Tumor necrosis factor alpha induces early morphologic and metabolic alterations in Friend leukemia cell tumors and fibrosarcomas in mice.

abstract：:Although the combination of cisplatin and etoposide has been used as standard therapy for small-cell lung cancer, it is difficult to demonstrate combination effects between cisplatin and etoposide in vitro. We therefore adopted a 3-dimensional (3-D) model to analyze the combination effects of anticancer drugs, and com...

journal_title：International journal of cancer

authors： Kanzawa F,Nishio K,Fukuoka K,Fukuda M,Kunimoto T,Saijo N

更新日期：1997-05-02 00:00:00

abstract：:We investigated the marker profile of human ascitic and cultured mesothelial cells, and compared it to that of ovarian carcinoma cells which are related in terms of their histogenesis, unrelated colon carcinomas being used as reference. Mesothelial and ovarian carcinoma cells could not be distinguished by (intermediat...

journal_title：International journal of cancer

authors： van Niekerk CC,Jap PH,Thomas CM,Smeets DF,Ramaekers FC,Poels LG

更新日期：1989-06-15 00:00:00

abstract：:Socioeconomic status (SES) is a determinant of outcome in various types of cancer. The aim of this study is to analyze the impact of the SES in Hodgkin's lymphoma (HL). From 2001 to 2005, 194 consecutive patients were prospectively followed in 5 institutions. Patients answered a questionnaire with a set of items used ...

journal_title：International journal of cancer

authors： Soares A,Biasoli I,Scheliga A,Luiz RR,Costa MA,Land M,Romano S,Morais JC,Spector N

更新日期：2007-02-15 00:00:00

abstract：:Fresh-frozen biopsies were obtained from 61 patients at diagnosis of squamous cell carcinoma of the head and neck (HNSCC) for study of the prevalence and physical status of human papillomavirus (HPV) DNA. The frequency of HPV DNA and genotypes were determined by SPF10 PCR screening with a general probe hybridization a...

journal_title：International journal of cancer

authors： Koskinen WJ,Chen RW,Leivo I,Mäkitie A,Bäck L,Kontio R,Suuronen R,Lindqvist C,Auvinen E,Molijn A,Quint WG,Vaheri A,Aaltonen LM

更新日期：2003-11-10 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) plays a role as a genome mutator in activated B cells, and inappropriate expression of AID has been implicated in the immunopathological phenotype of human B-cell malignancies. Notably, we found that the transgenic mice overexpressing AID developed lung adenocarcinoma and he...

journal_title：International journal of cancer

authors： Kou T,Marusawa H,Kinoshita K,Endo Y,Okazaki IM,Ueda Y,Kodama Y,Haga H,Ikai I,Chiba T

更新日期：2007-02-01 00:00:00

abstract：:The effect of cyclic phosphatidic acid, a unique analogue of lysophosphatidic acid, on the induction of bombesin-enhanced peritoneal metastases from intestinal adenocarcinomas induced by azoxymethane was investigated in male Wistar rats. Rats were given 10 weekly injections of azoxymethane (7.4 mg/kg body weight, s.c....

journal_title：International journal of cancer

authors： Ishihara R,Tatsuta M,Iishi H,Baba M,Uedo N,Higashino K,Mukai M,Ishiguro S,Kobayashi S,Murakami-Murofushi K

更新日期：2004-06-10 00:00:00

abstract：:We have employed the DNA-mediated gene transfer method to introduce the allogenic major-histocompatibility-complex(MHC)-class-I gene H-2Kb into the K36.16 tumor cells, H-2k, in order to generate tumor-specific immunity. The acquisition of immunogenicity by the H-2Kb-transformed clones following gene transfer is associ...

journal_title：International journal of cancer

authors： Chia KY,Lim SP,Oei AA,Sabapathy TK,Hui KM

更新日期：1994-04-15 00:00:00

abstract：:Prostate-specific antigen (PSA) is a serine protease secreted by prostatic epithelial cells and is widely used as a marker for prostate cancer. The tissue specificity of PSA makes it a potential target for active specific immunotherapy, especially in prostate cancer patients who have undergone prostatectomy and in who...

journal_title：International journal of cancer

authors： Hodge JW,Schlom J,Donohue SJ,Tomaszewski JE,Wheeler CW,Levine BS,Gritz L,Panicali D,Kantor JA

更新日期：1995-10-09 00:00:00

abstract：:A panel of human breast cancer specimens was examined for single base change mutations by DNA sequencing and for larger deletions using a PCR-based assay. In the cancer specimens examined, no sequencing variants were detected other than a previously characterized polymorphism. Although most of the specimens contained ...

journal_title：International journal of cancer

authors： Anandappa SY,Sibson R,Platt-Higgins A,Winstanley JH,Rudland PS,Barraclough R

更新日期：2000-10-15 00:00:00

abstract：:Small-cell-lung-cancer (SCLC) is characterized by rapid development of resistance to cytotoxic agents, such as cisplatin (cDDP) and anthracyclines. c-myc over-expression is one of the reported genetic alterations in this tumor. Amplification of the c-myc gene in this and other cancers is often correlated with poor pro...

