Abstract:
:Cell kinetic studies are of interest for clarifying the concepts of chemotherapeutic strategy in the multimodality therapy of advanced squamous-cell carcinoma of the head and neck. A poorly-differentiated squamous-cell carcinoma of the head and neck heterotransplanted to nude mice was used for analyses of chemotherapeutically induced cell cycle perturbations. The heterotransplanted tumour, in its 15th or later passages in nude mice, was treated with either Mitomycin C or cisplatin. After determination of dose-response relationships and toxicity, treated tumours were biopsied at different times and cell cycle distribution pattern, 3HTdR incorporation into DNA, histology and tumour volume were recorded. Mitomycin C and cisplatin gave the same pattern of cell cycle perturbations, although the changes induced by cisplatin were more profound. There was an initial increase of the fraction of cells in the S phase, concomitant with a reduction of the fraction of cells in G0 + G1 phase. When these perturbations were normalized a transient increase of the fraction of cells in G2 + M phase was observed. However, while cisplatin caused an initial transient depression of DNA synthesis, the Mitomycin-C-treated tumours exhibited a short-lasting increase of DNA-synthesis. The maxima of the induced changes in cell cycle phase distribution and DNA-synthesis lasted for only 24-48 h, which may be of importance for scheduling combinations of drugs. Though both drugs induced profound changes in tumour volume growth and cell kinetics, there was no change in the histopathological picture of the treated tumours. Routine histopathological examination is thus not likely to be of value evaluating the effect of chemotherapy.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Wennerberg J,Alm P,Biörklund A,Killander D,Långström E,Tropé Cdoi
10.1002/ijc.2910330209subject
Has Abstractpub_date
1984-02-15 00:00:00pages
213-22issue
2eissn
0020-7136issn
1097-0215journal_volume
33pub_type
杂志文章abstract::Paclitaxel exerts its cytotoxic effect by kinetic suppression of microtubules that block cells in the G2/M phase of the cell cycle and trigger apoptosis. To investigate apoptosis induced by paclitaxel in nasopharyngeal carcinoma (NPC), and its possible molecular mechanism of action, the human NPC cell lines HNE-1 (bea...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1591
更新日期:2002-01-10 00:00:00
abstract::The selective targets for HTLV-III/LAV, the causal infectious agent of AIDS and AIDS-related complex (ARC), are T4 cells, apparently because the virus receptor is associated with T4 antigen determinants. This accounts for T4 cell depletion in AIDS and for a decrease of IL-2 production by AIDS peripheral blood lymphocy...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910380507
更新日期:1986-11-15 00:00:00
abstract::The stroma of ductal infiltrating carcinoma of the human breast shows characteristic and localized areas of collagen rarefaction and fragmentation. This finding has been correlated with a peculiar type of fibrillar damage, observed in a small percentage of collagen fibrils isolated in the native state from the tumour ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390510
更新日期:1987-05-15 00:00:00
abstract::A substantial proportion of women with cervical cancer that have participated in cervical screening have a history of an abnormal cytology result. Our objective was to assess the impact of histological investigation and treatment of women with abnormal cytology on the subsequent risk of invasive cervical cancer. All i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25749
更新日期:2011-09-15 00:00:00
abstract::Electroporation-based mono-gene therapy has received great interest in recent years but coadministration of different therapeutic genes for treatment of tumors has not been well explored. We hypothesize that electroporation is capable of delivering multiple genes that induce an additive or synergistic antitumor effect...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22100
更新日期:2006-11-01 00:00:00
abstract::Tumour cell anaerobic metabolism has been reported to be a prognostic factor in colorectal cancer. The present study investigated the association between monocarboxylate transporter (MCT) 1, MCT 2, lactate dehydrogenase (LDH) 1 and LDH 5, the tumour microenvironment, and outcome in patients with colorectal cancer. A c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32045
更新日期:2019-05-01 00:00:00
abstract::Myf-3 is the human homologue of the murine Myo-D1 gene involved in muscle-cell differentiation. Using Southern blot analysis, we examined methylation of Myf-3 in histologically normal colonic mucosae, adenomas and carcinomas from a large series of patients with primary colorectal cancer. Hypermethylation of this gene ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990420)84:2<109::aid-ijc
更新日期:1999-04-20 00:00:00
