Statin use and mortality among ovarian cancer patients: A population-based cohort study.

abstract：:The MDR1 gene product P-glycoprotein (Pgp) plays a key role in multidrug resistance of cancer cells. Pgp is an ATP-driven efflux pump that extrudes a variety of dissimilar hydrophobic cytotoxic compounds. P-glycoprotein overexpression results in multidrug resistance (MDR) of tumor cell lines in vitro as well as in can...

journal_title：International journal of cancer

authors： Niv R,Assaraf YG,Segal D,Pirak E,Reiter Y

更新日期：2001-12-15 00:00:00

abstract：:A diet high in linoleic acid (an ω-6 PUFA) increased the formation of miscoding etheno (ε)--DNA adducts in WBC-DNA of women, but not in men (Nair et al., Cancer Epidemiol Biomark Prev 1997;6:597-601). This gender specificity could result from an interaction between ω-6 PUFA intake and estrogen catabolism, via redox-cy...

journal_title：International journal of cancer

authors： Sun X,Nair J,Linseisen J,Owen RW,Bartsch H

更新日期：2012-11-01 00:00:00

abstract：:Clinical trials utilizing strategies to manipulate tumor oxygenation, blood flow and angiogenesis are under way, although limited quantitative information exists regarding basic tumor pathophysiology. The current study utilized murine KHT fibrosarcomas, spontaneous mammary carcinomas and first-generation spontaneous t...

journal_title：International journal of cancer

authors： Fenton BM,Lord EM,Paoni SF

更新日期：2001-09-01 00:00:00

abstract：:Monoclonal antibody 38.13 was raised against the Burkitt lymphoma cell line Daudi and has been previously shown to recognize a globotriaosylceramide (Pk) determinant expressed selectively on Burkitt and a few other B-cell lymphomas. We report here that 38.13 binds to a subset of normal B lymphocytes in germinal centre...

journal_title：International journal of cancer

authors： Murray LJ,Habeshaw JA,Wiels J,Greaves MF

更新日期：1985-11-15 00:00:00

abstract：:Prostate-specific antigen (PSA) is a serine protease secreted by prostatic epithelial cells and is widely used as a marker for prostate cancer. The tissue specificity of PSA makes it a potential target for active specific immunotherapy, especially in prostate cancer patients who have undergone prostatectomy and in who...

journal_title：International journal of cancer

authors： Hodge JW,Schlom J,Donohue SJ,Tomaszewski JE,Wheeler CW,Levine BS,Gritz L,Panicali D,Kantor JA

更新日期：1995-10-09 00:00:00

abstract：:Cancer initiation is presumed to occur in utero for many childhood cancers and it has been hypothesized that advanced paternal age may have an impact due to the increasing number of mutations in the sperm DNA with increasing paternal age. We examined the association between paternal age and specific types of childhood...

journal_title：International journal of cancer

authors： Urhoj SK,Raaschou-Nielsen O,Hansen AV,Mortensen LH,Andersen PK,Nybo Andersen AM

更新日期：2017-06-01 00:00:00

abstract：:To examine the relationship between human T-lymphotrophic virus type I (HTLV-I) proviral DNA and its expression in the lymph nodes, HTLV-I DNA and tax/rex mRDA were directly amplified by polymerase chain reaction in situ hybridization (PCR/ISH), and reverse transcription (RT)-PCR/ISH [RT-PCR/ISH]. We studied 24 lymph ...

journal_title：International journal of cancer

authors： Ohshima K,Suzumiya J,Izumo S,Mukai Y,Tashiro K,Kikuchi M

更新日期：1996-03-28 00:00:00

abstract：:In a formal prospective-retrospective analysis of the phase III SBG0102 clinical trial randomizing metastatic breast cancer patients to gemcitabine-docetaxel or to single agent docetaxel, patients with basal-like tumors by PAM50 gene expression had significantly better overall survival in the gemcitabine arm. By immun...

