Visuomotor task acquisition is reduced by priming paired associative stimulation in older adults.

abstract：:The basal forebrain (BF) cholinergic system is selectively vulnerable in human brain diseases, while the cholinergic groups in the upper pons of the brainstem (BS) resist neurodegeneration. Cholinergic neurons (200 per region per animal) were laser-microdissected from five young (8 months) and five aged (24 months) F3...

journal_title：Neurobiology of aging

authors： Baskerville KA,Kent C,Personett D,Lai WR,Park PJ,Coleman P,McKinney M

更新日期：2008-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease) is a progressive debilitating neurodegenerative disease with no cure. We propose a novel molecular model for the pathogenesis of ALS that involves an adenosine triphosphate (ATP)-dependent muscle neuronal lactate shuttle (MNLS) at the neuromuscular junction (NM...

journal_title：Neurobiology of aging

authors： Vadakkadath Meethal S,Atwood CS

更新日期：2012-03-01 00:00:00

abstract：:Brain-specific glutathione S-transferase Mu 3 (GSTM3) colocalizes with amyloid-beta plaques in Alzheimer's disease (AD). A functional polymorphism rs7483 in GSTM3 may contribute to the decrease in GSTM3 expression in AD. The association of the rs7483 SNP with late-onset AD and mild cognitive impairment (MCI) was evalu...

journal_title：Neurobiology of aging

authors： Maes OC,Schipper HM,Chong G,Chertkow HM,Wang E

更新日期：2010-01-01 00:00:00

abstract：:An extensive literature reports changes in quantitative electroencephalogram (QEEG) with aging and a relationship between magnitude of changes and degree of clinical deterioration in progressive dementia. Longitudinal studies have demonstrated QEEG differences between mild cognitively impaired (MCI) elderly who go on ...

journal_title：Neurobiology of aging

authors： Prichep LS,John ER,Ferris SH,Rausch L,Fang Z,Cancro R,Torossian C,Reisberg B

更新日期：2006-03-01 00:00:00

abstract：:Parkinson's disease (PD) is a degenerative disorder of the nervous system and the cause of the majority of sporadic cases is unknown. Females are relatively protected from PD as compared with males and linkage studies suggested a PD susceptibility locus on the X chromosome. To determine a putative association of skewe...

journal_title：Neurobiology of aging

authors： Sharma A,Kaut O,Pavlova A,Fröhlich H,Ahmad A,Schmitt I,El-Maarri O,Oldenburg J,Wüllner U

更新日期：2017-09-01 00:00:00

abstract：:The study aimed to evaluate the effects of noninvasive brain stimulation on cognitive function in healthy older adults and patients with Alzheimer's disease. A comprehensive literature search was performed on noninvasive stimulation studies published from January 1990 to November 2014 in Pubmed and Web of Science. Fou...

journal_title：Neurobiology of aging

authors： Hsu WY,Ku Y,Zanto TP,Gazzaley A

更新日期：2015-08-01 00:00:00

abstract：:Flavonoids, a group of dietary polyphenols have been shown to possess cognitive health benefits. Epidemiologic evidence suggests that they could play a role in risk reduction in dementia. Amyloid precursor protein processing and the subsequent generation of amyloid beta (Aβ) are central to the pathogenesis of Alzheime...

journal_title：Neurobiology of aging

authors： Cox CJ,Choudhry F,Peacey E,Perkinton MS,Richardson JC,Howlett DR,Lichtenthaler SF,Francis PT,Williams RJ

更新日期：2015-01-01 00:00:00

abstract：:Oligomers of beta-amyloid (Aβ) are implicated in the early memory impairment seen in Alzheimer's disease before to the onset of discernable neurodegeneration. Here, the capacity of a novel orally bioavailable, central nervous system-penetrating small molecule 5-aryloxypyrimidine, SEN1500, to prevent cell-derived (7PA2...

journal_title：Neurobiology of aging

authors： O'Hare E,Scopes DI,Kim EM,Palmer P,Jones M,Whyment AD,Spanswick D,Amijee H,Nerou E,McMahon B,Treherne JM,Jeggo R

更新日期：2013-04-01 00:00:00

abstract：:The increased life expectancy of people living with HIV-1/AIDS is accompanied by increased prevalence of HIV-1-associated neurocognitive disorder. As well, these individuals are increasingly experiencing Alzheimer's disease (AD)-like neurocognitive problems and neuropathological features such as increased deposition o...

journal_title：Neurobiology of aging

authors： Chen X,Hui L,Geiger NH,Haughey NJ,Geiger JD

更新日期：2013-10-01 00:00:00

abstract：:Neuroimage measures from magnetic resonance (MR) imaging, such as cortical thickness, have been playing an increasingly important role in searching for biomarkers of Alzheimer's disease (AD). Recent studies show that, AD, mild cognitive impairment (MCI) and normal control (NC) can be distinguished with relatively high...

