abstract：:Reduced nigrostriatal uptake on N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-[123I]iodophenyl) nortropane (123I-FP-CIT) SPECT reflects dopamine dysfunction, while other imaging markers could be complementary when used together. We assessed how well 123I-FP-CIT SPECT differentiates dementia with Lewy bodies (DLBs) from Alz...

journal_title：Neurobiology of aging

authors： Miyagawa T,Przybelski SA,Maltais D,Min HK,Jordan L,Lesnick TG,Chen Q,Graff-Radford J,Jones D,Savica R,Knopman D,Petersen R,Kremers WK,Forsberg LK,Fields JA,Ferman TJ,Allen L,Parisi J,Reichard RR,Murray M,Dickson D

更新日期：2020-12-15 00:00:00

abstract：:The aim of this study is to investigate the relationship between aging and brain vasculature health. Three groups of mice, 3, 17-18, and 24 months, comparable to young adult, middle age, and old human were studied. Prussian blue histology and fast imaging with steady precession T2∗-weighted magnetic resonance imaging ...

journal_title：Neurobiology of aging

authors： Wang Y,Taylor E,Zikopoulos B,Seta F,Huang N,Hamilton JA,Kantak KM,Morgan KG

更新日期：2020-12-09 00:00:00

abstract：:Patients with posterior cortical atrophy (PCA-AD) show more severe visuospatial and perceptual deficits than those with typical AD (tAD). The aim of this study was to investigate whether functional alterations measured by electroencephalography can help understand the mechanisms that explain this clinical heterogeneit...

journal_title：Neurobiology of aging

authors： Briels CT,Eertink JJ,Stam CJ,van der Flier WM,Scheltens P,Gouw AA

更新日期：2020-12-01 00:00:00

abstract：:One major pathological process in Alzheimer's disease is mediated by hyperphosphorylated tau, which includes altered microtubules (MTs) and functions associated with tau. A potential way to compensate for altered MT function is to use an MT stabilizer, such as epothilone D (EpoD). Previous studies have demonstrated im...

journal_title：Neurobiology of aging

authors： Guo B,Huang Y,Gao Q,Zhou Q

更新日期：2020-12-01 00:00:00

abstract：:The levels of tau phosphorylation differ between sexes in Alzheimer's disease (AD). Transcriptome-wide associations of sex by disease interaction could indicate whether specific genes underlie sex differences in tau pathology; however, no such study has been reported yet. We report the first analysis of the effect of ...

journal_title：Neurobiology of aging

authors： Cáceres A,González JR

更新日期：2020-12-01 00:00:00

abstract：:Fractal dimensionality (FD) measures the complexity within the folds and ridges of cortical and subcortical structures. We tested the degree that FD might provide a new perspective on the atrophy-compensation hypothesis: age or disease-related atrophy causes a compensatory neural response in the form of increased brai...

journal_title：Neurobiology of aging

authors： McDonough IM,Madan CR

更新日期：2020-11-14 00:00:00

abstract：:The complement system has been shown to have a critical pathogenetic role in amyotrophic lateral sclerosis (ALS). Recently a C7 variant in rs3792646 was linked to neurodegenerative diseases in a Chinese population. We used whole exome sequencing to evaluate the role of C7 (rs3792646) in ALS in a Chinese cohort with 19...

journal_title：Neurobiology of aging

authors： He J,Fu J,Fan D

更新日期：2020-11-13 00:00:00

abstract：:White matter hyperintensities (WMH) are generally considered to be associated with cerebral small vessel disease, especially, in older age. Although significant sex differences have been reported in the severity of WMH, it is not yet known if the risk factors for WMH differ in men and women. In this study, magnetic re...

journal_title：Neurobiology of aging

authors： Alqarni A,Jiang J,Crawford JD,Koch F,Brodaty H,Sachdev P,Wen W

更新日期：2020-11-10 00:00:00

abstract：:Cerebral small vessel disease (SVD) and inflammation are increasingly recognized as key contributors to Alzheimer's disease (AD), although the timing, trajectory, and relation between them early in the disease process is unclear. Therefore, to investigate very early-stage changes, we compared 158 healthy midlife adult...