journal_title：International journal of cancer

authors： Asleh K,Lyck Carstensen S,Tykjaer Jørgensen CL,Burugu S,Gao D,Won JR,Jensen MB,Balslev E,Laenkholm AV,Nielsen DL,Ejlertsen B,Nielsen TO

更新日期：2019-05-15 00:00:00

abstract：:Circadian disruption has been classified as probably carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. The circadian clock is subject to environmental factors, particularly light exposure and food intake rhythms. However, the association between nutritional circadia...

journal_title：International journal of cancer

authors： Srour B,Plancoulaine S,Andreeva VA,Fassier P,Julia C,Galan P,Hercberg S,Deschasaux M,Latino-Martel P,Touvier M

更新日期：2018-11-15 00:00:00

abstract：:Fatty acids play a key role in cellular bioenergetics, membrane biosynthesis and intracellular signaling processes and thus may be involved in cancer development and progression. In the present study, we comprehensively assessed associations of 14,522 common single-nucleotide polymorphisms (SNPs) in 149 genes of the f...

journal_title：International journal of cancer

authors： Dai W,Liu H,Xu X,Ge J,Luo S,Zhu D,Amos CI,Fang S,Lee JE,Li X,Nan H,Li C,Wei Q

更新日期：2019-11-15 00:00:00

abstract：:Although human NK cells lyse a wide spectrum of target cells, the precise target structure recognized by NK cells has not yet been elucidated. In order to define a possible relationship between gangliosides on human target cells and susceptibility to NK lysis, 14 human leukemia and lymphoma cell lines were studied. A ...

journal_title：International journal of cancer

authors： Ando I,Hoon DS,Suzuki Y,Saxton RE,Golub SH,Irie RF

更新日期：1987-07-15 00:00:00

abstract：:High-grade serous epithelial ovarian cancer (HGS-EOC) is a systemic disease, with marked intra and interpatient tumor heterogeneity. The issue of spatial and temporal heterogeneity has long been overlooked, hampering the possibility to identify those genomic alterations that persist, before and after therapy, in the g...

journal_title：International journal of cancer

authors： Ballabio S,Craparotta I,Paracchini L,Mannarino L,Corso S,Pezzotta MG,Vescio M,Fruscio R,Romualdi C,Dainese E,Ceppi L,Calura E,Pileggi S,Siravegna G,Pattini L,Martini P,Delle Marchette M,Mangioni C,Ardizzoia A,Pelleg

更新日期：2019-11-15 00:00:00

abstract：:In the last decade, mitochondrial DNA (mtDNA) haplogroups have been associated with the occurrence of breast cancer. However, the underlying mechanism is not known. Combining a case-control study with a large cohort of women from Southern China with breast cancer and functional analyses with trans-mitochondrial techno...

journal_title：International journal of cancer

authors： Ma L,Fu Q,Xu B,Zhou H,Gao J,Shao X,Xiong J,Gu Q,Wen S,Li F,Shen L,Chen G,Fang H,Lyu J

更新日期：2018-05-01 00:00:00

abstract：:Wilms' tumor development, like most tumors, involves multiple genetic alterations affecting diverse genes. Only one of these has thus far been identified, the Wilms' tumor 1 (WT1) gene on 11p13, which functions as a tumor suppressor gene. We assessed the involvement of the WT1 gene constitutionally and somatically in ...

journal_title：International journal of cancer

authors： Nordenskjöld A,Friedman E,Sandstedt B,Söderhäll S,Anvret M

更新日期：1995-11-15 00:00:00

abstract：:A glucuronide doxorubicin prodrug N-[4-doxorubicin-N-carbonyl (oxymethyl) phenyl] O-beta-glucuronyl carbamate (DOX-GA3) has been developed to improve the antitumor effects of doxorubicin (DOX). The prodrug was originally designed to be activated into drug by human beta-glucuronidase (GUS) released from tumor cells in ...

journal_title：International journal of cancer

authors： Houba PH,Boven E,van der Meulen-Muileman IH,Leenders RG,Scheeren JW,Pinedo HM,Haisma HJ

