Immunological characterization of the Epstein-Barr virus phosphoprotein PP58 and deoxyribonuclease expressed in the baculovirus expression system.

abstract：:We performed microsatellite analysis and tested telomerase activity in paired tissue and urine of bladder cancer patients from frozen archived samples. DNA obtained from microdissected tumor and urine sediment was analyzed and compared to peripheral lymphocytes for microsatellite alterations (loss of heterozygosity [L...

journal_title：International journal of cancer

authors： Linn JF,Lango M,Halachmi S,Schoenberg MP,Sidransky D

更新日期：1997-12-19 00:00:00

abstract：:Production of interleukin-6 (IL-6) by human pancreatic carcinoma cells inversely correlates with potentials for blood-borne metastasis to the liver in nude mice. IL-6 cDNA was transfected to PCI-43, one of our cultured pancreatic carcinoma cell lines that does not produce IL-6 and generates numerous metastases to the ...

journal_title：International journal of cancer

authors： Saito K,Ishikura H,Kishimoto T,Kawarada Y,Yano T,Takahashi T,Kato H,Yoshiki T

更新日期：1998-01-19 00:00:00

abstract：:To compare the presentation and prognosis of non-Hodgkin lymphoma (NHL) in people with AIDS (PWA) and in the general Italian population, a record linkage study was carried out. The fraction of NHLs attributable to HIV/AIDS was also estimated. Information from the National AIDS Registry (RAIDS) was linked with records ...

journal_title：International journal of cancer

authors： Dal Maso L,Rezza G,Zambon P,Tagliabue G,Crocetti E,Vercelli M,Zanetti R,Falcini F,Tonini G,Mangone L,De Lisi V,Ferretti S,Tumino R,Stanta G,Vitarelli S,Serraino D,Franceschi S,Cancer and AIDS Registry Linkage Study.

更新日期：2001-08-01 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is a molecular chaperone that promotes the conformational maturation of numerous client proteins, many of which play critical roles in tumor cell growth and survival. The ansamycin-based Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) is currently in Phase III clinical tes...

journal_title：International journal of cancer

authors： Yin X,Zhang H,Lundgren K,Wilson L,Burrows F,Shores CG

更新日期：2010-03-01 00:00:00

abstract：:Multiple myeloma (MM) is a B lymphocyte malignancy that remains incurable despite extensive research efforts. This is due, in part, to frequent disease recurrences associated with the persistence of myeloma cancer stem cells (mCSCs). Bone marrow mesenchymal stromal cells (BMSCs) play critical roles in supporting mCSCs...

journal_title：International journal of cancer

authors： Choi DS,Stark DJ,Raphael RM,Wen J,Su J,Zhou X,Chang CC,Zu Y

更新日期：2015-03-01 00:00:00

abstract：:The serine protease urokinase-type plasminogen activator (uPA) plays a significant role in tumor cell invasion and metastasis when bound to its specific receptor, uPAR (also known as CD87). In addition to the uPA-uPAR system, matrix metalloproteinases (MMPs) are involved in tumor cell invasion and metastasis. In this ...

journal_title：International journal of cancer

authors： Kunigal S,Lakka SS,Gondi CS,Estes N,Rao JS

更新日期：2007-11-15 00:00:00

abstract：:A series of 722 lung carcinomas, surgically resected and typed some years ago according to the 1967 WHO classification, was independently reviewed by 2 observers in order to test the reproducibility of histopathological typing when using the criteria of the 1981 WHO classification. Typing was fully agreed upon in 87% ...

journal_title：International journal of cancer

authors： Campobasso O,Andrion A,Ribotta M,Ronco G

更新日期：1993-01-21 00:00:00

abstract：:The absolute risk reduction by prophylaxis in chemotherapy-induced febrile neutropenia (FN) is largest in patients at highest underlying risk. Therefore, reliable predictive models are needed. Here, we develop and validate such a model for risk of FN during chemotherapy cycles 2-6. A prediction score for risk of FN du...

