RPR-115135, a farnesyltransferase inhibitor, increases 5-FU- cytotoxicity in ten human colon cancer cell lines: role of p53.

abstract：:Breast cancer is heterogeneous in clinical behavior by subtypes; however, it is unclear how this heterogeneity is related to epidemiological factors. To evaluate the differences in epidemiological factors by breast tumor subtypes, we investigated the associations of epidemiological factors between tumor subtypes in Ko...

journal_title：International journal of cancer

authors： Song N,Choi JY,Sung H,Chung S,Song M,Park SK,Han W,Lee JW,Kim MK,Yoo KY,Ahn SH,Noh DY,Kang D

更新日期：2014-08-01 00:00:00

abstract：:Clinical and experimental scintigraphic studies have found that radiolabelled antibodies are not only taken up by tumour(s) but also by normal liver. The accumulation of radionuclides in this organ poses a major problem to the use of radiolabelled antibodies as diagnostic and therapeutic tools. In an attempt to unders...

journal_title：International journal of cancer

authors： Boyle CC,Paine AJ,Mather SJ

更新日期：1992-04-01 00:00:00

abstract：:Microarray analysis of paired cultures of normal and cancerous urothelial cells revealed differences in cytokeratin and adhesion gene expression. Normal cells expressed autocrine growth factor genes more strongly whereas carcinoma cells were distinguished by concomitant expression of urothelial and epidermal different...

journal_title：International journal of cancer

authors： Dokun OY,Florl AR,Seifert HH,Wolff I,Schulz WA

更新日期：2008-12-15 00:00:00

abstract：:Over 10% of children with Wilms tumor (WT) have an underlying cancer predisposition syndrome (CPS). Cognizant of increasing demand for genetic evaluation and limited resources across health care settings, there is an urgent need to rationalize genetic referrals for this population. The McGill Interactive Pediatric Onc...

journal_title：International journal of cancer

authors： Cullinan N,Villani A,Mourad S,Somers GR,Reichman L,van Engelen K,Stephens D,Weksberg R,Foulkes WD,Malkin D,Grant R,Goudie C

更新日期：2020-02-15 00:00:00

abstract：:Cells were isolated from post-radiation fibrosis biopsies of patients with recurrent breast carcinoma. These cells were identified as fibroblasts and compared with fibroblasts from normal breast tissues for their proliferative activities, chromosome number and for the presence of various components of the extracellula...

journal_title：International journal of cancer

authors： Brouty-Boyé D,Raux H,Azzarone B,Tamboise A,Tamboise E,Béranger S,Magnien V,Pihan I,Zardi L,Israël L

更新日期：1991-03-12 00:00:00

abstract：:The effects of a new metalloproteinase inhibitor, BE16627B [L-N-(N-hydroxy-2-isobutylsuccinynamoyl)-seryl-L-valine, MW: 375.2] isolated from microbial cultures, on human tumor cell growth in nude mice were investigated. BE16627B inhibited metalloproteinases in enzyme assays, as well as gelatinolysis and collagenolysis...

journal_title：International journal of cancer

authors： Naito K,Kanbayashi N,Nakajima S,Murai T,Arakawa K,Nishimura S,Okuyama A

更新日期：1994-09-01 00:00:00

abstract：:Androgen deprivation therapy (ADT) remains a key approach in the treatment of prostate cancer (PCa). However, PCa inevitably relapses and becomes ADT resistant. Besides androgens, there is evidence that thyroid hormone thyroxine (T4) and its active form 3,5,3'-triiodo-L-thyronine (T3) are involved in the progression o...

journal_title：International journal of cancer

authors： Aksoy O,Pencik J,Hartenbach M,Moazzami AA,Schlederer M,Balber T,Varady A,Philippe C,Baltzer PA,Mazumder B,Whitchurch JB,Roberts CJ,Haitel A,Herac M,Susani M,Mitterhauser M,Marculescu R,Stangl-Kremser J,Hassler MR,Kr

