Abstract:
:The selective targets for HTLV-III/LAV, the causal infectious agent of AIDS and AIDS-related complex (ARC), are T4 cells, apparently because the virus receptor is associated with T4 antigen determinants. This accounts for T4 cell depletion in AIDS and for a decrease of IL-2 production by AIDS peripheral blood lymphocytes (PBL) after in vitro PHA activation. By contrast, T8 cells are not targets for HTLV-III/LAV, since T8 cells from PBL and from long-term cultured T cells (CTC) could not be infected by the virus. We describe 2 samples of PBL from Zairian patients with HTLV-III infection in which HTLV-III was expressed by T8 cells. Evidence that T8 cells were expressing virus was obtained by complement cytotoxicity experiments performed in the presence of OKT8 monoclonal antibody (MAb), which removed HTLV-III-positive cells from cultured T cells producing the virus, and by double labelling experiments, in which some cells exhibit both T8 antigens detected either by IFA (rhodamine) or by rosetting in presence of OKT8 MAbs and HTLV-III antigens detected by IFA (fluorescein) with of anti-HTLV-III p24 and p15 MAbs. Since normal T cells have previously been shown to undergo antigenic diversity, we think these results can be explained by HTLV-III infection of T4 cells which later lost T4 antigens and acquired the T8 phenotype.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Fouchard M,Reveil B,Mbayo K,Lurhuma A,Sarin PS,Gallo RC,Zagury Ddoi
10.1002/ijc.2910380507subject
Has Abstractpub_date
1986-11-15 00:00:00pages
657-9issue
5eissn
0020-7136issn
1097-0215journal_volume
38pub_type
杂志文章abstract::Benign breast disease (BBD) is an established breast cancer (BC) risk factor, but it is unclear whether the magnitude of the association applies to women at familial or genetic risk. This information is needed to improve BC risk assessment in clinical settings. Using the Prospective Family Study Cohort, we used Cox pr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32112
更新日期:2019-07-15 00:00:00
abstract::Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies have reported inconsistent associations between blood lipids and cancer risk. To reduce biases from unmeasured confounding, we performed a bidirectio...
journal_title:International journal of cancer
pub_type: 杂志文章
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abstract::OK-432, a streptococcal preparation, and BCG effectively inhibited splenomegaly in Friend leukemia virus (FLV)-infected mice. Divided drug dosage resulted in stronger inhibition than single administration. When the second dose was fixed at the 3rd pre-infection day, the best timing for the first dose was approximately...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910250117
更新日期:1980-01-15 00:00:00
abstract::Chimeric bcr/abl fusion proteins are thought to be the molecular 'pathogen' of chronic myelogenous leukaemia (CML). Expression levels of the respective fusion RNAs reflect disease progression as well as remission upon therapeutic intervention in CML patients. However, there is no quick and reliable method that would a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000601)86:5<741::aid-ijc
更新日期:2000-06-01 00:00:00
abstract::The deleted in liver cancer 1 (DLC1) tumor suppressor is an important RhoGTP activating protein (RhoGAP) that plays a crucial role in many types of human cancers. Small GTPases regulate normal cellular processes but aberrant expression and activation of GTPases contribute to tumorigenesis. RhoGAP suppresses Rho activi...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.28505
更新日期:2014-07-15 00:00:00
abstract::Angiogenesis is essential for tumor growth and metastasis. In the process of angiogenesis, the interaction between adhesive proteins of endothelial cells and extracellular matrix components plays an important role by mediating cell attachment, which is indispensable for their motility, and by transmitting the regulato...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960529)66:5<664::AID-IJC
更新日期:1996-05-29 00:00:00
abstract::Monoclonal antibodies (MAbs) reactive with the ganglioside fucosyl GM1 (Fuc-GM1), an antigen associated with small-cell carcinoma of the lung (SCLC), were tested for their ability to mediate tumor-cell killing in vitro in conjunction with humoral and cellular effectors and to inhibit tumor engraftment in nude mice in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490619
更新日期:1991-12-02 00:00:00
