Detection of human T-lymphotropic virus type-I DNA and mRNA in the lymph nodes; using polymerase chain reaction in situ hybridization (PCR/ISH) and reverse transcription (RT-PCR/ISH).


:To examine the relationship between human T-lymphotrophic virus type I (HTLV-I) proviral DNA and its expression in the lymph nodes, HTLV-I DNA and tax/rex mRDA were directly amplified by polymerase chain reaction in situ hybridization (PCR/ISH), and reverse transcription (RT)-PCR/ISH [RT-PCR/ISH]. We studied 24 lymph nodes from patients with adult T-cell leukemia/lymphoma (ATLL), incipient ATLL (I-ATLL), and HTLV-I associated lymphadenitis dermatopathic type (HAL-D) and enlarged paracortical type (HAL-EP). In ATLL, 40-60% of the nucleated cells were positive for for HTLV-I proviral DNA by PCR/ISH, while in I-ATLL and HAL, respectively 5-20% and less than 1-5% of cells were positive. The number of mRNA expressing cells was smaller than that of the proviral DNA-positive cells. The mRNA-expressing cells varied in number among the ATLL and I-ATLL cases, while they were only rarely observed in HAL-D and HAL-EP. These results show that HTLV-I infection and activation might increase with malignant transformation of the target T helper cells.


Int J Cancer


Ohshima K,Suzumiya J,Izumo S,Mukai Y,Tashiro K,Kikuchi M




Has Abstract


1996-03-28 00:00:00














  • Changes in tumor-specific antigen expression during passage in vitro and in vivo of newly derived methylcholanthrene-induced sarcomas of BALB/C mice.

    abstract::The characteristics of tumor antigens of the transplantation type, TATA, were studied in a series of methylcholanthrene-induced sarcomas in pedigreed BALB/cAN mice. Each of the six sarcomas exhibited unique TATA when assayed for tumor rejection in syngeneic hosts. In three instances, however, in sarcomas CI-I, CII-5 a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Law LW

    更新日期:1980-02-15 00:00:00

  • Risk factors for prostate cancer incidence and progression in the health professionals follow-up study.

    abstract::Risk factors for prostate cancer could differ for various sub-groups, such as for "aggressive" and "non-aggressive" cancers or by grade or stage. Determinants of mortality could differ from those for incidence. Using data from the Health Professionals Follow-Up Study, we re-examined 10 factors (cigarette smoking histo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Giovannucci E,Liu Y,Platz EA,Stampfer MJ,Willett WC

    更新日期:2007-10-01 00:00:00

  • Alterations of 3p21.31 tumor suppressor genes in head and neck squamous cell carcinoma: Correlation with progression and prognosis.

    abstract::The aim of our study was to analyze the alterations of some candidate tumor suppressor genes (TSGs) viz. LIMD1, LTF, CDC25A, SCOTIN, RASSF1A and CACNA2D2 located in the chromosomal region 3p21.31 associated with the development of early dysplastic lesions of head and neck. In analysis of 72 dysplastic lesions and 116 ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ghosh S,Ghosh A,Maiti GP,Alam N,Roy A,Roy B,Roychoudhury S,Panda CK

    更新日期:2008-12-01 00:00:00

  • The ability of normal mouse cells to reduce the malignant potential of transformed mouse bladder epithelial cells depends on their somatic origin.

    abstract::Somatic cell hybrids have been made between a transformed mouse bladder carcinoma cell line and normal mouse bladder epithelium and mesenchyme. In the epithelial tumour/mesenchyme hybrids the malignant phenotype was expressed dominantly whereas in the carcinoma/normal epithelium hybrids the malignant potential was gre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cowell JK,Franks LM

    更新日期:1984-05-15 00:00:00

  • International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons.

    abstract::Osteosarcoma incidence rates in the United States peak in adolescence and in the elderly. The international patterns of osteosarcoma incidence in children have been described, whereas those for young, middle age or elderly adults have not. Using the Cancer Incidence in Five Continents, International Agency for Cancer ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mirabello L,Troisi RJ,Savage SA

    更新日期:2009-07-01 00:00:00

  • Protein kinase B modulates the sensitivity of human neuroblastoma cells to insulin-like growth factor receptor inhibition.

    abstract::The potential of the novel insulin-like growth factor receptor (IGF-IR) inhibitor NVP-AEW541 as an antiproliferative agent in human neuroblastoma was investigated. Proliferation of a panel of neuroblastoma cell lines was inhibited by NVP-AEW541 with IC(50) values ranging from 0.15 to 5 microM. Experiments using an IGF...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Guerreiro AS,Boller D,Shalaby T,Grotzer MA,Arcaro A

    更新日期:2006-12-01 00:00:00

  • Pyrimethamine sensitizes pituitary adenomas cells to temozolomide through cathepsin B-dependent and caspase-dependent apoptotic pathways.

