Abstract:
:To examine the relationship between human T-lymphotrophic virus type I (HTLV-I) proviral DNA and its expression in the lymph nodes, HTLV-I DNA and tax/rex mRDA were directly amplified by polymerase chain reaction in situ hybridization (PCR/ISH), and reverse transcription (RT)-PCR/ISH [RT-PCR/ISH]. We studied 24 lymph nodes from patients with adult T-cell leukemia/lymphoma (ATLL), incipient ATLL (I-ATLL), and HTLV-I associated lymphadenitis dermatopathic type (HAL-D) and enlarged paracortical type (HAL-EP). In ATLL, 40-60% of the nucleated cells were positive for for HTLV-I proviral DNA by PCR/ISH, while in I-ATLL and HAL, respectively 5-20% and less than 1-5% of cells were positive. The number of mRNA expressing cells was smaller than that of the proviral DNA-positive cells. The mRNA-expressing cells varied in number among the ATLL and I-ATLL cases, while they were only rarely observed in HAL-D and HAL-EP. These results show that HTLV-I infection and activation might increase with malignant transformation of the target T helper cells.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Ohshima K,Suzumiya J,Izumo S,Mukai Y,Tashiro K,Kikuchi Mdoi
10.1002/(SICI)1097-0215(19960328)66:1<18::AID-IJC4subject
Has Abstractpub_date
1996-03-28 00:00:00pages
18-23issue
1eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(19960328)66:1<18::AID-IJC4journal_volume
66pub_type
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