Age-related defects in short-term plasticity are reversed by acetyl-L-carnitine at the mouse calyx of Held.

abstract：:Pituitary-adrenal responsiveness to stress induced by either psychological (novelty) or physiological (ether) stimuli was examined in young (3 to 6 months) and old (24 to 27 months) male and female rats. In Experiment 1, subjects were placed in a novel environment for 3 min. Blood samples were collected at 0, 15, 30, ...

journal_title：Neurobiology of aging

authors： Brett LP,Chong GS,Coyle S,Levine S

更新日期：1983-07-01 00:00:00

abstract：:Individuals with Down syndrome (DS), caused by trisomy of chromosome 21, inevitably develop characteristic Alzheimer's disease (AD) neuropathology, including neuritic plaques, neurofibrillary tangles, and neuronal loss. Amyloid-β protein, the major component of neuritic plaques, is the proteolytic product of amyloid-β...

journal_title：Neurobiology of aging

authors： Wu Y,Deng Y,Zhang S,Luo Y,Cai F,Zhang Z,Zhou W,Li T,Song W

更新日期：2015-01-01 00:00:00

abstract：:Vascular risk factors have been implicated in the pathogenesis of vascular dementia and Alzheimer's disease. The identification of a novel vascular disease susceptibility locus at 9p21.3 has recently generated great interest. In the present study, we sought to determine whether a common genetic variant (tagged by rs13...

journal_title：Neurobiology of aging

authors： Emanuele E,Lista S,Ghidoni R,Binetti G,Cereda C,Benussi L,Maletta R,Bruni AC,Politi P

更新日期：2011-07-01 00:00:00

abstract：:A variety of studies have shown an effect of estrogen on dopamine function and suggest that estrogen may modulate central dopaminergic activity. Positron emission tomography (PET) and the dopamine metabolism tracer, [18F]6-fluoro-L-m-tyrosine (FMT) were used to evaluate dopaminergic function in the frontal cortex and ...

journal_title：Neurobiology of aging

authors： Eberling JL,Roberts JA,Taylor SE,VanBrocklin HF,O'Neil JP,Nordahl TE

更新日期：2002-05-01 00:00:00

abstract：:Longitudinal human studies suggest that as we age, sociality provides protective benefits against cognitive decline. However, little is known about the underlying neural mechanisms. Rodent studies, which are ideal for studying cognition, fail to examine the independent effects of social housing while controlling for p...

journal_title：Neurobiology of aging

authors： Templer VL,Wise TB,Heimer-McGinn VR

更新日期：2019-03-01 00:00:00

abstract：:Mutations in the profilin 1 (PFN1) gene, encoding a member of the profilin family of small actin-binding proteins, have been recently reported in patients with familial amyotrophic lateral sclerosis (ALS). In this study we aimed to determine the prevalence of PFN1 mutations by sequencing the coding region of this gene...

journal_title：Neurobiology of aging

authors： Daoud H,Dobrzeniecka S,Camu W,Meininger V,Dupré N,Dion PA,Rouleau GA

更新日期：2013-04-01 00:00:00

abstract：:Aging is accompanied by declines in memory performance, and particularly affects memories that rely on hippocampal-cortical systems, such as episodic and explicit. With aged populations significantly increasing, the need for preventing or rescuing memory deficits is pressing. However, effective treatments are lacking....

journal_title：Neurobiology of aging

authors： Steinmetz AB,Johnson SA,Iannitelli DE,Pollonini G,Alberini CM

更新日期：2016-08-01 00:00:00

abstract：:Activated microglia are instrumental to neurodegeneration in Parkinson's disease (PD). Fractalkine, as an exclusive ligand for CX3CR1 expressed on microglia, has recently been reported to be released out by neurons, and induce microglial activation as a neuron-to-glia signal in the spinal cord. However, the role of fr...

journal_title：Neurobiology of aging

authors： Shan S,Hong-Min T,Yi F,Jun-Peng G,Yue F,Yan-Hong T,Yun-Ke Y,Wen-Wei L,Xiang-Yu W,Jun M,Guo-Hua W,Ya-Ling H,Hua-Wei L,Ding-Fang C

更新日期：2011-03-01 00:00:00

abstract：:Alzheimer's disease (AD) is a late-onset and progressive neurodegenerative disorder characterized clinically by memory loss, impairment of other cognitive functions, and changes in behavior and personality. The overall aim of this review is to summarize recent advances in studies of AD progression and the use of anima...

journal_title：Neurobiology of aging

authors： Reddy PH,McWeeney S

更新日期：2006-08-01 00:00:00

abstract：:An age-related increase in stimulation-evoked fractional norepinephrine release has been demonstrated in tail artery of Fischer-344 rats from 6 to 20 months of age. Previous studies have ruled out alterations in function of uptake mechanisms, metabolism, or feedback via prejunctional alpha-2 adrenoceptors, suggesting ...

