Accelerated growth of syngeneic tumors in mice treated with methylcholanthrene.

abstract：:It is generally assumed that inflammation influences carcinogenesis. We previously reported that dextran sodium sulfate (DSS) strongly enhances colon carcinogenesis in the Apc(Min/+) mice and the over-expression of inducible nitric oxide synthase (iNOS) contributes to this enhancement. In the current study, we investi...

journal_title：International journal of cancer

authors： Kohno H,Takahashi M,Yasui Y,Suzuki R,Miyamoto S,Kamanaka Y,Naka M,Maruyama T,Wakabayashi K,Tanaka T

更新日期：2007-08-01 00:00:00

abstract：:Epstein-Barr virus (EBV) type 2 is considered to be a much less potent transformer of lymphocytes than type 1. However, type-2 EBV may be involved in the pathogenesis of non-Hodgkin's lymphomas (NHLs) arising in immunocompromised patients, i.e., subjects with malaria or HIV-1 infection. To determine whether type-2 EBV...

journal_title：International journal of cancer

authors： De Re V,Boiocchi M,De Vita S,Dolcetti R,Gloghini A,Uccini S,Baroni C,Scarpa A,Cattoretti G,Carbone A

更新日期：1993-07-30 00:00:00

abstract：:The partition-defective 3 (PAR-3) protein is implicated in the development and maintenance of cell polarity and is associated with proteins that mediate the changes in cytoskeleton organization required for cell polarity establishment. In this work, we used two original primary cell lines (R-180 and R-305) derived fro...

journal_title：International journal of cancer

authors： Dugay F,Le Goff X,Rioux-Leclerq N,Chesnel F,Jouan F,Henry C,Cabillic F,Verhoest G,Vigneau C,Arlot-Bonnemains Y,Belaud-Rotureau MA

更新日期：2014-05-01 00:00:00

abstract：:T24 human bladder carcinoma cells reveal a high locomotor activity (70% locomoting cells) within a 3-dimensional collagen matrix. This high migratory activity is induced by an autocrine engagement of the interleukin-8 receptor A, as was shown by antibodies neutralizing the secreted interleukin-8. Treatment of the cell...

journal_title：International journal of cancer

authors： Lang K,Niggemann B,Zanker KS,Entschladen F

更新日期：2002-06-10 00:00:00

abstract：:The incidence of cutaneous melanoma in children aged 0-14 years was examined in Queensland, Australia. Details of notifications were collected from the population-based Australian Paediatric Cancer Registry. Between 1987 and 1994, the age-adjusted incidence rates of invasive cutaneous melanoma occurring in Queensland ...

journal_title：International journal of cancer

authors： Whiteman D,Valery P,McWhirter W,Green A

更新日期：1995-12-11 00:00:00

abstract：:Fischer rat thyroid epithelial cella (FRT) growing continuously in culture were infected with the Kirsten murine sarcoma virus KiMSV(KiMuLV) and found to produce this virus constitutively. Although the morphology of the FRT cells did not change appreciably, the cells became malignant after infection with KiMSV(KiMuLV)...

journal_title：International journal of cancer

authors： Fusco A,Pinto A,Ambesi-Impiombato FS,Vecchio G,Tsuchida N

更新日期：1981-11-15 00:00:00

abstract：:Tissue recombinants (TRs) composed of mouse urogenital mesenchyme (mUGM) plus an immortalized nontumorigenic human prostatic epithelial cell line (BPH-1) were grown under the kidney capsule of male athymic nude mice under different hormonal conditions. The objectives were to determine temporal plasma concentrations of...

journal_title：International journal of cancer

authors： Ricke WA,Ishii K,Ricke EA,Simko J,Wang Y,Hayward SW,Cunha GR

更新日期：2006-05-01 00:00:00

abstract：:Telomerase, the enzyme responsible for maintenance of the telomeres, is absent from the vast majority of somatic cells but is present in most tumours. Little is known about how telomerase is activated in cancer, although it is thought vital for immortalisation to occur. The aim of our study was to identify genetic cha...

