当前位置： SCI文献检索 > NEUROBIOLOGY OF AGING期刊下所有文献 > Apolipoprotein E epsilon4 is associated with atrophy of the amygdala in Alzheimer's disease.

Apolipoprotein E epsilon4 is associated with atrophy of the amygdala in Alzheimer's disease.

Abstract：

:Although the ApoE epsilon4 allele is well-established as the most important genetic risk factor for Alzheimer's disease (AD), the effects of this allele on regional brain atrophy in AD patients remain controversial. We performed MRI-based volumetric measurements of the hippocampus and amygdala (normalized to intracranial volume) in 32 epsilon4+ AD patients, 23 epsilon4- AD patients, and 42 cognitively normal elderly control subjects. Analysis of covariance revealed that amygdaloid volume was significantly smaller (19.2%) in ApoE epsilon4+ than epsilon4- AD patients, controlling for disease severity (F = 10.62; d.f. = 1,52; p = 0.002; ANCOVA). Alternatively, when ApoE epsilon4 dose was considered, this effect appeared to accrue from a difference between the 0epsilon4 and each of the other two AD groups, with no significant difference between the 1epsilon4 and 2epsilon4 AD groups. Hippocampal volumes and asymmetry indices for hippocampus and amygdala did not differ between epsilon4 carriers and noncarriers. These results suggest accelerated atrophy of the amygdala in AD in association with ApoE epsilon4 and provide further evidence for regionally specific effects of this allele.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Basso M,Gelernter J,Yang J,MacAvoy MG,Varma P,Bronen RA,van Dyck CH

doi

10.1016/j.neurobiolaging.2005.08.002

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

1416-24

issue

10

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(05)00224-1

journal_volume

27

pub_type

杂志文章

相关文献

NEUROBIOLOGY OF AGING文献大全
  • Effects of caloric restriction on O-GlcNAcylation, Ca(2+) signaling, and learning impairment in the hippocampus of ob/ob mice.

    abstract：:Diabetes may adversely affect cognitive function and, conversely, caloric restriction (CR) increases longevity and improves memory. To shed light on the unknown underlying mechanisms involved in these observations, we examined the effects of CR on serum metabolic parameters and hippocampal protein expression in the ob...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.05.002

    authors： Jeon BT,Heo RW,Jeong EA,Yi CO,Lee JY,Kim KE,Kim H,Roh GS

    更新日期：2016-08-01 00:00:00

  • Heterozygous TYROBP deletion (PLOSLFIN) is not a strong risk factor for cognitive impairment.

    abstract：:Biallelic loss-of-function mutations in TYROBP and TREM2 cause a rare disease that resembles early-onset frontotemporal dementia with bone lesions called polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Some PLOSL-causing variants in TREM2 have also been associated with Alzheimer's...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.12.008

    authors： Kaivola K,Jansson L,Saarentaus E,Kiviharju A,Rantalainen V,Eriksson JG,Strandberg TE,Polvikoski T,Myllykangas L,Tienari PJ

    更新日期：2018-04-01 00:00:00

  • Lack of efficacy of clonidine on memory in aged cebus monkeys.

    abstract：:Using a dosing paradigm and an automated behavioral testing procedure designed to maximize potential drug efficacy, we evaluated the ability of clonidine to improve performance of aged monkeys on a trial-specific memory task. These results indicated that neither acutely administered (0.0025-0.04 mg/kg) or subchronical...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(88)80089-7

    authors： Bartus RT,Dean RL

    更新日期：1988-07-01 00:00:00

  • The effects of aging on the frequency of nerve fibers in rhesus monkey striate cortex.

    abstract：:In the rhesus monkey primary visual cortex, there are bundles of vertically oriented myelinated axons, which mainly contain efferent fibers originating from pyramidal cells. At the level of layer 4Cbeta, the bundles are regularly arranged and the nerve fibers in them are closely packed. In order to determine if a sign...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(00)00169-x

    authors： Nielsen K,Peters A

    更新日期：2000-09-01 00:00:00

  • Comprehensive targeted next-generation sequencing in Japanese familial amyotrophic lateral sclerosis.

    abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by loss of motor neurons. We have recently identified SOD1 and FUS mutations as the most common causes in a consecutive series of 111 familial ALS pedigrees in Japan. To reveal possible genetic causes for the remaining 51 pat...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.01.004

    authors： Nishiyama A,Niihori T,Warita H,Izumi R,Akiyama T,Kato M,Suzuki N,Aoki Y,Aoki M

    更新日期：2017-05-01 00:00:00

  • Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats.

    abstract：:Mutations in fused in sarcoma (Fus) cause familial amyotrophic lateral sclerosis (ALS) and occasionally frontotemporal dementia. Here we report the establishment and characterization of a novel knockin (KI) rat model expressing a Fus point mutation (R521C) via CRISPR/Cas9. The mutant animals developed adult-onset lear...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.08.025

    authors： Zhang T,Jiang X,Xu M,Wang H,Sang X,Qin M,Bao P,Wang R,Zhang C,Lu H,Li Y,Ren J,Chang HC,Yan J,Sun Q,Xu J

    更新日期：2018-12-01 00:00:00

  • Loss of place specificity in hippocampal complex spike cells of senescent rat.

    abstract：:Firing characteristics of "place" cells in dorsal CA1 of hippocampus were recorded from 5 young (10-14 months) and 5 old (25-29 months) Fischer-344 rats. Animals were trained to obtain food reward on a radial 8-arm maze. Entry to the arms was controlled by the experimenter so that all 8-arm were visited in random sequ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(83)90034-9

    authors： Barnes CA,McNaughton BL,O'Keefe J

    更新日期：1983-07-01 00:00:00

  • Progranulin plasma levels predict the presence of GRN mutations in asymptomatic subjects and do not correlate with brain atrophy: results from the GENFI study.

    abstract：:We investigated whether progranulin plasma levels are predictors of the presence of progranulin gene (GRN) null mutations or of the development of symptoms in asymptomatic at risk members participating in the Genetic Frontotemporal Dementia Initiative, including 19 patients, 64 asymptomatic carriers, and 77 noncarrier...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.10.016

    authors： Galimberti D,Fumagalli GG,Fenoglio C,Cioffi SMG,Arighi A,Serpente M,Borroni B,Padovani A,Tagliavini F,Masellis M,Tartaglia MC,van Swieten J,Meeter L,Graff C,de Mendonça A,Bocchetta M,Rohrer JD,Scarpini E,Genetic FTD I

    更新日期：2018-02-01 00:00:00

  • Effects of age on a new animal model of tardive dyskinesia.

    abstract：:The effects of age were studied on a new animal model of tardive dyskinesia, i.e., the quantification of oral dyskinesia in rats repeatedly treated with reserpine. Adult and old rats received two injections of reserpine (0.5 or 1.0 mg/kg s.c.) or vehicle, separated by 48 h. One, 10, 25 and 40 days after the second inj...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(97)00152-8

    authors： Bergamo M,Abílio VC,Queiroz CM,Barbosa-Júnior HN,Abdanur LR,Frussa-Filho R

    更新日期：1997-11-01 00:00:00

  • Cognitive reserve moderates the association between functional network anti-correlations and memory in MCI.

    abstract：:Cognitive reserve (CR) shows protective effects on cognitive function in older adults. Here, we focused on the effects of CR at the functional network level. We assessed in patients with amnestic mild cognitive impairment (aMCI) whether higher CR moderates the association between low internetwork cross-talk on memory ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.11.013

    authors： Franzmeier N,Buerger K,Teipel S,Stern Y,Dichgans M,Ewers M,Alzheimer's Disease Neuroimaging Initiative (ADNI).

