Isolation and analysis of two strongly transforming isoforms of the Epstein-Barr-Virus(EBV)-encoded latent membrane protein-1 (LMP1) from a single Hodgkin's lymphoma.

abstract：:The variable domain of functional heavy chain antibodies (VHH) devoid of light chains, found in camels, constitute the smallest intact antigen-binding domain fragment. Two camel single-domain fragments, cAb-Lys2 and cAb-Lys3, recognizing an overlapping epitope of lysozyme with a dissociation constant of 2 nM and 65 nM...

journal_title：International journal of cancer

authors： Cortez-Retamozo V,Lauwereys M,Hassanzadeh Gh G,Gobert M,Conrath K,Muyldermans S,De Baetselier P,Revets H

更新日期：2002-03-20 00:00:00

abstract：:Breast carcinomas were examined by the immunoperoxidase technique using antisera specific for lymphocyte subsets, monocytes, NK cells and major histocompatibility antigens (HLA-A, -B, -C; Ia-like). Sixty-four per cent of the patients had a moderate or strong mononuclear cell infiltration, 77% of the patients without m...

journal_title：International journal of cancer

authors： Hurlimann J,Saraga P

更新日期：1985-06-15 00:00:00

abstract：:The effect on tumor progression produced by the injection of VCN-treated tumor cells in dogs with spontaneous mammary tumors was investigated. Untreated dogs of different races and different ages with at least two palpable spontaneous mammary tumors were selected. One of the tumors was left in the animal for further c...

journal_title：International journal of cancer

authors： Sedlacek HH,Meesmann H,Seiler FR

更新日期：1975-03-15 00:00:00

abstract：:The CpG island methylator phenotype (CIMP) is a distinct form of epigenomic instability. Many CIMP-high colorectal cancers (CRCs) with BRAF mutation are considered to arise from serrated pathway. We recently reported that microRNA-31 (miR-31) is associated with BRAF mutation in colorectal tumors. Emerging new approach...

journal_title：International journal of cancer

authors： Ito M,Mitsuhashi K,Igarashi H,Nosho K,Naito T,Yoshii S,Takahashi H,Fujita M,Sukawa Y,Yamamoto E,Takahashi T,Adachi Y,Nojima M,Sasaki Y,Tokino T,Baba Y,Maruyama R,Suzuki H,Imai K,Yamamoto H,Shinomura Y

更新日期：2014-12-01 00:00:00

abstract：:We have investigated the effect of interferon-gamma (IFN-gamma) treatment of neuroblastoma cells on the susceptibility to lysis by lymphokine-activated killer (LAK) cells and examined the participation of cell-adhesion molecules on the target cells in LAK cell lysis. Untreated neuroblastoma cells expressed lymphocyte-...

journal_title：International journal of cancer

authors： Naganuma H,Kiessling R,Patarroyo M,Hansson M,Handgretinger R,Grönberg A

更新日期：1991-02-20 00:00:00

abstract：:Insulin-like growth factor-1 receptor (IGF-1R) and human epidermal growth factor receptor-2 (HER2) receptor expression has been found to be a key regulator of tumorigenesis. The purpose of our study was to establish the prognostic significance of IGF-1R in esophageal cancer and to determine the effect of IGF-1R and HE...

journal_title：International journal of cancer

authors： Kalinina T,Bockhorn M,Kaifi JT,Thieltges S,Güngör C,Effenberger KE,Strelow A,Reichelt U,Sauter G,Pantel K,Izbicki JR,Yekebas EF

更新日期：2010-10-15 00:00:00

abstract：:In an ongoing case-control study in Athens on the etiology of hepatocellular carcinoma (HCC), an analysis was made in order to assess whether HCV genotype 1b is associated with hepatocellular carcinoma (HCC). The HCV genotype was determined in 17 HCC patients, 87 patients with chronic hepatitis C (CHC) without cirrhos...

journal_title：International journal of cancer

authors： Hatzakis A,Katsoulidou A,Kaklamani E,Touloumi G,Koumantaki Y,Tassopoulos NC,Karvountzis G,Gioustozi A,Hadziyannis S,Trichopoulos D