journal_title：International journal of cancer

authors： Aagaard T,Reekie J,Roen A,Daugaard G,Specht L,Sengeløv H,Mocroft A,Lundgren J,Helleberg M

更新日期：2020-01-15 00:00:00

abstract：:An epithelioid cell line, started from a human pancreatic carcinoma of ductal cell origin, has been maintained in culture for over 2 years and has been subcultured more than 40 times. The PANC-1 cell line has a doubling time of 52 h and G6PD activity of the slow mobility of B type. Chromosome studies show a modal numb...

journal_title：International journal of cancer

authors： Lieber M,Mazzetta J,Nelson-Rees W,Kaplan M,Todaro G

更新日期：1975-05-15 00:00:00

abstract：:The aim of this prospective study was to assess the uptake of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNPCC) and its associations with sociodemographic and other factors, and long-term satisfaction with taking the test. The test was offered to all high-risk members (n = 446) of 36 Fi...

journal_title：International journal of cancer

authors： Aktan-Collan K,Mecklin JP,Järvinen H,Nyström-Lahti M,Peltomäki P,Söderling I,Uutela A,de la Chapelle A,Kääriäinen H

更新日期：2000-01-20 00:00:00

abstract：:Invasiveness is one of the key features of aggressive prostate cancer; however, our understanding of the precise mechanisms effecting invasion remains limited. The ceramide hydrolyzing enzyme acid ceramidase (AC), overexpressed in most prostate tumors, causes an aggressive and invasive phenotype through downstream eff...

journal_title：International journal of cancer

authors： Beckham TH,Lu P,Cheng JC,Zhao D,Turner LS,Zhang X,Hoffman S,Armeson KE,Liu A,Marrison T,Hannun YA,Liu X

更新日期：2012-11-01 00:00:00

abstract：:p16(INK4a), a cell cycle regulation protein, accumulates in abnormal epithelial cells infected with high-risk human papilloma virus (HPV). In immunostaining studies, p16(INK4a) has shown potential as a marker of high grade cervical intraepithelial neoplasia (CIN) and invasive cervical cancer. To evaluate its potential...

journal_title：International journal of cancer

authors： Mao C,Balasubramanian A,Yu M,Kiviat N,Ridder R,Reichert A,Herkert M,von Knebel Doeberitz M,Koutsky LA

更新日期：2007-06-01 00:00:00

abstract：:Postmenopausal hormone replacement therapy (HRT) was found to be associated with lower risk of colorectal cancer (CRC). However, little is known regarding associations with molecular subtypes of CRC. The current study includes female participants of a large German population-based case-control study (922 CRC cases and...

journal_title：International journal of cancer

authors： Amitay EL,Carr PR,Jansen L,Alwers E,Roth W,Herpel E,Kloor M,Bläker H,Chang-Claude J,Brenner H,Hoffmeister M

更新日期：2020-08-15 00:00:00

abstract：:CD44 is a transmembrane glycoprotein that binds hyaluronan, extracellular matrix proteins and growth factors. Multiple isoforms of CD44 are generated by alternative splicing of 10 separate exons (V1-V10). Expression of the variable exons has been correlated with tumour progression and metastasis in a range of cell typ...

journal_title：International journal of cancer

authors： Hudson DL,Speight PM,Watt FM

更新日期：1996-05-16 00:00:00

abstract：:In a proportion of patients presenting mismatch repair (MMR)-deficient tumors, no germline MMR mutations are identified, the so-called Lynch-like syndrome (LLS). Recently, MMR-deficient tumors have been associated with germline mutations in POLE and MUTYH or double somatic MMR events. Our aim was to elucidate the mole...

journal_title：International journal of cancer

authors： Vargas-Parra GM,González-Acosta M,Thompson BA,Gómez C,Fernández A,Dámaso E,Pons T,Morak M,Del Valle J,Iglesias S,Velasco À,Solanes A,Sanjuan X,Padilla N,de la Cruz X,Valencia A,Holinski-Feder E,Brunet J,Feliubadaló L