更新日期：2021-02-01 00:00:00

abstract：:Synchronous gastric carcinomas are found in 4% to 10% of all gastric carcinomas, and the tumor multiplicity is believed to be related to genetic predisposition. To investigate the role of mismatch repair error in synchronous gastric carcinomas, we analyzed the microsatellite instability (MSI) status of 101 cancers fro...

journal_title：International journal of cancer

authors： Lee HS,Lee BL,Kim SH,Woo DK,Kim HS,Kim WH

更新日期：2001-03-01 00:00:00

abstract：:We report that the Rhesus (Rh)-negative phenotype is more prevalent in patients with small-cell lung cancer (SCLC) than in the normal Caucasian population (SCLC: 25% Rh-negative vs. 15% expected, p less than 0.0001). This finding has been validated for a Central and a Northern European population (Switzerland and UK)....

journal_title：International journal of cancer

authors： Cerny T,Fey MF,Oppliger R,Castiglione M,Nachbur B,Gertsch M,Gasser A,Joss RA,Thatcher N,Lind M

更新日期：1992-09-30 00:00:00

abstract：:The transcription factor grainyhead-like 2 (GRHL2) plays a crucial role in various developmental processes. Although GRHL2 recently has attracted considerable interest in that it could be identified as a novel suppressor of the epithelial-to-mesenchymal transition, evidence is emerging that GRHL2 also exhibits tumour-...

journal_title：International journal of cancer

authors： Riethdorf S,Frey S,Santjer S,Stoupiec M,Otto B,Riethdorf L,Koop C,Wilczak W,Simon R,Sauter G,Pantel K,Assmann V

更新日期：2016-02-15 00:00:00

abstract：:The mismatch repair (MMR) genes are involved in the maintenance of genomic integrity. Recently, we showed that common variants in these genes are unlikely to contribute significantly to colorectal cancer risk. The aim of this study was to investigate the role of common variants in the mismatch repair pathway as progno...

journal_title：International journal of cancer

authors： Koessler T,Azzato EM,Perkins B,Macinnis RJ,Greenberg D,Easton DF,Pharoah PD

更新日期：2009-04-15 00:00:00

abstract：:The mechanisms involved in mucosal immune control of cervical human papillomavirus (HPV) infection remain ill defined. Because toll-like receptors (TLRs) are key players in innate immune responses, we investigated the association between TLR expression and viral persistence or clearance in young women with incident in...

journal_title：International journal of cancer

authors： Daud II,Scott ME,Ma Y,Shiboski S,Farhat S,Moscicki AB

更新日期：2011-02-15 00:00:00

abstract：:It is increasingly appreciated that host factors within the tumor center and microenvironment play a key role in dictating colorectal cancer (CRC) outcomes. As a result, the metastatic process has now been defined as a result of epithelial-mesenchymal transition (EMT). Establishment of the role of EMT within the tumor...

journal_title：International journal of cancer

authors： Roseweir AK,Kong CY,Park JH,Bennett L,Powell AGMT,Quinn J,van Wyk HC,Horgan PG,McMillan DC,Edwards J,Roxburgh CS

更新日期：2019-01-01 00:00:00

abstract：:Interleukin-12 (IL-12) is a disulfide-linked p40-p35 heterodimeric cytokine and plays a key role in linking innate cellular immunity to an adaptive Th1 response against pathogens and tumor cells and in counteracting a Th2 immune response. The pathogenesis of Hodgkin's disease (HD) is partially attributed to a Th2 domi...

journal_title：International journal of cancer

authors： Heuser C,Diehl V,Abken H,Hombach A

更新日期：2003-09-10 00:00:00

abstract：:Within the Netherlands Cohort Study on diet and cancer, we investigated associations between total alcohol consumption, specific alcoholic beverage consumption and risk of colorectal cancer (CRC) according to anatomical subsite. Hazard Ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional...