    更新日期：2017-02-01 00:00:00

  • Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis.

    abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder involving the progressive degeneration of motor neurons in the brain and spinal cord. Mitochondrial dysfunction plays a key role in ALS disease progression and has been observed in several ALS cellular and animal models. Here, we show that fibro...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2013.11.025

    authors： Allen SP,Rajan S,Duffy L,Mortiboys H,Higginbottom A,Grierson AJ,Shaw PJ

    更新日期：2014-06-01 00:00:00

  • The amyloid hypothesis: let sleeping dogmas lie?

    abstract：:The 'amyloid hypothesis' has guided research into Alzheimer's disease (AD) for more than a decade. A detailed review of the relevant data led us to conclude that some data, particularly those from transgenic mice, are inconsistent with the predictions of the amyloid hypothesis. Instead, most data are consistent with t...

    journal_title：Neurobiology of aging

    pub_type： 评论,杂志文章,评审

    doi：10.1016/s0197-4580(02)00050-7

    authors： Bishop GM,Robinson SR

    更新日期：2002-11-01 00:00:00

  • The release and uptake of excitatory amino acids in rat brain: effect of aging and oxidative stress.

    abstract：:The excitatory amino acids (EAAs) L-aspartate and L-glutamate constitute the major neurotransmitters in the mammalian brain. This study established the influence of aging and oxidative stress on the release and uptake of EAAs. The high affinity uptake of D-[3H]aspartate in synaptosomal fractions of the neostriatum, hi...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(94)90150-3

    authors： Palmer AM,Robichaud PJ,Reiter CT

    更新日期：1994-01-01 00:00:00

  • A reliable MR measurement of medial temporal lobe width from the Sunnybrook Dementia Study.

    abstract：:We studied the hippocampal angle and spatial relationships of medial temporal lobe (MTL) structures, using midbrain colliculi and inter-collicular sulcus (ICS) as landmarks, and measured MTL width on axial 3D-T1-weighted MRI at ICS level in 41 normal, aged participants. Mean hippocampal angle was 29 degrees (range 17-...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(02)00013-1

    authors： Gao FQ,Black SE,Leibovitch FS,Callen DJ,Lobaugh NJ,Szalai JP

    更新日期：2003-01-01 00:00:00

  • Clearance of the mutant androgen receptor in motoneuronal models of spinal and bulbar muscular atrophy.

    abstract：:Spinal and bulbar muscular atrophy (SBMA) is an X-linked motoneuron disease caused by an abnormal expansion of a tandem CAG repeat in exon 1 of the androgen receptor (AR) gene that results in an abnormally long polyglutamine tract (polyQ) in the AR protein. As a result, the mutant AR (ARpolyQ) misfolds, forming cytopl...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2013.05.026

    authors： Rusmini P,Crippa V,Giorgetti E,Boncoraglio A,Cristofani R,Carra S,Poletti A

    更新日期：2013-11-01 00:00:00

  • Motor function in young and aged hemiplegic rats: effects of a Ginkgo biloba extract.

    abstract：:We have previously shown beneficial effects of a Ginkgo biloba extract (EGb761-IPSEN) in accelerating functional recovery from hemiplegia induced by unilateral motor cortex ablation. Here, we report the behavioral and histological effects of various dose regimes of EGb761. In young rats (3 months), 10 mg/kg/day for 7 ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(97)00007-9

    authors： Brailowsky S,Montiel T

    更新日期：1997-03-01 00:00:00

  • Amyloid binding ligands as Alzheimer's disease therapies.

    abstract：:Extracellular senile plaques (SPs) are hallmark brain lesions of sporadic Alzheimer's disease (AD) and the likely consequence of genetic mutations that cause familial AD by increasing production of amyloidogenic amyloid-beta (Abeta). Although Abeta vaccines and inhibitors of amyloidogenic secretases are potential AD t...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章,评审

    doi：10.1016/s0197-4580(02)00121-5

    authors： Lee VM

    更新日期：2002-11-01 00:00:00

  • No vasopressin cell loss in the human hypothalamus in aging and Alzheimer's disease.