更新日期：2017-10-01 00:00:00

abstract：:Radiotherapy and chemotherapy are known risk factors for second cancers after lymphoma. The role of genetic influences, however, remains largely unknown. We assessed risk of second cancers associated with family history of any cancer in 41,181 patients with Hodgkin lymphoma (HL) (n = 7,476), non-Hodgkin lymphoma (NHL)...

journal_title：International journal of cancer

authors： Landgren O,Pfeiffer RM,Stewart L,Gridley G,Mellemkjaer L,Hemminki K,Goldin LR,Travis LB

更新日期：2007-03-01 00:00:00

abstract：:Three aspects of the rat model of HTLV-I/II infection were investigated. (i) The efficacy of HTLV-I-transformed rat cell lines in infecting different strains of rats: WKY and Lewis HTLV-I-transformed cell lines were injected into adult WKY, Lewis and Brown Norway rats, representing syngeneic and allogeneic combination...

journal_title：International journal of cancer

authors： Kazanji M,Ibrahim F,Fiette L,Bomford R,De Thé G

更新日期：1997-09-26 00:00:00

abstract：:Sex steroid hormones influence prostate development and maintenance through their roles in prostate cellular proliferation, differentiation and apoptosis. Although suspected to be involved in prostate carcinogenesis, an association between circulating androgens and prostate cancer has not been clearly established in e...

journal_title：International journal of cancer

authors： Weiss JM,Huang WY,Rinaldi S,Fears TR,Chatterjee N,Hsing AW,Crawford ED,Andriole GL,Kaaks R,Hayes RB

更新日期：2008-05-15 00:00:00

abstract：:The morphology of rat liver cells containing alpha-feto-protein (AFP) during early stages of carcinogenesis induced by 3'methyl-4-dimethylaminoazobenzene and 2-acetylaminofluorene was investigated. Indirect immunofluorescence was used to detect AFP. AFP was not found in the cells of hyperplastic nodules but was presen...

journal_title：International journal of cancer

authors： Tchipysheva TA,Guelstein VI,Bannikov GA

更新日期：1977-09-15 00:00:00

abstract：:The utility of EBV load as a tumor marker in nasopharyngeal carcinoma (NPC) patients suggests that it might also serve as a screening test for individuals who are at high risk for developing NPC. We previously demonstrated that unaffected individuals from high-risk families had elevated anti-EBV antibody levels compar...

journal_title：International journal of cancer

authors： Yang X,Goldstein AM,Chen CJ,Rabkin CS,Chen JY,Cheng YJ,Hsu WL,Sun B,Diehl SR,Liu MY,Walters M,Shao W,Ortiz-Conde BA,Whitby D,Elmore SH,Gulley ML,Hildesheim A

更新日期：2006-02-01 00:00:00

abstract：:Residential proximity to electrical power lines of different voltage in relation to childhood leukemia was investigated through a case-control study undertaken in Greece during 1993-1994. The study comprised 117 incident cases of childhood leukemia and 202 age-, gender- and place-of-residence-matched controls. Four me...

journal_title：International journal of cancer

authors： Petridou E,Trichopoulos D,Kravaritis A,Pourtsidis A,Dessypris N,Skalkidis Y,Kogevinas M,Kalmanti M,Koliouskas D,Kosmidis H,Panagiotou JP,Piperopoulou F,Tzortzatou F,Kalapothaki V

更新日期：1997-11-04 00:00:00

abstract：:The roles of fibroblast growth factor-2 (FGF-2) in the hepatocellular carcinoma (HCC) development are still controversial. In this study, we investigated the expression of FGF-2 in chronic hepatitis (CH) type C patients with or without HCC and the immunoregulation of FGF-2 in NK sensitivity of HCC cells. The FGF-2 exp...

journal_title：International journal of cancer

authors： Tsunematsu H,Tatsumi T,Kohga K,Yamamoto M,Aketa H,Miyagi T,Hosui A,Hiramatsu N,Kanto T,Hayashi N,Takehara T

