Abstract:
:TAAs of the MAGE family are mostly studied as targets of specific immune responses. Their potential relevance as tumor markers has also been underlined. We used a MAb, 57B, recognizing MAGE-A4 protein in paraffin-embedded sections, to evaluate its expression in bladder cancers by employing TMA including 2,317 samples from 1,849 patients. In 2,090/2,317 cases (90.2%), immunostaining yielded interpretable results. Since for some patients more than 1 sample was available, only interpretable first biopsies (n = 1,628) were considered. MAGE-A4 protein was expressed at significantly (p < 0.001) higher frequency in squamous (25/55, 45.5%) than in adeno (4/15, 26.7%), sarcomatoid (4/14, 28.6%), small cell (5/20, 25%) or transitional cell (281/1,522, 18.5%) carcinomas. In TCCs, overall MAGE-A4 positivity was significantly correlated with invasive phenotype (p < 0.001) and high tumor grade (p < 0.0001). Clinical data from 908 TCC patients were retrospectively evaluated, revealing that strong 57B staining was highly significantly associated with decreased tumor-specific survival (p < 0.0001). These data suggest that evaluation of MAGE-A4 protein expression is useful in the identification of groups of TCCs characterized by severe prognosis, thus possibly providing indications for early MAGE TAA-targeted immunotherapy.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Kocher T,Zheng M,Bolli M,Simon R,Forster T,Schultz-Thater E,Remmel E,Noppen C,Schmid U,Ackermann D,Mihatsch MJ,Gasser T,Heberer M,Sauter G,Spagnoli GCdoi
10.1002/ijc.10540keywords:
subject
Has Abstractpub_date
2002-08-20 00:00:00pages
702-5issue
6eissn
0020-7136issn
1097-0215journal_volume
100pub_type
杂志文章abstract::Reverse-transcriptase polymerase chain reaction has been used to analyze the expression of 2 latent genes (EBNA-1 and LMP-1) and one replicative gene (BZLF-1) of Epstein-Barr virus in mononuclear cells from bone marrow and peripheral blood of healthy donors. EBV-gene transcription was detected in 8 out of 15 bone-marr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970304)70:5<524::aid-ijc
更新日期:1997-03-04 00:00:00
abstract::The role of miRNAs with tumor suppressive activity in liver cancer has been well studied. However, little is known about potential oncomiRs in HCC. In our study, we conducted a systematic evaluation of candidate oncomiRs and found that upregulation of miR-18a and miR-25 in HCC was associated with poor patient survival...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31857
更新日期:2019-01-15 00:00:00
abstract::A PCR assay using capillary electrophoresis was designed for the detection of c-erbB-2 gene amplification in alcohol-formalin-acetic acid (AFA)-fixed, paraffin-embedded biopsies from 81 consecutive breast tumors. c-erbB-2 expression was analyzed in the same samples using immuno-histochemistry (IHC). In the competitive...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/(sici)1097-0215(19991008)83:2<157::aid-ijc
更新日期:1999-10-08 00:00:00
abstract::Cervical cancer is the second most common malignancy in women worldwide, with high risk subtypes of human papillomavirus (HPV) constituting the major etiological agent. However, only a small percentage of women infected by the virus develop disease, suggesting that additional host genetic alterations are necessary for...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22335
更新日期:2007-01-15 00:00:00
abstract::Cyclic AMP (cAMP) analogues that selectively bind to either one of the two binding sites of cAMP-dependent protein kinase demonstrate a potent inhibition of the growth stimulated by estrogen in MCF-7 human breast-cancer cells in culture. The site-selective analogues, which are more potent activators of protein kinase ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410616
更新日期:1988-06-15 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with a very high mortality. Because the success of the conventional therapies is limited, gene therapy may represent an alternative for HCC management. Our earlier study has shown that Bid plays a role in the development of HCC. The aim of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22040
更新日期:2006-10-15 00:00:00
abstract::Pancreatic cancer is almost always fatal, in part because of its delayed diagnosis, poor prognosis, rapid progression and chemoresistance. Oncogenic proteins are stabilized by the Hsp90, making it a potential therapeutic target. We investigated the oxidative stress-mediated dysfunction of Hsp90 and the hindrance of it...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27687
更新日期:2013-02-01 00:00:00