更新日期：1996-09-27 00:00:00

abstract：:The metastatic spread of tumor cells is the most lethal aspect of cancer and can occur via various routes, including the lymphatic vasculature. Studies of tumor models in animals and clinicopathological data have indicated that growth of lymphatic vessels (lymphangiogenesis) in the vicinity of solid tumors may contrib...

journal_title：International journal of cancer

authors： Achen MG,Stacker SA

更新日期：2006-10-15 00:00:00

abstract：:In a previous study, we showed that targeted delivery of bovine liver catalase to hepatocytes by direct galactosylation augmented the inhibitory effect of the enzyme on experimental hepatic metastasis of colon carcinoma cells (unpublished data). Here, we examined the ability of catalase to inhibit tumor metastasis to ...

journal_title：International journal of cancer

authors： Nishikawa M,Tamada A,Kumai H,Yamashita F,Hashida M

更新日期：2002-05-20 00:00:00

abstract：:In a retrospective analysis of 203 patients with small cell lung cancer (SCLC), we examined the prognostic value of c-kit expression on survival. Expression of c-kit was examined immunohistochemically in formalin-fixed, paraffin-embedded tissue sections. c-kit was observed in 87.7% of SCLC tumors. Using the Kaplan-Mei...

journal_title：International journal of cancer

authors： Rohr UP,Rehfeld N,Pflugfelder L,Geddert H,Müller W,Steidl U,Fenk R,Gräf T,Schott M,Thiele KP,Gabbert HE,Germing U,Kronenwett R,Haas R

更新日期：2004-08-20 00:00:00

abstract：:The antigen recognized by the MOv18 MAb (Ca-MOv18) was recently shown to be a glycosylphosphatidylinositol (GPI)-linked protein. In this report we show that GPI-anchorage is not limited to IGROVI cells nor to other ovary carcinoma cell lines, but Ca-MOv18 was also found to be sensitive to phosphatidylinositol-specific...

journal_title：International journal of cancer

authors： Miotti S,Alberti S,Facheris P,Mantovani L,Fornaro M,Stella M,Ménard S,Canevari S,Colnaghi MI

更新日期：1992-05-28 00:00:00

abstract：:It has been demonstrated that the chemopreventive agent N-(4-hydroxyphenyl)retinamide (4-HPR) induces apoptotic cell death, but recent data has suggested that late stage/recurrent tumours lose their response to 4-HPR-induced cell death by mechanisms that are unknown. Our study investigated the ability of 4-HPR to indu...

journal_title：International journal of cancer

authors： Davies M,Paterson IC,Ganapathy A,Prime SS

更新日期：2006-12-15 00:00:00

abstract：:The effects of single-agent therapy with two clinically useful drugs, 5-fluorouracil (5-FU) and 1-3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) against nine human colorectal tumors (rectum T 157 and T 348, lung metastasis T 84, lymph-node metastasis T 245, colon, T 183, T 219, T 347, T 362 and T 380) transplanted and pas...

journal_title：International journal of cancer

authors： Giuliani FC,Zirvi KA,Kaplan NO,Goldin A

更新日期：1981-01-15 00:00:00

abstract：:The cytokines that regulate angiogenesis in normal and malignant prostate tissue are not well studied. Using an RT-PCR-based screen, we observed that cultured, low-passage normal human prostate epithelial cells (PrECs) express a variety of cytokines which have been shown to have angiogenic and/or endothelial cell-acti...

journal_title：International journal of cancer

authors： Campbell CL,Savarese DM,Quesenberry PJ,Savarese TM

更新日期：1999-03-15 00:00:00

abstract：:We found that rhabdomyosarcoma (RMS) subcellular membranes contain sialyltransferase activities for LcOse4Cer and GgOse4Cer acceptors. Chromatographic analyses and neuraminidase lability of the sialyltransferase products indicated that the principal site of sialylation was the non-reducing terminal galactosyl moiety. ...

