Summative effects of vascular risk factors on cortical thickness in mild cognitive impairment.

abstract：:The activity of beta-secretase (BACE1), the endo-protease essential for the production of amyloid beta (Abeta) peptides, is increased in brain of late-onset sporadic Alzheimer's disease (AD), and oxidative stress is the potential cause of this event. Oxidative stress up-regulates the expression and the activity of BAC...

journal_title：Neurobiology of aging

authors： Tamagno E,Guglielmotto M,Giliberto L,Vitali A,Borghi R,Autelli R,Danni O,Tabaton M

更新日期：2009-10-01 00:00:00

abstract：:In order to investigate inflammation and apoptosis in Creutzfeldt-Jakob disease (CJD) patients, we analyzed astrocytes, microglia and apoptotic neurons in brain and IL-1beta in cerebrospinal fluid (CSF). Our results showed increased numbers of astrocytes in CJD and increased numbers of microglia and apoptotic neurons ...

journal_title：Neurobiology of aging

authors： Van Everbroeck B,Dewulf E,Pals P,Lübke U,Martin JJ,Cras P

更新日期：2002-01-01 00:00:00

abstract：:Amyloid beta (Aβ) peptide, the main component of senile plaques in patients with Alzheimer's disease (AD), is derived from proteolytic cleavage of amyloid precursor protein (APP) by β- and γ-secretases. Alpha-cleavage of APP by α-secretase has a potential to preclude the generation of Aβ because it occurs within the A...

journal_title：Neurobiology of aging

authors： Ohno M,Hiraoka Y,Lichtenthaler SF,Nishi K,Saijo S,Matsuoka T,Tomimoto H,Araki W,Takahashi R,Kita T,Kimura T,Nishi E

更新日期：2014-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder involving the progressive degeneration of motor neurons in the brain and spinal cord. Mitochondrial dysfunction plays a key role in ALS disease progression and has been observed in several ALS cellular and animal models. Here, we show that fibro...

journal_title：Neurobiology of aging

authors： Allen SP,Rajan S,Duffy L,Mortiboys H,Higginbottom A,Grierson AJ,Shaw PJ

更新日期：2014-06-01 00:00:00

abstract：:In the rhesus monkey primary visual cortex, there are bundles of vertically oriented myelinated axons, which mainly contain efferent fibers originating from pyramidal cells. At the level of layer 4Cbeta, the bundles are regularly arranged and the nerve fibers in them are closely packed. In order to determine if a sign...

journal_title：Neurobiology of aging

authors： Nielsen K,Peters A

更新日期：2000-09-01 00:00:00

abstract：:Several polymorphisms in hepatic lipase (LIPC) are similar to apoE4 because they associate with cholesterol concentrations and, for rs6084, coronary artery disease (CAD). Since apoE4 is also a primary genetic risk factor for late-onset Alzheimer's disease (LOAD), LIPC single nucleotide polymorphisms (SNP)s represent e...

journal_title：Neurobiology of aging

authors： Zhu H,Taylor JW,Bennett DA,Younkin SG,Estus S

更新日期：2008-05-01 00:00:00

abstract：:The observation that neurons containing neurofibrillary tangles are usually adjacent to neurons free of any morphological indication of disease, suggests the hypothesis that it is NFT-bearing neurons that are primarily responsible for the loss of function in AD. Quantitative Golgi postmortem studies from our laborator...

journal_title：Neurobiology of aging

authors： Callahan LM,Coleman PD

更新日期：1995-05-01 00:00:00

abstract：:Spinal and bulbar muscular atrophy (SBMA) is an X-linked motoneuron disease caused by an abnormal expansion of a tandem CAG repeat in exon 1 of the androgen receptor (AR) gene that results in an abnormally long polyglutamine tract (polyQ) in the AR protein. As a result, the mutant AR (ARpolyQ) misfolds, forming cytopl...

journal_title：Neurobiology of aging

authors： Rusmini P,Crippa V,Giorgetti E,Boncoraglio A,Cristofani R,Carra S,Poletti A

更新日期：2013-11-01 00:00:00

abstract：:Proceptive and receptive behaviors were examined in aging and young ovariectomized female rats treated with estradiol benzoate and progesterone. Young females approached males confined in wire mesh cages more frequently and exhibited more proceptive behaviors toward these males than did middle-aged females. Both middl...

journal_title：Neurobiology of aging

authors： Chambers KC,Phoenix CH

更新日期：1986-05-01 00:00:00

abstract：:We examined the interaction of brain atrophy and white matter lesions (WML) with cognitive functioning in 605 patients (mean age, 58±10; 76% men) with atherosclerotic disease from the Second Manifestations of ARTerial disease-MR substudy (SMART-MR study). Automated brain segmentation was used to quantify volumes of br...