journal_title：International journal of cancer

authors： Van Waardenburg RC,Meijer C,Burger H,Nooter K,De Vries EG,Mulder NH,De Jong S

更新日期：1997-11-14 00:00:00

abstract：:There is a familial aggregation of prostate cancer, and 5 to 10% of all prostate cancers are estimated to be inherited in an autosomal-dominant mode. A population-based cohort study was performed in order to study familial prostate cancer and associated malignancies. A nation-wide register cohort study was conducted u...

journal_title：International journal of cancer

authors： Damber L,Grönberg H,Damber JE

更新日期：1998-10-29 00:00:00

abstract：:Women affected by gross cystic disease of the breast have an increased risk of breast cancer. We report here the incidence of breast cancer by cyst type and intracystic epidermal growth factor (EGF) concentration. Our retrospective study included 504 women who had at least 1 cyst aspiration between 1985 and 1993. Cyst...

journal_title：International journal of cancer

authors： Boccardo F,Marenghi C,Ghione G,Pepe A,Parodi S,Rubagotti A

更新日期：2001-07-20 00:00:00

abstract：:We have previously demonstrated that the delta isoform of protein kinase C (PKCdelta) is importantly involved in cell growth inhibition and tumor suppression in colon cancer cells. To investigate further the activity and mechanism of action of PKCdelta, we have retrovirally transduced a PKCdelta cDNA in HCT116 human c...

journal_title：International journal of cancer

authors： Perletti G,Marras E,Dondi D,Osti D,Congiu T,Ferrarese R,de Eguileor M,Tashjian AH Jr

更新日期：2005-01-01 00:00:00

abstract：:Oncogenic PIK3CA mutations contribute to colorectal tumorigenesis by activating AKT signaling to decrease apoptosis and increase tumor invasion. A synergistic association of PIK3CA mutation with KRAS mutation has been suggested to increase AKT signaling and resistance to antiepidermal growth factor receptor inhibitor ...

journal_title：International journal of cancer

authors： Whitehall VL,Rickman C,Bond CE,Ramsnes I,Greco SA,Umapathy A,McKeone D,Faleiro RJ,Buttenshaw RL,Worthley DL,Nayler S,Zhao ZZ,Montgomery GW,Mallitt KA,Jass JR,Matsubara N,Notohara K,Ishii T,Leggett BA

更新日期：2012-08-15 00:00:00

abstract：:T-cell responses have been reported to be impaired in cancer patients, and lymphocytes infiltrating human tumors (T-TIL) appear to be more affected than those in the peripheral blood. T-TIL display a poor proliferative response when compared to peripheral blood T (T-PBL) cells that show a strong response to all stimul...

journal_title：International journal of cancer

authors： Kudoh S,Stanley J,Edinger MG,Tubbs RR,Klein E,Bukowski RM,Finke JH

更新日期：1994-08-01 00:00:00

abstract：:The surface and intracellular expression of mdrI-P-glycoprotein in parental drug-sensitive human breast cancer cells (MCF-7) and their multidrug-resistant (MDR) variants has been studied by using the monoclonal antibodies (MAbs) MM4.17 and MRK-16, which recognize 2 different epitopes of the drug efflux pump molecule. ...

journal_title：International journal of cancer

authors： Molinari A,Cianfriglia M,Meschini S,Calcabrini A,Arancia G

更新日期：1994-12-15 00:00:00

abstract：:The role of IL-33/ST2 pathway in antitumor immunity is unclear. Using 4T1 breast cancer model we demonstrate time-dependent increase of endogenous IL-33 at both the mRNA and protein levels in primary tumors and metastatic lungs during cancer progression. Administration of IL-33 accelerated tumor growth and development...

journal_title：International journal of cancer

authors： Jovanovic IP,Pejnovic NN,Radosavljevic GD,Pantic JM,Milovanovic MZ,Arsenijevic NN,Lukic ML

更新日期：2014-04-01 00:00:00

abstract：:The hedgehog (Hh) signaling pathway is essential for the development of tissues and organs. Hyperactive Hh signaling has been implicated in many gastric cancers, including esophageal cancer. However, the interaction between the Hh pathway and other potential signaling pathways in primary esophageal tumorigenesis has n...

journal_title：International journal of cancer

authors： Wei L,Xu Z

更新日期：2011-07-15 00:00:00

abstract：:Etiological risk factors for proximal (right-sided) colon cancers may be different to those of distal colon and rectal (left-sided) cancers if these tumors develop along distinct pathways. The CpG Island Methylator Phenotype (CIMP+) occurs in approximately 15% of colorectal cancers (CRC) and predominantly in the proxi...

journal_title：International journal of cancer

authors： Iacopetta B,Heyworth J,Girschik J,Grieu F,Clayforth C,Fritschi L

更新日期：2009-07-01 00:00:00

abstract：:It has been demonstrated that the chemopreventive agent N-(4-hydroxyphenyl)retinamide (4-HPR) induces apoptotic cell death, but recent data has suggested that late stage/recurrent tumours lose their response to 4-HPR-induced cell death by mechanisms that are unknown. Our study investigated the ability of 4-HPR to indu...