    abstract::Invasive pituitary adenomas (PAs) are generally refractory to conventional therapy and salvage treatment with temozolomide (TMZ). In addition to antiprotozoan effects, pyrimethamine (PYR) has recently shown its strong antitumor activity as an antineoplastic agent or in combination with TMZ in metastatic melanoma cells...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dai C,Zhang B,Liu X,Guo K,Ma S,Cai F,Yang Y,Yao Y,Feng M,Bao X,Deng K,Jiao Y,Wei Z,Junji W,Xing B,Lian W,Wang R

    更新日期:2013-10-15 00:00:00

  • Lifetime recreational moderate-to-vigorous physical activity and ovarian cancer risk: A case-control study.

    abstract::Results of epidemiologic studies of physical activity and ovarian cancer risk are inconsistent. Few have attempted to measure physical activity over the lifetime or in specific age windows, which may better capture etiologically relevant exposures. We examined participation in moderate-to-vigorous recreational physica...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Grundy A,Ho V,Abrahamowicz M,Parent MÉ,Siemiatycki J,Arseneau J,Gilbert L,Gotlieb WH,Provencher DM,Koushik A

    更新日期:2020-04-01 00:00:00

  • CpG methylation of viral DNA in EBV-associated tumours.

    abstract::In EBV-immortalized lymphoblastoid cell lines (LCLs) a small number of "latent" proteins are expressed. These are the EBV nuclear antigens, EBNAs 1-6, and a latent membrane protein, LMP. We have investigated the expression of these proteins in a variety of EBV-associated tumours and cell lines. Whereas transplant and ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Allday MJ,Kundu D,Finerty S,Griffin BE

    更新日期:1990-06-15 00:00:00

  • Tissue and serum metabolomic phenotyping for diagnosis and prognosis of hepatocellular carcinoma.

    abstract::More than two-thirds of patients with hepatocellular carcinoma (HCC) cannot receive curative therapy and have poor survival due to late diagnosis and few prognostic directions. In our study, nontargeted and targeted metabolomics analyses were conducted by liquid chromatography-mass spectrometry to characterize metabol...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Han J,Han ML,Xing H,Li ZL,Yuan DY,Wu H,Zhang H,Wang MD,Li C,Liang L,Song YY,Xu AJ,Wu MC,Shen F,Xie Y,Yang T

    更新日期:2020-03-15 00:00:00

  • Gene expression analysis in Interleukin-12-induced suppression of mouse mammary carcinoma.

    abstract::Interleukin-12 (IL-12) has potent antitumor activities via natural killer cells and cytotoxic T lymphocytes. However, the molecular mechanisms whereby IL-12 induces tumoricidal activities are poorly understood. Here, we report the genome-wide analysis of gene expression in a primary murine mammary carcinoma model that...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shi X,Liu J,Xiang Z,Mitsuhashi M,Wu RS,Ma X

    更新日期:2004-07-01 00:00:00

  • Heat shock and cytokines modulate the expression of adhesion molecules on different human gastric-cancer cell lines.

    abstract::In order to understand the expression and modulation of adhesion molecules (AMs) on the surface of different gastric cancers, we studied 4 gastric-cancer cell lines including SC-M1, KATO-III, AGS and AZ-521. The expression of E-cadherin, integrins (beta1, beta2 and beta3), ICAMs (1 and 2), and CD11 (a, b and c) on the...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hsieh MC,Wu CW,Wu LH,Lui WY,P'eng FK,Yu CL

    更新日期:1996-09-04 00:00:00

  • Ganglioside GM2 on the K562 cell line is recognized as a target structure by human natural killer cells.

    abstract::Although human NK cells lyse a wide spectrum of target cells, the precise target structure recognized by NK cells has not yet been elucidated. In order to define a possible relationship between gangliosides on human target cells and susceptibility to NK lysis, 14 human leukemia and lymphoma cell lines were studied. A ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ando I,Hoon DS,Suzuki Y,Saxton RE,Golub SH,Irie RF

    更新日期:1987-07-15 00:00:00

  • SET complex in serous epithelial ovarian cancer.

    abstract::With low cure rates but increasing diverse treatment options that provide variable remission times, ovarian cancer is increasingly being recognized as a chronic disease. This reality indicates the need for a better understanding of factors influencing disease progression. In a previous global analysis of gene expressi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ouellet V,Le Page C,Guyot MC,Lussier C,Tonin PN,Provencher DM,Mes-Masson AM

    更新日期:2006-11-01 00:00:00

  • Over-expression of p53 protein in human laryngeal carcinoma.