journal_title：Neurobiology of aging

authors： Muller M,Appelman AP,van der Graaf Y,Vincken KL,Mali WP,Geerlings MI

更新日期：2011-05-01 00:00:00

abstract：:This study investigated the role of genetic and environmental influences on individual differences in brain volumes measured at 2 time points in normal elderly males from the National Heart, Lung, and Blood Institute Twin Study. The magnetic resonance imaging (MRI) scans were conducted 4 years apart on 33 monozygotic ...

journal_title：Neurobiology of aging

authors： Lessov-Schlaggar CN,Hardin J,DeCarli C,Krasnow RE,Reed T,Wolf PA,Swan GE,Carmelli D

更新日期：2012-04-01 00:00:00

abstract：:The abnormal accumulation of amyloid fibrils in the brain is pathognomonic of Alzheimer's disease. Amyloid fibrils induce significant neuroinflammation characterized by the activation of microglia and impairment of synaptic plasticity in the brain that eventually leads to cognitive decline. Chemokine fractalkine recep...

journal_title：Neurobiology of aging

authors： Wu J,Bie B,Yang H,Xu JJ,Brown DL,Naguib M

更新日期：2013-12-01 00:00:00

abstract：:Prion diseases are a diverse group of neurodegenerative conditions, caused by the templated misfolding of prion protein. Aside from the strong genetic risk conferred by multiple variants of the prion protein gene (PRNP), several other variants have been suggested to confer risk in the most common type, sporadic Creutz...

journal_title：Neurobiology of aging

authors： Lukic A,Uphill J,Brown CA,Beck J,Poulter M,Campbell T,Adamson G,Hummerich H,Whitfield J,Ponto C,Zerr I,Lloyd SE,Collinge J,Mead S

更新日期：2015-05-01 00:00:00

abstract：:Flavonoids, a group of dietary polyphenols have been shown to possess cognitive health benefits. Epidemiologic evidence suggests that they could play a role in risk reduction in dementia. Amyloid precursor protein processing and the subsequent generation of amyloid beta (Aβ) are central to the pathogenesis of Alzheime...

journal_title：Neurobiology of aging

authors： Cox CJ,Choudhry F,Peacey E,Perkinton MS,Richardson JC,Howlett DR,Lichtenthaler SF,Francis PT,Williams RJ

更新日期：2015-01-01 00:00:00

abstract：:Rats with electrolytic lesions of the medial septum or ibotenic acid lesions of the nucleus basalis magnocellularis (NBM) were tested in an order memory task for an 8-item list of varying spatial locations within an 8-arm radial maze. Results indicated that rats with small medial septal lesions resulting in small AchE...

journal_title：Neurobiology of aging

authors： Kesner RP,Crutcher KA,Measom MO

更新日期：1986-07-01 00:00:00

abstract：:In this study, the Purkinje neurons and granule neurons in the cerebellar cortex were studied in male Fischer 344 rats at 3, 9, 18, and 27 months of age. The numbers of Purkinje cells (PC) and granule cells (GC) in folia IV, VII, and X of the vermis were quantitated with the disector stereological technique. The numbe...

journal_title：Neurobiology of aging

authors： Dlugos CA,Pentney RJ

更新日期：1994-07-01 00:00:00

abstract：:Pertinent animal models of age-related learning deficiencies are required to elucidate the mechanism of age-related learning deficiencies and to develop novel therapeutic drugs for age-related diseases such as learning defects. Among many strains of accelerated senescence prone, senescence-accelerated mouse (SAM), SAM...

journal_title：Neurobiology of aging

authors： Nomura Y,Okuma Y

更新日期：1999-03-01 00:00:00

abstract：:It has been suggested that the A beta fragment of the amyloid precursor protein in Alzheimer's disease arises from internal translation initiation at Met596 (1). Here we use the recently described in vitro model of A beta production and secretion (2) to examine this hypothesis. We show that A beta is no longer detecta...

journal_title：Neurobiology of aging

authors： Citron M,Haass C,Selkoe DJ

更新日期：1993-11-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by loss of motor neurons. We have recently identified SOD1 and FUS mutations as the most common causes in a consecutive series of 111 familial ALS pedigrees in Japan. To reveal possible genetic causes for the remaining 51 pat...

journal_title：Neurobiology of aging

authors： Nishiyama A,Niihori T,Warita H,Izumi R,Akiyama T,Kato M,Suzuki N,Aoki Y,Aoki M

更新日期：2017-05-01 00:00:00

abstract：:Plaques found in the brains of patients suffering from Alzheimer's disease (AD) mainly consist of beta-amyloid (Abeta), which is produced by sequential cleaving of amyloid precursor protein (APP) by two proteolytic enzymes, beta- and gamma-secretases. Any change in the fine balance between these enzymes and their subs...

