Cerebrospinal fluid progranulin is associated with increased cortical thickness in early stages of Alzheimer's disease.

abstract：:Age-dependent cognitive impairments have been correlated with functional and structural modifications in the hippocampal formation. In particular, the brain endogenous steroid pregnenolone-sulfate (Preg-S) is a cognitive enhancer whose hippocampal levels have been linked physiologically to cognitive performance in sen...

journal_title：Neurobiology of aging

authors： Mayo W,Lemaire V,Malaterre J,Rodriguez JJ,Cayre M,Stewart MG,Kharouby M,Rougon G,Le Moal M,Piazza PV,Abrous DN

更新日期：2005-01-01 00:00:00

abstract：:The hippocampal perforant pathway originates in the entorhinal cortex (ERC) and terminates in the outer molecular layer of the dentate gyrus (DG). To compare the effects of normal aging and Alzheimer's disease (AD) on the elements of the perforant pathway, we compared relative perikaryal numbers (determined by countin...

journal_title：Neurobiology of aging

authors： Lippa CF,Hamos JE,Pulaski-Salo D,DeGennaro LJ,Drachman DA

更新日期：1992-05-01 00:00:00

abstract：:We recently reported evidence for an association between the individual variation in normal human episodic memory and a common variant of the KIBRA gene, KIBRA rs17070145 (T-allele). Since memory impairment is a cardinal clinical feature of Alzheimer's disease (AD), we investigated the possibility of an association be...

journal_title：Neurobiology of aging

authors： Corneveaux JJ,Liang WS,Reiman EM,Webster JA,Myers AJ,Zismann VL,Joshipura KD,Pearson JV,Hu-Lince D,Craig DW,Coon KD,Dunckley T,Bandy D,Lee W,Chen K,Beach TG,Mastroeni D,Grover A,Ravid R,Sando SB,Aasly JO,Heun R

更新日期：2010-06-01 00:00:00

abstract：:We have developed a cell-based phenotypic automated high-content screening approach for N2a cells expressing the pro-aggregant repeat domain of tau protein (tauRDΔK), which allows analysis of a chemogenomic library of 1649 compounds for their effect on the inhibition or stimulation of intracellular tau aggregation. We...

journal_title：Neurobiology of aging

authors： Pickhardt M,Tassoni M,Denner P,Kurkowsky B,Kitanovic A,Möhl C,Fava E,Mandelkow E

更新日期：2019-04-01 00:00:00

abstract：:The aim of this study was to estimate the number of new cells and neurons added to the dentate gyrus across the lifespan, and to compare the rate of age-associated decline in neurogenesis across species. Data from mice (Mus musculus), rats (Rattus norvegicus), lesser hedgehog tenrecs (Echinops telfairi), macaques (Mac...

journal_title：Neurobiology of aging

authors： Lazic SE

更新日期：2012-08-01 00:00:00

abstract：:Deletions of the mitochondrial DNA (mtDNA) have been shown to accumulate with age in a variety of species regardless of mean or maximal life span. This implies that such mutations are either a molecular biomarker of senescence or that they are more causally linked to senescence itself. One assay that can be used to de...

journal_title：Neurobiology of aging

authors： Melov S,Schneider JA,Coskun PE,Bennett DA,Wallace DC

更新日期：1999-09-01 00:00:00

abstract：:Neuroimage measures from magnetic resonance (MR) imaging, such as cortical thickness, have been playing an increasingly important role in searching for biomarkers of Alzheimer's disease (AD). Recent studies show that, AD, mild cognitive impairment (MCI) and normal control (NC) can be distinguished with relatively high...

journal_title：Neurobiology of aging

authors： Li Y,Wang Y,Wu G,Shi F,Zhou L,Lin W,Shen D,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2012-02-01 00:00:00

abstract：:We assessed whether polymers of N-acetylglucosamine (GlcNAc) have any pathogenetic role in Alzheimer's disease (AD). First, by using specific dyes, we found deposits of polymers of GlcNAc in sporadic but not in familial AD. We found that neurons and microglia exposed to GlcNAc and uridine diphosphate (UDP)-GlcNAc are ...

journal_title：Neurobiology of aging

authors： Turano E,Busetto G,Marconi S,Guzzo F,Farinazzo A,Commisso M,Bistaffa E,Angiari S,Musumeci S,Sotgiu S,Bonetti B

更新日期：2015-05-01 00:00:00

abstract：:In this study, the Purkinje neurons and granule neurons in the cerebellar cortex were studied in male Fischer 344 rats at 3, 9, 18, and 27 months of age. The numbers of Purkinje cells (PC) and granule cells (GC) in folia IV, VII, and X of the vermis were quantitated with the disector stereological technique. The numbe...

journal_title：Neurobiology of aging

authors： Dlugos CA,Pentney RJ

更新日期：1994-07-01 00:00:00

abstract：:SORL1 encodes a 250-kDa protein named sorLA, a functional sorting receptor for the amyloid precursor protein (APP). Several single nucleotide polymorphisms of the gene SORL1, encoding sorLA, are genetically associated with Alzheimer's disease (AD). In the existing literature, SORL1 is insufficiently described at the t...

