当前位置： SCI文献检索 > NEUROBIOLOGY OF AGING期刊下所有文献 > Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study.

Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study.

Abstract：

:There is ample evidence that phosphodiesterase 4 (PDE4) inhibition can improve memory performance in animal studies. In the present study, we examined the acute effects of the PDE4 inhibitor roflumilast on memory performance in healthy individuals (60-80 years of age). We tested the effects of acute roflumilast administration (100, 250, 1000 μg) in a double-blind, placebo-controlled, 4-way crossover design. Participants were first screened for their verbal word memory performance to ensure normal memory performance (within 0.5 standard deviation from norm score; n = 20) Drug effects on memory performance were tested in a verbal memory test and a spatial memory test. Reported side effects of drug treatment were registered. Roflumilast (100 μg) improved the delayed recall performance of the participants (Cohen's d, 0.69). No effects were observed in the spatial memory task. Roflumilast was well tolerated at this low dose. Although no clear adverse side effects were reported at the low dose, mild adverse events (including headache, dizziness, insomnia, and diarrhea) were reported after the 1000 μg dose. The present study provides first evidence that the PDE4 inhibitor roflumilast improves verbal memory performance in old participants. The current data encourage further development of PDE4 inhibitors for improving memory.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Blokland A,Van Duinen MA,Sambeth A,Heckman PRA,Tsai M,Lahu G,Uz T,Prickaerts J

doi

10.1016/j.neurobiolaging.2019.01.014

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

37-43

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(19)30028-4

journal_volume

77

pub_type

杂志文章,随机对照试验

相关文献

NEUROBIOLOGY OF AGING文献大全
  • GRN deletion in familial frontotemporal dementia showing association with clinical variability in 3 familial cases.

    abstract：:Progranulin (GRN) gene mutations have been genetically associated with frontotemporal dementia (FTD) and are present in about 23% of patients with familial FTD. However, the neurobiology of this secreted glycoprotein remains unclear. Here, we report the identification of 3 pedigrees of Southern Italian extraction in w...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.12.030

    authors： Milan G,Napoletano S,Pappatà S,Gentile MT,Colucci-D'Amato L,Della Rocca G,Maciag A,Rossetti CP,Fucci L,Puca A,Grossi D,Postiglione A,Vitale E

    更新日期：2017-05-01 00:00:00

  • Critical period for dopaminergic neuroprotection by hormonal replacement in menopausal rats.

    abstract：:The neuroprotective effects of menopausal hormonal therapy in Parkinson's disease have not yet been clarified, and it is not known whether there is a critical period. Estrogen induced significant protection against 6-hydroxydopamine-induced dopaminergic degeneration when administered immediately or 6 weeks, but not 20...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.10.028

    authors： Rodriguez-Perez AI,Borrajo A,Valenzuela R,Lanciego JL,Labandeira-Garcia JL

    更新日期：2015-02-01 00:00:00

  • Widespread distribution of tauopathy in preclinical Alzheimer's disease.

    abstract：:The objective of this study was to examine the distribution and severity of tau-PET binding in cognitively normal adults with preclinical Alzheimer's disease as determined by positive beta-amyloid PET. 18F-AV-1451 tau-PET data from 109 cognitively normal older adults were processed with 34 cortical and 9 subcortical F...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.08.022

    authors： Schultz SA,Gordon BA,Mishra S,Su Y,Perrin RJ,Cairns NJ,Morris JC,Ances BM,Benzinger TLS

    更新日期：2018-12-01 00:00:00

  • Mutation analysis of patients with neurodegenerative disorders using NeuroX array.

    abstract：:Genetic analyses of patients with neurodegenerative disorders have identified multiple genes that need to be investigated for the presence of damaging variants. However, mutation analysis by Sanger sequencing is costly and time consuming. We tested the utility of a recently designed semi-custom genome-wide array (Neur...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.07.038

    authors： Ghani M,Lang AE,Zinman L,Nacmias B,Sorbi S,Bessi V,Tedde A,Tartaglia MC,Surace EI,Sato C,Moreno D,Xi Z,Hung R,Nalls MA,Singleton A,St George-Hyslop P,Rogaeva E