abstract::Topically applied vasoconstrictor is a new strategy to prevent oral mucositis and alopecia, two complications of chemotherapy and stem-cell transplant. We sought to determine whether mice treated with topical vasoconstrictor minutes before chemotherapy to suppress L1210 leukemia would develop a vasoconstrictor-induced...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30037
更新日期:2016-06-15 00:00:00
abstract::RAGE is a central driver of tumorigenesis by sustaining an inflammatory tumor microenvironment. This study links the soluble forms of RAGE (sRAGE and esRAGE) with clinical outcome of melanoma patients. Moreover, tissue expression of RAGE was analyzed using immunohistochemistry on two independent tissue microarrays (TM...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29619
更新日期:2015-12-01 00:00:00
abstract::Colorectal cancer is a heterogeneous disease at the histomorphological, clinical and molecular level. Approximately 20% of cases may progress through the "serrated" pathway characterized by BRAF mutation and high-level CpG Island Methylator Phenotype (CIMP). A large subgroup are additionally microsatellite instable (M...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28564
更新日期:2014-05-15 00:00:00
abstract::Mismatch repair-deficient (dMMR) and/or microsatellite instability-high (MSI) colorectal cancers (CRC) represent about 5% of metastatic CRC (mCRC). Prognosis and chemosensitivity of dMMR/MSI mCRC remain unclear. This multicenter study included consecutive patients with dMMR/MSI mCRC from 2007 to 2017. The primary endp...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32879
更新日期:2020-07-01 00:00:00
abstract::During 2000, marine antitumor pharmacology research aimed at the discovery of novel antitumor agents was published in 85 peer-reviewed articles. The purpose of this article is to present a structured review of the antitumor and cytotoxic properties of 143 marine natural products, many of them novel compounds that belo...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.11080
更新日期:2003-06-20 00:00:00
abstract::The APTIMA HPV Assay (AHPV) allows detection of 14 high-risk human papillomavirus (HPV) RNA types in cervical specimens. Until present, the assay has been compared to HPV DNA tests only in triage settings. Herein, we compare AHPV with a DNA assay (Hybrid Capture 2; HC2) and liquid-based cytology (LBC; using PreservCyt...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25726
更新日期:2011-08-01 00:00:00
abstract::The effect of interferon on the long-term clinical outcome of patients with chronic hepatitis C remains unclear. This study included 594 patients with chronic hepatitis C who received interferon-alpha therapy (Interferon group) and 144 patients with chronic hepatitis C who did not receive interferon (Control group). T...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract::Studies have shown an increased risk of malignancies in women with endometriosis. Little is known about the impact of endometriosis on cancer survival. We investigated whether the survival after a diagnosis of a malignancy differs in women with a previously diagnosed endometriosis compared to other women. Women with a...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.25718
更新日期:2011-08-15 00:00:00
abstract::A mammographic breast cancer screening programme has been ongoing in the Florence District (Italy) since 1970 and a favourable impact of screening on breast cancer mortality of women aged 50-70 has been shown by means of a case-control study. Two hundred and eleven screen- and 116 interval-detected cancers in the peri...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910460209
更新日期:1990-08-15 00:00:00
abstract::A case-control study of 374 patients with primary epithelial cancers of the oral cavity, oro- and hypopharynx, and larynx is reported, the controls being patients with selected other cancers, matched for age and sex. Of all eligible patients, 93% were interviewed. Increased risks were seen with alcohol consumption and...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340504
更新日期:1984-11-15 00:00:00
abstract::The ability to monitor breast cancer initiation and progression on the molecular level would provide an effective tool for early diagnosis and therapy. In the present study, we focused on the underglycosylated MUC-1 tumor antigen (uMUC-1), which is directly linked to tumor progression from pre-malignancy to advanced m...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27872
更新日期:2013-04-15 00:00:00
abstract::Progress against cancer through prevention and treatment is often measured by survival statistics only instead of analyzing trends in incidence, survival and mortality simultaneously because of interactive influences. This study combines these parameters of major cancers to provide an overview of the progress achieved...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26315
