Expression and functional activity of fibroblast growth factors and their receptors in human pancreatic cancer.

abstract：:Incidence of upper gastrointestinal cancers of the oesophagus and stomach show a strong unexplained male predominance. Hormonal and reproductive factors have been associated with upper gastrointestinal cancers in women but there is little available data on men. To investigate this, we included 219,425 men enrolled in ...

journal_title：International journal of cancer

authors： Mc Menamin ÚC,Kunzmann AT,Cook MB,Johnston BT,Murray LJ,Spence AD,Cantwell MM,Cardwell CR

更新日期：2018-08-15 00:00:00

abstract：:Neuroblastoma (NB) is the most common extracranial solid tumor of childhood. In advanced disease stages, prognosis is poor and treatments have limited efficacy, thus novel strategies are warranted. The synthetic retinoid Fenretinide (HPR) induces apoptosis in NB and melanoma cell lines. We reported an in vitro potenti...

journal_title：International journal of cancer

authors： Raffaghello L,Pagnan G,Pastorino F,Cosimo E,Brignole C,Marimpietri D,Montaldo PG,Gambini C,Allen TM,Bogenmann E,Ponzoni M

更新日期：2003-05-01 00:00:00

abstract：:Antitumor immunity in chronic lymphocytic leukemia (CLL) is hampered by highly dysfunctional T-cells. Although certain T-cell subsets have been reported to be of prognostic significance in this disease, their interplay is complex and it remains incompletely understood which of these subsets significantly drive CLL pro...

journal_title：International journal of cancer

authors： Rissiek A,Schulze C,Bacher U,Schieferdecker A,Thiele B,Jacholkowski A,Flammiger A,Horn C,Haag F,Tiegs G,Zirlik K,Trepel M,Tolosa E,Binder M

更新日期：2014-11-15 00:00:00

abstract：:Apurinic/apyrimidinic (AP) sites are common mutagenic and cytotoxic DNA lesions that arise from the loss of normal bases. APE1, the major AP endonuclease of human cells, plays a central role in the repair of AP sites through both its endonuclease and phosphodiesterase activities. A common APE1 polymorphism, a T-->G tr...

journal_title：International journal of cancer

authors： Terry PD,Umbach DM,Taylor JA

更新日期：2006-06-15 00:00:00

abstract：:We investigated whether cilengitide could amplify the antitumor effects of radiotherapy in an orthotopic rat glioma xenograft model. Cilengitide is a specific inhibitor of alphav series integrins, and acts as an antiangiogenic. U251 human glioma cells express alphavbeta3 and alphavbeta5 integrins. We used in vitro ass...

journal_title：International journal of cancer

authors： Mikkelsen T,Brodie C,Finniss S,Berens ME,Rennert JL,Nelson K,Lemke N,Brown SL,Hahn D,Neuteboom B,Goodman SL

更新日期：2009-06-01 00:00:00

abstract：:The enzyme alpha1,3galactosyltransferase synthesizes the alphaGal epitope, a carbohydrate structure (Galalpha1,3Galbeta1,4GlcNAc-R), on glycoconjugates in lower mammals. The enzyme is absent in humans but large amounts of natural antibodies that recognize alphaGal epitopes are present in human serum. It is likely that...

journal_title：International journal of cancer

authors： Aubert M,Crotte C,Bernard JP,Lombardo D,Sadoulet MO,Mas E

更新日期：2003-12-20 00:00:00

abstract：:We have examined the effects of the synthetic matrix metalloproteinase inhibitor, batimastat (BB-94) and the angiotensin-converting enzyme inhibitor, captopril, on metalloproteinase activity of murine Lewis-lung-carcinoma cells (3LL) in vitro, and on local growth and lung metastasis of the same tumor implanted intramu...

journal_title：International journal of cancer

authors： Prontera C,Mariani B,Rossi C,Poggi A,Rotilio D

更新日期：1999-05-31 00:00:00

abstract：:Breast cancer is a common malignancy with current biological therapies tailored to steroid hormone (ER, PR) and HER2 receptor status. Understanding the biological basis of resistance to current targeted therapies and the identification of new potential therapeutic targets is an ongoing challenge. The PI3K pathway is a...

journal_title：International journal of cancer

authors： López-Knowles E,O'Toole SA,McNeil CM,Millar EK,Qiu MR,Crea P,Daly RJ,Musgrove EA,Sutherland RL

更新日期：2010-03-01 00:00:00

abstract：:As with cyclooxygenase (COX)-2, genetic disruption of COX-1 gene or pharmacologic inhibition of its activity has been shown to decrease the number of intestinal polyps in Apc gene-deficient mice. The present study was designed to investigate the combined effects of COX-1 and COX-2 selective inhibitors on spontaneous p...

journal_title：International journal of cancer

authors： Kitamura T,Itoh M,Noda T,Matsuura M,Wakabayashi K

更新日期：2004-04-20 00:00:00

abstract：:More women are surviving after breast cancer due to early detection and modern treatment strategies. Body weight also influences survival. We aimed to characterize associations between postdiagnosis weight change and prognosis in postmenopausal long-term breast cancer survivors. We used data from a prospective populat...

