Detection of human T-lymphotropic virus type-I DNA and mRNA in the lymph nodes; using polymerase chain reaction in situ hybridization (PCR/ISH) and reverse transcription (RT-PCR/ISH).


:To examine the relationship between human T-lymphotrophic virus type I (HTLV-I) proviral DNA and its expression in the lymph nodes, HTLV-I DNA and tax/rex mRDA were directly amplified by polymerase chain reaction in situ hybridization (PCR/ISH), and reverse transcription (RT)-PCR/ISH [RT-PCR/ISH]. We studied 24 lymph nodes from patients with adult T-cell leukemia/lymphoma (ATLL), incipient ATLL (I-ATLL), and HTLV-I associated lymphadenitis dermatopathic type (HAL-D) and enlarged paracortical type (HAL-EP). In ATLL, 40-60% of the nucleated cells were positive for for HTLV-I proviral DNA by PCR/ISH, while in I-ATLL and HAL, respectively 5-20% and less than 1-5% of cells were positive. The number of mRNA expressing cells was smaller than that of the proviral DNA-positive cells. The mRNA-expressing cells varied in number among the ATLL and I-ATLL cases, while they were only rarely observed in HAL-D and HAL-EP. These results show that HTLV-I infection and activation might increase with malignant transformation of the target T helper cells.


Int J Cancer


Ohshima K,Suzumiya J,Izumo S,Mukai Y,Tashiro K,Kikuchi M




Has Abstract


1996-03-28 00:00:00














  • Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC.

    abstract::Immune checkpoint inhibition leads to response in some patients with head and neck squamous cell carcinoma (HNSCC). Robust biomarkers are lacking to date. We analyzed viral status, gene expression signatures, mutational load and mutational signatures in whole exome and RNA-sequencing data of the HNSCC TCGA dataset (n ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Messerschmidt C,Obermayer B,Klinghammer K,Ochsenreither S,Treue D,Stenzinger A,Glimm H,Fröhling S,Kindler T,Brandts CH,Schulze-Osthoff K,Weichert W,Tinhofer I,Klauschen F,Keilholz U,Beule D,Rieke DT

    更新日期:2020-10-15 00:00:00

  • Production of P-glycoprotein from the MDR1 upstream promoter is insufficient to affect the response to first-line chemotherapy in advanced breast cancer.

    abstract::Multidrug resistance, the phenomenon by which cells treated with a drug become resistant to the cytotoxic effect of a variety of other structurally and functionally unrelated drugs, is often associated with the expression of P-glycoprotein, an efflux membrane pump coded by the MDR1 (ABCB1) gene. Transcription from MDR...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Raguz S,Randle RA,Sharpe ER,Foekens JA,Sieuwerts AM,Meijer-van Gelder ME,Melo JV,Higgins CF,Yagüe E

    更新日期:2008-03-01 00:00:00

  • IGFBP-3 prolongs the p53 response and enhances apoptosis following UV irradiation.

    abstract::Neoplastic transformation is characterised by an imbalance in favour of cell growth over programmed cell death (apoptosis). The tumour-suppressor gene p53, responsible for maintaining cell-cycle control, is mutated in the majority of human cancers. Loss of function of the target genes of p53 are therefore important in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hollowood AD,Lai T,Perks CM,Newcomb PV,Alderson D,Holly JM

    更新日期:2000-11-01 00:00:00

  • Biallelic mutations of the Tsc2 gene in chemically induced rat renal cell carcinoma.

    abstract::A number of cancer genes have been identified by the study of hereditary human cancers and shown to be involved in sporadic genesis of the same tumors. We have identified a germline mutation in the rat homologue of the human tuberous sclerosis (TSC2) predisposing gene in the Eker rat model. In this study, we searched ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Satake N,Urakami S,Hirayama Y,Izumi K,Hino O

    更新日期:1998-09-11 00:00:00

  • Transformation of rabbit kidney cells by BKV(MM) human papovavirus.

    abstract::Primary rabbit kidney cells were transformed by BKV(MM), a papovavirus isolated from the urine of a child with the Wiskott-Aldrich syndrome. The transformed cells contained BK T-antigen, but no antigen that reacted with SV40 U-antiserum. The transformed cells failed to produce tumors in nude mice, and BKV (MM) was not...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mason DH Jr,Takemoto KK

    更新日期:1977-03-15 00:00:00

  • The importance of 5-HT for tumor cell lodgement in the liver.

    abstract::Arrest and lodgement of circulating tumor cells in the microvasculature is a prerequisite for metastasis formation. Aggregation of activated platelets and subsequent release of bioactive substances seem to influence the lodgement process. Since thrombocytopenia has been shown to reduce lodgement and since 5-HT is one ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Skolnik G,Bagge U,Dahlström A,Ahlman H

    更新日期:1984-04-15 00:00:00

  • FoxP3+ regulatory T cells are distinct from leukemia cells in HTLV-1-associated adult T-cell leukemia.

    abstract::Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATLL). It has been postulated that ATLL cells might act as regulatory T cells (T(regs)) which, in common with ATLL cells, express both CD25 and FoxP3, and so contribute to the severe immune suppression typical of ATLL....

