Expanding the role of education in frontotemporal dementia: a functional dynamic connectivity (the chronnectome) study.

Abstract:

:In the present study, we aim at investigating whether education modulates dynamical properties of time-varying whole-brain network connectivity (the chronnectome) in frontotemporal dementia (FTD) at a given level of symptom severity. Dynamic connectivity parameters were evaluated in 128 patients with FTD using independent component analysis, sliding-time window correlation, and k-means approach to resting state-magnetic resonance imaging data. We evaluated the relationship between education, a proxy measure of cognitive reserve, and 4 indexes of metastate dynamic connectivity: (1) the number of distinct metastates a patient passes through, (2) the number of switches from one metastate to another, (3) the span of the realized metastates, and (4) the total distance traveled in the state space. We found a significant inverse correlation between years of education and the 4 indexes of metastate dynamic fluidity (all p-values ≤ 0.03, false discovery rate-corrected). This study suggests that patients with FTD with higher education but comparable clinical severity show more global functional brain impairment, suggesting that patients with higher cognitive reserve can cope with more global brain fluidity reduction.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Premi E,Cristillo V,Gazzina S,Benussi A,Alberici A,Cotelli MS,Calhoun VD,Iraji A,Magoni M,Cotelli M,Micheli A,Gasparotti R,Padovani A,Borroni B

doi

10.1016/j.neurobiolaging.2020.04.021

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

35-43

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(20)30141-X

journal_volume

93

pub_type

杂志文章
  • 'Increased calcium-current' hypothesis of brain aging.

    abstract::Based on evidence that high Mg2+ counteracts age-related declines in synaptic plasticity, and that aged rat hippocampal neurons exhibit prolonged Ca2+-dependent K+ currents, it is proposed that an underlying cause of altered Ca2+ homeostasis during brain aging may be an increased membrane conductance to Ca2+. An appar...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/0197-4580(87)90074-1

    authors: Landfield PW

    更新日期:1987-07-01 00:00:00

  • Drug induced hypothermia in adult and senescent rats.

    abstract::Temperature regulation was evaluated in senescent (34-40 month old) and adult (8-9 month old) female Iva:WIWU and Emd:Wi-AF/Han rats. Injection of 1.5 mg/kg BW apomorphine HCl or 1.0 mg/kg BW oxotremorine sesquifumarate produced comparable maximal hypothermic responses in adult and senescent rats. However, the latency...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/0197-4580(85)90029-6

    authors: Martin JR,Fuchs A,Harting J

    更新日期:1985-07-01 00:00:00

  • Neural synchrony indexes impaired motor slowing after errors and novelty following white matter damage.

    abstract::In humans, action errors and perceptual novelty elicit activity in a shared frontostriatal brain network, allowing them to adapt their ongoing behavior to such unexpected action outcomes. Healthy and pathologic aging reduces the integrity of white matter pathways that connect individual hubs of such networks and can i...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2015.10.014

    authors: Wessel JR,Ullsperger M,Obrig H,Villringer A,Quinque E,Schroeter ML,Bretschneider KJ,Arelin K,Roggenhofer E,Frisch S,Klein TA

    更新日期:2016-02-01 00:00:00

  • Elevated adenosine monophosphate deaminase activity in Alzheimer's disease brain.

    abstract::Abnormal elevations in ammonia have been implicated in the pathogenesis of Alzheimer's disease. However, the biochemical mechanism(s) leading to increased ammonia in Alzheimer's disease have not yet been identified. A potential source of increased ammonia production is adenosine monophosphate (AMP) deaminase, an impor...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/s0197-4580(98)00083-9

    authors: Sims B,Powers RE,Sabina RL,Theibert AB

    更新日期:1998-09-01 00:00:00

  • The effects of aging on the frequency of nerve fibers in rhesus monkey striate cortex.

    abstract::In the rhesus monkey primary visual cortex, there are bundles of vertically oriented myelinated axons, which mainly contain efferent fibers originating from pyramidal cells. At the level of layer 4Cbeta, the bundles are regularly arranged and the nerve fibers in them are closely packed. In order to determine if a sign...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/s0197-4580(00)00169-x

    authors: Nielsen K,Peters A

    更新日期:2000-09-01 00:00:00

  • Distinctive age-related temporal cortical thinning in asymptomatic granulin gene mutation carriers.

    abstract::Studies in asymptomatic granulin gene (GRN) mutation carriers are essential to improve our understanding of the pattern and timing of early morphologic brain changes in frontotemporal lobar degeneration. The main objectives of this study were to assess the effect of age in cortical thickness changes (CTh) in preclinic...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2012.11.005

    authors: Moreno F,Sala-Llonch R,Barandiaran M,Sánchez-Valle R,Estanga A,Bartrés-Faz D,Sistiaga A,Alzualde A,Fernández E,Martí Massó JF,López de Munain A,Indakoetxea B

    更新日期:2013-05-01 00:00:00

  • Paranodal reorganization results in the depletion of transverse bands in the aged central nervous system.

    abstract::Paranodal axo-glial junctional complexes anchor the myelin sheath to the axon and breakdown of these complexes presumably facilitates demyelination. Myelin deterioration is also prominent in the aging central nervous system (CNS); however, the stability of the paranodal complexes in the aged CNS has not been examined....