journal_title：International journal of cancer

authors： Jung AY,Hüsing A,Behrens S,Krzykalla J,Obi N,Becher H,Chang-Claude J

更新日期：2021-01-01 00:00:00

abstract：:Sexual behavior has been consistently identified as a major risk factor for cervical cancer. Population-based studies have demonstrated that risk related to sexual activity is mediated by human papillomavirus (HPV) infection. We conducted a case-control study of 199 cases with low-grade squamous intraepithelial lesion...

journal_title：International journal of cancer

authors： Kjaer SK,van den Brule AJ,Bock JE,Poll PA,Engholm G,Sherman ME,Walboomers JM,Meijer CJ

更新日期：1996-03-01 00:00:00

abstract：:Cyclin D1 is a major positive regulator of the G1 restriction point promoting inactivation of the retinoblastoma protein (RB). The cyclin D1 gene is rearranged, amplified and/or over-expressed in several human neoplasms. In the present series of 64 human breast carcinomas, cyclin D1 amplification (4- to 8-fold) was se...

journal_title：International journal of cancer

authors： Barbareschi M,Pelosio P,Caffo O,Buttitta F,Pellegrini S,Barbazza R,Dalla Palma P,Bevilacqua G,Marchetti A

更新日期：1997-04-22 00:00:00

abstract：:A study was conducted in northern Iran in areas of very high, high and moderately low incidence of oesophageal cancer. Morphine metabolites in urine as an indicator of opium use, and a variety of nutritional and biochemical measures, including salivary antipyrine half-life, were determined in households with a case of...

journal_title：International journal of cancer

authors： Ghadirian P,Stein GF,Gorodetzky C,Roberfroid MB,Mahon GA,Bartsch H,Day NE

更新日期：1985-05-15 00:00:00

abstract：:In low and middle income countries (LMIC), high-quality disease registration is difficult to achieve in the setting of inadequate healthcare infrastructure and political or economical instability. In this article, we explore the potential of geographic information systems (GIS) to add value to the understanding of chi...

journal_title：International journal of cancer

authors： Bailony MR,Hararah MK,Salhab AR,Ghannam I,Abdeen Z,Ghannam J

更新日期：2011-09-01 00:00:00

abstract：:Because of the absence of data on smoking history for patients in cancer registries, large population-based studies have been unable to directly assess the role of smoking in the risk of multiple primary cancers. In a random sample of 618 adults diagnosed with invasive cancer in 2002 and reported to the population-bas...

journal_title：International journal of cancer

authors： Polednak AP

更新日期：2006-07-01 00:00:00

abstract：:Obesity is considered a chronic inflammatory state characterized by continued secretion of adipokines and cytokines. Experimental and epidemiological evidence indicates that circulating adipokines may be associated with the development of obesity-related cancers, but it is unclear if these associations are causal or c...

journal_title：International journal of cancer

authors： Dimou NL,Papadimitriou N,Mariosa D,Johansson M,Brennan P,Peters U,Chanock SJ,Purdue M,Bishop DT,Gago-Dominquez M,Giles GG,Moreno V,Platz EA,Tangen CM,Wolk A,Zheng W,Wu X,Campbell PT,Giovannucci E,Lin Y,CCFR, Endom

更新日期：2020-10-10 00:00:00

abstract：:Mouse-transformed keratinocytes cultured in the presence of transforming growth factor beta1 (TGF-beta1) acquire an array of morphologic and functional properties that give rise to a migratory phenotype that expresses mesenchymal molecular markers. This cellular conversion involves activation of the Ras-ERK pathway, e...

journal_title：International journal of cancer

authors： Santibáñez JF,Olivares D,Guerrero J,Martínez J

更新日期：2003-12-10 00:00:00

abstract：:RB1 gene expression has been reported to be upregulated in colorectal carcinomas (CRC) at both the mRNA and protein levels when compared to normal colonic mucosa. However, allelic loss at the genomic level has been detected in CRC with widely differing frequencies ranging from 11.5% to 50%. To determine whether there ...

journal_title：International journal of cancer

authors： Lai PS,Cheah PY,Kadam P,Chua CL,Lie DK,Li HH,Eu KW,Seow-Choen F,Lee AS

更新日期：2006-09-01 00:00:00

abstract：:HPP1 is a recently discovered gene that is epigenetically silenced in a number of tumor types, suggesting a potential role as a tumor suppressor. However, whether HPP1 has tumor suppressor activity is not clearly known. We have sought to investigate the effects of HPP1 on tumor growth and survival and to identify sign...

journal_title：International journal of cancer

authors： Elahi A,Zhang L,Yeatman TJ,Gery S,Sebti S,Shibata D

更新日期：2008-04-01 00:00:00

abstract：:Cells from reticulum-cell sarcomas (RCS), tumors with a probable B-cell origin in the SJL/J mouse strain, induced a high degree of proliferation in O-bearing syngeneic lymph-node and thymus cells obtained from young non-tumours mice. Although of considerably lower magnitude, a proliferation of SJL/J thymus cells to sy...

