Cervical carcinoma: detection of herpes simplex virus RNA in cells undergoing neoplastic change.

abstract：:During malignant progression cancer cells undergo a series of changes, which promote their survival, invasiveness and metastatic process. One of them is a change in glucose metabolism. Unlike normal cells, which mostly rely on the tricarboxylic acid cycle (TCA), many cancer types rely on glycolysis. Pyruvate dehydroge...

journal_title：International journal of cancer

authors： Golias T,Kery M,Radenkovic S,Papandreou I

更新日期：2019-02-15 00:00:00

abstract：:Secreted frizzled-related proteins (SFRPs) are antagonists of the Wnt signaling pathway whose epigenetic downregulation have been shown to be involved in hepatocarcinogenesis. However, dysregulation of SFRPs induced by hepatitis B virus (HBV) X protein (HBx) has never been studied in HBV-related hepatocellular carcino...

journal_title：International journal of cancer

authors： Xie Q,Chen L,Shan X,Shan X,Tang J,Zhou F,Chen Q,Quan H,Nie D,Zhang W,Huang AL,Tang N

更新日期：2014-08-01 00:00:00

abstract：:Very recently, BRAF mutations were found in about 2/3 of malignant melanomas and at lower frequencies in other human cancers. The BRAF gene codes for a protein in the mitogen-activated protein kinase (MAPK) pathway. All mutations identified to date are within the kinase domain, with a single missense mutation (V599E) ...

journal_title：International journal of cancer

authors： Meyer P,Klaes R,Schmitt C,Boettger MB,Garbe C

更新日期：2003-08-10 00:00:00

abstract：:Initial studies have investigated the association between inflammation and colorectal cancer (CRC) using C-reactive protein (CRP) as a proinflammatory biomarker and have noted inconsistent results among women. We here report the findings from a large prospective study with repeat measurements of CRP, as well as serum ...

journal_title：International journal of cancer

authors： Toriola AT,Cheng TY,Neuhouser ML,Wener MH,Zheng Y,Brown E,Miller JW,Song X,Beresford SA,Gunter MJ,Caudill MA,Ulrich CM

更新日期：2013-06-01 00:00:00

abstract：:Comparisons of patients receiving different cancer treatments reflect the effects of both treatment and patient selection. In breast cancer, however, if radiotherapy decisions are unrelated to laterality, comparisons of left-sided and right-sided cancers can demonstrate the causal effects of higher-versus-lower cardia...

journal_title：International journal of cancer

authors： Henson KE,McGale P,Darby SC,Parkin M,Wang Y,Taylor CW

更新日期：2020-09-01 00:00:00

abstract：:Invasive pituitary adenomas (PAs) are generally refractory to conventional therapy and salvage treatment with temozolomide (TMZ). In addition to antiprotozoan effects, pyrimethamine (PYR) has recently shown its strong antitumor activity as an antineoplastic agent or in combination with TMZ in metastatic melanoma cells...

journal_title：International journal of cancer

authors： Dai C,Zhang B,Liu X,Guo K,Ma S,Cai F,Yang Y,Yao Y,Feng M,Bao X,Deng K,Jiao Y,Wei Z,Junji W,Xing B,Lian W,Wang R

更新日期：2013-10-15 00:00:00

abstract：:Cetuximab is a human/mouse chimeric IgG1 monoclonal antibody (mAb) to epidermal growth factor receptor, approved for colorectal carcinoma treatment in combination with chemotherapy. The immune-mediated effects elicited by its human fraction of crystallization moiety might critically contribute to the overall anti-tumo...

journal_title：International journal of cancer

authors： Correale P,Botta C,Cusi MG,Del Vecchio MT,De Santi MM,Gori Savellini G,Bestoso E,Apollinari S,Mannucci S,Marra M,Abbruzzese A,Aquino A,Turriziani M,Bonmassar L,Caraglia M,Tagliaferri P

