Age-related changes in cortical connectivity influence the neuromodulatory effects of transcranial electrical stimulation.

abstract：:Exercise has emerged as a powerful variable that can improve cognitive function and delay age-associated cognitive decline and Alzheimer's disease (AD); however, the underlying mechanisms are poorly understood. To determine if protective mechanisms may occur at the transcriptional level, we used microarrays to investi...

journal_title：Neurobiology of aging

authors： Berchtold NC,Prieto GA,Phelan M,Gillen DL,Baldi P,Bennett DA,Buchman AS,Cotman CW

更新日期：2019-06-01 00:00:00

abstract：:The goal of this experiment was to determine the correlations among different behavioral and neurobiological measures in aged rats. Aged Sprague-Dawley rats were given a battery of cognitive and sensorimotor tests, followed by electrophysiological assessment of sleep and biochemical measurements of various neurotransm...

journal_title：Neurobiology of aging

authors： Markowska AL,Stone WS,Ingram DK,Reynolds J,Gold PE,Conti LH,Pontecorvo MJ,Wenk GL,Olton DS

更新日期：1989-01-01 00:00:00

abstract：:Nonhuman primates (NHPs) are useful for the study of age-associated changes in the brain as a model that is biologically closely related to humans. For example, with age, all NHPs analyzed to date, develop β-amyloid (Aβ) plaques as seen in humans. Nevertheless, it is still unclear if NHPs have human-like age-associate...

journal_title：Neurobiology of aging

authors： Yue F,Lu C,Ai Y,Chan P,Zhang Z

更新日期：2014-07-01 00:00:00

abstract：:Amnestic mild cognitive impairment (aMCI) is accompanied by the accelerated cognitive decline and rapid brain degeneration with aging. However, the age-related alterations of the topological organization of the brain connectome in aMCI patients remained largely unknown. In this study, we constructed the brain structur...

journal_title：Neurobiology of aging

authors： Zhao T,Sheng C,Bi Q,Niu W,Shu N,Han Y

更新日期：2017-11-01 00:00:00

abstract：:We evaluated the autophagy-lysosomal pathway and membrane fluidity in brain cells and mitochondrial membranes obtained from senescence-accelerated (SAMP(8)) and senescence-resistant (SAMR(1)) mice at 5 and 10 months of age. Moreover, we studied whether chronic treatment from age 1 to 10 months with melatonin stabilize...

journal_title：Neurobiology of aging

authors： García JJ,Piñol-Ripoll G,Martínez-Ballarín E,Fuentes-Broto L,Miana-Mena FJ,Venegas C,Caballero B,Escames G,Coto-Montes A,Acuña-Castroviejo D

更新日期：2011-11-01 00:00:00

abstract：:We sought to examine the relations between age, gender and brain volumes in an elderly population; we also sought to examine ways of measuring these relations. Three sets of analyses were used: correlational analyses, in which correlations between independent variables and brain volumes were calculated without correct...

journal_title：Neurobiology of aging

authors： Greenberg DL,Messer DF,Payne ME,Macfall JR,Provenzale JM,Steffens DC,Krishnan RR

更新日期：2008-02-01 00:00:00

abstract：:In these experiments, potential cognitive deficits in aged rats were studied using an odor-reward association task. Aged Fischer 344 rats first performed to an odor-reward association task. After five daily sessions of 60 trials, the aged rats were globally impaired in comparison to the control rats. However, consider...

journal_title：Neurobiology of aging

authors： Roman FS,Alescio-Lautier B,Soumireu-Mourat B

更新日期：1996-01-01 00:00:00

abstract：:Despite very numerous studies on Alzheimer's disease (AD), especially on amyloid plaques and neurofibrillary tangles, little information has been obtained thus on the causes of the disease. Evidence is described here that implicates firstly herpes simplex virus type 1 (HSV1) as a strong risk factor when it is present ...

journal_title：Neurobiology of aging

authors： Itzhaki RF,Wozniak MA,Appelt DM,Balin BJ

更新日期：2004-05-01 00:00:00

abstract：:A variety of studies have shown an effect of estrogen on dopamine function and suggest that estrogen may modulate central dopaminergic activity. Positron emission tomography (PET) and the dopamine metabolism tracer, [18F]6-fluoro-L-m-tyrosine (FMT) were used to evaluate dopaminergic function in the frontal cortex and ...

journal_title：Neurobiology of aging

authors： Eberling JL,Roberts JA,Taylor SE,VanBrocklin HF,O'Neil JP,Nordahl TE

更新日期：2002-05-01 00:00:00

abstract：:I propose that North American investigators who depend largely on individual external grants would benefit from the creation of regional facilities designed to support studies of aging in transgenic models. In general, academic institutions cannot achieve the most cost effectiveness because their facilities are not de...