journal_title：Neurobiology of aging

authors： Tsai H,Duckles SP,Buchholz J

更新日期：1995-09-01 00:00:00

abstract：:In frontotemporal dementia (FTD), the behavioral variant (bv-FTD) and nonfluent variant of primary progressive aphasia (nfv-PPA) reflect a prominent neurodegenerative involvement of the frontal lobe networks, which may include the premotor and motor areas and thus cause heterogeneous clinical symptoms including parkin...

journal_title：Neurobiology of aging

authors： Di Stasio F,Suppa A,Fabbrini A,Marsili L,Asci F,Conte A,Trebbastoni A,De Lena C,Berardelli A

更新日期：2018-09-01 00:00:00

abstract：:Compared to young rats, old age increases susceptibility and caloric restriction decreases susceptibility for the loss of retinal ganglion cells and displaced amacrine cells following retinal ischemia/reperfusion. In retinas of old animals before ischemia, reactive gliosis, including activation of Muller cells, microg...

journal_title：Neurobiology of aging

authors： Kim KY,Ju WK,Neufeld AH

更新日期：2004-04-01 00:00:00

abstract：:The brains of 14 rhesus monkeys (Macaca mulatta) between 4 and 35 years old were examined to determine the effects of aging on the thickness, neuronal frequency, fine structure, surface area, and volume of striate cortex. The effects of aging were ascertained by comparing the striate cortex in the six monkeys between ...

journal_title：Neurobiology of aging

authors： Peters A,Nigro NJ,McNally KJ

更新日期：1997-01-01 00:00:00

abstract：:Threshold and suprathreshold sensitivities to 13 bitter compounds were determined for 16 young adults (mean age = 27.4 years) and 18 elderly persons (mean age = 81.3 years). Half of the subjects in each age group were tasters of the bitter compound phenylthiocarbamide (PTC) and half were nontasters. Both detection and...

journal_title：Neurobiology of aging

authors： Schiffman SS,Gatlin LA,Frey AE,Heiman SA,Stagner WC,Cooper DC

更新日期：1994-11-01 00:00:00

abstract：:Middle-aged and aged rats received dorsal hippocampal lesions before performance was evaluated on the radial-arm maze. The maze task contained simultaneous spatial working memory and visually cued reference memory components. Both middle-aged and aged rats that received lesions committed more errors of both types than...

journal_title：Neurobiology of aging

authors： Ward MT,Stoelzel CR,Markus EJ

更新日期：1999-07-01 00:00:00

abstract：:Older adults have altered perception of the relative timing between auditory and visual stimuli, even when stimuli are scaled to equate detectability. To help understand why, this study investigated the neural correlates of audiovisual synchrony judgments in older adults using electroencephalography (EEG). Fourteen yo...

journal_title：Neurobiology of aging

authors： Chan YM,Pianta MJ,Bode S,McKendrick AM

更新日期：2017-07-01 00:00:00

abstract：:Calmodulin (CaM) and tubulin were analyzed by radioimmunoassay in subcellular fractions prepared from cerebral cortex and striatum of aging male C57BL/6J mice. Three fractions were prepared by a new procedure: cytosol (soluble); EGTA-releasable, membrane-bound; and detergent-extractable (Triton X-100), membrane-bound ...

journal_title：Neurobiology of aging

authors： May PC,Severson JA,Osterburg HH,Finch CE

更新日期：1987-03-01 00:00:00

abstract：:The amyloid beta-peptide (A beta)-associated free radical oxidative stress model for neuronal death in Alzheimer's disease (AD) brain predicts that neuronal protein oxidation is a consequence of A beta-associated free radicals [8]. In this study we have used both in vitro and in vivo models of beta-amyloid (A beta) to...

journal_title：Neurobiology of aging

authors： Yatin SM,Varadarajan S,Link CD,Butterfield DA

更新日期：1999-05-01 00:00:00

abstract：:Abnormal interaction of beta-amyloid 42 (Abeta42) with copper, zinc and iron induce peptide aggregation and oxidation in Alzheimer's disease (AD). However, in health, Abeta degradation is mediated by extracellular metalloproteinases, neprilysin, insulin degrading enzyme (IDE) and matrix metalloproteinases. We investig...

journal_title：Neurobiology of aging

authors： Strozyk D,Launer LJ,Adlard PA,Cherny RA,Tsatsanis A,Volitakis I,Blennow K,Petrovitch H,White LR,Bush AI

更新日期：2009-07-01 00:00:00

abstract：:The number of Alzheimer's disease sufferers shows an alarming increase throughout the world. Therefore elucidation of the pathogenic mechanisms leading to Alzheimer's disease and the design of effective treatment, preventive or curative, became imperative. In the last few years several groups have found evidence indic...