更新日期：2012-04-01 00:00:00

abstract：:Phenotypic and functional characteristics of tumor-infiltrating lymphocytes (TIL) obtained from human primary and metastatic liver tumors were studied. Lymphocytes isolated from 18 tumors and autologous (A) peripheral blood (6 cases) were phenotyped by 2-color flow cytometry and cloned in a limiting dilution system, w...

journal_title：International journal of cancer

authors： Shimizu Y,Iwatsuki S,Herberman RB,Whiteside TL

更新日期：1990-11-15 00:00:00

abstract：:There is little long-term follow-up information about how the number of melanoma deaths and case fatality vary over time according to the measured thickness of melanoma at diagnosis. This population-based longitudinal cohort study examines patterns and trends in case fatality among 44,531 people in Queensland (Austral...

journal_title：International journal of cancer

authors： Baade PD,Whiteman DC,Janda M,Cust AE,Neale RE,Smithers BM,Green AC,Khosrotehrani K,Mar V,Soyer HP,Aitken JF

更新日期：2020-09-01 00:00:00

abstract：:Ganglioside GM2 is expressed on cell surface membranes of a variety of human malignant cells and has been demonstrated to be immunogenic in humans. We have assessed the role of the antigen GM2 on melanoma cells as a recognition structure for lymphokine-activated killer (LAK) cells. LAK cells were generated by stimulat...

journal_title：International journal of cancer

authors： Hoon DS,Ando I,Sviland G,Tsuchida T,Okun E,Morton DL,Irie RF

更新日期：1989-05-15 00:00:00

abstract：:A panel of monoclonal antibodies and other markers (e.g., terminal deoxynucleotidyl transferase, sheep erythrocyte rosettes, peanut agglutinin) have been used in conjunction with flow cytometry and biochemical analysis to monitor the induction of maturation in human thymic (T) leukaemic cell lines by phorbol ester (TP...

journal_title：International journal of cancer

authors： Delia D,Greaves MF,Newman RA,Sutherland DR,Minowada J,Kung P,Goldstein G

更新日期：1982-01-15 00:00:00

abstract：:N-deformyl-N-[4-N,N-bis(2-chloroethylamino)benzoyl] distamycin-A (FCE 24517) is a new cytotoxic anti-tumor agent in phase-1 clinical trials. We have isolated stable FCE-24517-resistant cell sublines from murine leukemia L1210 cells by in vitro exposure to the drug. FCE 24517 selects a mixed population of resistant cel...

journal_title：International journal of cancer

authors： Geroni C,Pesenti E,Tagliabue G,Ballinari D,Mongelli N,Broggini M,Erba E,D'Incalci M,Spreafico F,Grandi M

更新日期：1993-01-21 00:00:00

abstract：:Acrylamide, a probable human carcinogen, is formed during the cooking of many commonly consumed foods. Data are scant on whether dietary acrylamide represents an important cancer risk in humans. We studied the association between acrylamide and prostate cancer risk using 2 measures of acrylamide exposure: intake from ...

journal_title：International journal of cancer

authors： Wilson KM,Bälter K,Adami HO,Grönberg H,Vikström AC,Paulsson B,Törnqvist M,Mucci LA

更新日期：2009-05-15 00:00:00

abstract：:Previous studies have been inconsistent with respect to the reported associations between phospho-Akt (p-Akt) overexpression and lung cancer prognosis. In this study, we conducted a systematic review and meta-analysis to assess the prognostic value of p-Akt in patients with non-small cell lung carcinoma (NSCLC). Relev...

journal_title：International journal of cancer

authors： Yang Y,Luo J,Zhai X,Fu Z,Tang Z,Liu L,Chen M,Zhu Y

更新日期：2014-09-15 00:00:00

abstract：:Human conventional renal cell carcinoma (CCC) remains resistant to current therapies. Focal Adhesion Kinase (FAK) is upregulated in many epithelial tumors and clearly implicated in nearly all facets of cancer. However, only few reports have assessed whether FAK may be associated with renal tumorigenesis. In this study...

journal_title：International journal of cancer

authors： Béraud C,Dormoy V,Danilin S,Lindner V,Béthry A,Hochane M,Coquard C,Barthelmebs M,Jacqmin D,Lang H,Massfelder T