journal_title：Neurobiology of aging

authors： Li Y,Wang Y,Wu G,Shi F,Zhou L,Lin W,Shen D,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2012-02-01 00:00:00

abstract：:Magnetic resonance (MR)-based volume measurements of atrophy are potential markers of disease progression in patients with amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Longitudinal changes in (1)H MR spectroscopy ((1)H MRS) metabolite markers have not been characterized in MCI subjects. Our o...

journal_title：Neurobiology of aging

authors： Kantarci K,Weigand SD,Petersen RC,Boeve BF,Knopman DS,Gunter J,Reyes D,Shiung M,O'Brien PC,Smith GE,Ivnik RJ,Tangalos EG,Jack CR Jr

更新日期：2007-09-01 00:00:00

abstract：:While aged monkeys of several species show cerebral amyloid deposition in senile plaques and blood vessels similar to that seen in human aging and Alzheimer's disease (AD), studies of great apes have been limited. Using histological and immunohistochemical methods, we examined the brains of four orangutans aged 10, 28...

journal_title：Neurobiology of aging

authors： Gearing M,Tigges J,Mori H,Mirra SS

更新日期：1997-03-01 00:00:00

abstract：:Here we report the relationship between age at onset, clinical course and genotype in a family with combined LRRK2 G2019S and Parkin exon 2 deletions. In the combined mutation carriers the age at onset and clinical course was highly variable and not always younger than in the carriers of LRRK2 G2019S mutations alone. ...

journal_title：Neurobiology of aging

authors： Marras C,Klein C,Lang AE,Wakutani Y,Moreno D,Sato C,Yip E,Munhoz RP,Lohmann K,Djarmati A,Bi A,Rogaeva E

更新日期：2010-04-01 00:00:00

abstract：:Cell culture systems for evaluating the biological effects of the beta-amyloid protein are potentially important tools in the study of the pathogenesis of Alzheimer's disease. In this report, methodological considerations in the assessment of beta-amyloid neurotoxicity are discussed. Chronic incubation of beta 1-40 in...

journal_title：Neurobiology of aging

authors： Busciglio J,Lorenzo A,Yankner BA

更新日期：1992-09-01 00:00:00

abstract：:Deletions of the mitochondrial DNA (mtDNA) have been shown to accumulate with age in a variety of species regardless of mean or maximal life span. This implies that such mutations are either a molecular biomarker of senescence or that they are more causally linked to senescence itself. One assay that can be used to de...

journal_title：Neurobiology of aging

authors： Melov S,Schneider JA,Coskun PE,Bennett DA,Wallace DC

更新日期：1999-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is a uniquely human brain disorder characterized by the accumulation of amyloid-beta protein (Aβ) into extracellular plaques, neurofibrillary tangles (NFT) made from intracellular, abnormally phosphorylated tau, and selective neuronal loss. We analyzed a large group of aged chimpanzees (n = 20...

journal_title：Neurobiology of aging

authors： Edler MK,Sherwood CC,Meindl RS,Hopkins WD,Ely JJ,Erwin JM,Mufson EJ,Hof PR,Raghanti MA

更新日期：2017-11-01 00:00:00

abstract：:To obtain information on the mechanisms responsible of the generation of ragged red fibers (RRF) during aging, we analyzed the mitochondrial genotype of single skeletal muscle fibers of healthy individuals having an age comprised between 45 and 92 years. The sequencing of the D-loop region showed many sequence changes...

journal_title：Neurobiology of aging

authors： Cormio A,Milella F,Vecchiet J,Felzani G,Gadaleta MN,Cantatore P

更新日期：2005-05-01 00:00:00

abstract：:The Asp620Asn mutation in the vacuolar protein sorting protein 35 (VPS35) gene and the Arg1205His mutation in the eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) gene were identified in autosomal dominant late-onset familial and sporadic Parkinson disease (PD) patients in a Caucasian population. However, t...

journal_title：Neurobiology of aging

authors： Chen Y,Chen K,Song W,Chen X,Cao B,Huang R,Zhao B,Guo X,Burgunder J,Li J,Shang HF

更新日期：2013-06-01 00:00:00

abstract：:Homozygous mutations of the glucocerebrosidase gene (GBA) cause Gaucher disease (GD), and heterozygous mutations of GBA are a major risk factor for Parkinson's disease (PD). This study examined the impact of GBA mutations on the longitudinal clinical course of PD patients by retrospective cohort design. GBA-coding reg...

journal_title：Neurobiology of aging

authors： Oeda T,Umemura A,Mori Y,Tomita S,Kohsaka M,Park K,Inoue K,Fujimura H,Hasegawa H,Sugiyama H,Sawada H

更新日期：2015-12-01 00:00:00

abstract：:Decline in fluid abilities in normal aging is associated with increased white matter lesions, measured on T1-weighted images as white matter signal abnormalities (WMSAs). WMSAs are particularly evident in hypertensive older adults, suggesting vascular involvement. However, because hypertension is assessed systemically...

journal_title：Neurobiology of aging

authors： Tan CH,Low KA,Chiarelli AM,Fletcher MA,Navarra R,Burzynska AZ,Kong TS,Zimmerman B,Maclin EL,Sutton BP,Gratton G,Fabiani M

