cells stained positive for c-kit had a mean overall survival time of 424 (+/-72) compared to 295 (+/-67) days for patients with 25-75% c-kit(+) tumor cells. Patients with tumors containing <25% c-kit(+) cells had the worst survival, with 164 (+/-24) days (p = 0.0033). Further parameters associated with short survival times were low performance status, elevated levels of lactate dehydrogenase and higher stage according to the TNM classification. Multivariate analysis using the Cox regression model showed that the proportion of c-kit(+) cells within the tumor specimen was one of 3 independent prognostic parameters (p = 0.004) for overall survival next to TNM classification (p = 0.001) and performance status (p < 0.001).
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Rohr UP,Rehfeld N,Pflugfelder L,Geddert H,Müller W,Steidl U,Fenk R,Gräf T,Schott M,Thiele KP,Gabbert HE,Germing U,Kronenwett R,Haas Rdoi
10.1002/ijc.20252keywords:
subject
Has Abstractpub_date
2004-08-20 00:00:00pages
259-63issue
2eissn
0020-7136issn
1097-0215journal_volume
111pub_type
杂志文章abstract::Murine mammary aplastic carcinoma, when it is passed from one alloxan-diabetic animal to another, after several passages becomes conditioned to hypoinsulinemia by secreting its own substance(s) immunologically cross-reactive with insulin (SICRI). Although not cytotoxic, the total daily dose of 2.5 mg of synthetic line...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290614
更新日期:1982-06-15 00:00:00
abstract::The antineoplastic effect of paclitaxel is mainly related to its ability to bind the beta subunit of tubulin, thus preventing tubulin chain depolarization and inducing apoptosis. The relevance of the Class I beta-tubulin characteristics have also been confirmed in the clinical setting where mutations of paclitaxel-bin...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22557
更新日期:2007-05-15 00:00:00
abstract::In 584 consecutive patients with no previous history of cancer or polypectomy, 769 adenomas were excised endoscopically and classified retrospectively according to the following parameters: macroscopic growth pattern, size, histological type, grade of dysplasia, anatomical site, presence of adenocarcinoma (ADK), numbe...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490406
更新日期:1991-10-21 00:00:00
abstract::Multiple genetic changes occur during the evolution of normal cells into cancer cells. It has been reported that both cyclin D1 and p53 genes play major roles in oncogenesis and/or cell cycle control in various cancers. In this study, we examined the overexpression of cyclin D1 and p53 by the immunohistochemical metho...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970620)74:3<310::aid-ijc
更新日期:1997-06-20 00:00:00
abstract::The heterogeneous nuclear ribonucleoprotein (hnRNP) K is an essential RNA and DNA binding protein involved in gene expression and signal transduction including DNA transcription, RNA splicing, RNA stability and translation. The role of hnRNP K in cancer is relatively understudied. However, several cellular functions s...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24744
更新日期:2010-01-15 00:00:00
abstract::Neuroblastoma (NB) is the most common extracranial solid tumor of childhood. In advanced disease stages, prognosis is poor and treatments have limited efficacy, thus novel strategies are warranted. The synthetic retinoid Fenretinide (HPR) induces apoptosis in NB and melanoma cell lines. We reported an in vitro potenti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10991
更新日期:2003-05-01 00:00:00
abstract::Cancer is associated with epigenetic (i.e., histone hypoacetylation) and metabolic (i.e., aerobic glycolysis) alterations. Levels of N-acetyl-L-aspartate (NAA), the primary storage form of acetate in the brain, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis to generate acetate, are reduced in glio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28465
更新日期:2014-03-15 00:00:00
abstract::Due to the large scale use of asbestos (more than 3.5 million tons produced or imported until its definitive banning in 1992), a specific national surveillance system of mesothelioma incident cases is active in Italy, with direct and individual anamnestic etiological investigation. In the period between 1993 and 2004,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26229
更新日期:2012-05-01 00:00:00