更新日期：2001-02-15 00:00:00

abstract：:Low ionic strength (50 to 100 mM NaCl) and pH 6.0 were found to be optimal conditions for in vitro conversion of Epstein-Barr virus (EBV)-determined nuclear antigen (EBNA)-negative nuclei to EBNA-positive nuclei by addition of the complement-fixing (CF) antigen extracted from Raji cells. In vitro conversion of nuclei ...

journal_title：International journal of cancer

authors： Hirsch I,Suchánková A,Závadová H,Vonka V

更新日期：1978-11-15 00:00:00

abstract：:Natural cell-mediated immunity against autologous tumor cells, autologous endometrial epithelium, and allogeneic epidermoid carcinoma cell line HeLa was tested in 8 patients with endometrial carcinoma and one patient with endometrial stromal sarcoma. The average cytotoxicity of unstimulated peripheral blood lymphocyte...

journal_title：International journal of cancer

authors： Timonen T,Lehtovirta P,Saksela E

更新日期：1987-10-15 00:00:00

abstract：:In order to evaluate whether the SCID mouse can provide the microenvironment for the growth of human immature T-cell leukemias and if in vivo growth alters their phenotype, we examined the behavior of 3 well-characterized T-cell acute lymphoblastic leukemia (T-ALL)-derived T-cell lines which are at different stages of...

journal_title：International journal of cancer

authors： Uittenbogaart CH,Anisman DJ,Tary-Lehmann M,Vollger LW,Breit TM,Van Dongen JJ,Saxon A

更新日期：1994-02-15 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors, such as valproic acid (VPA), constitute a novel class of anticancer agents that cause an increase in acetylated histones and thus restore the expression of dormant tumor-suppressor and other genes related to cell differentiation, cell-cycle arrest or apoptosis of tumor cells. The...

journal_title：International journal of cancer

authors： Biran A,Brownstein M,Haklai R,Kloog Y

更新日期：2011-02-01 00:00:00

abstract：:Distribution of miscarriages, stillbirths and infant deaths in the families of a population-based series of children with soft-tissue sarcoma was examined in relation to index case histology (rhabdomyosarcoma or other soft-tissue sarcoma) and to the possible presence of genetic predisposition to cancer in the families...

journal_title：International journal of cancer

authors： Hartley AL,Birch JM,Blair V,Kelsey AM,Morris Jones PH

更新日期：1994-03-01 00:00:00

abstract：:We have shown that the loss of p53 function contributed to resistance of tumor cells to TNF-induced cytotoxicity. In the present study, we evaluated the effect of wild-type p53 (wt-p53) expression on TNF sensitivity, by introducing wt-p53 into MCF7/Adr cells in which p53 was deleted, via a recombinant adenovirus encod...

journal_title：International journal of cancer

authors： Shatrov VA,Ameyar M,Bouquet C,Cai Z,Stancou R,Haddada H,Chouaib S

更新日期：2000-01-01 00:00:00

abstract：:The nature of 15 immortal mouse liver epithelial cell (MLEC) lines established from normal C3H mice was investigated specifically in terms of ras oncogene activation. Neither transforming activity nor point mutation within codon 61 of c-H-ras could be demonstrated in any of the cell lines by DNA transfection in a NIH/...

journal_title：International journal of cancer

authors： Lee GH,Sakai R,Nagao M,Kitagawa T

更新日期：1991-01-02 00:00:00

abstract：:Oncogenic PIK3CA mutations contribute to colorectal tumorigenesis by activating AKT signaling to decrease apoptosis and increase tumor invasion. A synergistic association of PIK3CA mutation with KRAS mutation has been suggested to increase AKT signaling and resistance to antiepidermal growth factor receptor inhibitor ...