journal_title：Neurobiology of aging

authors： Low A,Su L,Stefaniak JD,Mak E,Dounavi ME,Muniz-Terrera G,Ritchie K,Ritchie CW,Markus HS,O'Brien JT

更新日期：2020-11-02 00:00:00

abstract：:Age-related macular degeneration (AMD) has been linked to memory deficits, with no established neural mechanisms. We collected resting-state brain functional magnetic resonance imaging and standardized verbal recall tests from 42 older adults with AMD and 41 age-matched controls. We used seed-based whole brain analysi...

journal_title：Neurobiology of aging

authors： Zuo X,Zhuang J,Chen NK,Cousins S,Cunha P,Lad EM,Madden DJ,Potter G,Whitson HE

更新日期：2020-11-01 00:00:00

abstract：:Cerebral cortex thinning and cerebral blood flow (CBF) reduction are typically observed during normal healthy aging. However, imaging-based age prediction models have primarily used morphological features of the brain. Complementary physiological CBF information might result in an improvement in age estimation. In thi...

journal_title：Neurobiology of aging

authors： MacDonald ME,Williams RJ,Rajashekar D,Stafford RB,Hanganu A,Sun H,Berman AJL,McCreary CR,Frayne R,Forkert ND,Pike GB

更新日期：2020-11-01 00:00:00

abstract：:Synaptic failure underlies cognitive impairment in Alzheimer's disease (AD). Cumulative evidence suggests a strong link between mitochondrial dysfunction and synaptic deficits in AD. We previously found that oligomycin-sensitivity-conferring protein (OSCP) dysfunction produces pronounced neuronal mitochondrial defects...

journal_title：Neurobiology of aging

authors： Gauba E,Sui S,Tian J,Driskill C,Jia K,Yu C,Rughwani T,Wang Q,Kroener S,Guo L,Du H

更新日期：2020-10-16 00:00:00

abstract：:Damaged mitochondria may be one of the earliest manifestations of Alzheimer's disease. Because oxidative phosphorylation is a primary source of neuronal energy, unlike glycolysis-dependent energy production in inflamed glia, mitochondrial respiration could provide a selective biomarker of neuronal deterioration in Alz...

journal_title：Neurobiology of aging

authors： Barron AM,Ji B,Fujinaga M,Zhang MR,Suhara T,Sahara N,Aoki I,Tsukada H,Higuchi M

更新日期：2020-10-01 00:00:00

abstract：:APOE-ε4 is a major genetic risk factor for late-onset Alzheimer's disease that interacts with other risk factors, but the nature of such combined effects remains poorly understood. We quantified the impact of APOE-ε4, family history (FH) of dementia, and obesity on white matter (WM) microstructure in 165 asymptomatic ...

journal_title：Neurobiology of aging

authors： Mole JP,Fasano F,Evans J,Sims R,Hamilton DA,Kidd E,Metzler-Baddeley C

更新日期：2020-10-01 00:00:00

abstract：:In the present study, we aim at investigating whether education modulates dynamical properties of time-varying whole-brain network connectivity (the chronnectome) in frontotemporal dementia (FTD) at a given level of symptom severity. Dynamic connectivity parameters were evaluated in 128 patients with FTD using indepen...

journal_title：Neurobiology of aging

authors： Premi E,Cristillo V,Gazzina S,Benussi A,Alberici A,Cotelli MS,Calhoun VD,Iraji A,Magoni M,Cotelli M,Micheli A,Gasparotti R,Padovani A,Borroni B

更新日期：2020-09-01 00:00:00

abstract：:A circular-transcriptome-wide study has recently linked differential expression of circular RNAs (circRNAs) in brain tissue with Alzheimer's disease (AD). We aimed at replicating the major findings in an independent series of sporadic and familial AD. We also included cases with frontotemporal lobar degeneration (FTLD...

journal_title：Neurobiology of aging

authors： Cervera-Carles L,Dols-Icardo O,Molina-Porcel L,Alcolea D,Cervantes-Gonzalez A,Muñoz-Llahuna L,Clarimon J

