Abstract:
:The effect of aging on acquisition of a learned suppression of photopositive tendencies was studied in 1-7-week-old flies of both sexes. Flies had to choose in a T-maze between an alley leading to a lighted vial associated with an aversive stimulus, a quinine hydrochloride solution, and another alley leading to a darkened vial free of quinine. Control groups with either no quinine or water in the lighted vial, respectively, did not learn at any age to avoid the lighted vial or had lower scores than flies trained with quinine. Flies of all ages trained with quinine learned to avoid the lighted vial and a slight decrease of the learning score was observed after the first week of age, no other effect of age being clearly observed. This study also tested whether pretraining enhanced (or impaired) learning score. Pretraining was obtained by subjecting 1-6-week-old flies to trials with a lighted vial without quinine before to subject them to trials with quinine in the lighted vial: pretraining increased learning scores to the same extent at all ages.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Le Bourg Edoi
10.1016/j.neurobiolaging.2003.12.004subject
Has Abstractpub_date
2004-10-01 00:00:00pages
1241-52issue
9eissn
0197-4580issn
1558-1497pii
S0197458004000326journal_volume
25pub_type
杂志文章abstract::We examined the interaction of brain atrophy and white matter lesions (WML) with cognitive functioning in 605 patients (mean age, 58±10; 76% men) with atherosclerotic disease from the Second Manifestations of ARTerial disease-MR substudy (SMART-MR study). Automated brain segmentation was used to quantify volumes of br...
journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/0197-4580(93)90093-q
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章,评审
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2012.04.014
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abstract::Magnetic resonance (MR)-based volume measurements of atrophy are potential markers of disease progression in patients with amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Longitudinal changes in (1)H MR spectroscopy ((1)H MRS) metabolite markers have not been characterized in MCI subjects. Our o...
journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2006.06.018
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2006.04.004
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2015.04.003
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abstract::Subcortical structural changes have been reported to occur in some elderly subjects with late age onset depression. Given the association between diseases affecting subcortical structures and affective disorders, this suggests that these structural changes may be involved in the etiology of late age onset depression i...
journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/0197-4580(91)90104-r
更新日期:1991-05-01 00:00:00
abstract::We recently reported that mutations in the valosin-containing protein (VCP) gene are a cause of 1%-2% of familial amyotrophic lateral sclerosis (ALS) cases, but their role in the pathogenesis of sporadic ALS is unclear. We undertook mutational screening of VCP in 701 sporadic ALS cases. Three pathogenic variants (p.Ar...
journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2012.04.005
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