    abstract：:The total number of immunocytochemically identified vasopressin (AVP) cells was determined morphometrically in the paraventricular (PVN) and dorsolateral part of the supraoptic nucleus (dl-SON) of the human hypothalamus in 30 subjects ranging in age from 15 to 97 years, including 10 Alzheimer's disease (AD) patients. ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(95)80003-a

    authors： Van der Woude PF,Goudsmit E,Wierda M,Purba JS,Hofman MA,Bogte H,Swaab DF

    更新日期：1995-01-01 00:00:00

  • Peripheral infection and aging interact to impair hippocampal memory consolidation.

    abstract：:We report that a peripheral injection of Escherichia coli produces both anterograde and retrograde amnesia in 24 month old, but not 3 month old rats for memories that depend on the hippocampus, that is, memory of context, contextual fear, and place learning. The anterograde effect was restricted to measures of long-te...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2005.03.010

    authors： Barrientos RM,Higgins EA,Biedenkapp JC,Sprunger DB,Wright-Hardesty KJ,Watkins LR,Rudy JW,Maier SF

    更新日期：2006-05-01 00:00:00

  • Beta-Amyloid peptide25-35 depresses excitatory synaptic transmission in the rat basolateral amygdala "in vitro".

    abstract：:The effects of beta-amyloid peptide25-35 on resting membrane potential, spontaneous and evoked action potential and synaptic activity have been studied in basolateral amygdaloid complex on slices obtained from adult rats. Intracellular recordings reveal that perfusion with beta-amyloid peptide25-35 at concentrations o...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2004.05.008

    authors： Ashenafi S,Fuente A,Criado JM,Riolobos AS,Heredia M,Yajeya J

    更新日期：2005-04-01 00:00:00

  • Neuron-glia interactions underlie ALS-like axonal cytoskeletal pathology.

    abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating disorder involving loss of movement due to degeneration of motor neurons. Studies suggest that in ALS axonal dysfunction precedes the death of motor neurons. Pathologically, ALS is characterized by neurofilamentous swellings (spheroids) within the axons of motor neu...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2009.04.004

    authors： King AE,Dickson TC,Blizzard CA,Woodhouse A,Foster SS,Chung RS,Vickers JC

    更新日期：2011-03-01 00:00:00

  • Candidate gene analysis for Alzheimer's disease in adults with Down syndrome.

    abstract：:Individuals with Down syndrome (DS) overexpress many genes on chromosome 21 due to trisomy and have high risk of dementia due to the Alzheimer's disease (AD) neuropathology. However, there is a wide range of phenotypic differences (e.g., age at onset of AD, amyloid β levels) among adults with DS, suggesting the import...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.04.018

    authors： Lee JH,Lee AJ,Dang LH,Pang D,Kisselev S,Krinsky-McHale SJ,Zigman WB,Luchsinger JA,Silverman W,Tycko B,Clark LN,Schupf N

    更新日期：2017-08-01 00:00:00

  • Absence of A673T amyloid-β precursor protein variant in Alzheimer's disease and other neurological diseases.

    abstract：:The rare variant A673T in the amyloid-β precursor protein (APP) gene has been shown to reduce the risk of cognitive impairment. We genotyped the variant in 8721 Asian individuals comprising 552 with Alzheimer's disease and vascular dementia, 790 with Parkinson's disease, and 7379 controls. The A673T variant was absent...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2013.04.012

    authors： Ting SK,Chong MS,Kandiah N,Hameed S,Tan L,Au WL,Prakash KM,Pavanni R,Lee TS,Foo JN,Bei JX,Yu XQ,Liu JJ,Zhao Y,Lee WL,Tan EK

    更新日期：2013-10-01 00:00:00

  • Unbiased estimation of neuronal numbers in the human nucleus coeruleus during aging.