更新日期：2020-08-01 00:00:00

abstract：:During aging, lifestyle-related factors shape the brain's response to insults and modulate the progression of neurodegenerative pathologies such as Alzheimer's disease (AD). This is the case for chronic hyperglycemia associated with type 2 diabetes, which reduces the brain's ability to handle the neurodegenerative bur...

journal_title：Neurobiology of aging

authors： Ferreiro E,Lanzillo M,Canhoto D,Carvalho da Silva AM,Mota SI,Dias IS,Ferreira IL,Fontes AR,Mastrella G,Pinheiro P,Valero J,Rego AC

更新日期：2020-08-01 00:00:00

abstract：:GRN mutations are frequent causes of familial frontotemporal degeneration. Although there is no clear consensual threshold, plasma progranulin levels represent an efficient biomarker for predicting GRN mutations when decreased. We evaluated plasma levels to determine whether it could also predict age at onset, clinica...

journal_title：Neurobiology of aging

authors： Sellami L,Rucheton B,Ben Younes I,Camuzat A,Saracino D,Rinaldi D,Epelbaum S,Azuar C,Levy R,Auriacombe S,Hannequin D,Pariente J,Barbier M,Boutoleau-Bretonnière C,Couratier P,Pasquier F,Deramecourt V,Sauvée M,Sarazin M

更新日期：2020-07-01 00:00:00

abstract：:The adaption of movement to changes in the environment varies across life span. Recent evidence has linked motor adaptation and its reduction with age to differences in "explicit" learning processes. We examine differences in brain structure and cognition underlying motor adaptation in a population-based cohort (n = 3...

journal_title：Neurobiology of aging

authors： Wolpe N,Ingram JN,Tsvetanov KA,Henson RN,Wolpert DM,Cam-CAN.,Rowe JB

更新日期：2020-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia and, despite decades of effort, there is no effective treatment. In the last decade, many association studies have identified genetic markers that are associated with AD status. Two of these studies suggest that an epistatic interaction between variants rs1...

journal_title：Neurobiology of aging

authors： Vance E,Gonzalez Murcia JD,Miller JB,Alzheimer's Disease Genetics Consortium (ADGC).,Staley L,Crane PK,Mukherjee S,Kauwe JSK

更新日期：2020-05-01 00:00:00

abstract：:Progranulin plays an important role in neuroinflammation in Alzheimer's disease (AD) pathophysiology, being upregulated by activated microglia. This study assessed whether cerebrospinal fluid levels of progranulin correlated with structural neuroimaging measures and cognition in 122 cognitively normal individuals, 81 ...

journal_title：Neurobiology of aging

authors： Batzu L,Westman E,Pereira JB,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2020-04-01 00:00:00

abstract：:We examined whether cognitive reserve (CR) impacts level of, or rate of change in, biomarkers of Alzheimer's disease (AD) and small-vessel cerebrovascular disease in >250 individuals who were cognitively normal and middle-aged and older at the baseline. The four primary biomarker categories commonly examined in studie...

journal_title：Neurobiology of aging

authors： Pettigrew C,Soldan A,Zhu Y,Cai Q,Wang MC,Moghekar A,Miller MI,Singh B,Martinez O,Fletcher E,DeCarli C,Albert M

更新日期：2020-04-01 00:00:00

abstract：:Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are the 2 most common causes of dementia. We compared the regional metabolism on 18F-fluorodeoxyglucose positron emission tomography (PET) among 21 control subjects and cognitively impaired patients due to DLB (N = 63) and AD (N = 38). All participants under...

journal_title：Neurobiology of aging

authors： Ye BS,Lee S,Yoo H,Chung SJ,Lee YH,Choi Y,Lee PH,Sohn YH,Yun M

更新日期：2020-03-01 00:00:00

abstract：:Accumulating evidence suggests that the propagation of hyperphosphorylation of tau protein and the amyloid-β peptide can be mediated by extracellular vesicles (EVs) and be associated with the onset and the progression of Alzheimer's disease (AD). As EVs may transfer between the brain and the blood, we have thus hypoth...