journal_title：Neurobiology of aging

authors： Zohar O,Pick CG,Cavallaro S,Chapman J,Katzav A,Milman A,Alkon DL

更新日期：2005-08-01 00:00:00

abstract：:Deletions of the mitochondrial DNA (mtDNA) have been shown to accumulate with age in a variety of species regardless of mean or maximal life span. This implies that such mutations are either a molecular biomarker of senescence or that they are more causally linked to senescence itself. One assay that can be used to de...

journal_title：Neurobiology of aging

authors： Melov S,Schneider JA,Coskun PE,Bennett DA,Wallace DC

更新日期：1999-09-01 00:00:00

abstract：:Astrocytes play a crucial role in supporting motor neurons in health and disease. However, there have been few attempts to understand how aging may influence this effect. Here, we report that rat astrocytes show an age-dependent senescence phenotype and a significant reduction in their ability to support motor neurons...

journal_title：Neurobiology of aging

authors： Das MM,Svendsen CN

更新日期：2015-02-01 00:00:00

abstract：:We have used structural equation models to explicitly distinguish functional status and therefore "dementia-relevant" variance in cognitive task performance (i.e., "δ" for dementia). Our approach is modular and can be directed to other targets. In this analysis, we construct a δ ortholog representing the "cognitive co...

journal_title：Neurobiology of aging

authors： Royall DR,Bishnoi RJ,Palmer RF

更新日期：2015-07-01 00:00:00

abstract：:Aging is accompanied by declines in memory performance, and particularly affects memories that rely on hippocampal-cortical systems, such as episodic and explicit. With aged populations significantly increasing, the need for preventing or rescuing memory deficits is pressing. However, effective treatments are lacking....

journal_title：Neurobiology of aging

authors： Steinmetz AB,Johnson SA,Iannitelli DE,Pollonini G,Alberini CM

更新日期：2016-08-01 00:00:00

abstract：:Although important in neurodegeneration, systematic studies of nicotinic acetylcholine receptor expression in normal aging human brains are difficult to perform. We have studied the expression of nicotinic receptor alpha 4-1 and alpha 5 mRNA in the frontal and parietal isocortex of 3- (young adult), 24- (late middle a...

journal_title：Neurobiology of aging

authors： Birtsch C,Wevers A,Traber J,Maelicke A,Bloch W,Schröder H

更新日期：1997-05-01 00:00:00

abstract：:The relationship between the neurofibrillary tangles and the intellectual deficit observed in senile dementia of the Alzheimer type was studied in 27 patients over the age of 75. The presence and density of tau positive tangles were assessed in six areas including limbic, paralimbic, and isocortical cortices. In the i...

journal_title：Neurobiology of aging

authors： Duyckaerts C,Bennecib M,Grignon Y,Uchihara T,He Y,Piette F,Hauw JJ

更新日期：1997-05-01 00:00:00

abstract：:The classic hallmarks of Alzheimer's disease are the deposition of amyloid in plaques and in the cerebrovasculature, and the emergence of neurofibrillary tangles in neurons. The interplay between these two pathologic processes, on the one hand, and the degeneration of neurons and loss of cognitive functions on the oth...

journal_title：Neurobiology of aging

authors： Neve RL,Boyce FM,McPhie DL,Greenan J,Oster-Granite ML

更新日期：1996-03-01 00:00:00

abstract：:Aging has been related to diminished cognitive function, which could be a result of ineffective synaptic function. We have previously shown that synaptic plasma membrane proteins supporting synaptic integrity and neurotransmission were downregulated in docosahexaenoic acid (DHA)-deprived brains, suggesting an importan...

journal_title：Neurobiology of aging

authors： Sidhu VK,Huang BX,Desai A,Kevala K,Kim HY

更新日期：2016-05-01 00:00:00

abstract：:Counts of neurons in locus coeruleus of Fisher 344 rats of ages from 12 to 32 months showed no loss with advancing age. Species comparisons of age changes in locus coeruleus neuron counts and measures of catecholamine systems suggested that the human and nonhuman primate locus coeruleus shows age changes and seen in r...

journal_title：Neurobiology of aging

authors： Goldman G,Coleman PD

更新日期：1981-04-01 00:00:00

abstract：:Decline in cognitive functions, including hippocampus-dependent spatial memory, is commonly observed at a later stage of aging (e.g., >20 months old in rodents) and typically studied after a discrete learning event. How normal aging, particularly at an early stage, affects the modulatory aspect of memory persistence i...

journal_title：Neurobiology of aging

authors： Gros A,Wang SH

更新日期：2018-07-01 00:00:00