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Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease.

Abstract：

:The loss of presynaptic markers is thought to represent a strong pathologic correlate of cognitive decline in Alzheimer's disease (AD). Spinophilin is a postsynaptic marker mainly located to the heads of dendritic spines. We assessed total numbers of spinophilin-immunoreactive puncta in the CA1 and CA3 fields of hippocampus and area 9 in 18 elderly individuals with various degrees of cognitive decline. The decrease in spinophilin-immunoreactivity was significantly related to both Braak neurofibrillary tangle (NFT) staging and clinical severity but not A beta deposition staging. The total number of spinophilin-immunoreactive puncta in CA1 field and area 9 were significantly related to MMSE scores and predicted 23.5 and 61.9% of its variability. The relationship between total number of spinophilin-immunoreactive puncta in CA1 field and MMSE scores did not persist when adjusting for Braak NFT staging. In contrast, the total number of spinophilin-immunoreactive puncta in area 9 was still significantly related to the cognitive outcome explaining an extra 9.6% of MMSE and 25.6% of the Clinical Dementia Rating scores variability. Our data suggest that neocortical dendritic spine loss is an independent parameter to consider in AD clinicopathologic correlations.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Akram A,Christoffel D,Rocher AB,Bouras C,Kövari E,Perl DP,Morrison JH,Herrmann FR,Haroutunian V,Giannakopoulos P,Hof PR

doi

10.1016/j.neurobiolaging.2007.03.007

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

1296-307

issue

9

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(07)00110-8

journal_volume

29

pub_type

杂志文章

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