Abstract:
:Menopausal hormone therapy (HT) may influence colorectal cancer risk. A total of 136,275 postmenopausal women from the European Prospective Investigation into Cancer and Nutrition were followed for an average of 9 years, during which time 1,186 colorectal cancers were diagnosed. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models stratified by center and age, and adjusted for body mass index, smoking, diabetes, physical activity and alcohol consumption. Compared to never use of HT at study enrollment, current use of estrogen-only (HR, 1.02; 95% CI, 0.79-1.31) or estrogen plus progestin (HR, 0.94; 95% CI, 0.77-1.14) was not significantly associated with the risk of colorectal cancer, and these associations did not vary by recency, duration, route of administration, regimen or specific constituent of HT. Our results show no significant association of estrogen-only or estrogen plus progestin therapy with colorectal cancer risk.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Tsilidis KK,Allen NE,Key TJ,Sanjoaquin MA,Bakken K,Berrino F,Fournier A,Lund E,Overvad K,Olsen A,Tjønneland A,Byrnes G,Chajes V,Rinaldi S,Boutron-Ruault MC,Clavel-Chapelon F,Chang-Claude J,Kaaks R,Bergmann M,Boeingdoi
10.1002/ijc.25504subject
Has Abstractpub_date
2011-04-15 00:00:00pages
1881-9issue
8eissn
0020-7136issn
1097-0215journal_volume
128pub_type
杂志文章,多中心研究abstract::Low levels of anti-viral activity, mainly interferon alpha/beta (IFN-alpha/beta), are regularly found in lymphoid tissues of BALB/c mice infected with the C3H strain of mammary tumor virus. At the time of tumor development, significant amounts of anti-viral activity were detected in homogenates of spleen and mammary t...
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