    更新日期：2015-01-01 00:00:00

  • Different MAPT haplotypes are associated with Parkinson's disease and progressive supranuclear palsy.

    abstract：:The H1 MAPT haplotype in the 17q21 chromosomal region has been associated with several neurodegenerative diseases. Some reports have suggested that there is an association between genetic variants within the H1 haplotype with Parkinson's disease (PD), progressive supranuclear palsy (PSP) and corticobasal degeneration ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2009.09.011

    authors： Ezquerra M,Pastor P,Gaig C,Vidal-Taboada JM,Cruchaga C,Muñoz E,Martí MJ,Valldeoriola F,Aguilar M,Calopa M,Hernandez-Vara J,Tolosa E

    更新日期：2011-03-01 00:00:00

  • Expression of alpha 4-1 and alpha 5 nicotinic cholinoceptor mRNA in the aging rat cerebral cortex.

    abstract：:Although important in neurodegeneration, systematic studies of nicotinic acetylcholine receptor expression in normal aging human brains are difficult to perform. We have studied the expression of nicotinic receptor alpha 4-1 and alpha 5 mRNA in the frontal and parietal isocortex of 3- (young adult), 24- (late middle a...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(97)80316-8

    authors： Birtsch C,Wevers A,Traber J,Maelicke A,Bloch W,Schröder H

    更新日期：1997-05-01 00:00:00

  • Age-related effects on eyeblink conditioning in the F344 x BN F1 hybrid rat.

    abstract：:Young, middle-aged, old, and senescent Fischer 344 x Brown Norway F1 hybrid rats were trained in either the trace or delay eyeblink conditioning task in order to investigate how aging affects associative learning and memory over the life span. Senescent rats at 34-35 months showed severe impairments in acquisition of ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(00)00194-9

    authors： Knuttinen MG,Gamelli AE,Weiss C,Power JM,Disterhoft JF

    更新日期：2001-01-01 00:00:00

  • Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice.

    abstract：:Amyloid deposits are one of the hallmarks of Alzheimer's disease. Recent studies, in transgenic mice modeling Alzheimer's disease showed that, using in vivo, contrast agent-free, MRI, thalamic amyloid plaques are more easily detected than other plaques of the brain. Our study evaluated the characteristics of these tha...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2007.05.018

    authors： Dhenain M,El Tannir El Tayara N,Wu TD,Guégan M,Volk A,Quintana C,Delatour B

    更新日期：2009-01-01 00:00:00

  • Candidate gene analysis for Alzheimer's disease in adults with Down syndrome.

    abstract：:Individuals with Down syndrome (DS) overexpress many genes on chromosome 21 due to trisomy and have high risk of dementia due to the Alzheimer's disease (AD) neuropathology. However, there is a wide range of phenotypic differences (e.g., age at onset of AD, amyloid β levels) among adults with DS, suggesting the import...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.04.018

    authors： Lee JH,Lee AJ,Dang LH,Pang D,Kisselev S,Krinsky-McHale SJ,Zigman WB,Luchsinger JA,Silverman W,Tycko B,Clark LN,Schupf N

    更新日期：2017-08-01 00:00:00

  • Fixation effects on synaptic vesicle density in neuromuscular junctions of young and old mice.

    abstract：:It was previously reported that in soleus neuromuscular junctions of old mice, synaptic vesicle density was decreased while transmitter release was increased (compared to results in young mice). In the present study, two hypotheses that might resolve this disparity were tested. The first was that the density of readil...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(87)90061-3

    authors： Fahim MA,Robbins N,Price R

    更新日期：1987-01-01 00:00:00

  • Aging alters envelope representations of speech-like sounds in the inferior colliculus.