journal_title：International journal of cancer

authors： Liepkans VA

更新日期：1990-05-15 00:00:00

abstract：:Breast cancer is the leading cancer diagnosis and second most common cause of cancer deaths in sub-Saharan Africa (SSA). Yet, there are few population-level survival data from Africa and none on the survival differences by stage at diagnosis. Here, we estimate breast cancer survival within SSA by area, stage and count...

journal_title：International journal of cancer

authors： Joko-Fru WY,Miranda-Filho A,Soerjomataram I,Egue M,Akele-Akpo MT,N'da G,Assefa M,Buziba N,Korir A,Kamate B,Traore C,Manraj S,Lorenzoni C,Carrilho C,Hansen R,Finesse A,Somdyala N,Wabinga H,Chingonzoh T,Borok M,Chok

更新日期：2020-03-01 00:00:00

abstract：:Regional lymph-node (LN) lymphocytes may constitute an important defence against the spread of human melanoma beyond regional LNs. The present study was directed to clonal analysis of lymphocytes cultured either directly from the LNs or after stimulation in cultures with autologous melanoma (MLTC). T-cell clones deriv...

journal_title：International journal of cancer

authors： Chen Q,Hersey P

更新日期：1992-05-08 00:00:00

abstract：:Expression of sialyl Lewis(x) (sLe(x)) and sLe(a) on tumor cells is thought to facilitate metastasis by promoting cell adhesion to selectins on vascular endothelial cells. Experiments supporting this concept usually bypass the early steps of the metastatic process by employing tumor cells that are injected directly in...

journal_title：International journal of cancer

authors： Monzavi-Karbassi B,Whitehead TL,Jousheghany F,Artaud C,Hennings L,Shaaf S,Slaughter A,Korourian S,Kelly T,Blaszczyk-Thurin M,Kieber-Emmons T

更新日期：2005-11-10 00:00:00

abstract：:Azacytidine and decitabine are approved for treatment of acute myeloid leukemias and myelodysplastic syndromes. While clinical responses are attributed to epigenetic effects and induction of apoptosis in malignant cells, these azanucleosides also affect antitumor immune responses. NK cells as components of innate immu...

journal_title：International journal of cancer

authors： Schmiedel BJ,Arélin V,Gruenebach F,Krusch M,Schmidt SM,Salih HR

更新日期：2011-06-15 00:00:00

abstract：:MicroRNAs (miRNAs) play an important role in the regulation of a variety of cellular processes, including cell growth, differentiation, apoptosis and carcinogenesis. The purpose of this study was to elucidate the molecular mechanisms by which miR-148b acts as a tumor suppressor in colorectal cancer. The expression of ...

journal_title：International journal of cancer

authors： Song Y,Xu Y,Wang Z,Chen Y,Yue Z,Gao P,Xing C,Xu H

更新日期：2012-09-01 00:00:00

abstract：:Somatic mutations in the TP53 gene are the most frequently observed genetic alterations in human malignancies, including breast cancer, which is one of the leading causes of death among women in Brazil. In our study, we determined the frequency and the pattern of TP53 mutations in malignant breast tumors from 120 pati...

journal_title：International journal of cancer

authors： Simão TA,Ribeiro FS,Amorim LM,Albano RM,Andrada-Serpa MJ,Cardoso LE,Mendonça GA,de Moura-Gallo CV

更新日期：2002-09-01 00:00:00

abstract：:The kinetics of the immune response of hamsters transplanted with virus-free SV40 tumor cells (TSV5) to two SV40-coded non-structural proteins of 94,000 daltons (T antigen) and 17,000 daltons (t antigen) was studied in order to determine if the variation in the immune reactivity of serum from tumor-bearing animals tow...

journal_title：International journal of cancer

authors： Ransom JH,Thompson DL,Tevethia SS

更新日期：1982-02-15 00:00:00

abstract：:Human papillomavirus (HPV) vaccination of a birth cohort of girls in the 9-13 age range is recommended as a priority, but decreases in HPV vaccine cost may make catch-up of a few additional cohorts more attractive not only in high-income countries. We assessed the reduction in HPV16 and 18 infections that could be ach...