journal_title：Neurobiology of aging

authors： Perrotte M,Haddad M,Le Page A,Frost EH,Fulöp T,Ramassamy C

更新日期：2020-02-01 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS), a noninvasive brain stimulation technique, has emerged as a promising treatment for mild cognitive impairment (MCI) and Alzheimer's disease (AD). Currently, however, the effectiveness of this therapy is unclear because of the low statistical power and heterogeneity ...

journal_title：Neurobiology of aging

authors： Chou YH,Ton That V,Sundman M

更新日期：2020-02-01 00:00:00

abstract：:A promising intervention for Alzheimer's disease (AD) would ideally target key pathological factors that are involved in AD pathogenesis. Soluble factors produced by engrafted mesenchymal stem cells (MSCs) mediate potential therapeutic effects in AD. However, these therapeutic benefits are largely hampered by the limi...

journal_title：Neurobiology of aging

authors： Li A,Zhao J,Fan C,Zhu L,Huang C,Li Q,Gan D,Wen C,Chen M,Lu D

更新日期：2020-02-01 00:00:00

abstract：:Recently, a mutation in NUS1 has been reported to be associated with Parkinson's disease (PD) in a Chinese population. To further investigate the relationship between NUS1 and sporadic PD, we sequenced all exons and exon-intron boundaries of NUS1 in Chinese Han population including 494 PD patients and 478 healthy cont...

journal_title：Neurobiology of aging

authors： Chen X,Xiao Y,Zhou M,Lin Y,Guo W,Huang S,Qiu J,Peng G,Mo M,Li Z,Zhu X,Xu P

更新日期：2020-02-01 00:00:00

abstract：:Variants in exon 4 of gene encoding GLT8D1 (glycosyltransferase 8 domain containing 1) gene have recently been suggested as a novel cause of amyotrophic lateral sclerosis (ALS). In addition, there is a synergism between GLT8D1 and ARPP21 (cAMP Regulated Phosphoprotein 21) variants for ALS. However, this observation ha...

journal_title：Neurobiology of aging

authors： Li W,Liu Z,Sun W,Yuan Y,Hu Y,Ni J,Jiao B,Fang L,Li J,Shen L,Tang B,Wang J

更新日期：2020-01-01 00:00:00

abstract：:DNA methylation is an important regulatory mechanism of Parkinson's disease (PD). To investigate the relationship between DNA methylation and hydroxymethylation genes and PD, we performed gene-targeted sequencing using molecular inversion probes in a Chinese PD population. We sequenced 12 genes related to DNA methylat...

journal_title：Neurobiology of aging

authors： Shu L,Qin L,Min S,Pan H,Zhong J,Guo J,Sun Q,Yan X,Chen C,Tang B,Xu Q

更新日期：2019-12-01 00:00:00

abstract：:Decline in fluid abilities in normal aging is associated with increased white matter lesions, measured on T1-weighted images as white matter signal abnormalities (WMSAs). WMSAs are particularly evident in hypertensive older adults, suggesting vascular involvement. However, because hypertension is assessed systemically...

journal_title：Neurobiology of aging

authors： Tan CH,Low KA,Chiarelli AM,Fletcher MA,Navarra R,Burzynska AZ,Kong TS,Zimmerman B,Maclin EL,Sutton BP,Gratton G,Fabiani M

更新日期：2019-12-01 00:00:00

abstract：:The associations of 4 proteins-AK4, ITPK1, HSPB2, and IGFBP5-with cognitive function in older adults were largely unexplained by known brain pathologies. We examined the extent to which individual protein associations with cognitive decline were attributable to microstructural changes in the brain. This study included...

journal_title：Neurobiology of aging

authors： Kim N,Yu L,Dawe R,Petyuk VA,Gaiteri C,De Jager PL,Schneider JA,Arfanakis K,Bennett DA

更新日期：2019-12-01 00:00:00

abstract：:A key question for the design of clinical trials for Alzheimer's disease (AD) is whether the timing of conversion from mild cognitive impairment (MCI) to AD can be predicted. This is also an important question for the clinical management of MCI. This study aims to address this question by exploring the contribution of...

journal_title：Neurobiology of aging

authors： Tabatabaei-Jafari H,Shaw ME,Walsh E,Cherbuin N,Alzheimer's Disease Neuroimaging Initiative (ADNI).