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2010.08.001

    authors: Shepherd MN,Pomicter AD,Velazco CS,Henderson SC,Dupree JL

    更新日期:2012-01-01 00:00:00

  • Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation.

    abstract::Alzheimer's disease (AD) and age-related macular degeneration (AMD) are both neurodegenerative disorders which share common pathological and biochemical features of the complement pathway. The aim of this study was to investigate whether there is an association between well replicated AMD genetic risk factors and AD. ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.neurobiolaging.2011.12.036

    authors: Proitsi P,Lupton MK,Dudbridge F,Tsolaki M,Hamilton G,Daniilidou M,Pritchard M,Lord K,Martin BM,Johnson J,Craig D,Todd S,McGuinness B,Hollingworth P,Harold D,Kloszewska I,Soininen H,Mecocci P,Velas B,Gill M,Lawlor

    更新日期:2012-08-01 00:00:00

  • Object recognition memory and BDNF expression are reduced in young TgCRND8 mice.

    abstract::The TgCRND8 mouse model of Alzheimer's disease exhibits progressive cortical and hippocampal β-amyloid accumulation, resulting in plaque pathology and spatial memory impairment by 3 months of age. We tested whether TgCRND8 cognitive function is disrupted prior to the appearance of macroscopic plaques in an object reco...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2010.04.003

    authors: Francis BM,Kim J,Barakat ME,Fraenkl S,Yücel YH,Peng S,Michalski B,Fahnestock M,McLaurin J,Mount HT

    更新日期:2012-03-01 00:00:00

  • Relationship between neural functional connectivity and memory performance in age-related macular degeneration.

    abstract::Age-related macular degeneration (AMD) has been linked to memory deficits, with no established neural mechanisms. We collected resting-state brain functional magnetic resonance imaging and standardized verbal recall tests from 42 older adults with AMD and 41 age-matched controls. We used seed-based whole brain analysi...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2020.07.020

    authors: Zuo X,Zhuang J,Chen NK,Cousins S,Cunha P,Lad EM,Madden DJ,Potter G,Whitson HE

    更新日期:2020-11-01 00:00:00

  • Age-related subsensitivity of cerebellar Purkinje neurons to locally applied beta 1-selective adrenergic agonist.

    abstract::Previous electrophysiological studies in aged rats have revealed a number of deficits in noradrenergic neurotransmission in the central nervous system. Such deficits include subsensitivity to the depressant effects of norepinephrine on cerebellar Purkinje neurons, which has been attributed specifically to altered beta...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/0197-4580(90)90022-r

    authors: Parfitt KD,Bickford-Wimer P

    更新日期:1990-11-01 00:00:00

  • Resting-state fMRI evidence for early episodic memory consolidation: effects of age.

    abstract::Aging-related episodic memory decline is often attributed to insufficient encoding of new information, although the underlying neural processes remain elusive. We here tested the hypothesis that impaired memory consolidation contributes to aging-related memory decline. To this end, we used resting state functional mag...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2016.06.004

    authors: Kukolja J,Göreci DY,Onur ÖA,Riedl V,Fink GR

    更新日期:2016-09-01 00:00:00

  • Intelligence moderates the relationship between age and inter-connectivity of resting state networks in older adults.

    abstract::Age-related changes in the interactive behavior of default mode network (DMN) with other resting state networks are poorly understood. We hypothesized that age would positively correlate with inter-network connectivity in late life and intellectual functioning was expected to moderate this relationship. The sample con...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2019.02.014

    authors: Lindbergh CA,Zhao Y,Lv J,Mewborn CM,Puente AN,Terry DP,Renzi-Hammond LM,Hammond BR,Liu T,Miller LS

    更新日期:2019-06-01 00:00:00

  • Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.

