Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer's disease mouse model.

abstract：:The growth hormone (GH) response to the dopamine (DA) receptor agonist, apomorphine HCl (Apo) (0.5 mg SC) was studied in young and elderly normal subjects as well as in patients with dementia of the Alzheimer type (DAT) and controls matched for age, gender and Quetelet index. The GH response was significantly decrease...

journal_title：Neurobiology of aging

authors： Lal S,Nair NP,Thavundayil JX,Tawar V,Tesfaye Y,Dastoor D,Gauthier S,Guyda H

更新日期：1989-05-01 00:00:00

abstract：:The neurobiology of aging continues to attract scientists and techniques from the more fundamental disciplines, as witness the great strides now being made from molecular genetic approaches to Alzheimer's disease. The present report is a commentary on reviews of immune mechanisms and tissue culture methods applied to ...

journal_title：Neurobiology of aging

authors： Rogers J,Rovigatti U

更新日期：1988-09-01 00:00:00

abstract：:Data are emerging that the altered development of adrenocortical and emotional reactivity in individuals exposed perinatally to adverse events is reflected in cognitive change and that maternal care is an important determinant. However, early trauma does not cause a generalized cognitive decline at older age, but rath...

journal_title：Neurobiology of aging

authors： de Kloet ER,Oitzl MS

更新日期：2003-05-01 00:00:00

abstract：:It is well established that mitochondrial fragmentation plays a key role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial fission is mediated by dynamin-related protein 1 (Drp1), which is highly expressed in nervous system and regulated by various posttranslational modifications including phosphorylation...

journal_title：Neurobiology of aging

authors： Yan J,Liu XH,Han MZ,Wang YM,Sun XL,Yu N,Li T,Su B,Chen ZY

更新日期：2015-01-01 00:00:00

abstract：:The effects of age were studied on a new animal model of tardive dyskinesia, i.e., the quantification of oral dyskinesia in rats repeatedly treated with reserpine. Adult and old rats received two injections of reserpine (0.5 or 1.0 mg/kg s.c.) or vehicle, separated by 48 h. One, 10, 25 and 40 days after the second inj...

journal_title：Neurobiology of aging

authors： Bergamo M,Abílio VC,Queiroz CM,Barbosa-Júnior HN,Abdanur LR,Frussa-Filho R

更新日期：1997-11-01 00:00:00

abstract：:The gap between symptoms and pathology in Alzheimer's disease has been explained by the hypothetical construct of "cognitive reserve"--a set of variables including education, intelligence, and mental stimulation which putatively allow the brain to adapt to-and hence mask--underlying pathologies by maintaining cognitiv...

journal_title：Neurobiology of aging

authors： Robertson IH

更新日期：2013-01-01 00:00:00

abstract：:We conducted genetic analysis of the fused in sarcoma gene (FUS) in Chinese Han patients with essential tremor (ET) in a case-control association study. One hundred eighty unrelated patients with ET were screened for mutations in the coding region and exon-intron boundaries of FUS. Reverse transcriptase polymerase cha...

journal_title：Neurobiology of aging

authors： Zheng W,Deng X,Liang H,Song Z,Gao K,Yang Y,Deng H

更新日期：2013-08-01 00:00:00

abstract：:In the axon terminals of the locus coeruleus (LC) neurons, a high level of axonal branching was occurred in the middle-aged brain, and the increased branching was maintained in the aged brain. In the present study, we hypothesized that neurotrophic support is necessary for the morphological age-related changes seen in...

journal_title：Neurobiology of aging

authors： Matsunaga W,Shirokawa T,Isobe K

更新日期：2004-03-01 00:00:00

abstract：:In order to investigate inflammation and apoptosis in Creutzfeldt-Jakob disease (CJD) patients, we analyzed astrocytes, microglia and apoptotic neurons in brain and IL-1beta in cerebrospinal fluid (CSF). Our results showed increased numbers of astrocytes in CJD and increased numbers of microglia and apoptotic neurons ...

journal_title：Neurobiology of aging

authors： Van Everbroeck B,Dewulf E,Pals P,Lübke U,Martin JJ,Cras P

更新日期：2002-01-01 00:00:00

abstract：:The visual processing of complex motion is impaired in Alzheimer's disease (AD). However, it is unclear whether these impairments are biased toward the motion stream or part of a general disruption of global visual processing, given some reports of impaired static form processing in AD. Here, for the first time, we di...

journal_title：Neurobiology of aging

authors： Porter G,Wattam-Bell J,Bayer A,Haworth J,Braddick O,Atkinson J,Tales A

更新日期：2017-08-01 00:00:00

abstract：:The current study describes both Abeta and tau abnormalities that accumulate in the brains of aged (16-21 years), but not young (<4 years) clinically characterized cats. Diffuse plaques that were morphologically different from what is typically observed in the human brain could be detected with 4G8 (Abeta17-24) or an ...