journal_title：International journal of cancer

authors： Loveday RL,Greenman J,Drew PJ,Monson JR,Kerin MJ

更新日期：1999-10-22 00:00:00

abstract：:Effects of pretreatment with BCG, strain Japan, on tumor growth were studied using a transplatable methylcholanthrene (MCA)-induced fibrosarcoma in C3H/He mice. Injection of BCG7 weeks before tumor inoculation at a site distant from the tumor caused a slight inhibition of tumor growth. A low dose of tumor cells did no...

journal_title：International journal of cancer

authors： Ishibashi T,Yamada H,Harada S,Harada Y,Takamoto M,Sugiyama K

更新日期：1978-01-15 00:00:00

abstract：:In combination with xenogeneic immune RNA (l-RNA) and tumor antigen (TA), syngeneic spleen cells inhibited the growth of a N-methyl-N-nitrosourethane-induced colon carcinoma (CT-26) in BALB/c mice. The sequential administration of 1 X 10(7) spleen cells, l mg of anti-CT-26 l-RNA and 0.4 mg of CT-26 TA resulted in a 20...

journal_title：International journal of cancer

authors： Fukushima M,Colmerauer ME,Nayak SK,Koziol JA,Pilch YH

更新日期：1982-01-15 00:00:00

abstract：:Tonsillar squamous cell carcinoma (TSCC) is frequently associated with human papillomavirus (HPV) and chromosome instability. Data from cellular model systems are, however, controversial concerning a relation between HPV and chromosome instability development. Here we studied this association in 77 primary TSCC with k...

journal_title：International journal of cancer

authors： Mooren JJ,Kremer B,Claessen SM,Voogd AC,Bot FJ,Peter Klussmann J,Huebbers CU,Hopman AH,Ramaekers FC,Speel EJ

更新日期：2013-04-15 00:00:00

abstract：:We have established 3 new EBV-negative cell lines, designated Sc-1, Ri-1 and Ci-1, from patients with B-cell lymphoma/leukemia. We characterized them by cytogenetics and by study of surface membrane antigens with a panel of monoclonal antibodies (MAbs), surface and cytoplasmic immunoglobulin (Ig) expression and Ig hea...

journal_title：International journal of cancer

authors： Th'ng KH,Garewal G,Kearney L,Rassool F,Melo JV,White H,Catovsky D,Foroni L,Luzzatto L,Goldman JM

更新日期：1987-01-15 00:00:00

abstract：:The lck gene encodes a lymphocyte-specific tyrosine protein kinase, p56lck, the expression of which is almost exclusive in T-cells. The expression of lck in human T-cell leukemia virus type I (HTLV-I)-transformed T-cell lines is closely associated with interleukin-2 (IL-2) dependence for their growth. That is, IL-2-de...

journal_title：International journal of cancer

authors： Nakamura K,Koga Y,Yoshida H,Kimura G,Nomoto K

更新日期：1991-07-09 00:00:00

abstract：:In order to evaluate whether the SCID mouse can provide the microenvironment for the growth of human immature T-cell leukemias and if in vivo growth alters their phenotype, we examined the behavior of 3 well-characterized T-cell acute lymphoblastic leukemia (T-ALL)-derived T-cell lines which are at different stages of...

journal_title：International journal of cancer

authors： Uittenbogaart CH,Anisman DJ,Tary-Lehmann M,Vollger LW,Breit TM,Van Dongen JJ,Saxon A

更新日期：1994-02-15 00:00:00

abstract：:The 26S proteasome, consisting of the 20S core and 19S regulatory complexes, regulates intracellular protein concentration through proteolytic degradation of targeted substrates. Composition of the 19S regulatory complex as well as posttranslational modifications of the 19S subunits can effectively regulate the activi...

journal_title：International journal of cancer

authors： Thompson HG,Harris JW,Brody JP

更新日期：2004-09-01 00:00:00

abstract：:In advanced stages of malignant melanoma (MM), metastases to the CNS are frequently observed. Few results are available on trophic factors and immunological features involved in the process of invasion and adhesion of circulating metastatic cells into the CNS. A direct comparison of remote metastases found in differen...