abstract::In a hospital-based case-control study of esophageal cancer undertaken in Athens (1989-1991), 43 patients with incident esophageal squamous-cell carcinoma and 56 patients with incident esophageal adenocarcinoma were compared to 200 injury patients. Personal interviews were conducted in the hospital setting, and dietar...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19961104)68:3<300::AID-IJC
更新日期:1996-11-04 00:00:00
abstract::Trilaciclib is an intravenous CDK4/6 inhibitor administered prior to chemotherapy to preserve haematopoietic stem and progenitor cells and immune system function from chemotherapy-induced damage (myelopreservation). The effects of administering trilaciclib prior to carboplatin, etoposide and atezolizumab (E/P/A) were ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33453
更新日期:2020-12-21 00:00:00
abstract::After a steady increase between the 1950s and the 1970s, laryngeal cancer mortality has been levelling off since the early 1980s in men from most western and southern European countries and since the early 1990s in central and eastern Europe. To update trends in laryngeal cancer mortality, we analyzed data provided by...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29833
更新日期:2016-02-15 00:00:00
abstract::The relationship between the strength of the estrogenic and progestational components of combined oral contraceptives and risk of endometrial carcinoma was examined in a multinational hospital-based case-control study comparing 220 cases from 7 countries with 1,537 age- and hospital-matched controls. Oral contraceptiv...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490612
更新日期:1991-12-02 00:00:00
abstract::Loss of cell polarity is one of the hallmarks of malignant carcinomas. Most of the understanding about the link between cell polarity and proliferation control comes from studies on the Drosophila tumor suppressors discs large (Dlg), scribble (Scrib) and lethal giant larvae (lgl). Mammalian homologues of these protein...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21982
更新日期:2006-09-15 00:00:00
abstract::Laser scanning confocal microscopy has been used to follow the uptake and efflux of the 2-fluoroglycoside of doxorubicin, ME2303, in live cultures of the human ovarian cancer cell line A2780 and its doxorubicin-resistant variant A2780AD. Our methods combine confocal laser scanning microscopy and image analysis to exam...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910590118
更新日期:1994-10-01 00:00:00
abstract::Galectin-1 and galectin-3 are galactoside-binding proteins involved in different steps of tumor progression and potential targets for therapy. We have investigated the expression of these galectins in 38 human bladder transitional-cell carcinomas of different histological grade and clinical stage and in 5 normal uroth...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990219)84:1<39::aid-ijc8
更新日期:1999-02-19 00:00:00
abstract::EBV-specific cytotoxic T cells (Tc) induced in vitro have continuously proliferated in vitro for over 9 months. The long-term maintenance of the Tc growth was dependent on periodic supplementation of both irrediated EBV-transformed autologous lymphoblastoid cell line (LCL) cels and conditioned medium. The latter was d...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280205
更新日期:1981-08-15 00:00:00
abstract::Vitamin D has anticarcinogenic properties and might influence colorectal cancer (CRC) risk, but the epidemiological evidence is inconsistent. Many mechanisms of action for vitamin D have been proposed, with some of them initiating via its binding to the vitamin D receptor (VDR). Using a large Scottish case-control stu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23769
更新日期:2008-11-01 00:00:00
abstract::A population-based case-control study of risk factors for renal-cell carcinoma was conducted in Denmark from 1989 to 1992. A total of 368 histologically verified cases and 396 controls were included. Information on weight, height, physical activity and reproductive factors were collected in a structured interview, alo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560113
更新日期:1994-01-02 00:00:00
abstract::Recent clinical trials have indicated that addition of tamoxifen (TAM) to a combination of cisplatin (DDP), carmustine and dacarbazine markedly increases the overall objective response rate of patients with metastatic malignant melanoma. Previous studies have determined that there is remarkable synergy between TAM and...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550623
更新日期:1993-12-02 00:00:00
abstract::Primary breast diffuse large B-cell lymphoma (DLBCL) is an extremely rare presentation of non-Hodgkin's lymphoma that has been associated with poorer clinical outcomes compared with nodal DLBCL in the pre-rituximab era. The aim of this study was to investigate the impact of rituximab on clinical outcomes in patients w...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1002/ijc.26352