journal_title：Neurobiology of aging

authors： Blechingberg J,Poulsen ASA,Kjølby M,Monti G,Allen M,Ivarsen AK,Lincoln SJ,Thotakura G,Vægter CB,Ertekin-Taner N,Nykjær A,Andersen OM

更新日期：2018-11-01 00:00:00

abstract：:Striatal degeneration may contribute to cognitive impairment in older people. Here, we examine the relation of degeneration of the striatum and substructures to cognitive decline and dementia in subjects with a wide range of cognitive function. Data are from the prospective community-based Honolulu Asia Aging Study of...

journal_title：Neurobiology of aging

authors： de Jong LW,Wang Y,White LR,Yu B,van Buchem MA,Launer LJ

更新日期：2012-02-01 00:00:00

abstract：:White matter hyperintensities (WMH) are generally considered to be associated with cerebral small vessel disease, especially, in older age. Although significant sex differences have been reported in the severity of WMH, it is not yet known if the risk factors for WMH differ in men and women. In this study, magnetic re...

journal_title：Neurobiology of aging

authors： Alqarni A,Jiang J,Crawford JD,Koch F,Brodaty H,Sachdev P,Wen W

更新日期：2020-11-10 00:00:00

abstract：:The levels of tau phosphorylation differ between sexes in Alzheimer's disease (AD). Transcriptome-wide associations of sex by disease interaction could indicate whether specific genes underlie sex differences in tau pathology; however, no such study has been reported yet. We report the first analysis of the effect of ...

journal_title：Neurobiology of aging

authors： Cáceres A,González JR

更新日期：2020-12-01 00:00:00

abstract：:Association of the A2 allele of the human leukocyte antigen (HLA) with Alzheimer disease (AD) is still controversial. The authors evaluated HLA-A2 association with AD in 173 Italian AD patients, considering also the possible interaction with APOE pattern, age of onset and gender. No evidence of any association was fou...

journal_title：Neurobiology of aging

authors： Guerini FR,Calabrese E,Agliardi C,Zanzottera M,Franceschi M,Grimaldi LM,Nemni R,Ferrante P

更新日期：2009-12-01 00:00:00

abstract：:We recently demonstrated that retinal ganglion cell function, optic nerve head parameters and the retinal nerve fiber layer thickness are not altered in early dementia of the Alzheimer type (DAT). Our current objective was to assess whether the function of cells located more distally in the retina is also unaffected b...

journal_title：Neurobiology of aging

authors： Justino L,Kergoat M,Bergman H,Chertkow H,Robillard A,Kergoat H

更新日期：2001-07-01 00:00:00

abstract：:In the aging mammalian hypothalamus, a unique subpopulation of glial cells accumulates peroxidase-positive cytoplasmic inclusions distinct from lipofuscin. In adult rodents, this senescence-dependent glial granulation is accelerated by administration of estradiol valerate. In the present study, brain sections derived ...

journal_title：Neurobiology of aging

authors： Mydlarski MB,Liberman A,Schipper HM

更新日期：1995-11-01 00:00:00

abstract：:Vascular risk factors have been implicated in the pathogenesis of vascular dementia and Alzheimer's disease. The identification of a novel vascular disease susceptibility locus at 9p21.3 has recently generated great interest. In the present study, we sought to determine whether a common genetic variant (tagged by rs13...

journal_title：Neurobiology of aging

authors： Emanuele E,Lista S,Ghidoni R,Binetti G,Cereda C,Benussi L,Maletta R,Bruni AC,Politi P

更新日期：2011-07-01 00:00:00

abstract：:The application of beta-amyloid (Abeta) is cytotoxic to endothelial cells, promotes vasoconstriction and impairs nitric oxide (NO) generation or action. However, there is no information on the effect of intracellular Abeta on endothelial cell biology, although recent studies indicate that neuronal Abeta drives Alzheim...

journal_title：Neurobiology of aging

authors： Suhara T,Magrané J,Rosen K,Christensen R,Kim HS,Zheng B,McPhie DL,Walsh K,Querfurth H

更新日期：2003-05-01 00:00:00

abstract：:Brains were examined from 22 patients with Alzheimer's disease (AD) (mean age 80.5, S.D. 11.5) and were compared with brains from 20 nondiseased subjects (mean age 81.1, S.D. 10.2). Intraneuronal lipopigment in all layers of a region of the superior frontal cortex was identified by fluorescence microscopy. The areas e...

journal_title：Neurobiology of aging

authors： Dowson JH,Mountjoy CQ,Cairns MR,Wilton-Cox H

更新日期：1992-07-01 00:00:00

abstract：:Amyloid precursor protein (APP), a key molecule of Alzheimer disease, is metabolized in 2 antagonist pathways generating the soluble APP alpha (sAPPα) having neuroprotective properties and the beta amyloid (Aβ) peptide at the origin of neurotoxic oligomers, particularly Aβ1-42. Whether extracellular Aβ1-42 oligomers m...