journal_title：International journal of cancer

authors： Davies M,Paterson IC,Ganapathy A,Prime SS

更新日期：2006-12-15 00:00:00

abstract：:In advanced stages of malignant melanoma (MM), metastases to the CNS are frequently observed. Few results are available on trophic factors and immunological features involved in the process of invasion and adhesion of circulating metastatic cells into the CNS. A direct comparison of remote metastases found in differen...

journal_title：International journal of cancer

authors： Geertsen R,Zenklusen R,Kamarashev J,Burg G,Dummer R

更新日期：1999-09-24 00:00:00

abstract：:Liquid-based cytology (LBC) has replaced conventional cytology (CC) for cervical cancer screening in some countries. However, it remains unclear whether LBC is superior to CC. A randomized controlled trial was conducted between August 2007 and March 2009 in Germany to compare LBC, alone and in combination with compute...

journal_title：International journal of cancer

authors： Klug SJ,Neis KJ,Harlfinger W,Malter A,König J,Spieth S,Brinkmann-Smetanay F,Kommoss F,Weyer V,Ikenberg H

更新日期：2013-06-15 00:00:00

abstract：:Circadian disruption has been classified as probably carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. The circadian clock is subject to environmental factors, particularly light exposure and food intake rhythms. However, the association between nutritional circadia...

journal_title：International journal of cancer

authors： Srour B,Plancoulaine S,Andreeva VA,Fassier P,Julia C,Galan P,Hercberg S,Deschasaux M,Latino-Martel P,Touvier M

更新日期：2018-11-15 00:00:00

abstract：:Trends in incidence rates of cutaneous malignant melanoma in Western Australia from 1975-76 to 1980-1981 have been examined with reference to age, sex, body site, presence or absence of dermal invasion, tumour thickness, histological type, socioeconomic status and occupation. The incidence rates of all melanomas incre...

journal_title：International journal of cancer

authors： English DR,Heenan PJ,Holman CD,Armstrong BK,Blackwell JB,Kelsall GR,Matz LR,Singh A,ten Seldam RE

更新日期：1986-02-15 00:00:00

abstract：:The secretion of antibody by hybridoma cells allows the growth of individual cells to be measured by a hemolytic plaque assay. Similarly, plaque reduction assays were sensitive indicators of tumor immunity. A series of strains of hybridoma have been isolated from an original isolate which is sensitive to cytotoxic T c...

journal_title：International journal of cancer

authors： Ezaki T,Marbrook J

更新日期：1985-01-15 00:00:00

abstract：:Carcinoma of the breast is a leading hormone-dependent malignancy, resulting in a high rate of morbidity and mortality. During the complex multi-step process of tumor promotion, this common cancer is initiated as hormone-responsive (HR), non-metastatic cancer, followed by a gradual transition into a highly metastatic ...

journal_title：International journal of cancer

authors： Xing RH,Rabbani SA

更新日期：1999-05-05 00:00:00

abstract：:Folate is required for biological methylation and nucleotide synthesis, aberrations of which are thought to be the mechanisms that enhance colorectal carcinogenesis produced by folate inadequacy. These functions of folate also depend on the availability of other B-vitamins that participate in "one-carbon metabolism," ...

journal_title：International journal of cancer

authors： Liu Z,Choi SW,Crott JW,Smith DE,Mason JB

更新日期：2008-08-01 00:00:00

abstract：:B-cell chronic lymphocytic leukaemia (B-CLL) cells fail to undergo apoptosis. The mechanism underlying this resistance to cell death is still largely unknown. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) effectively kills tumour cells but not normal cells, and thus represents an attractive tool for...

journal_title：International journal of cancer

authors： Garofalo M,Romano G,Quintavalle C,Romano MF,Chiurazzi F,Zanca C,Condorelli G

更新日期：2007-03-15 00:00:00

abstract：:Mouse and human lymphoid cells were cultivated in the presence of T-cell growth factor (TCGF) and evaluated for their in vivo anti-tumor effect in mice. Cultured spleen cells of normal BALB/c mice or of mice bearing the M109 tumor had a high level of cytotoxic activity in vitro against a variety of tumor target cells ...

journal_title：International journal of cancer

authors： Gorelik E,Kedar E,Sredni B,Herberman R

更新日期：1981-08-15 00:00:00

abstract：:Duodenogastric reflux (DGR) causes glandular stomach carcinogenesis in rats without carcinogens. We aimed to investigate how this carcinogenesis might be prevented by a selective COX-2 inhibitor, meloxicam. A series of 188 Fisher 344 rats underwent a surgical DGR procedure and were divided into 2 groups. One group was...

journal_title：International journal of cancer

authors： Oba M,Miwa K,Fujimura T,Harada S,Sasaki S,Hattori T

更新日期：2008-10-01 00:00:00