In vitro and in vivo modulation of multi-drug resistance with amiodarone.

abstract：:A cDNA library specific for mRNA over-expressed in prostate cancer was generated by subtractive hybridization of transcripts originating from prostatic hyperplasia and cancer tissues. cDNA encoding ribosomal proteins L4, L5, L7a, L23a, L30, L37, S14 and S18 was found to be present among 100 analyzed clones. Levels of ...

journal_title：International journal of cancer

authors： Vaarala MH,Porvari KS,Kyllönen AP,Mustonen MV,Lukkarinen O,Vihko PT

更新日期：1998-09-25 00:00:00

abstract：:No clear relationship between whole grain products and risk of breast cancer has been established. In a large prospective cohort study, we investigated the association between intake of whole grain products and risk of breast cancer by tumour receptor status [oestrogen receptor (ER) and progesterone receptor (PR)] and...

journal_title：International journal of cancer

authors： Egeberg R,Olsen A,Loft S,Christensen J,Johnsen NF,Overvad K,Tjønneland A

更新日期：2009-02-01 00:00:00

abstract：:The effect of blockade of NF-kappaB activity on human pancreatic cancer angiogenesis was determined in an orthotopic xenograft model. Highly metastatic L3.3 human pancreatic cancer cells, which expressed an elevated level of constitutive NF-kappaB activity, were transfected with a mutated IkappaBalpha (IkappaBalphaM)....

journal_title：International journal of cancer

authors： Xiong HQ,Abbruzzese JL,Lin E,Wang L,Zheng L,Xie K

更新日期：2004-01-10 00:00:00

abstract：:The matrix metalloproteinase (MMP) family of proteins mediates various cellular pathways, including apoptosis and angiogenesis. Polymorphisms of MMP genes are associated with increased esophageal adenocarcinoma (EAC) risk. Gastroesophageal reflux disease (GERD) is an established EAC risk factor. We examined whether MM...

journal_title：International journal of cancer

authors： Cheung WY,Zhai R,Bradbury P,Hopkins J,Kulke MH,Heist RS,Asomaning K,Ma C,Xu W,Wang Z,Hooshmand S,Su L,Christiani DC,Liu G

更新日期：2012-12-01 00:00:00

abstract：:A series of 42 patients with malignant melanoma treated with BCG adjuvant immunotherapy were studied for sequential changes in cellular immune reactivity to non-specific mitogens. Lymphocyte preparations were made monthly and stored in a viable condition in liquid nitrogen. After 6 months of treatment, all lymphocyte ...

journal_title：International journal of cancer

authors： Golub SH,Forsythe AB,Morton DL

更新日期：1977-01-01 00:00:00

abstract：:We have studied the clonal heterogeneity of 2 spontaneously metastasizing mammary carcinomas which recently arose spontaneously in C3H/He female retired breeders. Cells of early (2nd to 5th) transplant generations of these tumors were cloned by a combination of semi-solid agarose colony formation and limiting dilution...

journal_title：International journal of cancer

authors： Brodt P,Parhar R,Sankar P,Lala PK

更新日期：1985-02-15 00:00:00

abstract：:The age-adjusted incidence rates of cutaneous melanoma in Queensland in 1987 have been analysed for 16 anatomic sites, taking into account their surface areas. In men, the incidence of invasive melanoma on the ears, a chronically sun-exposed site, was extraordinarily high with annual rates of over 200 per 10(5) units ...

journal_title：International journal of cancer

authors： Green A,MacLennan R,Youl P,Martin N

更新日期：1993-01-21 00:00:00

abstract：:Data from immunocytochemical assessment of estrogen receptor (ER) regulation in MCF-7 cells under estrogenic and anti-estrogenic stimulation were compared with those obtained by enzyme immunoassay (Abbott ER-EIA). Similar trends were observed, although ER level variations were less marked when assessed immunocytochemi...

journal_title：International journal of cancer

authors： Seo HS,Larsimont D,Querton G,El Khissiin A,Laios I,Legros N,Leclercq G

更新日期：1998-12-09 00:00:00

abstract：:Numerous prospective and retrospective studies have clearly demonstrated a dose-related increased lung cancer risk associated with cigarette smoking, with evidence also for a genetic component to risk. In this study, using the two-stage clonal expansion stochastic model framework, for the first time we investigated th...

journal_title：International journal of cancer

authors： Deng L,Kimmel M,Foy M,Spitz M,Wei Q,Gorlova O

更新日期：2009-05-01 00:00:00

abstract：:More than two-thirds of patients with hepatocellular carcinoma (HCC) cannot receive curative therapy and have poor survival due to late diagnosis and few prognostic directions. In our study, nontargeted and targeted metabolomics analyses were conducted by liquid chromatography-mass spectrometry to characterize metabol...

journal_title：International journal of cancer

authors： Han J,Han ML,Xing H,Li ZL,Yuan DY,Wu H,Zhang H,Wang MD,Li C,Liang L,Song YY,Xu AJ,Wu MC,Shen F,Xie Y,Yang T