    abstract：:Hearing impairment in older people is thought to arise from impaired temporal processing in auditory circuits. We used a systems-level (scalp recordings) and a microcircuit-level (extracellular recordings) approach to investigate how aging affects the sensitivity to temporal envelopes of speech-like sounds in rats. Sc...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.08.023

    authors： Parthasarathy A,Herrmann B,Bartlett EL

    更新日期：2019-01-01 00:00:00

  • An analog derived from phenylpropanoids ameliorates Alzheimer's disease-like pathology and protects mitochondrial function.

    abstract：:The abnormal proliferation and neurogenesis of neural progenitor cells (NPCs) is usually associated with the pathophysiology of neurodegenerative disorders such as Alzheimer's disease (AD). Mitochondrial stress is one of the most prominent features of AD and is thought to be involved in the impairment of the neurogene...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2019.05.002

    authors： Huang S,Cao X,Zhou Y,Shi F,Xin S,He S,An Y,Gao L,Yang Y,Yu B,Pei G

    更新日期：2019-08-01 00:00:00

  • 3-D reconstruction of the cholinergic basal forebrain system in young and aged rats.

    abstract：:The 3-dimensional (3-D) distribution of cholinergic neurons located throughout the extent of the entire basal forebrain of young (4-5 months old) and aged (24-25 months old) Fischer-344 rats was examined using choline acetyltransferase immunocytochemistry (ChAT-IR). The number and 3-D position of ChAT-IR neurons spann...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(93)90126-v

    authors： Smith ML,Deadwyler SA,Booze RM

    更新日期：1993-07-01 00:00:00

  • Differential effects of amyloid-beta 1-40 and 1-42 fibrils on 5-HT1A serotonin receptors in rat brain.

    abstract：:Evidence accumulates suggesting a complex interplay between neurodegenerative processes and serotonergic neurotransmission. We have previously reported an overexpression of serotonin 5-HT1A receptors (5-HT(1A)R) after intrahippocampal injections of amyloid-beta 1-40 (Aβ40) fibrils in rats. This serotonergic reactivity...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2015.12.008

    authors： Verdurand M,Chauveau F,Daoust A,Morel AL,Bonnefoi F,Liger F,Bérod A,Zimmer L

    更新日期：2016-04-01 00:00:00

  • Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease.

    abstract：:The loss of presynaptic markers is thought to represent a strong pathologic correlate of cognitive decline in Alzheimer's disease (AD). Spinophilin is a postsynaptic marker mainly located to the heads of dendritic spines. We assessed total numbers of spinophilin-immunoreactive puncta in the CA1 and CA3 fields of hippo...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2007.03.007

    authors： Akram A,Christoffel D,Rocher AB,Bouras C,Kövari E,Perl DP,Morrison JH,Herrmann FR,Haroutunian V,Giannakopoulos P,Hof PR

    更新日期：2008-09-01 00:00:00

  • Cross-talk between Aβ and endothelial SSAO/VAP-1 accelerates vascular damage and Aβ aggregation related to CAA-AD.

    abstract：:An association between semicarbazide-sensitive amine oxidase (SSAO) and cerebral amyloid angiopathy (CAA) related to Alzheimer's disease (AD) has been largely postulated. Increased SSAO activity and expression have been detected in cerebrovascular tissue and plasma of AD patients, colocalizing with cerebrovascular amy...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.09.030

    authors： Solé M,Miñano-Molina AJ,Unzeta M

    更新日期：2015-02-01 00:00:00

  • The APOE paradox: do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline.

    abstract：:Possession of an Apolipoprotein E (APOE) e4 allele is an established risk factor for Alzheimer's disease, whereas the less commonly studied e2 variant is premised to offer some protection. This research explores the purported deleterious-protective dichotomy of APOE variants on attentional control in mid-adulthood. Si...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.08.015

    authors： Lancaster C,Tabet N,Rusted J

    更新日期：2016-12-01 00:00:00

  • Low-level laser therapy for beta amyloid toxicity in rat hippocampus.