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Toulza F,Nosaka K,Takiguchi M,Pagliuca T,Mitsuya H,Tanaka Y,Taylor GP,Bangham CR

    更新日期:2009-11-15 00:00:00

  • Mortality and incidence trends from esophagus cancer in selected geographic areas of China circa 1970-90.

    abstract::China was one of the countries with the highest esophagus cancer risk in the world during the 1970s. This report provides data on time trends of esophagus cancer incidence and mortality during the 1970s-90s in selected geographic areas of China. Information on newly diagnosed cancer cases and cancer deaths is based on...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ke L

    更新日期:2002-11-20 00:00:00

  • ERK inhibitor PD98059 enhances docetaxel-induced apoptosis of androgen-independent human prostate cancer cells.

    abstract::Anticancer drugs docetaxel and vinorelbine suppress cell growth by altering microtubule assembly and activating the proapoptotic signal pathway. Vinorelbine and docetaxel have been approved for treating several advanced cancers. However, their efficacy in the management of advanced hormone-refractory prostate cancer r...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zelivianski S,Spellman M,Kellerman M,Kakitelashvilli V,Zhou XW,Lugo E,Lee MS,Taylor R,Davis TL,Hauke R,Lin MF

    更新日期:2003-11-10 00:00:00

  • Risk factors for renal-cell carcinoma in a French case-control study.

    abstract::A hospital-based case-control study of renal-cell carcinoma was conducted in France from 1987 to 1991. A total of 196 histologically confirmed cases (138 males and 58 females) and 347 controls (235 males and 112 females), matched for sex, age at interview, hospital and interviewer, were included. The risk of renal-cel...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Benhamou S,Lenfant MH,Ory-Paoletti C,Flamant R

    更新日期:1993-08-19 00:00:00

  • MLL/AF10(OM-LZ)-immortalized cells expressed cytokines and induced host cell proliferation in a mouse bone marrow transplantation model.

    abstract::Several mouse models studying the MLL fusion-induced leukemic transformation showed that a myeloproliferation stage precedes leukemia or occurred as the only phenotype of hematological disorder in mice. We established 6 MLL/AF10(OM-LZ)-immortalized cell lines by retrovirally transducing the fusion gene into bone marro...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fu JF,Hsu CL,Shih LY

    更新日期:2010-04-01 00:00:00

  • Long-term exposure to fine particulate matter air pollution and the risk of lung cancer among participants of the Canadian National Breast Screening Study.

    abstract::Recently, air pollution has been classified as a carcinogen largely on the evidence of epidemiological studies of lung cancer. However, there have been few prospective studies that have evaluated associations between fine particulate matter (PM2.5 ) and cancer at lower concentrations. We conducted a prospective analys...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tomczak A,Miller AB,Weichenthal SA,To T,Wall C,van Donkelaar A,Martin RV,Crouse DL,Villeneuve PJ

    更新日期:2016-11-01 00:00:00

  • Ovarian cancer-derived copy number alterations signatures are prognostic in chemoradiotherapy-treated head and neck squamous cell carcinoma.

    abstract::DNA copy number alterations (CNAs) are frequent in cancer, and recently developed CNA signatures revealed their value in molecular tumor stratification for patient prognosis and platinum resistance prediction in ovarian cancer. Head and neck squamous cell carcinoma (HNSCC) is also characterized by high CNAs. In this s...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Essers PBM,van der Heijden M,Vossen D,de Roest RH,Leemans CR,Brakenhoff RH,van den Brekel MWM,Bartelink H,Verheij M,Vens C

    更新日期:2020-09-15 00:00:00

  • Prognosis of early breast cancer by immunohistochemistry defined intrinsic sub-types in patients treated with adjuvant chemotherapy in the NEAT/BR9601 trial.

    abstract::Breast cancer can be classified into molecular sub-types that have distinct survival patterns. We evaluated the prognostic significance of breast cancer sub-types in a cohort of women taking part in the NEAT and BR9601 clinical trials comparing cyclophosphamide, methotrexate and fluorouracil (CMF) with ECMF (epirubici...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ali AM,Provenzano E,Bartlett JM,Abraham J,Driver K,Munro AF,Twelves C,Poole CJ,Hiller L,Dunn JA,Earl HM,Caldas C,Pharoah PD