更新日期：2019-11-01 00:00:00

abstract：:The perimenopausal transition at middle age is often associated with hot flashes and sleep disruptions, metabolic changes, and other symptoms. Whereas the mechanisms for these processes are incompletely understood, both aging (AG) and a loss of ovarian estrogens play contributing roles. Furthermore, the timing of when...

journal_title：Neurobiology of aging

authors： Yin W,Borniger JC,Wang X,Maguire SM,Munselle ML,Bezner KS,Tesfamariam HM,Garcia AN,Hofmann HA,Nelson RJ,Gore AC

更新日期：2019-11-01 00:00:00

abstract：:Transcranial electrical stimulation (tES) is a potentially viable tool for boosting cognitive performance in aging. However, most knowledge on tES effects is based on studies involving young adults. Here, we applied tES (transcranial random noise stimulation [tRNS] as an effective stimulation and anodal transcranial d...

journal_title：Neurobiology of aging

authors： Fertonani A,Pirulli C,Bollini A,Miniussi C,Bortoletto M

更新日期：2019-10-01 00:00:00

abstract：:Transcranial magnetic stimulation may represent an effective means for improving motor function in the elderly. The aim of this study was therefore to investigate the effects of paired associative stimulation (PAS; a plasticity-inducing transcranial magnetic stimulation paradigm) on acquisition of a novel visuomotor t...

journal_title：Neurobiology of aging

authors： Opie GM,Hand BJ,Coxon JP,Ridding MC,Ziemann U,Semmler JG

更新日期：2019-09-01 00:00:00

abstract：:Variants associated with modulation of c-reactive protein (CRP) and plasma lipids have been investigated for polygenic overlap with Alzheimer's disease risk variants. We examined pleiotropic genetic effects on cognitive impairment conditioned on genetic variants (SNPs) associated with systemic inflammation as measured...

journal_title：Neurobiology of aging

authors： Lutz MW,Casanova R,Saldana S,Kuchibhatla M,Plassman BL,Hayden KM

更新日期：2019-08-01 00:00:00

abstract：:The abnormal proliferation and neurogenesis of neural progenitor cells (NPCs) is usually associated with the pathophysiology of neurodegenerative disorders such as Alzheimer's disease (AD). Mitochondrial stress is one of the most prominent features of AD and is thought to be involved in the impairment of the neurogene...

journal_title：Neurobiology of aging

authors： Huang S,Cao X,Zhou Y,Shi F,Xin S,He S,An Y,Gao L,Yang Y,Yu B,Pei G

更新日期：2019-08-01 00:00:00

abstract：:Age-related hearing loss (or presbyacusis) is a progressive pathophysiological process. This study addressed the hypothesis that degeneration/dysfunction of multiple nonsensory cell types contributes to presbyacusis by evaluating tissues obtained from young and aged CBA/CaJ mouse ears and human temporal bones. Ultrast...

journal_title：Neurobiology of aging

authors： Liu T,Li G,Noble KV,Li Y,Barth JL,Schulte BA,Lang H

更新日期：2019-08-01 00:00:00

abstract：:Mitophagy and mitochondrial biogenesis are 2 pathways that regulate mitochondrial content and metabolism maintaining cellular homeostasis. The imbalance between these opposing processes impairs mitochondrial function and is suggested to be the pathophysiological basis of a variety of neurodegenerative diseases and agi...

journal_title：Neurobiology of aging

authors： Xiong H,Chen S,Lai L,Yang H,Xu Y,Pang J,Su Z,Lin H,Zheng Y

更新日期：2019-07-01 00:00:00

abstract：:Alertness is fundamental for the efficiency of information processing. A person's level of alertness refers to the system's state of general responsiveness and can be temporarily increased by presenting a neutral warning cue shortly before an event occurs (Posner and Petersen, 1990). However, effects of alerts on subs...

journal_title：Neurobiology of aging

authors： Wiegand I,Sander MC

更新日期：2019-07-01 00:00:00