更新日期：2015-10-01 00:00:00

abstract：:Twin studies suggest a familial aggregation of bladder cancer but elements of this increased familial risk of bladder cancer are not well understood. To characterize familial risk of bladder cancer, we examined the relationship between family history of bladder and other types of cancer among first-degree relatives an...

journal_title：International journal of cancer

authors： Koutros S,Decker KL,Baris D,Pardo LA,Johnson A,Hosain GMM,Rothman N,Karagas MR,Schwenn MR,Silverman DT

更新日期：2021-01-27 00:00:00

abstract：:The effects of three monoclonal antibodies (B3/25, 43/31, and 42/6) reactive with human transferrin (Tf) receptors on growth of normal and malignant myeloid cells were examined using in vitro culture techniques. When added directly to cultures, all three antibodies caused dose-dependent inhibition of normal granulocyt...

journal_title：International journal of cancer

authors： Taetle R,Honeysett JM,Trowbridge I

更新日期：1983-09-15 00:00:00

abstract：:We have used differential-display PCR (DD-PCR) to compare renal-cell carcinoma (RCC) and normal kidney gene expression with the aim of identifying genes specifically associated with RCC. Using a modified DD-PCR approach, which was non-radioactive, quicker and simpler than the conventional method, 24 cDNA samples were ...

journal_title：International journal of cancer

authors： Rae FK,Stephenson SA,Nicol DL,Clements JA

更新日期：2000-12-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is an angiogenic factor that also functions as an autocrine growth factor for VEGF receptor (VEGFR)-2(+) melanomas. In multiple studies, VEGFR-2 was detected by immunostaining in 78-89% of human melanoma cells, suggesting that most patients with melanoma would benefit from an...

journal_title：International journal of cancer

authors： Molhoek KR,Erdag G,Rasamny JK,Murphy C,Deacon D,Patterson JW,Slingluff CL Jr,Brautigan DL

更新日期：2011-12-15 00:00:00

abstract：:Our previous clinicopathologic study revealed an inverse association of liver metastasis of colorectal cancer and stromal expression of matrix metalloproteinase-9 (MMP-9) or urokinase receptor (uPAR). This suggests that host cells, particularly macrophages, expressing matrix-degrading enzymes/factors could be protecti...

journal_title：International journal of cancer

authors： Saito K,Takeha S,Shiba K,Matsuno S,Sorsa T,Nagura H,Ohtani H

更新日期：2000-04-01 00:00:00

abstract：:In a previous study, we showed that targeted delivery of bovine liver catalase to hepatocytes by direct galactosylation augmented the inhibitory effect of the enzyme on experimental hepatic metastasis of colon carcinoma cells (unpublished data). Here, we examined the ability of catalase to inhibit tumor metastasis to ...

journal_title：International journal of cancer

authors： Nishikawa M,Tamada A,Kumai H,Yamashita F,Hashida M

更新日期：2002-05-20 00:00:00

abstract：:Lung cancer is the leading cause of cancer mortality in the world. Although exposure to carcinogens is considered to be the main cause, genetic variation may contribute to lung cancer risk. Murine double minute 2, MDM2, is a key regulator of p53 activity and recently a polymorphism in the promoter region of the MDM2 g...

journal_title：International journal of cancer

authors： Lind H,Zienolddiny S,Ekstrøm PO,Skaug V,Haugen A

更新日期：2006-08-01 00:00:00

abstract：:HPP1 is a recently discovered gene that is epigenetically silenced in a number of tumor types, suggesting a potential role as a tumor suppressor. However, whether HPP1 has tumor suppressor activity is not clearly known. We have sought to investigate the effects of HPP1 on tumor growth and survival and to identify sign...

journal_title：International journal of cancer

authors： Elahi A,Zhang L,Yeatman TJ,Gery S,Sebti S,Shibata D

更新日期：2008-04-01 00:00:00

abstract：:This large population-based study compared breast-conserving surgery with radiation therapy (BCT) with mastectomy on (long-term) breast cancer-specific (BCSS) and overall survival (OS), and investigated the influence of several prognostic factors. Patients with primary T1-2N0-2M0 breast cancer, diagnosed between 1999 ...