journal_title：Neurobiology of aging

authors： Finch CE

更新日期：1999-03-01 00:00:00

abstract：:A large number of gene products that are enriched in the striatum have ill-defined functions, although they may have key roles in age-dependent neurodegenerative diseases affecting the striatum, especially Huntington disease (HD). In the present study, we focused on Abhd11os, (called ABHD11-AS1 in human) which is a pu...

journal_title：Neurobiology of aging

authors： Francelle L,Galvan L,Gaillard MC,Petit F,Bernay B,Guillermier M,Bonvento G,Dufour N,Elalouf JM,Hantraye P,Déglon N,de Chaldée M,Brouillet E

更新日期：2015-03-01 00:00:00

abstract：:Recent case-control studies reported an association between H. pylori infection and Alzheimer's disease (AD). Our aim was to compare cognitive impairment, neuroinflammation, and cerebrovascular lesion load in a group of AD patients according to their H. pylori status. For the 53 AD patients included, we assessed: clin...

journal_title：Neurobiology of aging

authors： Roubaud-Baudron C,Krolak-Salmon P,Quadrio I,Mégraud F,Salles N

更新日期：2012-05-01 00:00:00

abstract：:We identified and validated several novel inflammatory markers of cognitive performance in community-living older persons. An exploratory study (n = 83) correlated 177 inflammatory markers assayed by Luminex with the Mini-Mental State Examination (MMSE) and identified 8 inflammatory markers for enzyme-linked immunosor...

journal_title：Neurobiology of aging

authors： Gao Q,Camous X,Lu YX,Lim ML,Larbi A,Ng TP

更新日期：2016-03-01 00:00:00

abstract：:This proteomic study investigates the widely observed clinical phenomenon, that after comparable brain injuries, geriatric patients fare worse and recover less cognitive and neurologic function than younger victims. Utilizing a rat traumatic brain injury model, sham surgery or a neocortical contusion was induced in 3 ...

journal_title：Neurobiology of aging

authors： Mehan ND,Strauss KI

更新日期：2012-09-01 00:00:00

abstract：:Biochemical, genetic, and epidemiological evidence indicates that inflammation is an essential part of the pathogenesis of Alzheimer's disease. Over the last decade, we and others have focused on the mechanism by which specific inflammatory molecules contribute to the Alzheimer pathogenic pathway. In particular, we ha...

journal_title：Neurobiology of aging

authors： Potter H,Wefes IM,Nilsson LN

更新日期：2001-11-01 00:00:00

abstract：:Relationships between age-related changes in sleep patterns and neuronal activity have received scant attention. In the present study, reticularis pontis oralis (RPO) and ventral tegmental nucleus of Gudden (VTN) neurons were recorded in unanesthetized restrained young (3 months) and old (23 months) Sprague-Dawley rat...

journal_title：Neurobiology of aging

authors： Bassant MH,Poindessous-Jazat F

更新日期：2002-07-01 00:00:00

abstract：:Calmodulin (CaM) and tubulin were analyzed by radioimmunoassay in subcellular fractions prepared from cerebral cortex and striatum of aging male C57BL/6J mice. Three fractions were prepared by a new procedure: cytosol (soluble); EGTA-releasable, membrane-bound; and detergent-extractable (Triton X-100), membrane-bound ...

journal_title：Neurobiology of aging

authors： May PC,Severson JA,Osterburg HH,Finch CE

更新日期：1987-03-01 00:00:00

abstract：:Since the introduction of amyloid imaging nearly 10 years ago, this technique has gained widespread use and acceptance. More recently, published reports have begun to appear in which amyloid imaging is used to detect the effects of antiamyloid therapies. This review will consider the issues involved in the use of amyl...

journal_title：Neurobiology of aging

authors： Klunk WE

更新日期：2011-12-01 00:00:00

abstract：:The aim of our study was to discover genomic variations related to variant Creutzfeldt-Jakob disease (vCJD) susceptibility. A genome-wide association analysis with most vCJD samples available in the world was performed. A series of 93 vCJD UK patients and 1504 UK controls were included in the discovery stage. Our best...

journal_title：Neurobiology of aging

authors： Sanchez-Juan P,Bishop MT,Aulchenko YS,Brandel JP,Rivadeneira F,Struchalin M,Lambert JC,Amouyel P,Combarros O,Sainz J,Carracedo A,Uitterlinden AG,Hofman A,Zerr I,Kretzschmar HA,Laplanche JL,Knight RS,Will RG,van Duijn

更新日期：2012-07-01 00:00:00

abstract：:Basal forebrain cholinergic neurons (BFCN), a system involved in learning and memory processes, are highly dependent on a continuous supply of biologically active nerve growth factor (NGF). Age-related cholinergic atrophy and cell loss in normal brains is apparently not complemented by reductions in the levels of NGF ...

