Abstract:
:Epithelial-mesenchymal transition (EMT) describes a process occurring during development and oncogenesis by which epithelial cells obtain fibroblast-like properties and show reduced cell adhesion and increased motility. In this report, we demonstrated typical EMT in human mammary epithelial MCF10A small interfering (si)RNA gelsolin-knockdown cells. EMT was characterized by fibroblastic morphology, loss of contact inhibition and focus formation in monolayer growth, enhanced motility and invasiveness in vitro, increased actin filaments, overexpression of RAC, activation of both extracellular signal-regulated kinase and AKT, inactivation of glycogen synthase kinase-3, conversion of cadherin from the E- to N-type and induction of the transcription factor Snail. These results suggested that gelsolin functions as a switch that controls E- and N-cadherin conversion via Snail, and demonstrated that its knockdown leads to EMT in human mammary epithelial cells and possibly to the development of human mammary tumors.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Tanaka H,Shirkoohi R,Nakagawa K,Qiao H,Fujita H,Okada F,Hamada J,Kuzumaki S,Takimoto M,Kuzumaki Ndoi
10.1002/ijc.21559keywords:
subject
Has Abstractpub_date
2006-04-01 00:00:00pages
1680-91issue
7eissn
0020-7136issn
1097-0215journal_volume
118pub_type
杂志文章abstract::CD16 surface antigens represent activatory molecules in CD3-16+ NK cells. In order to target NK cells against relatively NK-resistant ovarian carcinomas, we used an anti-CD16 monoclonal antibody (MAb) (VD4), together with an anti-ovarian carcinoma-associated antigen (MOV19), to construct biMAbs. To this end, hybrid hy...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480213
更新日期:1991-05-10 00:00:00
abstract::Partial or total loss of chromosome 22 is often associated with tumors of the central nervous system and in particular with meningiomas. As in the case of other tumors, the ganglioside pattern is modified in transformed tissues. Cytogenetic analysis of 30 human meningiomas has been performed and the results compared t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470303
更新日期:1991-02-01 00:00:00
abstract::Tumor-induced immunosuppression remains a major challenge for immunotherapy of cancer patients. To further elucidate why an allogeneic gene-modified [interleukin-7 (IL-7)/CD80-cotransfected] renal cell cancer (RCC) vaccine failed to induce clinically relevant TH-1-polarized immune responses, peripheral blood mononucle...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29230
更新日期:2015-04-15 00:00:00
abstract::With low cure rates but increasing diverse treatment options that provide variable remission times, ovarian cancer is increasingly being recognized as a chronic disease. This reality indicates the need for a better understanding of factors influencing disease progression. In a previous global analysis of gene expressi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22054
更新日期:2006-11-01 00:00:00
abstract::We have recently shown that an adenovirus carrying REIC/Dkk-3 (Ad-REIC) exhibits a potent tumor-specific cell-killing function for various human cancers. It has also become evident that some human cancers are resistant to Ad-REIC-induced apoptosis. The aim of the present study was to determine the molecular mechanisms...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24764
更新日期:2010-04-01 00:00:00
abstract::The object of our multicenter retrospective study was to compare the new histologic World Health Organization (WHO) classification and the classical histologic Bernatz classification in terms of interobserver agreement and prognostic importance. The influence of coexisting diseases was also analyzed using the Charlson...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.10255
更新日期:2002-04-20 00:00:00
abstract::People living with lymphohematopoietic neoplasms (LHNs) are known to have increased risks of second cancer; however, the incidence of second cancers after LHNs has not been studied extensively in Australia. The Australian Cancer Database was used to analyze site-specific risk of second primary cancer after LHNs in 127...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25706
更新日期:2011-08-15 00:00:00
abstract::Although sunburn and intermittent sun exposures are associated with increased melanoma risk, most studies have found null or inverse associations between occupational (more continuous pattern) sun exposure and melanoma risk. The association of melanoma with occupational sun exposure may differ according to anatomical ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28603