journal_title：Neurobiology of aging

authors： Rose C,Dorard E,Audrain M,Gorisse-Hussonnois L,Cartier N,Braudeau J,Allinquant B

更新日期：2018-01-01 00:00:00

abstract：:We investigated whether individuals with impaired glucose tolerance (IGT) in midlife subsequently show regionally specific longitudinal changes in regional cerebral blood flow (rCBF) relative to those with normal glucose tolerance (NGT). Sixty-four cognitively normal participants in the neuroimaging substudy of the Ba...

journal_title：Neurobiology of aging

authors： Thambisetty M,Beason-Held LL,An Y,Kraut M,Metter J,Egan J,Ferrucci L,O'Brien R,Resnick SM

更新日期：2013-10-01 00:00:00

abstract：:Much experimental evidence suggests that an imbalance in cellular redox status is a major factor in the pathogenesis of Alzheimer's disease (AD). Our previous data showed a marked increase in membrane lipoperoxidation in primary fibroblasts from familial AD (FAD) patients. In the present study, we demonstrate that whe...

journal_title：Neurobiology of aging

authors： Cecchi C,Fiorillo C,Baglioni S,Pensalfini A,Bagnoli S,Nacmias B,Sorbi S,Nosi D,Relini A,Liguri G

更新日期：2007-06-01 00:00:00

abstract：:We have used structural equation models to explicitly distinguish functional status and therefore "dementia-relevant" variance in cognitive task performance (i.e., "δ" for dementia). Our approach is modular and can be directed to other targets. In this analysis, we construct a δ ortholog representing the "cognitive co...

journal_title：Neurobiology of aging

authors： Royall DR,Bishnoi RJ,Palmer RF

更新日期：2015-07-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder involving the progressive degeneration of motor neurons in the brain and spinal cord. Mitochondrial dysfunction plays a key role in ALS disease progression and has been observed in several ALS cellular and animal models. Here, we show that fibro...

journal_title：Neurobiology of aging

authors： Allen SP,Rajan S,Duffy L,Mortiboys H,Higginbottom A,Grierson AJ,Shaw PJ

更新日期：2014-06-01 00:00:00

abstract：:There is ample evidence that phosphodiesterase 4 (PDE4) inhibition can improve memory performance in animal studies. In the present study, we examined the acute effects of the PDE4 inhibitor roflumilast on memory performance in healthy individuals (60-80 years of age). We tested the effects of acute roflumilast admini...

journal_title：Neurobiology of aging

authors： Blokland A,Van Duinen MA,Sambeth A,Heckman PRA,Tsai M,Lahu G,Uz T,Prickaerts J

更新日期：2019-05-01 00:00:00

abstract：:Hippocampal atrophy rates are useful in both diagnosing and tracking Alzheimer's disease (AD). However, cohorts and methods used to determine such rates are heterogeneous, leading to differences in reported annualised rates. We performed a meta-analysis of hippocampal atrophy rates in AD patients and matched controls ...

journal_title：Neurobiology of aging

authors： Barnes J,Bartlett JW,van de Pol LA,Loy CT,Scahill RI,Frost C,Thompson P,Fox NC

更新日期：2009-11-01 00:00:00

abstract：:A common analogy to aging is that of a boulder being worn down to rubble by the unremitting onslaught of time. In contrast, Swaab's "use it or lose it" concept is important because it emphasizes some positive consequences of experience. For example, early exposure to complex experience may offer some protection from "...

journal_title：Neurobiology of aging

authors： Black JE,Isaacs KR,Greenough WT

更新日期：1991-07-01 00:00:00

abstract：:Mural cells (smooth muscle cells and pericytes) regulate blood flow and contribute to vessel stability. We examined whether mural cell changes accompany age-related alterations in the microvasculature of the central nervous system. The retinas of young adult and aged Wistar rats were subjected to immunohistofluorescen...

journal_title：Neurobiology of aging

authors： Hughes S,Gardiner T,Hu P,Baxter L,Rosinova E,Chan-Ling T

更新日期：2006-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a lethal neurological disease primarily involving the spinal cord, brainstem, and corticospinal tract. Recently, mutations in the GLE1 gene were reported in Caucasian ALS patients. To inquire whether Chinese ALS patients carried causal mutations in the gene, we screened all 16 co...

journal_title：Neurobiology of aging

authors： Zhang K,Liu Q,Shen D,Tai H,Fu H,Liu S,Chen J,Li X,Liu M,Zhang X,Cui L

更新日期：2018-06-01 00:00:00

abstract：:Mitophagy and mitochondrial biogenesis are 2 pathways that regulate mitochondrial content and metabolism maintaining cellular homeostasis. The imbalance between these opposing processes impairs mitochondrial function and is suggested to be the pathophysiological basis of a variety of neurodegenerative diseases and agi...

journal_title：Neurobiology of aging

authors： Xiong H,Chen S,Lai L,Yang H,Xu Y,Pang J,Su Z,Lin H,Zheng Y

更新日期：2019-07-01 00:00:00