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Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease: a combined [11C]DASB and [18F]altanserin-PET study.

Abstract：

:In patients with Alzheimer's disease (AD), postmortem and imaging studies have revealed early and prominent reductions in cerebral serotonin 2A (5-HT(2A)) receptors. To establish if this was due to a selective disease process of the serotonin system, we investigated the cerebral 5-HT(2A) receptor and the serotonin transporter binding, the latter as a measure of serotonergic projections and neurons. Twelve patients with AD (average Mini Mental State Examination [MMSE]: 24) and 11 healthy age-matched subjects underwent positron emission tomography (PET) scanning with [(18)F]altanserin and [(11)C]N,N-Dimethyl-2-(2-amino-4-cyanopheylthio)benzylamine ([(11)C]DASB). Overall [(18)F]altanserin binding was markedly reduced in AD by 28%-39% (p = 0.02), whereas the reductions in [(11)C]DASB binding were less prominent and mostly insignificant, except for a marked reduction of 33% in mesial temporal cortex (p = .0005). No change in [(11)C]DASB binding was found in the midbrain. We conclude that the prominent reduction in neocortical 5-HT(2A) receptor binding in early AD is not caused by a primary loss of serotonergic neurons or their projections.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Marner L,Frokjaer VG,Kalbitzer J,Lehel S,Madsen K,Baaré WF,Knudsen GM,Hasselbalch SG

doi

10.1016/j.neurobiolaging.2010.03.023

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

479-87

issue

3

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(10)00155-7

journal_volume

33

pub_type

杂志文章

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