Abstract:
:Expression levels of hTERT mRNA were investigated by RT-PCR in tissue specimens of patients with (Group A) and without (Group B) clinically overt bronchial carcinoma, respectively. Bronchial carcinoma (n = 9) and distant normal (n = 9) specimens were analyzed in Group A. The chance of carcinoma seemed to increase with increasing hTERT mRNA levels (OR = 6.04, 95% CI = 1.02-37). Group B was comprised of 21 patients who underwent autofluorescence bronchoscopy. After analysis of 66 bronchial biopsies the chance of prevalent carcinoma in situ or carcinoma increased with increasing hTERT mRNA levels (OR = 6.19, 95% CI = 1.55-25). Variables like age, gender, smoking history, history of cancer within the airways or the degree of lymphocyte infiltrate in the specimens did not modify this relation. In 7 Group B patients in whom bronchial cancer was diagnosed during follow-up, biopsies taken before cancer diagnosis from both the area of the newly developed tumor and distantly from this area had been analyzed for hTERT expression. The median hTERT mRNA level in the biopsies from the area of future cancer was significantly higher than in biopsies taken from distant sites (p < 0.03). These data indicate that elevated hTERT mRNA is associated with an increased relative risk of prevalent and incident bronchial squamous cell carcinoma (in situ).
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Snijders PJ,Breuer RH,Sutedja TG,Egging M,Voorhorst FJ,Steenbergen RD,van der Linden HC,Risse EK,Berkhof J,de Vries EG,van der Zee AG,Postmus PE,Meijer CJ,Smit EFdoi
10.1002/ijc.11732keywords:
subject
Has Abstractpub_date
2004-04-10 00:00:00pages
412-7issue
3eissn
0020-7136issn
1097-0215journal_volume
109pub_type
杂志文章abstract::Homozygous deletion and loss of heterozygosity (LOH) at chromosome 3p21 have been observed in several types of human cancer including lung cancer and breast cancer. In previous work, we cloned and identified the human RAS association domain family 1A gene (RASSF1A) from the lung tumor suppressor locus 3p21.3. The CpG ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1466
更新日期:2001-10-15 00:00:00
abstract::The major obstacle preventing effective treatment of melanoma is the biological heterogeneity of tumor cells. This study was performed to determine clonal genetic heterogeneity within primary melanoma and the evolution of these heterogeneous sub-clones during disease progression. DNA samples were obtained from 44 morp...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:2009-10-15 00:00:00
abstract::In Japan, cervical cancer incidence has increased since the late 1990s especially among young women, despite a decreasing trend in most developed countries. Here, we examined age, period and birth cohort trends in cervical cancer incidence rates from 1985 to 2012. Incidence rates were ascertained using three populatio...
journal_title:International journal of cancer
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pub_type: 杂志文章
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journal_title:International journal of cancer
pub_type: 杂志文章
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2002-07-10 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2005-09-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24400
更新日期:2009-09-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21022
更新日期:2005-08-20 00:00:00
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journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
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更新日期:1999-04-12 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
pub_type: 杂志文章,评审
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更新日期:2006-05-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章,meta分析
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更新日期:2019-08-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章,meta分析,评审
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更新日期:2014-05-15 00:00:00
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journal_title:International journal of cancer
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