    abstract::We examined the expression of tumor-suppressor protein p53 in a variety of laryngeal carcinomas from 43 patients (25 primary, 13 metastatic and 5 recurrent cases), 13 normal laryngeal tissues and 7 benign laryngeal nodule biopsy specimens, using the polyclonal antibody CM-1. Previously we have reported a high incidenc...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Anwar K,Nakakuki K,Imai H,Naiki H,Inuzuka M

    更新日期:1993-04-01 00:00:00

  • Lifetime and baseline alcohol intake and risk of cancer of the upper aero-digestive tract in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

    abstract::Recent alcohol consumption is an established risk factor for squamous cell carcinoma (SCC) of the upper aero-digestive tract. In contrast, the role of lifetime exposure to alcohol with regard to risk of SCC is not well established. Historical data on alcohol use are available in 271,253 participants of the European Pr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Weikert C,Dietrich T,Boeing H,Bergmann MM,Boutron-Ruault MC,Clavel-Chapelon F,Allen N,Key T,Lund E,Olsen A,Tjønneland A,Overvad K,Rohrmann S,Linseisen J,Pischon T,Trichopoulou A,Weinehall L,Johansson I,Sánchez MJ,Ag

    更新日期:2009-07-15 00:00:00

  • Residential and occupational exposure to 50-Hz magnetic fields and brain tumours in Norway: a population-based study.

    abstract::Our case-control study was conducted to investigate whether residential and occupational exposure to magnetic fields increased the risk for brain tumours in adults. Data from an occupational exposure matrix was also evaluated. The study population in this nested case-control study was made up of subjects aged 16 years...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Klaeboe L,Blaasaas KG,Haldorsen T,Tynes T

    更新日期:2005-05-20 00:00:00

  • Variable effects of sodium butyrate on the expression and function of the MDR1 (P-glycoprotein) gene in colon carcinoma cell lines.

    abstract::Expression of the MDR1 (P-glycoprotein) gene confers resistance to several classes of chemotherapeutic drugs (multi-drug resistance). Colon carcinomas frequently express high levels of MDR1 mRNA and P-glycoprotein, presumably reflecting the origin of these tumors from MDR1-expressing normal colonic cells. In 4 colon c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Frommel TO,Coon JS,Tsuruo T,Roninson IB

    更新日期:1993-09-09 00:00:00

  • Screening of human bladder tumors and urine sediments for the presence of H-ras mutations.

    abstract::A series of 111 human bladder tumors were screened using oligonucleotide mutant specific probes, restriction enzyme analysis and single-stranded confirmation polymorphism (SSCP) for the presence of H-ras activation events. Thirty-three tumors were found to harbor H-ras mutations where a glycine to valine (G-->T) chang...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Levesque P,Ramchurren N,Saini K,Joyce A,Libertino J,Summerhayes IC

    更新日期:1993-11-11 00:00:00

  • Premetastatic niches, exosomes and circulating tumor cells: Early mechanisms of tumor dissemination and the relation to surgery.

    abstract::The physiological stress response to surgery promotes wound healing and functional recovery and includes the activation of neural, inflammatory and proangiogenic signaling pathways. Paradoxically, the same pathways also promote metastatic spread and growth of residual cancer. Human and animal studies show that cancer ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Raskov H,Orhan A,Salanti A,Gögenur I

    更新日期:2020-06-15 00:00:00

  • Development of a replication-deficient adenoviral vector-based vaccine candidate for the interception of HPV16- and HPV18-induced infections and disease.

    abstract::High-risk Human papilloma virus (HPV) types are the causative agents of cervical cancer and several other anogenital malignancies. The viral proteins expressed in the (pre)malignant cells are considered ideal targets for immunological intervention. Many approaches have been evaluated for this purpose, mostly aiming at...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Khan S,Oosterhuis K,Wunderlich K,Bunnik EM,Bhaggoe M,Boedhoe S,Karia S,Steenbergen RDM,Bosch L,Serroyen J,Janssen S,Schuitemaker H,Vellinga J,Scheper G,Zahn R,Custers J

    更新日期:2017-07-15 00:00:00

  • Rectal cancer and occupational risk factors: a hypothesis-generating, exposure-based case-control study.

    abstract::In 1979, a hypothesis-generating, population-based case-control study was undertaken in Montreal, Canada, to explore the association between occupational exposure to 294 substances, 130 occupations and industries, and various cancers. Interviews were carried out with 3, 630 histologically confirmed cancer cases, of wh...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dumas S,Parent ME,Siemiatycki J,Brisson J

    更新日期:2000-09-15 00:00:00

  • In vitro and in vivo detection of somatostatin receptors in human malignant lymphomas.

    abstract::A wide variety of primary and metastatic human neoplasms express somatostatin receptors (SS-Rs). We evaluated the SS-R status of malignant lymphomas that had been surgically removed from 31 patients by use of in vitro SS-R autoradiography with the SS analog 125I-[Tyr3]-octreotide as radioligand. Of 11 low-grade-malign...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Reubi JC,Waser B,van Hagen M,Lamberts SW,Krenning EP,Gebbers JO,Laissue JA