    abstract::C9orf72 repeat expansions are a common cause of amyotrophic lateral sclerosis and frontotemporal dementia. To date, no large-scale study of dementia with Lewy bodies (DLB) has been undertaken to assess the role of C9orf72 repeat expansions in the disease. Here, we investigated the prevalence of C9orf72 repeat expansio...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2016.08.023

    authors: Kun-Rodrigues C,Ross OA,Orme T,Shepherd C,Parkkinen L,Darwent L,Hernandez D,Ansorge O,Clark LN,Honig LS,Marder K,Lemstra A,Scheltens P,van der Flier W,Louwersheimer E,Holstege H,Rogaeva E,St George-Hyslop P,Londos E,

    更新日期:2017-01-01 00:00:00

  • Cerebrospinal fluid progranulin is associated with increased cortical thickness in early stages of Alzheimer's disease.

    abstract::Progranulin plays an important role in neuroinflammation in Alzheimer's disease (AD) pathophysiology, being upregulated by activated microglia. This study assessed whether cerebrospinal fluid levels of progranulin correlated with structural neuroimaging measures and cognition in 122 cognitively normal individuals, 81 ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2019.12.012

    authors: Batzu L,Westman E,Pereira JB,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2020-04-01 00:00:00

  • Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex.

    abstract::Studies in vitro have suggested that acetylcholinesterase (AChE) may interact with beta-amyloid to promote deposition of amyloid plaques in the brain of patients with Alzheimer's disease. To test that hypothesis in vivo, we crossed Tg2576 mice, which express human amyloid precursor protein and develop plaques at 9 mon...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/s0197-4580(02)00230-0

    authors: Rees T,Hammond PI,Soreq H,Younkin S,Brimijoin S

    更新日期:2003-10-01 00:00:00

  • Age-related activation of microglia and astrocytes: in vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to down-regulation.

    abstract::Astrocytes and microglia from cerebral cortex of 3-, 6-, 12-, and 24-month-old F344 male rat donors showed progressively greater proliferation during primary culture. Microglia from aging donor brains exhibited an amoeboid-like morphology and express antigens characteristic of an activated state (e.g., major histocomp...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/s0197-4580(97)00169-3

    authors: Rozovsky I,Finch CE,Morgan TE

    更新日期:1998-01-01 00:00:00

  • Effects of noninvasive brain stimulation on cognitive function in healthy aging and Alzheimer's disease: a systematic review and meta-analysis.

    abstract::The study aimed to evaluate the effects of noninvasive brain stimulation on cognitive function in healthy older adults and patients with Alzheimer's disease. A comprehensive literature search was performed on noninvasive stimulation studies published from January 1990 to November 2014 in Pubmed and Web of Science. Fou...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.neurobiolaging.2015.04.016

    authors: Hsu WY,Ku Y,Zanto TP,Gazzaley A

    更新日期:2015-08-01 00:00:00

  • Cross-talk between Aβ and endothelial SSAO/VAP-1 accelerates vascular damage and Aβ aggregation related to CAA-AD.

    abstract::An association between semicarbazide-sensitive amine oxidase (SSAO) and cerebral amyloid angiopathy (CAA) related to Alzheimer's disease (AD) has been largely postulated. Increased SSAO activity and expression have been detected in cerebrovascular tissue and plasma of AD patients, colocalizing with cerebrovascular amy...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2014.09.030

    authors: Solé M,Miñano-Molina AJ,Unzeta M

    更新日期:2015-02-01 00:00:00

  • Development of amyloid burden in African Green monkeys.

    abstract::The vervet is an old world monkey increasingly being used as a model for human diseases. In addition to plaques and tangles, an additional hallmark of Alzheimer's disease is damage to neurons that synthesize noradrenaline (NA). We characterized amyloid burden in the posterior temporal lobe of young and aged vervets, a...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2013.03.023

    authors: Kalinin S,Willard SL,Shively CA,Kaplan JR,Register TC,Jorgensen MJ,Polak PE,Rubinstein I,Feinstein DL

    更新日期:2013-10-01 00:00:00

  • Neural correlates of age-related decline and compensation in visual attention capacity.

    abstract::We identified neural correlates of declined and preserved basic visual attention functions in aging individuals based on Bundesen "Theory of Visual Attention". In an interindividual difference approach, we contrasted electrophysiology of higher- and lower-performing younger and older participants. In both age groups, ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2014.02.023

    authors: Wiegand I,Töllner T,Dyrholm M,Müller HJ,Bundesen C,Finke K

    更新日期:2014-09-01 00:00:00

  • Nutrition and the brain: what advice should we give?

    abstract::The knowledge base of nutrition and the brain is steadily expanding. Much of the research is aimed at ways to protect the brain from damage. In adults, the major causes of brain damage are aging and dementia. The most prominent dementia, and the condition that grabs the most public attention, is Alzheimer's disease. T...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,评审

    doi:10.1016/j.neurobiolaging.2014.02.029

    authors: Cooper JK

    更新日期:2014-09-01 00:00:00

  • Inflammation occurs early during the Abeta deposition process in TgCRND8 mice.