abstract::Messenger RNA differential display was used to study liver-gene expression in paired tumor and non-tumor tissues from hepatocellular carcinoma (HCC) patients. mRNA differential display and Northern-blot analyses showed that a 0.8-kb cDNA fragment was diminished or absent from the tumorous tissues of 7 HCC patients. Th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980302)75:5<787::aid-ijc
更新日期:1998-03-02 00:00:00
abstract::The neural crest gives rise to a variety of tissues, including peripheral neurons, Schwann cells, melanocytes and ectomesenchymal cells, which include the smooth-muscle cells of large arteries. Cell lines derived from neuroblastoma (a neural-crest tumor) exhibit at least 2 distinct morphological cell types, a neurobla...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480221
更新日期:1991-05-10 00:00:00
abstract::Parathyroid hormone-related protein (PTHrP) is a causative factor of humoral hypercalcemia in malignancy. However, it is difficult to explain the mechanism of anorexia/cachexia with PTHrP secretion in detail. Previously, we demonstrated that the expressions of orexigenic peptides increased and anorexigenic peptides de...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25535
更新日期:2011-05-01 00:00:00
abstract::In this study the antigenic profile of Hodgkin (H) and Sternberg-Reed (SR) cells from cases of Hodgkin's disease was analysed using a large panel of monoclonal and polyclonal antibodies reactive with cells of lymphoid and haemotopoietic origin. The aim of this investigation was, firstly, to throw light on the origin o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910300411
更新日期:1982-10-15 00:00:00
abstract::Administration of highly purified interferon to DBA/2 mice inhibited the growth of interferon-sensitive or interferon-resistant Friend erythroleukemia cells implanted subcutaneously. Injection of interferon at the site of tumor inoculation was more effective than injection of interferon intraperitoneally. Histologic e...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910310518
更新日期:1983-05-15 00:00:00
abstract::We evaluated the therapeutic potential of the replication competent vector VA7-EGFP, which is based on the avirulent Semliki Forest virus (SFV) strain A7 (74) carrying the EGFP marker gene in an orthotopic lung cancer tumor model in nude mice. We have previously shown that this oncolytic vector destroys tumor cells ef...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23646
更新日期:2008-10-01 00:00:00
abstract::It is well known that tumors arising from tissues such as kidney, pancreas, liver and stomach are particularly refractory to treatment. Searching for new anticancer drugs using cells in culture has yielded some effective therapies, but these refractory tumors remain intractable. Studies that compare cells grown in sus...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.20671
更新日期:2005-03-01 00:00:00
abstract::Hybridoma CE7 produces a murine antibody (gamma 1/kappa) which binds to a 190-kDa cell-surface glycoprotein of human neuroblastoma. Because of its tumor specificity, it has been used routinely in clinical pathology to confirm diagnosis of neuroblastoma. We have isolated the gene segments coding for the variable region...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530127
更新日期:1993-01-02 00:00:00
abstract::Trifluorothymidine (TFT) is part of the oral drug formulation TAS-102. Both 5-fluorouracil (5-FU) and TFT can inhibit thymidylate synthase and be incorporated into DNA. TFT shows only moderate cross-resistance to 5-FU. Therefore, we examined whether mechanistic differences in cell death could underlie their different ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24943
更新日期:2010-05-15 00:00:00
abstract::The antitumor activity of highly purified tumor necrosis factor (TNF) was tested against eight kinds of murine tumor and five kinds of human tumor heterotransplanted into nude mice. Mice were treated by intravenous or intratumoral injection of TNF, commencing when the tumors were well established. TNF showed an excell...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340219
更新日期:1984-08-15 00:00:00
abstract::The role of MHC-class-I-antigen expression in intracerebral anti-tumor natural resistance was examined using MHC-positive Lym+ and MHC-negative Lym- lymphoma cell lines. Lym+ was sensitive to MHC-class-I-restricted CTL-mediated lysis, while lym- was resistant. Both lines were susceptible to NK-cell-mediated lysis. The...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960729)67:3<365::AID-IJC
更新日期:1996-07-29 00:00:00