    abstract：:Beta amyloid (Aβ) is well accepted to play a central role in the pathogenesis of Alzheimer's disease (AD). The present work evaluated the therapeutic effects of low-level laser irradiation (LLI) on Aβ-induced neurotoxicity in rat hippocampus. Aβ 1-42 was injected bilaterally to the hippocampus CA1 region of adult male...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.10.003

    authors： Lu Y,Wang R,Dong Y,Tucker D,Zhao N,Ahmed ME,Zhu L,Liu TC,Cohen RM,Zhang Q

    更新日期：2017-01-01 00:00:00

  • Pituitary adenylate cyclase-activating polypeptide protects against β-amyloid toxicity.

    abstract：:Pituitary adenylate cyclase activating polypeptide (PACAP) is a neurotrophin. However, its role in human Alzheimer's disease (AD) is largely unknown. We examined PACAP expression in postmortem human AD and triple transgenic mouse (3xTG, Psen1/APPSwe/TauP301L) brains. We established an in vitro model of primary neurona...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.03.022

    authors： Han P,Tang Z,Yin J,Maalouf M,Beach TG,Reiman EM,Shi J

    更新日期：2014-09-01 00:00:00

  • Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease.

    abstract：:Dietary restriction (DR) extends lifespan in diverse organisms and, in animal and cellular models, can delay a range of aging-related diseases including Alzheimer's disease (AD). A better understanding of the mechanisms mediating these interactions, however, may reveal novel pathways involved in AD pathogenesis, and p...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2009.10.015

    authors： Kerr F,Augustin H,Piper MD,Gandy C,Allen MJ,Lovestone S,Partridge L

    更新日期：2011-11-01 00:00:00

  • Screening of GLE1 mutations in Chinese amyotrophic lateral sclerosis patients.

    abstract：:Amyotrophic lateral sclerosis (ALS) is a lethal neurological disease primarily involving the spinal cord, brainstem, and corticospinal tract. Recently, mutations in the GLE1 gene were reported in Caucasian ALS patients. To inquire whether Chinese ALS patients carried causal mutations in the gene, we screened all 16 co...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.12.029

    authors： Zhang K,Liu Q,Shen D,Tai H,Fu H,Liu S,Chen J,Li X,Liu M,Zhang X,Cui L

    更新日期：2018-06-01 00:00:00

  • Brain atrophy and cognition: interaction with cerebrovascular pathology?

    abstract：:We examined the interaction of brain atrophy and white matter lesions (WML) with cognitive functioning in 605 patients (mean age, 58±10; 76% men) with atherosclerotic disease from the Second Manifestations of ARTerial disease-MR substudy (SMART-MR study). Automated brain segmentation was used to quantify volumes of br...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2009.05.005

    authors： Muller M,Appelman AP,van der Graaf Y,Vincken KL,Mali WP,Geerlings MI

    更新日期：2011-05-01 00:00:00

  • A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice.

    abstract：:Amyloid plaques are a characteristic feature in Alzheimer's disease (AD). A novel non-toxic contrast agent is presented, Gd-DTPA-K6Abeta1-30, which is homologous to Abeta, and allows plaque detection in vivo. microMRI was performed on AD model mice and controls prior to and following intracarotid injection with Gd-DTP...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2006.12.018

    authors： Sigurdsson EM,Wadghiri YZ,Mosconi L,Blind JA,Knudsen E,Asuni A,Scholtzova H,Tsui WH,Li Y,Sadowski M,Turnbull DH,de Leon MJ,Wisniewski T

    更新日期：2008-06-01 00:00:00

  • Serum IGF-BP2 strongly moderates age's effect on cognition: a MIMIC analysis.