更新日期：2020-03-15 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with high proliferative and metastatic phenotypes. CDCA7, a new member of the cell division cycle associated family of genes, is involved in embryonic development and dysregulated in various types of human cancer. However, the biologi...

journal_title：International journal of cancer

authors： Ye L,Li F,Song Y,Yu D,Xiong Z,Li Y,Shi T,Yuan Z,Lin C,Wu X,Ren L,Li X,Song L

更新日期：2018-11-15 00:00:00

abstract：:The nature of 15 immortal mouse liver epithelial cell (MLEC) lines established from normal C3H mice was investigated specifically in terms of ras oncogene activation. Neither transforming activity nor point mutation within codon 61 of c-H-ras could be demonstrated in any of the cell lines by DNA transfection in a NIH/...

journal_title：International journal of cancer

authors： Lee GH,Sakai R,Nagao M,Kitagawa T

更新日期：1991-01-02 00:00:00

abstract：:Cancers of the stomach, pancreas, colon and rectum are increasingly regarded as being diet-influenced. Migrants to Australia from England, Scotland, Ireland, Poland, Yugoslavia, Greece, and Italy have come from countries with varied dietary backgrounds and gastrointestinal cancer risks. Age-standardized cancer death r...

journal_title：International journal of cancer

authors： McMichael AJ,McCall MG,Hartshorne JM,Woodings TL

更新日期：1980-04-15 00:00:00

abstract：:Organochlorine insecticides have been studied extensively in relation to breast cancer incidence, and results from two meta-analyses have been null for late-life residues, possibly due to measurement error. Whether these compounds influence survival remains to be fully explored. We examined associations between organo...

journal_title：International journal of cancer

authors： Parada H Jr,Wolff MS,Engel LS,White AJ,Eng SM,Cleveland RJ,Khankari NK,Teitelbaum SL,Neugut AI,Gammon MD

更新日期：2016-02-01 00:00:00

abstract：:Natural killer (NK) activity of human peripheral blood lymphocytes (HPBL) was studied in 32 alcoholics and 15 control subjects in a 4-h chromium release assay using K562 tumor target cells. The natural killer activity of human peripheral blood lymphocytes in alcoholics was significantly higher than the level found in ...

journal_title：International journal of cancer

authors： Saxena QB,Mezey E,Adler WH

更新日期：1980-10-15 00:00:00

abstract：:Hormonal therapies targeting androgen receptor (AR) are effective in prostate cancer (PCa), but often the cancers progress to fatal castrate-resistant disease. Improved understanding of the cellular events during androgen deprivation would help to identify survival and stress pathways whose inhibition could synergize ...

journal_title：International journal of cancer

authors： Saeed K,Östling P,Björkman M,Mirtti T,Alanen K,Vesterinen T,Sankila A,Lundin J,Lundin M,Rannikko A,Nordling S,Mpindi JP,Kohonen P,Iljin K,Kallioniemi O,Rantala JK

更新日期：2015-06-01 00:00:00

abstract：:There is good evidence for an association between Epstein-Barr virus (EBV) and Hodgkin's disease (HD). In approximately one-third of cases, the EBV genome is detectable in Reed-Sternberg (RS) cells and there is expression of the viral nuclear antigen EBNA-1 and the latent membrane protein LMP-1. Expression of LMP-2 ha...

journal_title：International journal of cancer

authors： Bryden H,MacKenzie J,Andrew L,Alexander FE,Angus B,Krajewski AS,Armstrong AA,Gray D,Cartwright RA,Kane E,Wright DH,Taylor P,Jarrett RF

更新日期：1997-08-07 00:00:00

abstract：:Circadian disruption has been classified as probably carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. The circadian clock is subject to environmental factors, particularly light exposure and food intake rhythms. However, the association between nutritional circadia...

journal_title：International journal of cancer

authors： Srour B,Plancoulaine S,Andreeva VA,Fassier P,Julia C,Galan P,Hercberg S,Deschasaux M,Latino-Martel P,Touvier M

更新日期：2018-11-15 00:00:00

abstract：:Daphnane-type diterpene gnidimacrin isolated from the Chinese plant Stellera chamaejasme L. is an antitumor agent that activates protein kinase C (PKC). The mechanism of antitumor action of gnidimacrin and the possible involvement of PKC were examined using sensitive K562 and refractory HLE cells. Gnidimacrin did bind...

journal_title：International journal of cancer

authors： Yoshida M,Yokokura H,Hidaka H,Ikekawa T,Saijo N

更新日期：1998-07-17 00:00:00

abstract：:mTOR inhibition led to activation of upstream receptor tyrosine kinases (RTKs) and AKT, which may attenuate the efficacy of mTOR kinase inhibitors. We sought to discover efficient drug combination with mTOR inhibitors by elucidating the survival feedback loops induced by mTOR inhibition in breast cancer. The feedback ...

