Abstract：
:The goals were to investigate implicit learning in mild cognitive impairment (MCI), and to determine the relations of implicit learning systems to apolipoprotein E (ApoE) genotype in healthy controls. Elderly controls grouped by ApoE status (ApoE-e4 allele carriers versus ApoE-e4 allele non-carriers) and MCI patients participated in the study. Individuals in all three groups completed both contextual cueing and serial reaction time (SRT) tasks. In the former, people learn to use repeated spatial configurations to facilitate search for a target, whereas in the latter, they learn to use subtle sequence regularities to respond more quickly and accurately to a series of events. Results revealed that healthy elderly individuals carrying the ApoE-e4 allele showed contextual cueing deficits compared to those who did not carry the ApoE-e4 allele. Further, elderly controls carrying the ApoE-e4 allele revealed similar amounts of contextual cueing as the MCI group, while the non-carriers performed better. Sequence learning, by contrast, was uninfluenced by either MCI or by ApoE genotype in healthy controls. This study provides further support for the medial temporal lobe dysfunction and relative integrity of fronto-striatal systems in MCI, and indicates the influence of ApoE genotype on implicit learning even in healthy older individuals without cognitive impairment.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Negash S,Petersen LE,Geda YE,Knopman DS,Boeve BF,Smith GE,Ivnik RJ,Howard DV,Howard JH Jr,Petersen RCdoi
10.1016/j.neurobiolaging.2006.04.004subject
Has Abstractpub_date
2007-06-01 00:00:00pages
885-93issue
6eissn
0197-4580issn
1558-1497pii
S0197-4580(06)00118-7journal_volume
28pub_type
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journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
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pub_type： 临床试验,杂志文章
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更新日期：2000-01-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2009-05-01 00:00:00
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更新日期：1988-09-01 00:00:00
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pub_type： 杂志文章
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2011.09.012
更新日期：2012-05-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章,评审
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更新日期：2000-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2011.02.006
更新日期：2011-06-01 00:00:00
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journal_title：Neurobiology of aging
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更新日期：2018-02-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2006.02.007
更新日期：2007-03-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2007-12-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2012-08-01 00:00:00
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journal_title：Neurobiology of aging
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更新日期：2014-12-01 00:00:00
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journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：1990-07-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2003.04.002
更新日期：2003-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2002-07-01 00:00:00
