Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial.

abstract：:A loss of hippocampal neurons and synapses had been considered a hallmark of normal aging and, furthermore, to be a substrate of age-related learning and memory deficits. Recent stereological studies in humans have shown that only a relatively minor neuron loss occurs with aging and that this loss is restricted to spe...

journal_title：Neurobiology of aging

authors： Calhoun ME,Kurth D,Phinney AL,Long JM,Hengemihle J,Mouton PR,Ingram DK,Jucker M

更新日期：1998-11-01 00:00:00

abstract：:Increased life expectancy impacts directly on the number of older people worldwide with the associated increase in neurodegenerative diseases. Besides their social implications, the different forms of dementia, including Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies or frontotemporal dementia, sh...

journal_title：Neurobiology of aging

authors： Gámez-Valero A,Beyer K,Borràs FE

更新日期：2019-02-01 00:00:00

abstract：:We have shown previously that the TG-3 and MPM-2 antibodies recognize phosphoepitopes common to mitosis and degenerating neurons of Alzheimer's disease(AD) brain. Here, we have evaluated their occurrence in human brain biopsy tissue, and confirm that they are absent in mature neurons of adult brain, but reappear durin...

journal_title：Neurobiology of aging

authors： Vincent I,Zheng JH,Dickson DW,Kress Y,Davies P

更新日期：1998-07-01 00:00:00

abstract：:Posterior cortical atrophy (PCA) is an understudied visual impairment syndrome most often due to "posterior Alzheimer's disease (AD)" pathology. Case studies detected mutations in PSEN1, PSEN2, GRN, MAPT, and PRNP in subjects with clinical PCA. To detect the frequency and spectrum of mutations in known dementia genes ...

journal_title：Neurobiology of aging

authors： Carrasquillo MM,Barber I,Lincoln SJ,Murray ME,Camsari GB,Khan QUA,Nguyen T,Ma L,Bisceglio GD,Crook JE,Younkin SG,Dickson DW,Boeve BF,Graff-Radford NR,Morgan K,Ertekin-Taner N

更新日期：2016-01-01 00:00:00

abstract：:The injection of aluminum powder into the cerebrospinal fluid of adult rabbits induced a slowly progressing encephalomyelopathy characterized at first by alteration of posture and then by myoclonic jerks and muscle weakness. Neurofibrillary degeneration was the hallmark of the disease and involved most of the gray are...

journal_title：Neurobiology of aging

authors： Bugiani O,Ghetti B

更新日期：1982-10-01 00:00:00

abstract：:The objective of this study was to assess how longitudinal change in the quantity and quality of white matter signal abnormalities (WMSAs) contributes to the progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD). The Mahalanobis distance of WMSA from normal-appearing white matter using T1-, T2-,...

journal_title：Neurobiology of aging

authors： Lindemer ER,Salat DH,Smith EE,Nguyen K,Fischl B,Greve DN,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2015-09-01 00:00:00

abstract：:The genetic analysis of the yeast replicative life span has revealed the importance of metabolic control and resistance to stress. It has also illuminated the pivotal role in determining longevity that the RAS genes play by the maintenance of homeostasis. This role appears to be performed by the coordination of a vari...

journal_title：Neurobiology of aging

authors： Jazwinski SM

更新日期：1999-09-01 00:00:00

abstract：:Amyloid beta (Aβ) peptide, the main component of senile plaques in patients with Alzheimer's disease (AD), is derived from proteolytic cleavage of amyloid precursor protein (APP) by β- and γ-secretases. Alpha-cleavage of APP by α-secretase has a potential to preclude the generation of Aβ because it occurs within the A...

journal_title：Neurobiology of aging

authors： Ohno M,Hiraoka Y,Lichtenthaler SF,Nishi K,Saijo S,Matsuoka T,Tomimoto H,Araki W,Takahashi R,Kita T,Kimura T,Nishi E

更新日期：2014-01-01 00:00:00

abstract：:Plaques found in the brains of patients suffering from Alzheimer's disease (AD) mainly consist of beta-amyloid (Abeta), which is produced by sequential cleaving of amyloid precursor protein (APP) by two proteolytic enzymes, beta- and gamma-secretases. Any change in the fine balance between these enzymes and their subs...

journal_title：Neurobiology of aging

authors： Zohar O,Pick CG,Cavallaro S,Chapman J,Katzav A,Milman A,Alkon DL

更新日期：2005-08-01 00:00:00

abstract：:Calcium-binding proteins play potentially important roles in neurogenesis and neuroprotective mechanism(s). Some evidence exists that brain calbindin-D28K (CALB) is regulated by androgens. In the present study, calretinin (CALRET) and CALB patterns were determined by Western analysis in the medial basal hypothalamus (...

journal_title：Neurobiology of aging

authors： Lephart ED,Taylor H,Jacobson NA,Watson MA

更新日期：1998-05-01 00:00:00

abstract：:Kisspeptin neurons in the rostral periventricular area of the third ventricle (RP3V) play a key role in relaying the positive feedback effects of estradiol that activate gonadotropin-releasing hormone (GnRH) neurons and drive a surge in the GnRH/luteinizing hormone (LH) level. However, the precise role of kisspeptin n...