更新日期:2012-06-15 00:00:00
abstract::NK cell recognition of tumor cells is mediated by a delicate balance of signals received by MHC class I-binding inhibitory NK cell receptors and activating NK cell receptors, which mainly bind to virus-, stress- or tumor-induced ligands. In addition, adhesion molecules such as the intercellular adhesion molecule-1 (IC...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25442
更新日期:2011-03-01 00:00:00
abstract::We studied if bladder cancers respond to HAMLET (human alpha-lactalbumin made lethal to tumor cells) to establish if intravesical HAMLET application might be used to selectively remove cancer cells in vivo. Patients with nonmuscle invasive transitional cell carcinomas were included. Nine patients received 5 daily intr...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1002/ijc.22810
更新日期:2007-09-15 00:00:00
abstract::Previous studies reported an inverse relationship between body mass index (BMI) and upper aerodigestive tract (UADT) cancers. Examining change in BMI over time may clarify these previous observations. We used data from 2,048 cases and 2,173 hospital- and population-based controls from ten European countries (alcohol-r...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.25468
更新日期:2011-03-15 00:00:00
abstract::Our case-control study was conducted to investigate whether residential and occupational exposure to magnetic fields increased the risk for brain tumours in adults. Data from an occupational exposure matrix was also evaluated. The study population in this nested case-control study was made up of subjects aged 16 years...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20845
更新日期:2005-05-20 00:00:00
abstract::Three lymphoblastoid cell lines were established from splenic lymphocytes of a lymphomatous baboon (Papio hamadryas) by co-cultivation of the lymphocytes with X-irradiated cells of marmoset or baboon lymphoblastoid cell cultures; the baboon splenic lymphocytes failed to grow when cultured alone. A herpesvirus, associa...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910180611
更新日期:1976-12-15 00:00:00
abstract::Nitric oxide may serve as one cofactor for human papillomavirus (HPV)-induced development of cervical cancer. Therefore, we first assessed the levels of cervical fluid nitric oxide metabolite (NOx) in 283 women with and without high-risk (hr) HPV. The NOx level in women with hr HPV (48.4 μmol/L [95% CI: 39.4-56.6], n ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25637
更新日期:2011-06-15 00:00:00
abstract::Tumor cells of colorectal cancer (CRC) release exosomes into the circulation. These exosomes can mediate communication between cells and affect various tumor-related processes in their target cells. We present a quantitative proteomics analysis of the exosomes purified from serum of patients with CRC and normal volunt...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30496
更新日期:2017-02-15 00:00:00
abstract::AKR-2B mouse fibroblasts were treated with 50 micrograms/ml of crude transforming growth factor (TGF) of human origin. Cell surface proteins of treated cells were radioiodinated and compared to untreated cells at various times after the addition of TGF. Treated cells showed a severalfold increase (approximately 6-fold...
journal_title:International journal of cancer
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doi:10.1002/ijc.2910330121
更新日期:1984-01-15 00:00:00
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journal_title:International journal of cancer
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更新日期:2014-11-01 00:00:00
abstract::We have employed the DNA-mediated gene transfer method to introduce the allogenic major-histocompatibility-complex(MHC)-class-I gene H-2Kb into the K36.16 tumor cells, H-2k, in order to generate tumor-specific immunity. The acquisition of immunogenicity by the H-2Kb-transformed clones following gene transfer is associ...
journal_title:International journal of cancer
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更新日期:1994-04-15 00:00:00
abstract::The relative proportions of T, B and T gamma suppressor cells were determined sequentially in peripheral blood of melanoma patients before and after surgery. Concanavalin A (Con A)-induced suppression against lymphocyte mitogenesis of melanoma patients and age matched controls was measured concurrently. The mean perce...
journal_title:International journal of cancer
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doi:10.1002/ijc.2910280103
更新日期:1981-07-15 00:00:00