journal_title：Neurobiology of aging

authors： Head E,Moffat K,Das P,Sarsoza F,Poon WW,Landsberg G,Cotman CW,Murphy MP

更新日期：2005-05-01 00:00:00

abstract：:Alzheimer's disease (AD) has been suggested to be a systemic disease, and signal transduction abnormalities have been reported in non-neuronal AD cells. We have previously quantified the protein kinase C (PKC) subtypes in AD and control brains using a two-site enzyme immunoassay (EIA), and have shown that type II PKC ...

journal_title：Neurobiology of aging

authors： Matsushima H,Shimohama S,Tanaka S,Taniguchi T,Hagiwara M,Hidaka H,Kimura J

更新日期：1994-11-01 00:00:00

abstract：:Striatal dopamine (DA) and metabolite (DOPAC) levels in 8-, 21-, 52- and 104-week-old C57BL mice were compared with those in 11-week-old mice, 20 days after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. DA and DOPAC concentrations expressed relative to striatal wet weight did not change with age. In c...

journal_title：Neurobiology of aging

authors： Greenwood CE,Tatton WG,Seniuk NA,Biddle FG

更新日期：1991-09-01 00:00:00

abstract：:Decreases in the activity or density of dopamine D2 receptor (D2R) have been associated with age-related changes and neurodegenerative diseases such as Parkinson's disease. There are two isoforms of the D2R, termed the D2 long receptor (D2LR) and D2 short receptor (D2SR). To study the function of these two isoforms an...

journal_title：Neurobiology of aging

authors： Fetsko LA,Xu R,Wang Y

更新日期：2005-04-01 00:00:00

abstract：:Aged rats show decrements in performance on cognitive tasks that require the use of spatial learning and memory. We used the 8-arm radial water maze (RAWM) to measure spatial learning as a function of age in young (6 months) and old (21 months) male F344 rats. Rats were placed in the RAWM in different start arms with ...

journal_title：Neurobiology of aging

authors： Shukitt-Hale B,McEwen JJ,Szprengiel A,Joseph JA

更新日期：2004-02-01 00:00:00

abstract：:In patients with Alzheimer's disease (AD), postmortem and imaging studies have revealed early and prominent reductions in cerebral serotonin 2A (5-HT(2A)) receptors. To establish if this was due to a selective disease process of the serotonin system, we investigated the cerebral 5-HT(2A) receptor and the serotonin tra...

journal_title：Neurobiology of aging

authors： Marner L,Frokjaer VG,Kalbitzer J,Lehel S,Madsen K,Baaré WF,Knudsen GM,Hasselbalch SG

更新日期：2012-03-01 00:00:00

abstract：:Results from basic and clinical studies demonstrate that stress and depression decrease neurotrophic factor expression and neurogenesis in brain, and that antidepressant treatment blocks or reverses these effects, leading to a neurotrophic hypothesis of depression. Neurotrophic factor expression and neurogenesis are a...

journal_title：Neurobiology of aging

authors： Duman RS

更新日期：2005-12-01 00:00:00

abstract：:Although neuroactive steroids exert neuroprotective actions in different experimental models of neurodegenerative diseases, including those of Alzheimer's disease (AD), their relationships with aged related physiologic and pathologic brain changes remain to be clarified. In this study the levels of pregnenolone, dehyd...

journal_title：Neurobiology of aging

authors： Caruso D,Barron AM,Brown MA,Abbiati F,Carrero P,Pike CJ,Garcia-Segura LM,Melcangi RC

更新日期：2013-04-01 00:00:00

abstract：:The substantia innominata (SI) contains the nucleus basalis of Meynert, which provides the major cholinergic innervation to the entire cortical mantel and the amygdala; degeneration of nucleus basalis neurons correlates with cognitive decline in Alzheimer's disease (AD). However, whether SI atrophy occurs in individua...

journal_title：Neurobiology of aging

authors： George S,Mufson EJ,Leurgans S,Shah RC,Ferrari C,deToledo-Morrell L

更新日期：2011-10-01 00:00:00

abstract：:Age-related cognitive decline is a major public health concern facing a large segment of the US population. To identify genetic risk factors related to cognitive decline, we used nationally representative longitudinal data from the US Health and Retirement Study to conduct genome-wide association studies with 5765 par...

journal_title：Neurobiology of aging

authors： Zhang C,Pierce BL

更新日期：2014-06-01 00:00:00

abstract：:Remembering the location of objects, an integral part of everyday life, is known to decline with advancing age and early in the course of neurodegenerative dementia. Here, we aimed to test if object-location learning and its retention could be modified by noninvasive brain stimulation. In a group of 20 elderly (mean a...