abstract::Although tobacco habits have been associated with the risk of oral leukoplakia, alcohol drinking and body mass index (BMI) as risk factors have not been well established. The purpose of this study is to evaluate the independent effects of drinking, BMI, tobacco chewing and smoking on the risk of oral leukoplakia. A ca...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-10-01 00:00:00
abstract::CDKN2A (p16) disruption is reported as a frequent event in head and neck squamous cell carcinomas that confers poor prognosis. We investigated the frequency of different potential mechanisms of CDKN2A inactivation in oral tongue squamous cell carcinomas (OTSCC) and their impact on patient outcome. From a cohort of 153...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28727
更新日期:2014-08-15 00:00:00
abstract::MUC18/MCAM is a cell-surface glycoprotein that is strongly expressed on advanced human melanomas. Transfection of 3 MCAM-negative melanoma cell lines with MCAM cDNA led to cell-surface expression and to a MCAM-dependent homotypic adhesion. This adhesion was independent of divalent cations and was inhibited at 4 degree...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19971127)73:5<769::aid-ijc
更新日期:1997-11-27 00:00:00
abstract::Lethal phenotypes of human prostate cancer are characterized by progression to androgen-independence and metastasis. For want of a clinically relevant animal model, mechanisms behind this progression remain unclear. Our study used an in vivo model of androgen-sensitive LNCaP human prostate cancer cell xenografts in ma...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20206
更新日期:2004-07-20 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) represents the eighth frequent solid tumor and fourth leading cause of cancer death. Because current treatments against PDAC are still unsatisfactory, new anticancer strategies are required, including oncolytic viruses. Among these, autonomous parvoviruses (PV), like MVMp (minut...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24992
更新日期:2010-06-15 00:00:00
abstract::The recently discovered human polyomavirus (MCPyV) is frequently found in Merkel cell carcinoma (MCC) tissue and is believed to be causally linked to MCC pathogenesis. While cell lines established from MCC represent a valuable tool to study the contribution of MCPyV to MCC pathogenesis, hitherto only 1 MCPyV-positive ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24877
更新日期:2010-05-01 00:00:00
abstract::Classical midgut carcinoids are rare intestinal neuroendocrine tumors that often present with metastases at diagnosis. In contrast to foregut carcinoids, midgut carcinoids are not related to the multiple endocrine neoplasia type 1 syndrome, and the mechanisms involved in their tumorigenesis are unknown. Eight classica...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1276
更新日期:2001-06-15 00:00:00
abstract::The INK4A gene, localized to human chromosome 9p21, encodes p16INK4A, a tumor suppressor that functions at least in part through the inhibition of CDK4, a cyclin-dependent kinase encoded by a gene at 12q13. To examine INK4A gene alterations in uncultured samples of osteosarcoma and the relationship between INK4A and C...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0215(19990118)80:2<199::aid-ijc
更新日期:1999-01-18 00:00:00
abstract::Ocimum sp. is a traditionally used medicinal herb, which shows anti-oxidant, anti-carcinogenic, radio-protective and free radical scavenging properties. So far no detailed studies have been reported on its effects on human cancers. Thus, we analyzed its effects on human breast cancer utilizing in vitro and in vivo met...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22733
更新日期:2007-08-15 00:00:00
abstract::The early arrest patterns of a methylcholanthrene-induced fibrosarcoma were determined after injection of 125IUdR-labelled cells into the systemic circulation of mice bearing transplanted lymphosarcomas, and of normal animals. Similar experiments were performed using radiolabelled lymphosarcoma cells and normal or fib...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910180608
更新日期:1976-12-15 00:00:00
abstract::The 26S proteasome, consisting of the 20S core and 19S regulatory complexes, regulates intracellular protein concentration through proteolytic degradation of targeted substrates. Composition of the 19S regulatory complex as well as posttranslational modifications of the 19S subunits can effectively regulate the activi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20261
更新日期:2004-09-01 00:00:00