abstract::Overuse of antibiotic drugs alters the composition of gut microbiota and has detrimental effects on the host. In our study, we investigated association of gut flora and antibiotics in the prognosis of patients with liver cancer who have undergone chemotherapy by analyzing two independent clinical studies. We retrospec...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32339
更新日期:2019-11-15 00:00:00
abstract::In order to examine whether or not the expression of the apoptosis-related receptor Fas (CD-95/APO-1) and its ligand (FasL) has relevance for patient survival, immunohistochemistry was used to analyze the proteins of both factors in 164 non-small cell lung carcinomas. Patients with Fas-positive tumors exhibited signif...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990621)84:3<239::aid-ijc
更新日期:1999-06-21 00:00:00
abstract::W/Fu rats were injected subcutaneously with low numbers of cells from the Gross leukemia virus-induced lymphoma, (C58NT)D, which induced transient tumor growth and regression (regressors), or with high numbers of tumor cells resulting in progressive tumor growth (progressors). Spleen cells from regressors had a signif...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910160305
更新日期:1975-09-15 00:00:00
abstract::Human papillomavirus (HPV)-associated penile lesions in men may increase the risk of HPV transmission to their female partners. Risk factor data on HPV-associated penile lesions are needed from regions with a high burden of cervical cancer. Visual inspection of the penis was conducted using a colposcope at the 24-mont...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26196
更新日期:2012-04-15 00:00:00
abstract::Immunotherapy targeting programmed cell death-1 (PD-1) has become a standard pharmacological therapy. Although tumor mutation burden level was reported to depend on the tumor location in nonsmall cell lung cancer (NSCLC), predictive impact of the tumor location on the response to anti-PD-1 therapy is unknown. Two hund...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33030
更新日期:2020-10-15 00:00:00
abstract::Intracellular thiols have been proposed as mediators of resistance to alkylating agents and cisplatin. As metallothionein is the predominant protein thiol, we examined its relationship to cisplatin resistance in human ovarian cancer cell lines. A human ovarian carcinoma cell line, A2780, derived from an untreated pati...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450306
更新日期:1990-03-15 00:00:00
abstract::Serum samples from feral populations of African green monkeys (Cercopithecus aethiops) were screened for antibodies to the simian T-lymphotropic virus, type I (STLV-I). Blood samples had been collected from 336 monkeys in 4 regions of central and southern Kenya in 1978 and 1979, from 114 monkeys in central Ethiopia in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910380412
更新日期:1986-10-15 00:00:00
abstract::WAVE3, an actin cytoskeleton remodeling protein, is highly expressed in advanced stages of breast cancer and influences tumor cell invasion. Loss of miR-31 has been associated with cancer progression and metastasis. Here, we show that the activity of WAVE3 to promote cancer cell invasion is regulated by miR-31. An inv...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25793
更新日期:2011-09-15 00:00:00
abstract::It is considered that fruit and vegetable (F&V) protect against oesophagus and gastric cancer (GC). However, 2 recent meta-analyses suggest that the strength of association on GC seems to be weaker for vegetables than for fruit and weaker in cohort than in case-control studies. No evidence exists from cohort studies a...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.21678
更新日期:2006-05-15 00:00:00
abstract::Prostate cancer is an extremely heterogeneous disease; patients that do progress to late-stage metastatic prostate cancer have limited treatment options, mostly palliative. Molecules involved in the metastatic cascade may prove beneficial in stratifying patients to assign appropriate treatment modalities and may also ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28204
更新日期:2013-10-15 00:00:00
abstract::Although a screening program for gastric cancer, using barium X-ray examination, has been carried out widely in Japan for the past 3 decades, there is insufficient evidence to confirm its effectiveness in terms of reducing mortality. To evaluate the effectiveness of the screening, a population-based case-control study...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600106
更新日期:1995-01-03 00:00:00
abstract::This article has been retracted at the request of: Editor-in-Chief and Co-author 'Restoring sensitivity to oxaliplatin by a novel approach in gemcitabine-resistant pancreatic cancer cells in vitro and in vivo' by Banerjee, S., Kong, D., Azmi, A. S., Wang, Z., Ahmad, A., Sethi, S. and Sarkar, F. H. The above article, p...