journal_title：Neurobiology of aging

authors： Flöel A,Suttorp W,Kohl O,Kürten J,Lohmann H,Breitenstein C,Knecht S

更新日期：2012-08-01 00:00:00

abstract：:Recent reports have suggested that beta-amyloid (A beta) species of variable length C-termini are differentially deposited within early and late-stage plaques and the cerebrovasculature. Specifically, longer C-terminal length A beta 42/3 fragments (i.e., A beta forms extending to residues 42 and/or 43) are thought to ...

journal_title：Neurobiology of aging

authors： Cummings BJ,Satou T,Head E,Milgram NW,Cole GM,Savage MJ,Podlisny MB,Selkoe DJ,Siman R,Greenberg BD,Cotman CW

更新日期：1996-07-01 00:00:00

abstract：:Neuropeptide Y (NPY) has been implicated in the control of reproductive and cardiovascular function. We observed an age-related decrease in the number of males copulating to ejaculation and a moderate systolic hypertension in middle-aged (16- to 17-month-old) rats. NPY content was examined in microdissected brain nucl...

journal_title：Neurobiology of aging

authors： Clark JT

更新日期：1994-03-01 00:00:00

abstract：:The effects of age and estradiol on hypothalamic content and distribution of tubulin and calmodulin were examined by radioimmunoassay in ovariectomized C57BL/6J female mice. A small (14%) increase in particulate tubulin, but not soluble tubulin, was found in the hypothalamus of reproductively senescent mice (20 months...

journal_title：Neurobiology of aging

authors： May PC,Finch CE

更新日期：1985-01-01 00:00:00

abstract：:Macrophages or activated microglia in the subretinal space are considered a hallmark of some retinal pathologies. We investigated the effects of age, pigmentation and CX(3)CR1 deficiency on the accumulation of macrophages/activated microglia in the outer retina of young and old Cx(3)cr1(gfp/gfp) (CX(3)CR1-deficient) o...

journal_title：Neurobiology of aging

authors： Chinnery HR,McLenachan S,Humphries T,Kezic JM,Chen X,Ruitenberg MJ,McMenamin PG

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:To determine the patterns of cerebral glucose metabolism in frontotemporal dementia (FTD) and semantic dementia (SD). METHODS:25 patients with mild FTD and 9 patients with mild SD as well as 15 healthy age-matched control subjects underwent 18F-FDG- positron emission tomography. Patient scans were compared w...

journal_title：Neurobiology of aging

authors： Diehl J,Grimmer T,Drzezga A,Riemenschneider M,Förstl H,Kurz A

更新日期：2004-09-01 00:00:00

abstract：:We assessed whether polymers of N-acetylglucosamine (GlcNAc) have any pathogenetic role in Alzheimer's disease (AD). First, by using specific dyes, we found deposits of polymers of GlcNAc in sporadic but not in familial AD. We found that neurons and microglia exposed to GlcNAc and uridine diphosphate (UDP)-GlcNAc are ...

journal_title：Neurobiology of aging

authors： Turano E,Busetto G,Marconi S,Guzzo F,Farinazzo A,Commisso M,Bistaffa E,Angiari S,Musumeci S,Sotgiu S,Bonetti B

更新日期：2015-05-01 00:00:00

abstract：:The goals were to investigate implicit learning in mild cognitive impairment (MCI), and to determine the relations of implicit learning systems to apolipoprotein E (ApoE) genotype in healthy controls. Elderly controls grouped by ApoE status (ApoE-e4 allele carriers versus ApoE-e4 allele non-carriers) and MCI patients ...

journal_title：Neurobiology of aging

authors： Negash S,Petersen LE,Geda YE,Knopman DS,Boeve BF,Smith GE,Ivnik RJ,Howard DV,Howard JH Jr,Petersen RC

更新日期：2007-06-01 00:00:00

abstract：:Vascular disease and Alzheimer's disease are both common disorders, in particular among elderly subjects. Therefore, it can be expected that the joint occurrence of these two disorders is not a rare phenomenon. In recent years, evidence is increasing that the two may be more closely linked than just by chance. Epidemi...

journal_title：Neurobiology of aging

authors： Breteler MM

更新日期：2000-03-01 00:00:00

abstract：:Increased mitochondrial hydrogen peroxide (H2O2) is associated with Alzheimer's disease and brain aging. Peroxiredoxin 3 (Prdx3) is the key mitochondrial antioxidant defense enzyme in detoxifying H2O2. To investigate the importance of mitochondrial H2O2 in age-associated cognitive decline, we compared cognition betwee...

journal_title：Neurobiology of aging

authors： Chen L,Na R,Ran Q

更新日期：2014-11-01 00:00:00