更新日期:2014-06-01 00:00:00
abstract::Farnesyl transferase inhibitors (FTIs) were shown to be effective in modulating tumor growth in Ras-transformed tumor cells. Recent studies have focused on Rho GTPases as putative targets of FTI action. Previously, we demonstrated that FTIs were effective in inhibiting the growth and invasiveness of RhoC GTPase-overex...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25655
更新日期:2011-07-01 00:00:00
abstract::Proliferating cell nuclear antigen (PCNA) expression was studied by immunohistochemistry on paraffin-embedded sections of 293 primary colorectal adenocarcinomas and 56 corresponding lymph node metastases. PCNA-positive expression was detected in <25% of tumour cells in 172 (59%) cases and in > 25% in 121 (41%) cases. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960220)69:1<5::AID-IJC2>
更新日期:1996-02-20 00:00:00
abstract::Epigenetic inactivation by aberrant DNA methylation has been reported for many microRNA genes in various human malignancies. However, relatively little is known about microRNA gene methylation in hepatocellular carcinoma (HCC). Therefore, a systematic screen for identification of aberrantly hypermethylated microRNA ge...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28068
更新日期:2013-08-01 00:00:00
abstract::Data from an international case-control study of breast cancer that was conducted in the 1960s were used to examine whether multiple births affect the risk of breast cancer in the mother. Among 2821 parous breast-cancer patients, 88 had had one or more multiple births, whereas among 8882 controls 247 had had one or mo...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.2910540114
更新日期:1993-04-22 00:00:00
abstract::We analyzed the biodistribution of the 111In-labelled murine anti-tenascin-C MAb BC-2 after intralesional injection in 15 glioblastoma patients. The activated ligand DTPA was conjugated via the isothiocyanato-benzyl group onto BC-2. Conjugates were labelled with 111In, displaying immunoreactivity greater than 90% and ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970529)71:5<810::aid-ijc
更新日期:1997-05-29 00:00:00
abstract::Two hundred and twelve archival bladder-cancer biopsy specimens were analyzed immunohistochemically analysis were correlated to established histological and quantitative prognostic factors and survival of patients during a mean follow-up period of more than 10 years. Twenty-nine percent of tumours were positive for p5...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530304
更新日期:1993-02-01 00:00:00
abstract::To investigate the relationship between p16 methylation and Helicobacter pylori infection in precancerous gastric lesions, a population-based study was conducted in Linqu County, a high-risk area of gastric cancer in China. Methylation status of p16 was evaluated by methylation-specific polymerase chain reaction in 92...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23891
更新日期:2009-01-15 00:00:00
abstract::This study evaluates the association of antibodies against HPV-16-derived peptides with cervical cancer and estimates the sensitivity and specificity of the serological assays in relation to HPV DNA detection in cervical cells by PCR. Study subjects were derived from 4 case-control studies carried out in Spain and Col...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960328)66:1<70::AID-IJC1
更新日期:1996-03-28 00:00:00
abstract::In ovarian carcinomas, recurrence and acquired chemoresistance are the first leading causes of therapeutic failure and are responsible for the poor overall survival rate. Cisplatin exposure of sensitive cells has been previously associated with a down-regulation of Bcl-X(L) expression and apoptosis, whereas recurrence...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24787
更新日期:2010-02-15 00:00:00
abstract::Sera from 450 individuals between the age of 1 and 80 years, representing the general population of the Czech Republic, were tested for the presence of antibodies to human-papillomavirus(HPV)-derived antigens. The following antigens were used: (i) HPV1 virions; (ii) HPV16, -18 and -33-virus-like particles (VLP); (iii)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980831)77:5<689::aid-ijc
更新日期:1998-08-31 00:00:00
abstract::Tumors need to acquire an angiogenic phenotype for outgrowth and metastasis formation. Limited information on the angiogenic potential of specific tissues, especially human breast tissues is available. Here we describe an in vivo model, using the dorsal skin fold chamber in immunodeficient nude mice, where various tis...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980729)77:3<455::aid-ijc