    abstract::Alzheimer's disease (AD) is characterized by a progressive cognitive decline leading to dementia and involves the deposition of amyloid-beta (Abeta) peptides into senile plaques. Other neuropathological features that accompany progression of the disease include a decrease in synaptic density, neurofibrillary tangles, ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2003.08.008

    authors: Dudal S,Krzywkowski P,Paquette J,Morissette C,Lacombe D,Tremblay P,Gervais F

    更新日期:2004-08-01 00:00:00

  • Structural integrity of the substantia nigra and subthalamic nucleus predicts flexibility of instrumental learning in older-age individuals.

    abstract::Flexible instrumental learning is required to harness the appropriate behaviors to obtain rewards and to avoid punishments. The precise contribution of dopaminergic midbrain regions (substantia nigra/ventral tegmental area [SN/VTA]) to this form of behavioral adaptation remains unclear. Normal aging is associated with...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2013.03.030

    authors: Chowdhury R,Guitart-Masip M,Lambert C,Dolan RJ,Düzel E

    更新日期:2013-10-01 00:00:00

  • Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus.

    abstract::Aging increases the likelihood of cognitive decline after negative life events such as infection or injury. We have modeled this increased vulnerability in aged (24-month-old), but otherwise unimpaired F344xBN rats. In these animals, but not in younger (3-month-old) counterparts, a single intraperitoneal injection of ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2011.07.015

    authors: Chapman TR,Barrientos RM,Ahrendsen JT,Hoover JM,Maier SF,Patterson SL

    更新日期:2012-04-01 00:00:00

  • Pomegranate peel extract attenuates D-galactose-induced oxidative stress and hearing loss by regulating PNUTS/PP1 activity in the mouse cochlea.

    abstract::Oxidative stress is considered to be a major contributor to age-related hearing loss (ARHL). Here, we investigated whether pomegranate peel extract (PPE) protected against hearing loss by decreased oxidative stress in the cochlea of D-galactose-induced accelerated aging mice. The aging mice exhibited an increase in he...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2017.07.007

    authors: Liu S,Xu T,Wu X,Lin Y,Bao D,Di Y,Ma T,Dang Y,Jia P,Xian J,Wang A,Liu Y

    更新日期:2017-11-01 00:00:00

  • Amyloid imaging as a biomarker for cerebral β-amyloidosis and risk prediction for Alzheimer dementia.

    abstract::Since the introduction of amyloid imaging nearly 10 years ago, this technique has gained widespread use and acceptance. More recently, published reports have begun to appear in which amyloid imaging is used to detect the effects of antiamyloid therapies. This review will consider the issues involved in the use of amyl...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,评审

    doi:10.1016/j.neurobiolaging.2011.09.006

    authors: Klunk WE

    更新日期:2011-12-01 00:00:00

  • Anterior and posterior MTL networks in aging and MCI.

    abstract::Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI)-based functional conne...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2014.03.041

    authors: Das SR,Pluta J,Mancuso L,Kliot D,Yushkevich PA,Wolk DA

    更新日期:2015-01-01 00:00:00

  • Age-related changes in cortical connectivity influence the neuromodulatory effects of transcranial electrical stimulation.

    abstract::Transcranial electrical stimulation (tES) is a potentially viable tool for boosting cognitive performance in aging. However, most knowledge on tES effects is based on studies involving young adults. Here, we applied tES (transcranial random noise stimulation [tRNS] as an effective stimulation and anodal transcranial d...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2019.07.009

    authors: Fertonani A,Pirulli C,Bollini A,Miniussi C,Bortoletto M

    更新日期:2019-10-01 00:00:00

  • Population-based analysis of cholesteryl ester transfer protein identifies association between I405V and cognitive decline: the Cache County Study.

    abstract::Cholesterol has been implicated in the pathogenesis of late-onset Alzheimer's disease (LOAD) and the cholesteryl ester transfer protein (CETP) is critical to cholesterol regulation within the cell, making CETP an Alzheimer's disease candidate gene. Several studies have suggested that CETP I405V (rs5882) is associated ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章

    doi:10.1016/j.neurobiolaging.2014.08.022

    authors: Lythgoe C,Perkes A,Peterson M,Schmutz C,Leary M,Ebbert MT,Ridge PG,Norton MC,Tschanz JT,Munger RG,Corcoran CD,Kauwe JS

    更新日期:2015-01-01 00:00:00