journal_title：International journal of cancer

authors： Baussano I,Lazzarato F,Ronco G,Dillner J,Franceschi S

更新日期：2013-10-15 00:00:00

abstract：:This study evaluates the association of antibodies against HPV-16-derived peptides with cervical cancer and estimates the sensitivity and specificity of the serological assays in relation to HPV DNA detection in cervical cells by PCR. Study subjects were derived from 4 case-control studies carried out in Spain and Col...

journal_title：International journal of cancer

authors： De Sanjosé S,Hamsíková E,Muñoz N,Bosch FX,Hofmannová V,Gili M,Izarzugaza I,Viladiu P,Tormo MJ,Moreo P,Muñoz MT,Ascunce N,Tafur L,Shah KV,Vonka V

更新日期：1996-03-28 00:00:00

abstract：:Long-term survivors of childhood cancer suffer from a higher mortality than the general population. Here we evaluate late and very late mortality, and patterns of causes of death, in 5-year survivors after childhood and adolescent cancer in cases diagnosed during four decades in the five Nordic countries. The study is...

journal_title：International journal of cancer

authors： Garwicz S,Anderson H,Olsen JH,Winther JF,Sankila R,Langmark F,Tryggvadóttir L,Möller TR,Association of the Nordic Cancer Registries.,Nordic Society for Pediatric Hematology Oncology.

更新日期：2012-10-01 00:00:00

abstract：:The incidence of cervical adenocarcinoma (CA) is rising, whereas the incidence of cervical squamous cell carcinoma (CSCC) continues to decrease. However, it is still unclear whether different molecular characteristics underlie these 2 types of cervical carcinoma. To better understand the epigenetic characteristics of ...

journal_title：International journal of cancer

authors： Kang S,Kim JW,Kang GH,Lee S,Park NH,Song YS,Park SY,Kang SB,Lee HP

更新日期：2006-05-01 00:00:00

abstract：:Inbred rats were treated with extranuclear tumour membrane fractions or 3 M KCl-solubilized extracts of two antigenically distinct 3-methylcholanthrene-induced sarcomas, Mc7 and Mc57. The rats developed tumour-specific humoral antibody responses, but were not immune to tumour challenge. Moreover, they were unresponsiv...

journal_title：International journal of cancer

authors： Embleton MJ

更新日期：1976-11-15 00:00:00

abstract：:Wilms' tumor development, like most tumors, involves multiple genetic alterations affecting diverse genes. Only one of these has thus far been identified, the Wilms' tumor 1 (WT1) gene on 11p13, which functions as a tumor suppressor gene. We assessed the involvement of the WT1 gene constitutionally and somatically in ...

journal_title：International journal of cancer

authors： Nordenskjöld A,Friedman E,Sandstedt B,Söderhäll S,Anvret M

更新日期：1995-11-15 00:00:00

abstract：:Lethal phenotypes of human prostate cancer are characterized by progression to androgen-independence and metastasis. For want of a clinically relevant animal model, mechanisms behind this progression remain unclear. Our study used an in vivo model of androgen-sensitive LNCaP human prostate cancer cell xenografts in ma...

journal_title：International journal of cancer

authors： Zhou JR,Yu L,Zerbini LF,Libermann TA,Blackburn GL

更新日期：2004-07-20 00:00:00

abstract：:Folate receptor alpha (FRA) is a GPI-anchored glycoprotein and encoded by the FOLR1 gene. High expression of FRA is observed in specific malignant tumors of epithelial origin, including ovarian cancer, but exhibits very limited normal tissue expression, making it as an attractive target for the ovarian cancer therapy....

journal_title：International journal of cancer

authors： Kurosaki A,Hasegawa K,Kato T,Abe K,Hanaoka T,Miyara A,O'Shannessy DJ,Somers EB,Yasuda M,Sekino T,Fujiwara K

更新日期：2016-04-15 00:00:00