更新日期:1998-07-29 00:00:00
abstract::The prognostic significance of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) in patients with gastric cancer (GC) is controversial. The aims of our meta-analysis are to assess its correlation with clinicopathological characteristics and prognostic significance in GC. PubMed, Embase, the Cochrane d...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1002/ijc.28954
更新日期:2015-01-01 00:00:00
abstract::Previous studies have revealed a robust association between exposure to asbestos and human lung cancer. Accumulating evidence has highlighted the role of epigenome deregulation in the mechanism of carcinogen-induced malignancies. We examined the impact of asbestos on DNA methylation. Our genome-wide studies (using Ill...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30897
更新日期:2017-11-15 00:00:00
abstract::Although adult obesity is known to increase endometrial cancer risk, evidence for childhood obesity is limited. We prospectively examined the association between body fatness throughout life and endometrial cancer risk. 47,289 participants in the Nurses' Health Study (NHS) and 105,386 of the Nurses' Health Study II (N...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29427
更新日期:2015-08-01 00:00:00
abstract::The effects of androgen manipulation on epidermal growth factor (EGF) receptor, p185erbB-2 and transforming growth factor-alpha (TGF-alpha) levels were examined in prostatic adenocarcinoma. Male nude mice were inoculated with the CWR22 androgen-dependent human prostatic tumor or an androgen-independent (CWR22R) deriva...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990730)82:3<424::aid-ijc
更新日期:1999-07-30 00:00:00
abstract::Obesity is associated with an increased risk of fatal prostate cancer. We aimed to elucidate the importance and relevant timing of obesity and weight change for prostate cancer progression. We identified 5,158 men diagnosed with localized prostate cancer (clinical stage T1/T2) from 1986 to 2012 in the Health Professio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30803
更新日期:2017-09-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) results from the cumulative effects of deregulated tumor suppressor genes and oncogenes. The tumor suppressor and oncogenes commonly affected include growth factors, receptors and their downstream signaling pathway components. The overexpression of transforming growth factor alpha (TGF-a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25127
更新日期:2010-09-01 00:00:00
abstract::The modulating effect on drug resistance of amiodarone (AM) and its metabolite desethylamiodarone (DEA) was studied in a P-glycoprotein-positive human colon carcinoma cell line COLO 320, and a human small-cell lung carcinoma cell line GLC4 and its adriamycin (Adr)-resistant subline GLC4-Adr (both P-glycoprotein-negati...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480422
更新日期:1991-06-19 00:00:00
abstract::Metabolic syndrome (MetS) and its components may link to pancreatic cancer risk; however, current epidemiological evidence is limited, and the potential mechanisms underlying the associations remain unclear. To investigate this, we carried out this prospective cohort study of 474 929 participants without a diagnosis o...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.33172
更新日期:2020-12-15 00:00:00
abstract::Increased levels of hypoxia and hypoxia-inducible factor 1α (HIF-1α) in human sarcomas correlate with tumor progression and radiation resistance. Prolonged antiangiogenic therapy of tumors not only delays tumor growth but may also increase hypoxia and HIF-1α activity. In our recent clinical trial, treatment with the v...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27666
更新日期:2013-01-01 00:00:00
abstract::Tumor cells express the glycolytic regulator pyruvate kinase subtype M2 (M2-PK), which can occur in a tetrameric form with high affinity to its substrate phosphoenolpyruvate (PEP) and a dimeric form with a low PEP affinity. The transition between both conformations contributes to the control of glycolysis and is impor...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23512
更新日期:2008-07-15 00:00:00
abstract::The European Study Group for Pancreatic Cancer (ESPAC-1) study is the largest study of adjuvant treatment for pancreatic ductal adenocarcinoma to date and confirmed a survival advantage for adjuvant chemotherapy but not for chemoradiation. The importance of parallel evaluation of survival and quality of life (QoL) has...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.24270
更新日期:2009-06-15 00:00:00