journal_title：Neurobiology of aging

authors： Zhang J,Yang L,Lin N,Pan X,Zhu Y,Chen X

更新日期：2014-03-01 00:00:00

abstract：:Remembering the location of objects, an integral part of everyday life, is known to decline with advancing age and early in the course of neurodegenerative dementia. Here, we aimed to test if object-location learning and its retention could be modified by noninvasive brain stimulation. In a group of 20 elderly (mean a...

journal_title：Neurobiology of aging

authors： Flöel A,Suttorp W,Kohl O,Kürten J,Lohmann H,Breitenstein C,Knecht S

更新日期：2012-08-01 00:00:00

abstract：:Event-related fMRI studies have investigated age-related changes in encoding by identifying greater activity for items that are later remembered than for those that are forgotten (difference in memory, or Dm). The present study used hybrid blocked/event-related analyses to distinguish between transient Dm versus susta...

journal_title：Neurobiology of aging

authors： Dennis NA,Daselaar S,Cabeza R

更新日期：2007-11-01 00:00:00

abstract：:Genome-wide association studies (GWASs) have been effective approaches to dissect common genetic variability underlying complex diseases in a systematic and unbiased way. Recently, GWASs have led to the discovery of over 20 susceptibility loci for Alzheimer's disease (AD). Despite the evidence showing the contribution...

journal_title：Neurobiology of aging

authors： Sassi C,Nalls MA,Ridge PG,Gibbs JR,Ding J,Lupton MK,Troakes C,Lunnon K,Al-Sarraj S,Brown KS,Medway C,Clement N,Lord J,Turton J,Bras J,Almeida MR,ARUK Consortium.,Holstege H,Louwersheimer E,van der Flier WM,Schelte

更新日期：2016-10-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a complex fatal neurodegenerative disease characterized by progressive degeneration and loss of upper motor neurons in the cerebral cortex and lower motor neurons in brainstem and spinal cord. We established the frequencies of mutations in 4 major ALS-associated genes, SOD1, TARD...

journal_title：Neurobiology of aging

authors： Vrabec K,Koritnik B,Leonardis L,Dolenc-Grošelj L,Zidar J,Smith B,Vance C,Shaw C,Rogelj B,Glavač D,Ravnik-Glavač M

更新日期：2015-03-01 00:00:00

abstract：:Aging has been related to diminished cognitive function, which could be a result of ineffective synaptic function. We have previously shown that synaptic plasma membrane proteins supporting synaptic integrity and neurotransmission were downregulated in docosahexaenoic acid (DHA)-deprived brains, suggesting an importan...

journal_title：Neurobiology of aging

authors： Sidhu VK,Huang BX,Desai A,Kevala K,Kim HY

更新日期：2016-05-01 00:00:00

abstract：:The use of biomarkers has been proposed for diagnosing Alzheimer's disease in recent criteria, but some biomarkers have not been sufficiently investigated to justify their routine clinical use. Here, we evaluate in a literature review the clinical validity of amyloid positron emission tomography (PET) imaging using a ...

journal_title：Neurobiology of aging

authors： Chiotis K,Saint-Aubert L,Boccardi M,Gietl A,Picco A,Varrone A,Garibotto V,Herholz K,Nobili F,Nordberg A,Geneva Task Force for the Roadmap of Alzheimer's Biomarkers.

更新日期：2017-04-01 00:00:00

abstract：:Aging of the nervous system is characterized by reduced anatomical plasticity. The cause of this decreased plasticity is not known because it is usually not possible to distinguish between extrinsic and intrinsic factors that affect neuronal growth. One example of age-related reduced neuronal plasticity that is amenda...

journal_title：Neurobiology of aging

authors： Crutcher KA

更新日期：1990-05-01 00:00:00

abstract：:The abnormal accumulation of amyloid fibrils in the brain is pathognomonic of Alzheimer's disease. Amyloid fibrils induce significant neuroinflammation characterized by the activation of microglia and impairment of synaptic plasticity in the brain that eventually leads to cognitive decline. Chemokine fractalkine recep...

journal_title：Neurobiology of aging

authors： Wu J,Bie B,Yang H,Xu JJ,Brown DL,Naguib M

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Aging is a major risk factor for a variety of neurobiological diseases leading to variations of transcriptional expression in affected tissues. Reverse transcription of RNA followed by quantitative PCR is a powerful technique for detection and quantification of specific transcripts differentially expressed. ...

journal_title：Neurobiology of aging

authors： Sieber MW,Guenther M,Kohl M,Witte OW,Claus RA,Frahm C

更新日期：2010-04-01 00:00:00

abstract：:In order to assess peripheral levels and activities of a broad spectrum of non-enzymatic and enzymatic antioxidants in elderly subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD), plasma levels of water-soluble (Vitamin C and uric acid) and of lipophilic (Vitamin A, Vitamin E and carotenoids inc...