更新日期:2012-07-01 00:00:00
abstract::HER2 represents an important signaling pathway in breast and other cancers. Herceptin has demonstrated clinical activity, but resistance is common. Thus, new therapeutic approaches to the HER2 pathway are needed. Grb2 is an adaptor protein involved in Ras-dependent signaling induced by HER2 receptors. A specific Grb2-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22674
更新日期:2007-07-15 00:00:00
abstract::We studied dietary risk factors for lung cancer among never-smokers in a population-based case-control study in Stockholm, 1989-1995. Study subjects were older than 30 years of age and had never smoked regularly. A total of 124 cases (35 men, 89 women) and 235 controls (72 men, 163 women) participated. Exposure inform...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19981109)78:4<430::aid-ijc
更新日期:1998-11-09 00:00:00
abstract::Hereditary non-polyposis colorectal cancer, HNPCC, is an autosomal dominant condition predisposing to cancers of primarily the colorectum and the endometrium. The aim of our study was to identify persons at a high risk of hereditary colorectal cancer and to estimate their risk of colon and other HNPCC-associated tumou...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(200002)9999:9999<::aid-ijc1093>3
更新日期:2001-02-15 00:00:00
abstract::Seminoma lesions are characterized by a brisk inflammatory infiltrate containing both CD4 and CD8 T cells, which is of prognostic significance. However, whether seminoma cells express the HLA molecules required for classical T-cell recognition remains controversial. In the present study, we conducted a molecular, phen...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21894
更新日期:2006-08-15 00:00:00
abstract::Nanoparticle-based phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), exhibit strong efficacy, minimal invasion and negligible side effects in tumor treatment. These phototherapies have received considerable attention and been extensively studied in recent years. In addition to directly...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.31717
更新日期:2018-12-15 00:00:00
abstract::Our aim was to analyze the expression of the serine protease HtrA1 in human bladder tissue and urine in order to point out its possible association with the presence of urothelial bladder cancer. Bladder tissue and urine specimens from cancer patients with different tumor grades and stages (n = 68) and from individual...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28280
更新日期:2013-12-01 00:00:00
abstract::Folate-mediated one-carbon metabolism plays critical roles in DNA synthesis, repair and DNA methylation. The impact of single nucleotide polymorphisms (SNPs) in folate-metabolizing enzymes has been investigated in risk of breast cancer among European or Asian populations, but not among women of African ancestry. We co...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29434
更新日期:2015-08-01 00:00:00
abstract::Osteosarcoma incidence rates in the United States peak in adolescence and in the elderly. The international patterns of osteosarcoma incidence in children have been described, whereas those for young, middle age or elderly adults have not. Using the Cancer Incidence in Five Continents, International Agency for Cancer ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24320
更新日期:2009-07-01 00:00:00
abstract::Ninety-seven Japanese patients with so-called primary non-Hodgkin's lymphoma of the central nervous system (CNS-NHL), unrelated to the acquired immunodeficiency syndrome (AIDS) or organ transplantation, were reviewed. The patients' ages ranged from 1 to 87 years (median: 58 years) with a male to female ratio of 1.77:1...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450410
更新日期:1990-04-15 00:00:00
abstract::This work demonstrates the need for the continued presence of lipopolysaccharide (LPS) for tumor necrosis factor (TNF) production by thioglycollate-induced peritoneal macrophages. Removal of LPS at any time resulted in the abrupt cessation of further TNF production. The readdition of LPS resulted in further production...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910380121
更新日期:1986-07-15 00:00:00
abstract::The detection of CTCs prior to and during therapy is an independent and strong prognostic marker, and it is predictive of poor treatment outcome. A major challenge is that different technologies are available for isolation and characterization of CTCs in peripheral blood (PB). We compare the CellSearch system and Adna...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1002/ijc.26111
更新日期:2012-04-01 00:00:00