journal_title：International journal of cancer

authors： Bongaerts BW,van den Brandt PA,Goldbohm RA,de Goeij AF,Weijenberg MP

更新日期：2008-11-15 00:00:00

abstract：:TAAs of the MAGE family are mostly studied as targets of specific immune responses. Their potential relevance as tumor markers has also been underlined. We used a MAb, 57B, recognizing MAGE-A4 protein in paraffin-embedded sections, to evaluate its expression in bladder cancers by employing TMA including 2,317 samples ...

journal_title：International journal of cancer

authors： Kocher T,Zheng M,Bolli M,Simon R,Forster T,Schultz-Thater E,Remmel E,Noppen C,Schmid U,Ackermann D,Mihatsch MJ,Gasser T,Heberer M,Sauter G,Spagnoli GC

更新日期：2002-08-20 00:00:00

abstract：:The ganglioside composition of 20 human malignant melanomas and 5 normal tissues (muscle, spleen, kidney, liver and brain) was analyzed by high-performance thin-layer chromatography (HPTLC) and immune HPTLC using a panel of antiganglioside monoclonal antibodies, and quantified by photodensitometry. The most prominent ...

journal_title：International journal of cancer

authors： Hamilton WB,Helling F,Lloyd KO,Livingston PO

更新日期：1993-02-20 00:00:00

abstract：:Loss of heterozygosity (LOH) is an important event of tumorigenesis. In gastric cancer, we found a novel region of LOH in chromosome 9q having about 800 kb deletions at 9q31.1. The microsatellite marker D9S938 in that region exhibiting the highest LOH frequency, 56.5%. In addition, the LOH at 9q31.1 did not show any r...

journal_title：International journal of cancer

authors： Kakinuma N,Kohu K,Sato M,Yamada T,Nakajima M,Akiyama T,Ohwada S,Shibanaka Y

更新日期：2004-03-01 00:00:00

abstract：:Lytically infected EBV-positive lymphoblastoid cells enhance the growth of early-passage, but not late-passage, EBV-immortalized lymphoblastoid cell lines (LCLs) in SCID mice and have enhanced IL-6 secretion. Here, we have examined the importance of IL-6 for the growth of early-passage LCLs (EPL) in SCID mice, identif...

journal_title：International journal of cancer

authors： Jones RJ,Seaman WT,Feng WH,Barlow E,Dickerson S,Delecluse HJ,Kenney SC

更新日期：2007-09-15 00:00:00

abstract：:Heat shock protein (HSP) gp96/grp94 contains a signal peptide at the amino terminus and a -KDEL sequence at the carboxy terminus and is a major component of the lumen of the mammalian endoplasmic reticulum (ER). We show, by a number of immunolocalization methods using light and electron microscopy, that a significant ...

journal_title：International journal of cancer

authors： Altmeyer A,Maki RG,Feldweg AM,Heike M,Protopopov VP,Masur SK,Srivastava PK

更新日期：1996-08-22 00:00:00

abstract：:Serum alkaline DNase activity (SADA) was investigated in rats receiving s.c. transplants of tumor cells sensitive or resistant to chemotherapy. Serum samples from each animal were collected before transplantation, during the development of tumors and after therapy. Within a few days after transplantation of both tumor...

journal_title：International journal of cancer

authors： Economidou-Karaoglou A,Brasseur F,Lans M,Taper HS,Roberfroid MB

更新日期：1989-05-15 00:00:00

abstract：:Serum biomarkers are urgently needed for patient stratification and efficient treatment monitoring in pancreatic cancer (PC). Within a prospective diagnostic observation study, blood samples were obtained from 78 patients with advanced PC before and weekly during the course of palliative chemotherapy. Circulating nucl...

journal_title：International journal of cancer

authors： Wittwer C,Boeck S,Heinemann V,Haas M,Stieber P,Nagel D,Holdenrieder S

更新日期：2013-12-01 00:00:00

abstract：:Biopsies were obtained from 12 patients suspected of having nasopharyngeal carcinoma (NPC). A portion of the tissue was submitted for histopathology and another for Western blotting using a murine monoclonal antibody (MAb), MA6. Touch smears of the tissues were also prepared immediately prior to extraction and Western...