journal_title：International journal of cancer

authors： Whitehall VL,Rickman C,Bond CE,Ramsnes I,Greco SA,Umapathy A,McKeone D,Faleiro RJ,Buttenshaw RL,Worthley DL,Nayler S,Zhao ZZ,Montgomery GW,Mallitt KA,Jass JR,Matsubara N,Notohara K,Ishii T,Leggett BA

更新日期：2012-08-15 00:00:00

abstract：:ERK and RSK2 drive proliferation and invasion of many cancers. Phosphoprotein enriched in astrocytes 15 (PEA15) binds ERK and RSK2 and high PEA15 levels can impair ERK- and RSK2-dependent transcription. PEA15 expression also inversely correlates with cell motility and invasiveness. We therefore tested PEA15 effects on...

journal_title：International journal of cancer

authors： Gawecka JE,Geerts D,Koster J,Caliva MJ,Sulzmaier FJ,Opoku-Ansah J,Wada RK,Bachmann AS,Ramos JW

更新日期：2012-10-01 00:00:00

abstract：:A human cancer vaccine composed of autologous tumor cells modified with the hapten dinitrofluorobenzene (DNP) induces cell-mediated immunity to the tumor cells and the development of inflammatory responses within metastatic sites. In this study we determined whether DNP vaccine could induce regression of established m...

journal_title：International journal of cancer

authors： Berd D,Sato T,Cohn H,Maguire HC Jr,Mastrangelo MJ

更新日期：2001-11-01 00:00:00

abstract：:Infection by oncogenic human papillomavirus (HPV) is a necessary but not sufficient cause of cervical carcinoma. Several host genetic and viral factors have been reported to increase the risk of carcinoma development given an HPV infection. In our study, we have analysed the contribution of HPV 16 E6 sequence subtype ...

journal_title：International journal of cancer

authors： Beskow AH,Engelmark MT,Magnusson JJ,Gyllensten UB

更新日期：2005-11-20 00:00:00

abstract：:The DNA of 22 fibrosarcomas, newly induced in BALB/c mice by subcutaneous doses of 3-methylcholanthrene (3-MCA), was tested in NIH 3T3 transformation assay. Activation of K-ras and N-ras was found in 7 and 3 cases respectively. No H-ras activation was detected. Polymerase chain reaction and oligonucleotide hybridizati...

journal_title：International journal of cancer

authors： Carbone G,Borrello MG,Molla A,Rizzetti MG,Pierotti MA,Della Porta G,Parmiani G

更新日期：1991-02-20 00:00:00

abstract：:Suppressor of cytokine signaling 3 (SOCS3), as a key regulator of cytokine signaling, has the potential to modulate numerous cellular processes. Its involvement in inflammatory disease is well established, and there is increasing evidence for a role in breast cancer as a regulator of signal transducers and activators ...

journal_title：International journal of cancer

authors： Barclay JL,Anderson ST,Waters MJ,Curlewis JD

更新日期：2009-04-15 00:00:00

abstract：:The major obstacle for the treatment of gastric cancer is recurrence and metastasis; yet, its molecular mechanism is largely unknown. 2-methoxyestradiol (2-ME), a metabolite of the estradiol-17beta, has recently been demonstrated to have multifactorial effects against tumor proliferation and angiogenesis; how these ef...

journal_title：International journal of cancer

authors： Lin HL,Yang MH,Wu CW,Chen PM,Yang YP,Chu YR,Kao CL,Ku HH,Lo JF,Liou JP,Chi CW,Chiou SH

更新日期：2007-12-01 00:00:00

abstract：:Pancreatic cancer is almost always fatal, in part because of its delayed diagnosis, poor prognosis, rapid progression and chemoresistance. Oncogenic proteins are stabilized by the Hsp90, making it a potential therapeutic target. We investigated the oxidative stress-mediated dysfunction of Hsp90 and the hindrance of it...

journal_title：International journal of cancer

authors： Sarkar S,Dutta D,Samanta SK,Bhattacharya K,Pal BC,Li J,Datta K,Mandal C,Mandal C

更新日期：2013-02-01 00:00:00