更新日期：2019-12-01 00:00:00

abstract：:Cholesterol has been implicated in the pathogenesis of late-onset Alzheimer's disease (LOAD) and the cholesteryl ester transfer protein (CETP) is critical to cholesterol regulation within the cell, making CETP an Alzheimer's disease candidate gene. Several studies have suggested that CETP I405V (rs5882) is associated ...

journal_title：Neurobiology of aging

authors： Lythgoe C,Perkes A,Peterson M,Schmutz C,Leary M,Ebbert MT,Ridge PG,Norton MC,Tschanz JT,Munger RG,Corcoran CD,Kauwe JS

更新日期：2015-01-01 00:00:00

abstract：:Biallelic loss-of-function mutations in TYROBP and TREM2 cause a rare disease that resembles early-onset frontotemporal dementia with bone lesions called polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Some PLOSL-causing variants in TREM2 have also been associated with Alzheimer's...

journal_title：Neurobiology of aging

authors： Kaivola K,Jansson L,Saarentaus E,Kiviharju A,Rantalainen V,Eriksson JG,Strandberg TE,Polvikoski T,Myllykangas L,Tienari PJ

更新日期：2018-04-01 00:00:00

abstract：:Recent results support the hypothesis that microglia and/or macrophages of the brain, by producing oxidants, could play a role in the local inactivation of the Kunitz protease inhibitor (KPI) domain of beta-amyloid precursor protein (APP), thereby facilitating deposition of abnormal amyloid filaments in patients with ...

journal_title：Neurobiology of aging

authors： DeFeudis FV

更新日期：1989-09-01 00:00:00

abstract：:Lipid rafts are highly dynamic membrane microdomains intimately associated with cell signaling. Compelling evidence has demonstrated that alterations in lipid rafts are associated with neurodegenerative diseases such Alzheimer's disease, but at present, whether alterations in lipid raft microdomains occur in other typ...

journal_title：Neurobiology of aging

authors： Marin R,Fabelo N,Martín V,Garcia-Esparcia P,Ferrer I,Quinto-Alemany D,Díaz M

更新日期：2017-01-01 00:00:00

abstract：:Alzheimer's disease (AD) has been suggested to be a systemic disease, and signal transduction abnormalities have been reported in non-neuronal AD cells. We have previously quantified the protein kinase C (PKC) subtypes in AD and control brains using a two-site enzyme immunoassay (EIA), and have shown that type II PKC ...

journal_title：Neurobiology of aging

authors： Matsushima H,Shimohama S,Tanaka S,Taniguchi T,Hagiwara M,Hidaka H,Kimura J

更新日期：1994-11-01 00:00:00

abstract：:Adults with Down syndrome (DS) are at high risk for developing Alzheimer's disease after the age of 40 years. To detect white matter (WM) changes in the brain linked to dementia, fractional anisotropy (FA) from diffusion tensor imaging was used. We hypothesized that adults with DS without dementia (DS n = 10), DS with...

journal_title：Neurobiology of aging

authors： Powell D,Caban-Holt A,Jicha G,Robertson W,Davis R,Gold BT,Schmitt FA,Head E

更新日期：2014-07-01 00:00:00

abstract：:Genetic analyses of patients with neurodegenerative disorders have identified multiple genes that need to be investigated for the presence of damaging variants. However, mutation analysis by Sanger sequencing is costly and time consuming. We tested the utility of a recently designed semi-custom genome-wide array (Neur...

journal_title：Neurobiology of aging

authors： Ghani M,Lang AE,Zinman L,Nacmias B,Sorbi S,Bessi V,Tedde A,Tartaglia MC,Surace EI,Sato C,Moreno D,Xi Z,Hung R,Nalls MA,Singleton A,St George-Hyslop P,Rogaeva E

更新日期：2015-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a devastating age-related neurodegenerative disease with no specific treatment at present. Several healthy lifestyle options and over-the-counter drugs that it has been suggested delay the onset of the disease are in an experimental phase, but it is unclear whether they will have any therap...

journal_title：Neurobiology of aging

authors： García-Mesa Y,Giménez-Llort L,López LC,Venegas C,Cristòfol R,Escames G,Acuña-Castroviejo D,Sanfeliu C

更新日期：2012-06-01 00:00:00

abstract：:Open field behavior and age-related changes in anterior pituitary corticotropin-releasing hormone (CRH) receptors, as well as plasma ACTH levels, were measured in two inbred rat strains. The strains utilized were Wistar Kyoto (WKY) and Brown-Norway (BN), the former characterized by shorter life-span and hyper-reactivi...

journal_title：Neurobiology of aging

authors： Tizabi Y,Aguilera G,Gilad GM

更新日期：1992-03-01 00:00:00

abstract：:Support has recently been voiced for the genetic hypothesis of Alzheimer's disease; frequently at the expense of considerations of environmental factors. In the adult, genetic diseases rarely exist without modification by environment forces. Atherosclerosis leading to myocardial infarction may provide a useful model t...

journal_title：Neurobiology of aging

authors： Perl DP

更新日期：1989-09-01 00:00:00