    abstract：:The total number of the neuromelanin-containing neurons of the nucleus coeruleus was determined by means of a newly developed unbiased stereological counting scheme and a low-cost apparative set-up. The individuals (n = 20, age from 49-98 years) included in this study were carefully examined for absence of neurologica...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(97)00034-1

    authors： Ohm TG,Busch C,Bohl J

    更新日期：1997-07-01 00:00:00

  • Cortico-striatal-thalamic network functional connectivity in hemiparkinsonism.

    abstract：:Cortico-striatal-thalamic network functional connectivity (FC) and its relationship with levodopa (L-dopa) were investigated in 69 patients with hemiparkinsonism (25 drug-naïve [n-PD] and 44 under stable/optimized dopaminergic treatment [t-PD]) and 27 controls. Relative to controls, n-PD patients showed an increased F...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.05.032

    authors： Agosta F,Caso F,Stankovic I,Inuggi A,Petrovic I,Svetel M,Kostic VS,Filippi M

    更新日期：2014-11-01 00:00:00

  • Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease.

    abstract：:Magnetic resonance (MR)-based volume measurements of atrophy are potential markers of disease progression in patients with amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Longitudinal changes in (1)H MR spectroscopy ((1)H MRS) metabolite markers have not been characterized in MCI subjects. Our o...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2006.06.018

    authors： Kantarci K,Weigand SD,Petersen RC,Boeve BF,Knopman DS,Gunter J,Reyes D,Shiung M,O'Brien PC,Smith GE,Ivnik RJ,Tangalos EG,Jack CR Jr

    更新日期：2007-09-01 00:00:00

  • Serum cholesterol, precursors and metabolites and cognitive performance in an aging population.

    abstract：:The present study investigated if a causal relation exists between serum concentrations of precursors and metabolites of cholesterol and cognitive performance in a healthy aging population. Cognitive function addressing four domains of 144 individuals (30-80 years) was tested at baseline and after 6 years of follow-up...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(02)00061-1

    authors： Teunissen CE,De Vente J,von Bergmann K,Bosma H,van Boxtel MP,De Bruijn C,Jolles J,Steinbusch HW,Lütjohann D

    更新日期：2003-01-01 00:00:00

  • Medial septal beta-amyloid 1-40 injections alter septo-hippocampal anatomy and function.

    abstract：:Degeneration of septal neurons in Alzheimer's disease (AD) results in abnormal information processing at cortical circuits and consequent brain dysfunction. The septum modulates the activity of hippocampal and cortical circuits and is crucial to the initiation and occurrence of oscillatory activities such as the hippo...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2008.05.006

    authors： Colom LV,Castañeda MT,Bañuelos C,Puras G,García-Hernández A,Hernandez S,Mounsey S,Benavidez J,Lehker C

    更新日期：2010-01-01 00:00:00

  • Distinguishing between dementia with Lewy bodies and Alzheimer's disease using metabolic patterns.

    abstract：:Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are the 2 most common causes of dementia. We compared the regional metabolism on 18F-fluorodeoxyglucose positron emission tomography (PET) among 21 control subjects and cognitively impaired patients due to DLB (N = 63) and AD (N = 38). All participants under...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2019.10.020

    authors： Ye BS,Lee S,Yoo H,Chung SJ,Lee YH,Choi Y,Lee PH,Sohn YH,Yun M

    更新日期：2020-03-01 00:00:00

  • Longitudinal assessment of default-mode brain function in aging.

    abstract：:Age-related changes in the default-mode network (DMN) have been identified in prior cross-sectional functional magnetic resonance imaging studies. Here, we investigated longitudinal change in DMN activity and connectivity. Cognitively intact participants (aged 49-79 years at baseline) were scanned twice, with a 6-year...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.03.012

    authors： Persson J,Pudas S,Nilsson LG,Nyberg L

    更新日期：2014-09-01 00:00:00