journal_title：International journal of cancer

authors： Lagendijk M,van Maaren MC,Saadatmand S,Strobbe LJA,Poortmans PMP,Koppert LB,Tilanus-Linthorst MMA,Siesling S

更新日期：2018-01-01 00:00:00

abstract：:Up to 30% of stage II patients with curatively resected colorectal cancer (CRC) will develop disease recurrence. We evaluated whether examination of lymph nodes by multilevel sectioning and immunohistochemical staining can improve prognostication. Lymph nodes (n = 780) from 36 CRC patients who had developed disease re...

journal_title：International journal of cancer

authors： Doekhie FS,Mesker WE,Kuppen PJ,van Leeuwen GA,Morreau H,de Bock GH,Putter H,Tanke HJ,van de Velde CJ,Tollenaar RA

更新日期：2010-06-01 00:00:00

abstract：:Freshly isolated human peripheral blood monocytes from healthy volunteers are not cytotoxic to allogeneic A375 melanoma cells, but they were rendered tumoricidal by incubation in vitro with either liposomes containing 5 micrograms/mumol phospholipid of muramyl tripeptide phosphatidylethanolamine (liposome-MTP-PE; opti...

journal_title：International journal of cancer

authors： Sone S,Tandon P,Utsugi T,Ogawara M,Shimizu E,Nii A,Ogura T

更新日期：1986-10-15 00:00:00

abstract：:Tumor cells do not constitutively exhibit invasive activity, but rather, can be transiently induced to adhere and form lesions. We report here that the expression of seprase, a dominant EDTA-resistant gelatinase in malignant tumors, is dependent on tumor cell exposure to type I collagen gel (TICg). The induced seprase...

journal_title：International journal of cancer

authors： Kennedy A,Dong H,Chen D,Chen WT

更新日期：2009-01-01 00:00:00

abstract：:Melanocortin-1 receptor (MC1R) is a marker of melanoma risk in populations of European ancestry. However, MC1R effects on survival are much less studied. We investigated associations between variation at MC1R and survival in an international, population-based series of single primary melanoma patients enrolled into th...

journal_title：International journal of cancer

authors： Taylor NJ,Reiner AS,Begg CB,Cust AE,Busam KJ,Anton-Culver H,Dwyer T,From L,Gallagher RP,Gruber SB,Rosso S,White KA,Zanetti R,Orlow I,Thomas NE,Rebbeck TR,Berwick M,Kanetsky PA,GEM Study Group.

更新日期：2015-06-01 00:00:00

abstract：:Gallstones, a common gastrointestinal condition, can lead to several digestive complications and can result in inflammation. Risk factors for gallstones include obesity, diabetes, smoking and physical inactivity, all of which are known risk factors for colorectal cancer (CRC), as is inflammation. However, it is unclea...

journal_title：International journal of cancer

authors： Ward HA,Murphy N,Weiderpass E,Leitzmann MF,Aglago E,Gunter MJ,Freisling H,Jenab M,Boutron-Ruault MC,Severi G,Carbonnel F,Kühn T,Kaaks R,Boeing H,Tjønneland A,Olsen A,Overvad K,Merino S,Zamora-Ros R,Rodríguez-Barranc

更新日期：2019-09-15 00:00:00

abstract：:Protocadherin 10 (PCDH10), a novel tumor suppressor gene in human cancers, is located in a common deleted region at chromosome 4q28 in colorectal cancer (CRC). This study aimed to ascertain the genetic loss of PCDH10 and its clinical relevance in CRC and to explore the tumor suppressor function of PCDH10. The genetic ...

journal_title：International journal of cancer

authors： Jao TM,Tsai MH,Lio HY,Weng WT,Chen CC,Tzeng ST,Chang CY,Lai YC,Yen SJ,Yu SL,Yang YC

更新日期：2014-12-01 00:00:00