    abstract：:We have used structural equation models to explicitly distinguish functional status and therefore "dementia-relevant" variance in cognitive task performance (i.e., "δ" for dementia). Our approach is modular and can be directed to other targets. In this analysis, we construct a δ ortholog representing the "cognitive co...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2015.04.003

    authors： Royall DR,Bishnoi RJ,Palmer RF

    更新日期：2015-07-01 00:00:00

  • Female-specific risk of Alzheimer's disease is associated with tau phosphorylation processes: A transcriptome-wide interaction analysis.

    abstract：:The levels of tau phosphorylation differ between sexes in Alzheimer's disease (AD). Transcriptome-wide associations of sex by disease interaction could indicate whether specific genes underlie sex differences in tau pathology; however, no such study has been reported yet. We report the first analysis of the effect of ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2020.08.020

    authors： Cáceres A,González JR

    更新日期：2020-12-01 00:00:00

  • Parkinsonism is associated with altered primary motor cortex plasticity in frontotemporal dementia-primary progressive aphasia variant.

    abstract：:In frontotemporal dementia (FTD), the behavioral variant (bv-FTD) and nonfluent variant of primary progressive aphasia (nfv-PPA) reflect a prominent neurodegenerative involvement of the frontal lobe networks, which may include the premotor and motor areas and thus cause heterogeneous clinical symptoms including parkin...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.05.026

    authors： Di Stasio F,Suppa A,Fabbrini A,Marsili L,Asci F,Conte A,Trebbastoni A,De Lena C,Berardelli A

    更新日期：2018-09-01 00:00:00

  • APP-695 transcript prevalence is selectively reduced during Alzheimer's disease in cortex and hippocampus but not in cerebellum.

    abstract：:We previously found a selective loss of the brain specific APP-695 transcript in Alzheimer's disease (AD) cortex, which results in a 2.5-fold increase in the APP-751/APP-695 transcript ratio in AD (9). Here we report a similar increase in APP-751/APP-695 mRNA ratio in AD hippocampus. However, the cerebellum had a 6-fo...

    journal_title：Neurobiology of aging

    pub_type： 更正并重新发布的文章,杂志文章

    doi：10.1016/0197-4580(89)90017-1

    authors： Johnson SA,Rogers J,Finch CE

    更新日期：1989-11-01 00:00:00

  • Association of a neurokinin 3 receptor polymorphism with the anterior basal forebrain.

    abstract：:The neuropeptide neurokinin 3 (NK3) and its receptor modulate cholinergic activity of the basal forebrain (BF) and are implicated in learning and memory. In Alzheimer's disease, the rs2765 single-nucleotide polymorphism (SNP) of the NK3 receptor-coding gene TACR3 was correlated with the right hippocampus volume. Here,...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.12.031

    authors： Teipel SJ,Grothe MJ,Wittfeld K,Hoffmann W,Hegenscheid K,Völzke H,Homuth G,Grabe HJ

    更新日期：2015-06-01 00:00:00

  • Presenilin 1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin 1 FAD mutations.

    abstract：:Mutants of presenilin 1 (PS1) increase neuronal cell death causing autosomal-dominant familial Alzheimer's disease (FAD). Recent literature shows that treatment of neuronal cultures with low concentrations of trypsin, a member of the serine family of proteases, protects neurons from toxic insults by binding to the pro...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.02.028

    authors： Nikolakopoulou AM,Georgakopoulos A,Robakis NK

    更新日期：2016-06-01 00:00:00

  • Relationship between serum alpha 1-antichymotrypsin and Alzheimer's disease.

    abstract：:We obtained serum samples and measured alpha 1-antichymotrypsin (ACT) levels in 36 pairs of consecutive probable Alzheimer's disease (AD) patients and age- and sex-matched, cognitively intact control subjects. Serum ACT was measured by radial immunodiffusion. Unique to this study, we found that ACT levels rose signifi...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(94)90141-4

    authors： Hinds TR,Kukull WA,Van Belle G,Schellenberg GD,Villacres EC,Larson EB

    更新日期：1994-01-01 00:00:00