journal_title：International journal of cancer

authors： Geertsen R,Zenklusen R,Kamarashev J,Burg G,Dummer R

更新日期：1999-09-24 00:00:00

abstract：:Reverse-transcriptase polymerase chain reaction has been used to analyze the expression of 2 latent genes (EBNA-1 and LMP-1) and one replicative gene (BZLF-1) of Epstein-Barr virus in mononuclear cells from bone marrow and peripheral blood of healthy donors. EBV-gene transcription was detected in 8 out of 15 bone-marr...

journal_title：International journal of cancer

authors： Gonnella R,Angeloni A,Calogero A,Farina A,Santarelli R,Gentile G,Arcese W,Martino P,Mandelli F,Frati L,Faggioni A,Ragona G

更新日期：1997-03-04 00:00:00

abstract：:Tumorigenesis of head and neck squamous cell carcinomas (HNSCC) is associated with various genetic changes such as loss of heterozygosity (LOH) on human chromosome 18q21. This chromosomal region maps a gene cluster coding for a family of intracellular serine protease inhibitors (serpins), including SERPINB13. As SERPI...

journal_title：International journal of cancer

authors： de Koning PJ,Bovenschen N,Leusink FK,Broekhuizen R,Quadir R,van Gemert JT,Hordijk GJ,Chang WS,van der Tweel I,Tilanus MG,Kummer JA

更新日期：2009-10-01 00:00:00

abstract：:MM is a B-cell malignancy mainly characterized by monoclonal expansion of plasma cells in the BM, presence of paraprotein in serum and occurrence of osteolytic bone lesions. MMPs are a family of proteolytic enzymes that can contribute to cancer growth, invasion, angiogenesis, bone degradation and other processes impor...

journal_title：International journal of cancer

authors： Van Valckenborgh E,Bakkus M,Munaut C,Noël A,St Pierre Y,Asosingh K,Van Riet I,Van Camp B,Vanderkerken K

更新日期：2002-10-20 00:00:00

abstract：:The occurrence of metastasis severely affects prognosis and survival of breast cancer patients. In order to metastasize, breast cancer cells need to cross the basement membrane (BM) tissue boundaries. Matrix metalloproteases (MMPs) are enzymes with proteolytic activity towards extracellular matrix components (ECM) of ...

journal_title：International journal of cancer

authors： Giannelli G,Erriquez R,Fransvea E,Daniele A,Trerotoli P,Schittulli F,Grano M,Quaranta M,Antonaci S

更新日期：2004-05-01 00:00:00

abstract：:Artemisia asiatica Nakai has been used in traditional Asian medicine for the treatment of inflammatory and other disorders. Previous studies have revealed that the formulated ethanol extract (DA-9601) of A. asiatica has pronounced antioxidative and antiinflammatory activities and exhibits cytoprotective effects agains...

journal_title：International journal of cancer

authors： Seo HJ,Park KK,Han SS,Chung WY,Son MW,Kim WB,Surh YJ

更新日期：2002-08-01 00:00:00

abstract：:We recently reported the identification of a human SART3 gene that encodes a tumor-rejection antigen recognized by cytotoxic T lymphocytes (CTLs). The squamous-cell carcinoma antigen recognized by T cells-3 (SART3) is an RNA-binding protein expressed in the nucleus of the majority of proliferating cells, including nor...

journal_title：International journal of cancer

authors： Harada K,Yamada A,Yang D,Itoh K,Shichijo S

更新日期：2001-09-01 00:00:00

abstract：:We investigated whether cilengitide could amplify the antitumor effects of radiotherapy in an orthotopic rat glioma xenograft model. Cilengitide is a specific inhibitor of alphav series integrins, and acts as an antiangiogenic. U251 human glioma cells express alphavbeta3 and alphavbeta5 integrins. We used in vitro ass...