    更新日期:2013-09-15 00:00:00

  • Elevated risk for squamous cell carcinoma of the conjunctiva among adults with AIDS in the United States.

    abstract::Squamous cell carcinoma of the conjunctiva (SCCC) has been associated with HIV infection in equatorial Africa, but the evidence for association with HIV in developed countries, where SCCC is rarer, is controversial. We investigated the risk for SCCC and other eye cancers in the updated U.S. HIV/AIDS Cancer Match Regis...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Guech-Ongey M,Engels EA,Goedert JJ,Biggar RJ,Mbulaiteye SM

    更新日期:2008-06-01 00:00:00

  • Comparison of 131I-labelled anti-episialin 139H2 with cisplatin, cyclophosphamide or external-beam radiation for anti-tumor efficacy in human ovarian cancer xenografts.

    abstract::Three human ovarian cancer xenografts of different origin and grown s.c. in nude mice as well-established tumors were studied for their sensitivity to cisplatin (CDDP), cyclophosphamide (CTX), 131I-labelled anti-episialin monoclonal antibody (MAb) 139H2, or external-beam radiotherapy. The maximum tolerated dose of CDD...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Molthoff CF,Pinedo HM,Schlüper HM,Rutgers DH,Boven E

    更新日期:1992-04-22 00:00:00

  • RNAi-mediated downregulation of urokinase plasminogen activator receptor and matrix metalloprotease-9 in human breast cancer cells results in decreased tumor invasion, angiogenesis and growth.

    abstract::The serine protease urokinase-type plasminogen activator (uPA) plays a significant role in tumor cell invasion and metastasis when bound to its specific receptor, uPAR (also known as CD87). In addition to the uPA-uPAR system, matrix metalloproteinases (MMPs) are involved in tumor cell invasion and metastasis. In this ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kunigal S,Lakka SS,Gondi CS,Estes N,Rao JS

    更新日期:2007-11-15 00:00:00

  • Cytomatrix reorganization in dimethyl sulfoxide-induced "Qi" substate murine hepatic tumor cells.

    abstract::Cultured murine hepatic tumor (HT) cells respond to the polar solvent dimethylsulfoxide (DMSO) with specific alterations in morphology, proliferative kinetics, and biochemical properties. These include entrance into a quiescent "Qi" substate (characterized by accumulation of cells in G1 phase and lowered cellular RNA ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ryan MP,Higgins PJ

    更新日期:1988-08-15 00:00:00

  • Integrated gene copy number and expression microarray analysis of gastric cancer highlights potential target genes.

    abstract::We performed an integrated array comparative genomic hybridization (aCGH) and expression microarray analysis of 8 normal gastric tissues and 38 primary tumors, including 25 intestinal and 13 diffuse gastric adenocarcinomas to identify genes whose expression is deregulated in association with copy number alteration. Ou...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Myllykangas S,Junnila S,Kokkola A,Autio R,Scheinin I,Kiviluoto T,Karjalainen-Lindsberg ML,Hollmén J,Knuutila S,Puolakkainen P,Monni O

    更新日期:2008-08-15 00:00:00

  • Expression of Fas (CD95/APO-1) and Fas ligand in lung cancer, its prognostic and predictive relevance.

    abstract::In order to examine whether or not the expression of the apoptosis-related receptor Fas (CD-95/APO-1) and its ligand (FasL) has relevance for patient survival, immunohistochemistry was used to analyze the proteins of both factors in 164 non-small cell lung carcinomas. Patients with Fas-positive tumors exhibited signif...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Koomägi R,Volm M

    更新日期:1999-06-21 00:00:00

  • Induction of carcinoembryonic antigen (CEA)-specific cytotoxic T-lymphocyte responses in vitro using autologous dendritic cells loaded with CEA peptide or CEA RNA in patients with metastatic malignancies expressing CEA.

    abstract::The application of dendritic cells (DC) to the active immunotherapy of cancer currently relies on the generation of potent DC capable of presenting tumor antigens such as carcinoembryonic antigen (CEA). It is unknown whether the T cells of patients with advanced malignancies can be reliably stimulated against tumor an...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nair SK,Hull S,Coleman D,Gilboa E,Lyerly HK,Morse MA

    更新日期:1999-07-02 00:00:00

  • Transactivation of the CCL5/RANTES gene by Epstein-Barr virus latent membrane protein 1.

    abstract::Chemokines and chemokine receptors mediate lymphocyte migration and tissue localization. To analyze CCL5 (RANTES) expression by EBV-infected cells, we examined the expression of CCL5 in BL cell lines. Among 4 BL cell lines, those infected with EBV selectively expressed the CCL5 gene and secreted CCL5. Four cell lines ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,收录出版


    authors: Uchihara JN,Krensky AM,Matsuda T,Kawakami H,Okudaira T,Masuda M,Ohta T,Takasu N,Mori N