journal_title：Neurobiology of aging

authors： Bruno MA,Cuello AC

更新日期：2012-09-01 00:00:00

abstract：:Apolipoprotein E (APOE) alleles are associated with longevity in genome-wide scans, with ε4 correlated with shorter life, and ε2 with longer life, than ε3. We hypothesized that rare APOE variants with large individual effects might also contribute to long-term good health. The APOE exons and promoter were resequenced ...

journal_title：Neurobiology of aging

authors： Tindale LC,Leach S,Ushey K,Daley D,Brooks-Wilson AR

更新日期：2014-03-01 00:00:00

abstract：:4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer's disease (AD), we quantified levels of free and protein-b...

journal_title：Neurobiology of aging

authors： Lovell MA,Ehmann WD,Mattson MP,Markesbery WR

更新日期：1997-09-01 00:00:00

abstract：:Oxidative stress is considered to be a major contributor to age-related hearing loss (ARHL). Here, we investigated whether pomegranate peel extract (PPE) protected against hearing loss by decreased oxidative stress in the cochlea of D-galactose-induced accelerated aging mice. The aging mice exhibited an increase in he...

journal_title：Neurobiology of aging

authors： Liu S,Xu T,Wu X,Lin Y,Bao D,Di Y,Ma T,Dang Y,Jia P,Xian J,Wang A,Liu Y

更新日期：2017-11-01 00:00:00

abstract：:The objective of this study was to determine whether physiological fluctuations in white matter (PFWM) on resting-state functional magnetic resonance images could be used as an index of neurodegeneration and Alzheimer's disease (AD). Using resting-state functional magnetic resonance image data from participants in the...

journal_title：Neurobiology of aging

authors： Makedonov I,Chen JJ,Masellis M,MacIntosh BJ,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2016-01-01 00:00:00

abstract：:Open field behavior and age-related changes in anterior pituitary corticotropin-releasing hormone (CRH) receptors, as well as plasma ACTH levels, were measured in two inbred rat strains. The strains utilized were Wistar Kyoto (WKY) and Brown-Norway (BN), the former characterized by shorter life-span and hyper-reactivi...

journal_title：Neurobiology of aging

authors： Tizabi Y,Aguilera G,Gilad GM

更新日期：1992-03-01 00:00:00

abstract：:The adaption of movement to changes in the environment varies across life span. Recent evidence has linked motor adaptation and its reduction with age to differences in "explicit" learning processes. We examine differences in brain structure and cognition underlying motor adaptation in a population-based cohort (n = 3...

journal_title：Neurobiology of aging

authors： Wolpe N,Ingram JN,Tsvetanov KA,Henson RN,Wolpert DM,Cam-CAN.,Rowe JB

更新日期：2020-06-01 00:00:00

abstract：:Alzheimer's disease is characterized by amyloid plaques, neurofibrillary tangles, glial activation, and neurodegeneration. In mouse models, inflammatory activation of microglia accelerates tau pathology. The chemokine fractalkine serves as an endogenous neuronal modulator to quell microglial activation. Experiments wi...

journal_title：Neurobiology of aging

authors： Nash KR,Lee DC,Hunt JB Jr,Morganti JM,Selenica ML,Moran P,Reid P,Brownlow M,Guang-Yu Yang C,Savalia M,Gemma C,Bickford PC,Gordon MN,Morgan D

更新日期：2013-06-01 00:00:00

abstract：:Genes selectively expressed in the striatum may be involved in the preferential vulnerability of striatal neurons to Huntington's disease (HD). Here, we investigated whether perturbations of Capucin expression, which is enriched in the striatum and downregulated in Huntington's disease models, could modify the neuroto...

journal_title：Neurobiology of aging

authors： Galvan L,Lepejová N,Gaillard MC,Malgorn C,Guillermier M,Houitte D,Bonvento G,Petit F,Dufour N,Héry P,Gérard M,Elalouf JM,Déglon N,Brouillet E,de Chaldée M

更新日期：2012-08-01 00:00:00

abstract：:Vascular risk factors have been implicated in the pathogenesis of vascular dementia and Alzheimer's disease. The identification of a novel vascular disease susceptibility locus at 9p21.3 has recently generated great interest. In the present study, we sought to determine whether a common genetic variant (tagged by rs13...

journal_title：Neurobiology of aging

authors： Emanuele E,Lista S,Ghidoni R,Binetti G,Cereda C,Benussi L,Maletta R,Bruni AC,Politi P

更新日期：2011-07-01 00:00:00

abstract：:Etiologically heterogeneous subgroups of patients with Alzheimer's disease (AD) exist and need to be distinguished so as to better identify genetic causes of familial cases. Furthermore, the presence of AD neuropathology in Down syndrome (trisomy 21) subjects older than 35 years suggests that AD in some cases is cause...

journal_title：Neurobiology of aging

authors： Schapiro MB,Rapoport SI

更新日期：1989-09-01 00:00:00