journal_title：International journal of cancer

authors： Mikkelsen T,Brodie C,Finniss S,Berens ME,Rennert JL,Nelson K,Lemke N,Brown SL,Hahn D,Neuteboom B,Goodman SL

更新日期：2009-06-01 00:00:00

abstract：:Ocimum sp. is a traditionally used medicinal herb, which shows anti-oxidant, anti-carcinogenic, radio-protective and free radical scavenging properties. So far no detailed studies have been reported on its effects on human cancers. Thus, we analyzed its effects on human breast cancer utilizing in vitro and in vivo met...

journal_title：International journal of cancer

authors： Nangia-Makker P,Tait L,Shekhar MP,Palomino E,Hogan V,Piechocki MP,Funasaka T,Raz A

更新日期：2007-08-15 00:00:00

abstract：:Bromodomain and extraterminal domain (BET) inhibitors are broadly active against distinct types of cancer, including nonsmall cell lung cancer (NSCLC). Previous studies have addressed the effect of BET-inhibiting drugs on the expression of oncogenes such as c-Myc, but DNA damage repair pathways have also been reported...

journal_title：International journal of cancer

authors： Takashima Y,Kikuchi E,Kikuchi J,Suzuki M,Kikuchi H,Maeda M,Shoji T,Furuta M,Kinoshita I,Dosaka-Akita H,Sakakibara-Konishi J,Konno S

更新日期：2020-02-15 00:00:00

abstract：:Promoter hypermethylation of various tumor-related genes is extremely frequent in gastric carcinoma (GC) associated with Epstein-Barr virus (EBV). To investigate the significance of the promoter methylation in this type of GC, we examined the methylation densities of the promoter regions of p14ARF and p16INK4A in EBV-...

journal_title：International journal of cancer

authors： Sakuma K,Chong JM,Sudo M,Ushiku T,Inoue Y,Shibahara J,Uozaki H,Nagai H,Fukayama M

更新日期：2004-11-01 00:00:00

abstract：:The epidemiological literature reports inconsistent associations between consumption or circulating concentrations of micronutrients and breast cancer risk. We investigated associations between genetically predicted concentrations of 11 micronutrients (beta-carotene, calcium, copper, folate, iron, magnesium, phosphoru...

journal_title：International journal of cancer

authors： Papadimitriou N,Dimou N,Gill D,Tzoulaki I,Murphy N,Riboli E,Lewis SJ,Martin RM,Gunter MJ,Tsilidis KK

更新日期：2021-02-01 00:00:00

abstract：:Therapeutics targeting the phosphatidylinositol 3-kinase/mammalian target of rapamycin (PI3K/mTOR) pathway initially produce potent antitumor effects, but resistance frequently occurs. Using a phosphoproteome analysis, we found that colorectal cancer (CRC) cells exhibit resistance against PI3K/mTOR inhibition through ...

journal_title：International journal of cancer

authors： Lee HS,Lee S,Cho KH

更新日期：2020-11-15 00:00:00

abstract：:Immunotherapy targeting programmed cell death-1 (PD-1) has become a standard pharmacological therapy. Although tumor mutation burden level was reported to depend on the tumor location in nonsmall cell lung cancer (NSCLC), predictive impact of the tumor location on the response to anti-PD-1 therapy is unknown. Two hund...

journal_title：International journal of cancer

authors： Takamori S,Takada K,Shimokawa M,Matsubara T,Haratake N,Miura N,Toyozawa R,Yamaguchi M,Takenoyama M,Yoneshima Y,Tanaka K,Okamoto I,Tagawa T,Mori M

更新日期：2020-10-15 00:00:00

abstract：:Circadian disruption has been classified as probably carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. The circadian clock is subject to environmental factors, particularly light exposure and food intake rhythms. However, the association between nutritional circadia...

journal_title：International journal of cancer

authors： Srour B,Plancoulaine S,Andreeva VA,Fassier P,Julia C,Galan P,Hercberg S,Deschasaux M,Latino-Martel P,Touvier M

更新日期：2018-11-15 00:00:00