journal_title:International journal of cancer
pub_type: 杂志文章,撤回出版物
doi:10.1002/ijc.30271
更新日期:2016-11-01 00:00:00
abstract::Chromosome 17 is a frequent target during breast-cancer formation and progression. It has been shown to be affected by allele losses at multiple sites, as well as by DNA amplification. Our aim was to delineate a map of the genetic alterations on chromosome 17 in a given set of breast tumors. To this end we analyzed 15...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560208
更新日期:1994-01-15 00:00:00
abstract::Data from a series of case-control studies, conducted in Italy and Switzerland between 1991 and 2001, have been analyzed to evaluate the role of n-3 polyunsaturated fatty acid (PUFA) intake in the etiology of cancer of oral cavity and pharynx (736 cases, 1772 controls), esophagus (395 cases, 1066 controls), large bowe...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11018
更新日期:2003-05-20 00:00:00
abstract::The in vitro sponge-gel-supported three-dimensional histoculture chemosensitivity assay (Hoffman assay) allows the in vivo-like culture of human tumors. In this study, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H tetrazolium bromide (MTT) end point was applied to the Hoffman assay in an attempt to increase in vitr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910510325
更新日期:1992-05-28 00:00:00
abstract::Obesity is associated with an increased risk of fatal prostate cancer. We aimed to elucidate the importance and relevant timing of obesity and weight change for prostate cancer progression. We identified 5,158 men diagnosed with localized prostate cancer (clinical stage T1/T2) from 1986 to 2012 in the Health Professio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30803
更新日期:2017-09-01 00:00:00
abstract::Langerhans' cells (LCs) are thought to play an important role in presentation of tumour antigens for the induction of anti-tumour immunity. Epidermis overlying some transplanted murine skin tumours contains increased numbers of LCs; however, alterations in LC numbers are not related to tumour antigenicity or host immu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980119)75:2<210::aid-ijc
更新日期:1998-01-19 00:00:00
abstract::Risk factors for pancreatic cancer, other than smoking and diabetes, are not well-established, especially for women. In a cohort of 1.3 million middle-aged women, followed for 9.2 million person-years for cancer incidence and 11.5 million person-years for mortality, there were 1,338 incident pancreatic cancer cases an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24196
更新日期:2009-05-15 00:00:00
abstract::Epithelial ovarian cancer is the most lethal gynecological malignancy and the fifth leading cause of cancer deaths in women in the Western world. ETS transcription factors are known to act as positive or negative regulators of the expression of genes that are involved in various biological processes, including those t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26148
更新日期:2012-04-01 00:00:00
abstract::In chronic lymphocytic leukemia (CLL) cells, both interleukin-6 (IL-6) and the B-cell receptor (BCR) activate Janus kinase 2 (JAK2) and induce the phosphorylation of signal transduction and activator of transcription 3 (STAT3) on tyrosine 705 residues. However, whereas IL-6 phosphorylates STAT3 within 15 min, stimulat...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30892
更新日期:2017-11-15 00:00:00
abstract::The correlation between tumorigenicity and cell-surface adhesiveness was investigated in eight mouse fibroblastoid cell lines. Four of the lines (Mc 11-Mc 15) were derived from mouse MC-induced fibrosarcomas, two were derivatives of L cells (A9, A9HT), and two (clone 3 and clone 7 H7F4) were obtained by fusion of A9HT...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910230318
更新日期:1979-03-15 00:00:00
abstract::CD30 is selectively expressed on the tumor cells of a variety of malignant disorders of the immune system and can therefore be used as a target for an anti-CD30 antibody-based immunotherapy. However, CD30 is cleaved at the cell surface by tumor necrosis factor-alpha converting enzyme (TACE). This metalloproteinase rel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10182
更新日期:2002-03-10 00:00:00
abstract::Powerful analytical tools are vital for characterizing the complex molecular changes underlying oncogenesis and cancer treatment. This is particularly true, if information is to be collected in vivo by noninvasive approaches. In the recent past, hyperpolarized (13)C magnetic resonance (MR) spectroscopy has been employ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25072
更新日期:2010-08-01 00:00:00