journal_title：International journal of cancer

authors： Chen SM,Guo CL,Shi JJ,Xu YC,Chen Y,Shen YY,Su Y,Ding J,Meng LH

更新日期：2014-11-15 00:00:00

abstract：:A panel of conventional and monoclonal antibodies was used to examine the immunohistological characteristics of malignant epithelial cells and infiltrating lymphocytes in frozen sections of nasopharyngeal carcinoma (NPC) biopsies from 10 Tunisian patients. Three main categories of cells were identified. (1) Tumour cel...

journal_title：International journal of cancer

authors： Thomas JA,Iliescu V,Crawford DH,Ellouz R,Cammoun M,de-Thé G

更新日期：1984-06-15 00:00:00

abstract：:Previous literature, although not consistent, suggests that moderate alcohol consumption might be associated with decreased risk of renal cell carcinoma (RCC) in women. Thus, we examined the association between alcohol intake and the incidence of RCC by analyzing data from the Swedish Mammography Cohort, a population-...

journal_title：International journal of cancer

authors： Rashidkhani B,Akesson A,Lindblad P,Wolk A

更新日期：2005-12-10 00:00:00

abstract：:Although preliminary evidence suggests that germline variation in genes involved in steroid hormone metabolism may alter breast cancer prognosis, this has not been systematically evaluated. We examined associations between germline polymorphisms in 6 genes involved in the steroid hormone metabolism and signaling pathw...

journal_title：International journal of cancer

authors： Udler MS,Azzato EM,Healey CS,Ahmed S,Pooley KA,Greenberg D,Shah M,Teschendorff AE,Caldas C,Dunning AM,Ostrander EA,Caporaso NE,Easton D,Pharoah PD

更新日期：2009-12-01 00:00:00

abstract：:The involvement of 12-lipoxygenase (12-LOX) expression and function in tumor metastasis has been demonstrated in several murine tumor cell lines. In addition, 12-LOX expression was detected in human prostatic tumors and correlated to the clinical stage of disease. Here we provide data that human prostate cancer cell l...

journal_title：International journal of cancer

authors： Timár J,Rásó E,Döme B,Li L,Grignon D,Nie D,Honn KV,Hagmann W

更新日期：2000-07-01 00:00:00

abstract：:Few studies have examined cancer-related risk factors in relation to SES across the lifecourse in low to middle income countries. This analysis focuses on adult women in India, China, Mexico, Russia and South Africa, and examines the association between individual, parental and lifecourse SES with smoking, alcohol, BM...

journal_title：International journal of cancer

authors： Akinyemiju T,Ogunsina K,Okwali M,Sakhuja S,Braithwaite D

更新日期：2017-02-15 00:00:00

abstract：:As with cyclooxygenase (COX)-2, genetic disruption of COX-1 gene or pharmacologic inhibition of its activity has been shown to decrease the number of intestinal polyps in Apc gene-deficient mice. The present study was designed to investigate the combined effects of COX-1 and COX-2 selective inhibitors on spontaneous p...

journal_title：International journal of cancer

authors： Kitamura T,Itoh M,Noda T,Matsuura M,Wakabayashi K

更新日期：2004-04-20 00:00:00

abstract：:The causal role of wood-dust exposure in sinonasal cancer (SNC) has been established in epidemiological studies, but the mechanisms of SNC carcinogenesis are still largely unknown. Increased amounts of COX-2 are found in both premalignant and malignant tissues, and experimental evidence link COX-2 to development of ca...

journal_title：International journal of cancer

authors： Holmila R,Cyr D,Luce D,Heikkilä P,Dictor M,Steiniche T,Stjernvall T,Bornholdt J,Wallin H,Wolff H,Husgafvel-Pursiainen K

更新日期：2008-05-01 00:00:00

abstract：:Dickkopf1 (DKK1), a secreted inhibitor of the Wnt/β-catenin pathway, is a negative regulator of bone formation. DKK1 acts as a switch that transitions prostate cancer bone metastases from osteolytic to osteoblastic and also is an active indicator of poor outcome for multiple myeloma. However, in other tumor types, DKK...

journal_title：International journal of cancer

authors： Menezes ME,Devine DJ,Shevde LA,Samant RS

更新日期：2012-04-01 00:00:00

abstract：:Squamous cell carcinoma of the conjunctiva (SCCC) has been associated with HIV infection in equatorial Africa, but the evidence for association with HIV in developed countries, where SCCC is rarer, is controversial. We investigated the risk for SCCC and other eye cancers in the updated U.S. HIV/AIDS Cancer Match Regis...

journal_title：International journal of cancer

authors： Guech-Ongey M,Engels EA,Goedert JJ,Biggar RJ,Mbulaiteye SM

更新日期：2008-06-01 00:00:00

abstract：:PAX3 encodes a transcription factor, which with Zic1 is necessary for induction of the neural crest during early embryonic development. There are 7 human PAX3 isoforms (a-h). PAX3e is the full length isoform comprising 10 exons. PAX3c comprises 8 exons plus 5 codons of intron 8, while PAX3g has a truncated transactiva...

journal_title：International journal of cancer

authors： Wang Q,Kumar S,Mitsios N,Slevin M,Kumar P

更新日期：2007-03-15 00:00:00