更新日期：2012-01-15 00:00:00

abstract：:Human papillomavirus-induced cervical carcinomas often show impaired expression of MHC class I molecules resulting in the inability of tumor cells to directly present viral peptides to cytotoxic T lymphocytes. Loss of MHC class I expression combined with the expression of activating NK cell receptor ligands renders tu...

journal_title：International journal of cancer

authors： Textor S,Dürst M,Jansen L,Accardi R,Tommasino M,Trunk MJ,Porgador A,Watzl C,Gissmann L,Cerwenka A

更新日期：2008-11-15 00:00:00

abstract：:Immunogenicity of a long 20-mer NY-ESO-1f peptide vaccine was evaluated in a lung cancer patient TK-f01, immunized with the peptide with Picibanil OK-432 and Montanide ISA-51. We showed that internalization of the peptide was necessary to present CD8 T-cell epitopes on APC, contrasting with the direct presentation of ...

journal_title：International journal of cancer

authors： Eikawa S,Kakimi K,Isobe M,Kuzushima K,Luescher I,Ohue Y,Ikeuchi K,Uenaka A,Nishikawa H,Udono H,Oka M,Nakayama E

更新日期：2013-01-15 00:00:00

abstract：:The anti-tumor effects of actinomycin D (Act D) and recombinant human tumor necrosis factor (TNF)-alpha have been studied on 4 established murine tumor cell lines: MmB16 melanoma, Lewis lung (LL/2) carcinoma, L1 sarcoma and L1210 leukemia. During short-term incubation (24 hr) Act D produced dose-dependent cytostatic/c...

journal_title：International journal of cancer

authors： Lasek W,Giermasz A,Kuc K,Wańkowicz A,Feleszko W,Gołab J,Zagozdzon R,Stokłosa T,Jakóbisiak M

更新日期：1996-05-03 00:00:00

abstract：:Human lymphoblastoid interferon inhibited the growth in vitro of fibroblasts and epithelial cells from normal, hyperplastic and neoplastic human breast tissue. At an interferon concentration of 10(3) inter-national units (IU) per ml, the inhibitory effects on monolayer growth were completely reversible but the growth ...

journal_title：International journal of cancer

authors： Balkwill F,Watling D,Taylor-Papadimitriou J

更新日期：1978-09-15 00:00:00

abstract：:Tumor cells do not constitutively exhibit invasive activity, but rather, can be transiently induced to adhere and form lesions. We report here that the expression of seprase, a dominant EDTA-resistant gelatinase in malignant tumors, is dependent on tumor cell exposure to type I collagen gel (TICg). The induced seprase...

journal_title：International journal of cancer

authors： Kennedy A,Dong H,Chen D,Chen WT

更新日期：2009-01-01 00:00:00

abstract：:Breast cancer (BC) and diabetes mellitus (DM) are major health problems. We examined the association between DM and BC stage at diagnosis and subsequent survival in a Finnish cohort of female BC patients. All BC cases (N = 73,170) diagnosed in 1995-2013 with dates and causes of death were identified from the Finnish C...

journal_title：International journal of cancer

authors： Murto MO,Artama M,Pukkala E,Visvanathan K,Murtola TJ

更新日期：2018-06-01 00:00:00

abstract：:Seven-day-old mouse embryos were transplanted under the kidney capsule of adult syngeneic recipients which were either X-irradiated, treated with cyclophosphamide, splenectomized or immunized with teratocarcinoma cell lines prior to embryonic transplantation. The yield of malignant tumors was decreased in preirradiate...

journal_title：International journal of cancer

authors： Damjanov I,Bagasra O,Dominis M,Solter D

更新日期：1982-12-15 00:00:00

abstract：:A subline of the murine P815 mastocytoma passaged for a long period of time in histoincompatible hosts was found to be deficient in surface MHC class-I antigens by serological and biochemical methods. In agreement with the lack of restriction elements, this variant cell line was no longer susceptible to killing by cyt...

journal_title：International journal of cancer

authors： Bertschmann M,Käsermann D,Keller R

更新日期：1990-10-15 00:00:00