    更新日期:2005-05-01 00:00:00

  • CDKN2a mutation-negative melanoma families have increased risk exclusively for skin cancers but not for other malignancies.

    abstract::Germline CDKN2A mutations are found in 5-20% of melanoma families. Numerous studies have shown that carriers of CDKN2A mutations have increased risks of non-melanoma cancers, but so far there have been no studies investigating cancer risks in CDKN2A wild type (wt) melanoma families. In this prospective cohort study, i...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Helgadottir H,Höiom V,Tuominen R,Jönsson G,Månsson-Brahme E,Olsson H,Hansson J

    更新日期:2015-11-01 00:00:00

  • Chemical transformation of human revertant cells induced by murine sarcoma virus.

    abstract::A human revertant cell line, derived from non-producer human osteosarcoma cells (NP/KHOS) induced by Kirsten murine sarcoma virus, was treated in vitro with various levels of polycyclic aromatic hydrocarbons (3-methylcholanthrene, 7,12-dimethylbenz(alpha)anthracene, and benzo(alpha)pyrene [BP] or dimethyl sulfoxide (c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cho HY,Arnstein P,Rhim JS

    更新日期:1978-01-15 00:00:00

  • Genetic identification of multiple susceptibility genes involved in the development of endometrial carcinoma in a rat model.

    abstract::There are clear indications that inheritance plays an essential role in certain cases of human endometrial cancer, and there are at least 2 forms of early-onset heritable endometrial adenocarcinomas (EACs). Females of the BDII inbred rat strain are known to be genetically predisposed to endometrial carcinoma, and we h...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Roshani L,Wedekind D,Szpirer J,Taib Z,Szpirer C,Beckmann B,Rivière M,Hedrich HJ,Klinga-Levan K

    更新日期:2001-12-15 00:00:00

  • Transcription factor co-repressors in cancer biology: roles and targeting.

    abstract::Normal transcription displays a high degree of flexibility over the choice, timing and magnitude of mRNA expression levels that tend to oscillate and cycle. These processes allow for combinatorial actions, feedback control and fine-tuning. A central role has emerged for the transcriptional co-repressor proteins such a...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Battaglia S,Maguire O,Campbell MJ

    更新日期:2010-06-01 00:00:00

  • Scatter factor modulates the metastatic phenotype of the EMT6 mouse mammary tumor.

    abstract::EMT6 is a transplantable mouse mammary tumor cell line that has been utilized widely as a model system to study the effects of various treatments on local tumor growth and pulmonary metastasis. In this study, we examined the cellular mechanisms by which scatter factor (SF), a fibroblast-derived cytokine that stimulate...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rosen EM,Knesel J,Goldberg ID,Jin L,Bhargava M,Joseph A,Zitnik R,Wines J,Kelley M,Rockwell S

    更新日期:1994-06-01 00:00:00

  • Genetic downregulation of pregnancy-associated plasma protein-A (PAPP-A) by bikunin reduces IGF-I-dependent Akt and ERK1/2 activation and subsequently reduces ovarian cancer cell growth, invasion and metastasis.

    abstract::A Kunitz-type protease inhibitor, bikunin, downregulates expression of uPA and its receptor uPAR at the mRNA and protein levels in several types of tumor cells. Our recent work showed that, using a cDNA microarray analysis, pregnancy-associated plasma protein-A (PAPP-A) is a candidate bikunin target gene. To clarify h...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tanaka Y,Kobayashi H,Suzuki M,Hirashima Y,Kanayama N,Terao T

    更新日期:2004-04-10 00:00:00

  • Bispecific monoclonal antibodies directed to CD16 and to a tumor-associated antigen induce target-cell lysis by resting NK cells and by a subset of NK clones.

    abstract::CD16 surface antigens represent activatory molecules in CD3-16+ NK cells. In order to target NK cells against relatively NK-resistant ovarian carcinomas, we used an anti-CD16 monoclonal antibody (MAb) (VD4), together with an anti-ovarian carcinoma-associated antigen (MOV19), to construct biMAbs. To this end, hybrid hy...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ferrini S,Prigione I,Miotti S,Ciccone E,Cantoni C,Chen Q,Colnaghi MI,Moretta L

    更新日期:1991-05-10 00:00:00

  • Growth-factor-dependent migration of human lung-cancer cells.

    abstract::Human lung tumors express different types of growth-factor receptors and corresponding ligands that might modulate several biological functions such as proliferation, differentiation, adhesion, and chemotaxis. In the present study, we have investigated the expression of different growth-factor receptors and their liga...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bredin CG,Liu Z,Hauzenberger D,Klominek J

    更新日期:1999-07-30 00:00:00