journal_title：International journal of cancer

authors： Lerman SP,Chapman JM,Carswell EA,Thorbecke GJ

更新日期：1974-12-15 00:00:00

abstract：:Human cathelicidin LL-37, a host defense peptide derived from leukocytes and epithelial cells, plays a crucial role in innate and adaptive immunity. Not only does LL-37 eliminate pathogenic microbes directly but also modulates host immune responses. Emerging evidence from tumor biology studies indicates that LL-37 pla...

journal_title：International journal of cancer

authors： Wu WK,Wang G,Coffelt SB,Betancourt AM,Lee CW,Fan D,Wu K,Yu J,Sung JJ,Cho CH

更新日期：2010-10-15 00:00:00

abstract：:A long-term CD4-CD8- TCR alpha beta human T-cell line, as well as similar CD4-CD8- TCR gamma delta T-cell lines for comparison, were generated from various tissues by negative selection using anti-CD4 and anti-CD8 monoclonal antibodies (MAbs) followed by positive selection with specific anti-TCR MAb and then repeated ...

journal_title：International journal of cancer

authors： Maziarz RT,Groh V,Prendergast M,Fabbi M,Strominger JL,Burakoff SJ

更新日期：1991-04-22 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. To improve existing therapies and broaden the spectrum of cytotoxic agents that can be used in RMS treatment, we performed a phage-display-based screening for peptides that bind specifically to RMS cells. Two peptides binding to RMS and to othe...

journal_title：International journal of cancer

authors： Witt H,Hajdin K,Iljin K,Greiner O,Niggli FK,Schäfer BW,Bernasconi M

更新日期：2009-05-01 00:00:00

abstract：:A-kinase anchoring protein 3 (AKAP3) is a sperm protein and its expression appears to be restricted to the testis in normal adult tissues. We investigated AKAP3 mRNA expression in 20 normal ovaries and 54 ovarian cancers of different histological types, grades and stages by reverse transcription-polymerase chain react...

journal_title：International journal of cancer

authors： Hasegawa K,Ono T,Matsushita H,Shimono M,Noguchi Y,Mizutani Y,Kodama J,Kudo T,Nakayama E

更新日期：2004-01-01 00:00:00

abstract：:India has the highest burden of cervical cancer in the world. To estimate the consequences of delaying implementation of organized cervical cancer screening, we projected the avertable burden of disease under different implementation scenarios of a screening program. We used an individual-based microsimulation model o...

journal_title：International journal of cancer

authors： Campos NG,Tsu V,Jeronimo J,Regan C,Resch S,Clark A,Sy S,Kim JJ

更新日期：2019-02-15 00:00:00

abstract：:We have previously identified a region containing 16 CpGs within the MGMT CpG islands which is critical for the transcriptional control of MGMT (Malley, Acta Neuropathol 2011). To investigate the patterns and incidence of MGMT methylation in astrocytic and oligodendroglial tumors, we quantitatively assessed methylatio...

journal_title：International journal of cancer

authors： Mulholland S,Pearson DM,Hamoudi RA,Malley DS,Smith CM,Weaver JM,Jones DT,Kocialkowski S,Bäcklund LM,Collins VP,Ichimura K

更新日期：2012-09-01 00:00:00

abstract：:Streptovaricins (Sv), ansa macrolide antibiotics, inhibited Rauscher leukemia virus (RLV) splenomegaly by 25-50%. All streptovaricins tested were effective when administered orally either by diet ad lib or by intubation from infection to time of killing. When delivered by intubation, Sv was measurable in plasma for up...

journal_title：International journal of cancer

authors： Borden EC,Carter WA,Sensenbrenner LL,Owens AH,Lichtenstein J,Gray GD,Neil GL,Nichol FR,Li LH

更新日期：1974-12-15 00:00:00

abstract：:Beta-lapachone and camptothecin are structurally unrelated agents thought to inhibit topoisomerase-I activity through distinct mechanisms. We find that beta-lapachone is much more potent than camptothecin in inducing acute cytotoxic effects on human malignant glioma cells. Acute cytotoxicity induced by both drugs is a...

journal_title：International journal of cancer

authors： Weller M,Winter S,Schmidt C,Esser P,Fontana A,Dichgans J,Groscurth P

更新日期：1997-11-27 00:00:00

abstract：:Progression from an androgen-dependent to an androgen-independent state often occurs in patients with prostate cancer (PCa) who undergo hormonal therapy. We have investigated whether inhibition of the epidermal growth factor receptor (EGFR) signaling pathway affects the antitumor effect of a nonsteroidal antiandrogen....

journal_title：International journal of cancer

authors： Festuccia C,Gravina GL,Angelucci A,Millimaggi D,Muzi P,Vicentini C,Bologna M

更新日期：2005-07-01 00:00:00

abstract：:The relationship between breast cancer-associated fatty acid synthase (FAS; oncogenic antigen-519) and chemotherapy-induced cell damage has not been studied. We examined the ability of C75, a synthetic slow-binding inhibitor of FAS activity, to modulate the cytotoxic activity of the microtubule-interfering agent Taxol...

journal_title：International journal of cancer

authors： Menendez JA,Vellon L,Colomer R,Lupu R

更新日期：2005-05-20 00:00:00