    更新日期:1992-04-01 00:00:00

  • Plasma DNA microsatellite panel as sensitive and tumor-specific marker in lung cancer patients.

    abstract::The majority of lung cancer patients have tumor-derived genetic alterations in circulating plasma DNA that could be exploited as a diagnostic tool. We used fluorescent microsatellite analysis to detect alterations in plasma and tumor DNA in 34 patients who underwent bronchoscopy for lung cancer, including 11 small cel...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Beau-Faller M,Gaub MP,Schneider A,Ducrocq X,Massard G,Gasser B,Chenard MP,Kessler R,Anker P,Stroun M,Weitzenblum E,Pauli G,Wihlm JM,Quoix E,Oudet P

    更新日期:2003-06-20 00:00:00

  • Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development.

    abstract::Gab2, a docking-type signaling protein with demonstrated oncogenic potential, is overexpressed in breast cancer, but its prognostic significance and role in disease evolution remain unclear. Immunohistochemical detection of Gab2 in a large cohort of primary human breast cancers of known outcome revealed that while Gab...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fleuren ED,O'Toole S,Millar EK,McNeil C,Lopez-Knowles E,Boulghourjian A,Croucher DR,Schramek D,Brummer T,Penninger JM,Sutherland RL,Daly RJ

    更新日期:2010-09-01 00:00:00

  • TP53 mutation and survival in aggressive B cell lymphoma.

    abstract::TP53 is mutated in 20-25% of aggressive B-cell lymphoma (B-NHL). To date, no studies have addressed the impact of TP53 mutations in prospective clinical trial cohorts. To evaluate the impact of TP53 mutation to current risk models in aggressive B-NHL, we investigated TP53 gene mutations within the RICOVER-60 trial. Of...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Zenz T,Kreuz M,Fuge M,Klapper W,Horn H,Staiger AM,Winter D,Helfrich H,Huellein J,Hansmann ML,Stein H,Feller A,Möller P,Schmitz N,Trümper L,Loeffler M,Siebert R,Rosenwald A,Ott G,Pfreundschuh M,Stilgenbauer S,Ger

    更新日期:2017-10-01 00:00:00

  • A prospective study on the natural course of low-grade squamous intraepithelial lesions and the presence of HPV16 E2-, E6- and E7-specific T-cell responses.

    abstract::This study investigates the clinical course of low grade squamous intraepithelial lesions (LSIL), HPV status and HPV16-specific immune response in a large prospective study of 125 women with LSIL followed cytologically, virologically and histologically. Women with low-grade abnormal smears were recruited and followed-...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Woo YL,van den Hende M,Sterling JC,Coleman N,Crawford RA,Kwappenberg KM,Stanley MA,van der Burg SH

    更新日期:2010-01-01 00:00:00

  • Use of plasma MMP-2 and MMP-9 levels as a surrogate for tumour expression in colorectal cancer patients.

    abstract::Matrix metalloproteinases, and notably the gelatinases MMP-2 and MMP-9, have important roles in tumour invasion, metastasis and angiogenesis. Our study investigates the distribution of MMP-2 and MMP-9 in colorectal cancer, the correlation with plasma levels, changes following surgical resection and whether plasma leve...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tutton MG,George ML,Eccles SA,Burton S,Swift RI,Abulafi AM

    更新日期:2003-11-20 00:00:00

  • Distribution of the transferrin receptor in normal human fibroblasts and fibrosarcoma cells.

    abstract::Transferrin is required for proliferation of most cells in culture. This effect is presumably mediated by the binding of transferrin to its receptor, a surface glycoprotein which is preferentially expressed by actively growing cells. Here we show that normal human fibroblasts cultured in serum, and other media contain...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ekblom P,Thesleff I,Lehto VP,Virtanen I

    更新日期:1983-01-15 00:00:00

  • Trilaciclib prior to chemotherapy and atezolizumab in patients with newly diagnosed extensive-stage small cell lung cancer: A multicentre, randomised, double-blind, placebo-controlled Phase II trial.

    abstract::Trilaciclib is an intravenous CDK4/6 inhibitor administered prior to chemotherapy to preserve haematopoietic stem and progenitor cells and immune system function from chemotherapy-induced damage (myelopreservation). The effects of administering trilaciclib prior to carboplatin, etoposide and atezolizumab (E/P/A) were ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Daniel D,Kuchava V,Bondarenko I,Ivashchuk O,Reddy S,Jaal J,Kudaba I,Hart L,Matitashvili A,Pritchett Y,Morris SR,Sorrentino JA,Antal JM,Goldschmidt J

    更新日期:2020-12-21 00:00:00