journal_title：International journal of cancer

authors： Yip TC,Chan KH,Choy D,Chan CW,Ng MH

更新日期：1987-04-15 00:00:00

abstract：:Vaccination against oncogenic human papillomavirus (HPV) types is one key intervention for cervical cancer prevention. This follow-up study assessed the persistence of the systemic and mucosal immune responses together with the safety profile of the HPV-16/18 AS04-adjuvanted vaccine administered to young women aged 10...

journal_title：International journal of cancer

authors： Petäjä T,Pedersen C,Poder A,Strauss G,Catteau G,Thomas F,Lehtinen M,Descamps D

更新日期：2011-11-01 00:00:00

abstract：:The mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes a protein that plays a critical role in tumor suppression, in part by modulating bioavailability of a potent mitogen, insulin-like growth factor-2 (IGF2). We tested the hypothesis that the common nonsynonymous genetic variants in M6P/IGF...

journal_title：International journal of cancer

authors： Hoyo C,Schildkraut JM,Murphy SK,Chow WH,Vaughan TL,Risch H,Marks JR,Jirtle RL,Calingaert B,Mayne S,Fraumeni J Jr,Gammon MD

更新日期：2009-12-01 00:00:00

abstract：:Using high-throughput analyses and the TRANSFAC database, we characterized TF signatures of head and neck squamous cell carcinoma (HNSCC) subgroups by inferential analysis of target gene expression, correcting for the effects of DNA methylation and copy number. Using this discovery pipeline, we determined that human p...

journal_title：International journal of cancer

authors： Gaykalova DA,Manola JB,Ozawa H,Zizkova V,Morton K,Bishop JA,Sharma R,Zhang C,Michailidi C,Considine M,Tan M,Fertig EJ,Hennessey PT,Ahn J,Koch WM,Westra WH,Khan Z,Chung CH,Ochs MF,Califano JA

更新日期：2015-10-15 00:00:00

abstract：:To elucidate the individual impacts of insulin and blood glucose on cancer risk, we investigated the association of plasma C-peptide, a surrogated marker of insulin and glycated albumin (GA), a more stable marker of blood glucose, with all-site and site-specific cancer risk by mutually accounting for their confounding...

journal_title：International journal of cancer

authors： Hidaka A,Budhathoki S,Yamaji T,Sawada N,Tanaka-Mizuno S,Kuchiba A,Charvat H,Goto A,Shimazu T,Inoue M,Noda M,Tsugane S,Iwasaki M,JPHC Study Group.

更新日期：2019-02-15 00:00:00

abstract：:Telomerase activity is considered to be a diagnostic marker of malignancy since most malignant cells express this activity and most somatic cells do not. However, the detection of telomerase activity is rather complicated and is affected by many factors. Recently, human telomerase components were cloned and found to c...

journal_title：International journal of cancer

authors： Sumida T,Hamakawa H,Sogawa K,Sugita A,Tanioka H,Ueda N

更新日期：1999-01-05 00:00:00

abstract：:Patients with head-and-neck cancer commonly have immune defects. It was reported that these patients have raised serum IgA levels. We investigated whether IgA-anti-Fab autoantibodies, which occur in association with immune dysfunction, are present in patients with head-and-neck cancer. Sera of 101 patients with squamo...

journal_title：International journal of cancer

authors： Süsal C,Maier H,Lorenz K,Opelz G

更新日期：1994-04-01 00:00:00

abstract：:Evidence suggests that the majority of lung cancer patients have tumour-derived genetic alterations in circulating plasma DNA, and that this may be developed as a diagnostic tool. To this end, we have studied 60 individuals attending bronchoscopy clinic, with symptoms suspicious of lung cancer, for genetic alterations...

journal_title：International journal of cancer

authors： Allan JM,Hardie LJ,Briggs JA,Davidson LA,Watson JP,Pearson SB,Muers MF,Wild CP

更新日期：2001-02-01 00:00:00