journal_title：Neurobiology of aging

authors： Nagy Z

更新日期：2000-11-01 00:00:00

abstract：:Macrophages or activated microglia in the subretinal space are considered a hallmark of some retinal pathologies. We investigated the effects of age, pigmentation and CX(3)CR1 deficiency on the accumulation of macrophages/activated microglia in the outer retina of young and old Cx(3)cr1(gfp/gfp) (CX(3)CR1-deficient) o...

journal_title：Neurobiology of aging

authors： Chinnery HR,McLenachan S,Humphries T,Kezic JM,Chen X,Ruitenberg MJ,McMenamin PG

更新日期：2012-08-01 00:00:00

abstract：:Perhaps cognitive and brain imaging measures have been pushed almost as far as they can go in helping diagnose or understand AD. Their value may increase with the development of better models of the disease and the addition of new types of measurements to the armamentarium (e.g., eye-tracking, olfactory, and dermatogl...

journal_title：Neurobiology of aging

authors： Roberts E

更新日期：1988-01-01 00:00:00

abstract：:Vascular disease and Alzheimer's disease are both common disorders, in particular among elderly subjects. Therefore, it can be expected that the joint occurrence of these two disorders is not a rare phenomenon. In recent years, evidence is increasing that the two may be more closely linked than just by chance. Epidemi...

journal_title：Neurobiology of aging

authors： Breteler MM

更新日期：2000-03-01 00:00:00

abstract：:In the rhesus monkey primary visual cortex, there are bundles of vertically oriented myelinated axons, which mainly contain efferent fibers originating from pyramidal cells. At the level of layer 4Cbeta, the bundles are regularly arranged and the nerve fibers in them are closely packed. In order to determine if a sign...

journal_title：Neurobiology of aging

authors： Nielsen K,Peters A

更新日期：2000-09-01 00:00:00

abstract：:Long-term dietary supplementation with resveratrol protects against cardiovascular disease, osteoporesis, and metabolic decline. This study determined how long-term dietary resveratrol treatment protects against retinal ganglion cell (RGC) dendrite loss after optic nerve injury and alters the resolution of the unfolde...

journal_title：Neurobiology of aging

authors： Lindsey JD,Duong-Polk KX,Hammond D,Leung CK,Weinreb RN

更新日期：2015-05-01 00:00:00

abstract：:The genetic analysis of the yeast replicative life span has revealed the importance of metabolic control and resistance to stress. It has also illuminated the pivotal role in determining longevity that the RAS genes play by the maintenance of homeostasis. This role appears to be performed by the coordination of a vari...

journal_title：Neurobiology of aging

authors： Jazwinski SM

更新日期：1999-09-01 00:00:00

abstract：:There is a marked increase with advancing age of stimulation-evoked neurotransmitter release from vascular adrenergic nerves in the rat, an effect correlated with increased levels of plasma norepinephrine. This increase in norepinephrine release could not be accounted for by an alteration in neuronal and extraneuronal...

journal_title：Neurobiology of aging

authors： Buchholz J,Tsai H,Foucart S,Duckles SP

更新日期：1996-11-01 00:00:00

abstract：:In this study 5 patients with mild cognitive impairment (MCI) and 9 Alzheimer's disease (AD) patients underwent respectively 3- and 5-year follow-up positron emission tomography (PET) studies with N-methyl [(11)C] 2-(4-methylaminophenyl)-6-hydroxy-benzothiazole ((11)C-PIB) and (18)F-fluorodeoxyglucose ((18)F-FDG) to u...

journal_title：Neurobiology of aging

authors： Kadir A,Almkvist O,Forsberg A,Wall A,Engler H,Långström B,Nordberg A

更新日期：2012-01-01 00:00:00

abstract：:Vergence eye movements were recorded with the scleral search-coil system in 32 healthy subjects (ages 19-73 years) to characterize the age-related effects on the dynamic parameters of vergence responses to step (transient components) and ramp or sinusoidal targets (sustained components) under natural viewing condition...

journal_title：Neurobiology of aging

authors： Rambold H,Neumann G,Sander T,Helmchen C

更新日期：2006-01-01 00:00:00

abstract：:Aged rats show decrements in performance on cognitive tasks that require the use of spatial learning and memory. We used the 8-arm radial water maze (RAWM) to measure spatial learning as a function of age in young (6 months) and old (21 months) male F344 rats. Rats were placed in the RAWM in different start arms with ...

journal_title：Neurobiology of aging

authors： Shukitt-Hale B,McEwen JJ,Szprengiel A,Joseph JA

更新日期：2004-02-01 00:00:00