journal_title：Neurobiology of aging

authors： Rinaldi P,Polidori MC,Metastasio A,Mariani E,Mattioli P,Cherubini A,Catani M,Cecchetti R,Senin U,Mecocci P

更新日期：2003-11-01 00:00:00

abstract：:The knowledge base of nutrition and the brain is steadily expanding. Much of the research is aimed at ways to protect the brain from damage. In adults, the major causes of brain damage are aging and dementia. The most prominent dementia, and the condition that grabs the most public attention, is Alzheimer's disease. T...

journal_title：Neurobiology of aging

authors： Cooper JK

更新日期：2014-09-01 00:00:00

abstract：:The present study investigated if a causal relation exists between serum concentrations of precursors and metabolites of cholesterol and cognitive performance in a healthy aging population. Cognitive function addressing four domains of 144 individuals (30-80 years) was tested at baseline and after 6 years of follow-up...

journal_title：Neurobiology of aging

authors： Teunissen CE,De Vente J,von Bergmann K,Bosma H,van Boxtel MP,De Bruijn C,Jolles J,Steinbusch HW,Lütjohann D

更新日期：2003-01-01 00:00:00

abstract：:Cognitive reserve (CR) shows protective effects on cognitive function in older adults. Here, we focused on the effects of CR at the functional network level. We assessed in patients with amnestic mild cognitive impairment (aMCI) whether higher CR moderates the association between low internetwork cross-talk on memory ...

journal_title：Neurobiology of aging

authors： Franzmeier N,Buerger K,Teipel S,Stern Y,Dichgans M,Ewers M,Alzheimer's Disease Neuroimaging Initiative (ADNI).

更新日期：2017-02-01 00:00:00

abstract：:The apolipoprotein E (ApoE) ε4 allele has consistently been established as an Alzheimer's disease (AD) risk factor, but its pathological contribution to AD is obscure. Certain butyrylcholinesterase (BuChE) polymorphisms together with the ApoE ε4 allele synergistically increase the risk of AD. In addition, AD risk fact...

journal_title：Neurobiology of aging

authors： Darreh-Shori T,Modiri N,Blennow K,Baza S,Kamil C,Ahmed H,Andreasen N,Nordberg A

更新日期：2011-07-01 00:00:00

abstract：:The G4C2 hexanucleotide repeat expansion, located in the first intron of the C9ORF72 gene, represents a major genetic hallmark of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Several hypotheses have been proposed on how the transcribed repeat RNA leads to the development of amyotrophic lateral ...

journal_title：Neurobiology of aging

authors： Šket P,Pohleven J,Kovanda A,Štalekar M,Župunski V,Zalar M,Plavec J,Rogelj B

更新日期：2015-02-01 00:00:00

abstract：:Amyloid precursor protein (APP), a key molecule of Alzheimer disease, is metabolized in 2 antagonist pathways generating the soluble APP alpha (sAPPα) having neuroprotective properties and the beta amyloid (Aβ) peptide at the origin of neurotoxic oligomers, particularly Aβ1-42. Whether extracellular Aβ1-42 oligomers m...

journal_title：Neurobiology of aging

authors： Rose C,Dorard E,Audrain M,Gorisse-Hussonnois L,Cartier N,Braudeau J,Allinquant B

更新日期：2018-01-01 00:00:00

abstract：:Macrophages or activated microglia in the subretinal space are considered a hallmark of some retinal pathologies. We investigated the effects of age, pigmentation and CX(3)CR1 deficiency on the accumulation of macrophages/activated microglia in the outer retina of young and old Cx(3)cr1(gfp/gfp) (CX(3)CR1-deficient) o...

journal_title：Neurobiology of aging

authors： Chinnery HR,McLenachan S,Humphries T,Kezic JM,Chen X,Ruitenberg MJ,McMenamin PG

更新日期：2012-08-01 00:00:00

abstract：:SORL1 encodes a 250-kDa protein named sorLA, a functional sorting receptor for the amyloid precursor protein (APP). Several single nucleotide polymorphisms of the gene SORL1, encoding sorLA, are genetically associated with Alzheimer's disease (AD). In the existing literature, SORL1 is insufficiently described at the t...

journal_title：Neurobiology of aging

authors： Blechingberg J,Poulsen ASA,Kjølby M,Monti G,Allen M,Ivarsen AK,Lincoln SJ,Thotakura G,Vægter CB,Ertekin-Taner N,Nykjær A,Andersen OM

更新日期：2018-11-01 00:00:00

abstract：:Older adults have altered perception of the relative timing between auditory and visual stimuli, even when stimuli are scaled to equate detectability. To help understand why, this study investigated the neural correlates of audiovisual synchrony judgments in older adults using electroencephalography (EEG). Fourteen yo...

journal_title：Neurobiology of aging

authors： Chan YM,Pianta MJ,Bode S,McKendrick AM

更新日期：2017-07-01 00:00:00